Details for: C1QA

Gene ID: 712

Symbol: C1QA

Ensembl ID: ENSG00000173372

Description: complement C1q A chain

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 216.4389
    Cell Significance Index: 570.9600
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 148.7027
    Cell Significance Index: -23.1300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 47.2117
    Cell Significance Index: -24.2900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.6949
    Cell Significance Index: -23.0500
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 11.2519
    Cell Significance Index: 46.8300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 10.6077
    Cell Significance Index: 86.5000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.9987
    Cell Significance Index: -10.9400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 4.3712
    Cell Significance Index: 67.6300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 2.7315
    Cell Significance Index: 73.0700
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.2351
    Cell Significance Index: 10.0100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1707
    Cell Significance Index: 33.8700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.1355
    Cell Significance Index: 13.8400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0798
    Cell Significance Index: 10.2300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0290
    Cell Significance Index: 8.3600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0223
    Cell Significance Index: 16.8600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0022
    Cell Significance Index: -1.6000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0033
    Cell Significance Index: -1.8400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0037
    Cell Significance Index: -2.3300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0097
    Cell Significance Index: -1.6600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0115
    Cell Significance Index: -21.6700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0164
    Cell Significance Index: -3.4600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0239
    Cell Significance Index: -36.7500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0273
    Cell Significance Index: -37.1100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0304
    Cell Significance Index: -19.3100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0312
    Cell Significance Index: -22.8700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0508
    Cell Significance Index: -23.0700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0555
    Cell Significance Index: -6.3600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0611
    Cell Significance Index: -21.9300
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0627
    Cell Significance Index: -0.6400
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0662
    Cell Significance Index: -0.8800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0711
    Cell Significance Index: -12.8100
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0971
    Cell Significance Index: -1.4200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1141
    Cell Significance Index: -5.7700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1179
    Cell Significance Index: -17.1400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1322
    Cell Significance Index: -3.5300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1426
    Cell Significance Index: -17.5400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1470
    Cell Significance Index: -29.4800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1737
    Cell Significance Index: -22.4400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1812
    Cell Significance Index: -24.8900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1898
    Cell Significance Index: -21.6700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1943
    Cell Significance Index: -9.1300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2018
    Cell Significance Index: -23.8000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2200
    Cell Significance Index: -9.0200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2304
    Cell Significance Index: -23.9900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2504
    Cell Significance Index: -19.2200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2877
    Cell Significance Index: -22.7900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3014
    Cell Significance Index: -22.4600
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.3023
    Cell Significance Index: -2.5600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3144
    Cell Significance Index: -16.3300
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.3150
    Cell Significance Index: -5.3500
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.3267
    Cell Significance Index: -2.9900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3487
    Cell Significance Index: -16.2600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3709
    Cell Significance Index: -22.8000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3791
    Cell Significance Index: -24.4600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3815
    Cell Significance Index: -25.6500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3998
    Cell Significance Index: -24.5100
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.4004
    Cell Significance Index: -3.5000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4203
    Cell Significance Index: -26.4900
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.4551
    Cell Significance Index: -4.0100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4663
    Cell Significance Index: -26.1700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4684
    Cell Significance Index: -13.0900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.5032
    Cell Significance Index: -3.0400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5327
    Cell Significance Index: -27.9700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6574
    Cell Significance Index: -29.0800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.6768
    Cell Significance Index: -23.5200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.6874
    Cell Significance Index: -18.4200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.6882
    Cell Significance Index: -16.6700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.7131
    Cell Significance Index: -10.5300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.7584
    Cell Significance Index: -27.8400
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.7599
    Cell Significance Index: -10.8900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.7679
    Cell Significance Index: -29.0800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7965
    Cell Significance Index: -23.4600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.8224
    Cell Significance Index: -15.2000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.8390
    Cell Significance Index: -24.6400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.8550
    Cell Significance Index: -24.5100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.8580
    Cell Significance Index: -14.3600
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.8620
    Cell Significance Index: -10.1400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.8862
    Cell Significance Index: -14.9100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.8974
    Cell Significance Index: -25.6100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.9044
    Cell Significance Index: -31.7800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.9050
    Cell Significance Index: -13.1400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.9112
    Cell Significance Index: -31.9200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.9386
    Cell Significance Index: -30.7300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.9390
    Cell Significance Index: -24.6900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.9520
    Cell Significance Index: -24.4700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.9540
    Cell Significance Index: -16.0700
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.9604
    Cell Significance Index: -11.8800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.9666
    Cell Significance Index: -42.0300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.9865
    Cell Significance Index: -31.4200
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.9944
    Cell Significance Index: -10.3000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -1.0109
    Cell Significance Index: -19.7300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -1.0117
    Cell Significance Index: -25.2300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.0127
    Cell Significance Index: -25.8700
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -1.0161
    Cell Significance Index: -20.6800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -1.0232
    Cell Significance Index: -26.0700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -1.0587
    Cell Significance Index: -22.6300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -1.0858
    Cell Significance Index: -27.1200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -1.0916
    Cell Significance Index: -31.4500
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -1.0962
    Cell Significance Index: -9.9100
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -1.0967
    Cell Significance Index: -15.2100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure:** C1QA is a small, globular protein consisting of 212 amino acids, with a molecular weight of approximately 20 kDa. It is the A chain of the C1q complex, which is composed of three subunits: A, B, and C. 2. **Function:** C1QA is responsible for binding to specific ligands, including antibodies, collagen, and amyloid-beta, which triggers the classical complement pathway. It also interacts with other proteins, such as C1qB and C1qr, to form the C1q complex. 3. **Expression:** C1QA is expressed in various cells, including lung macrophages, alveolar macrophages, Kupffer cells, and myeloid leukocytes. It is also present in the extracellular matrix and on the surface of cells. 4. **Regulation:** C1QA is regulated by various factors, including antibodies, complement inhibitors, and other proteins that modulate the complement cascade. **Pathways and Functions:** 1. **Classical Complement Pathway:** C1QA is the initial component of the classical complement pathway, which is triggered by the binding of antibodies to antigens. This pathway leads to the activation of downstream components, including C4 and C2, and ultimately results in the formation of the membrane attack complex (MAC). 2. **Amyloid-Binding:** C1QA interacts with amyloid-beta, a protein associated with Alzheimer's disease, to regulate its clearance and prevent its toxic effects. 3. **Collagen-Binding:** C1QA binds to collagen, a key component of the extracellular matrix, to regulate its deposition and remodeling. 4. **Immune System Regulation:** C1QA plays a role in regulating the immune system by modulating the activity of immune cells, such as macrophages and dendritic cells. **Clinical Significance:** 1. **Autoimmune Diseases:** Dysregulation of the classical complement pathway, including the C1QA component, has been implicated in various autoimmune diseases, such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). 2. **Neurodegenerative Diseases:** C1QA's interaction with amyloid-beta has been linked to neurodegenerative diseases, such as Alzheimer's disease and amyotrophic lateral sclerosis (ALS). 3. **Infectious Diseases:** The classical complement pathway, including C1QA, plays a critical role in the clearance of pathogens, such as bacteria and viruses. 4. **Cancer:** C1QA has been implicated in cancer progression and metastasis, as it regulates the activity of immune cells and the clearance of tumor cells. In conclusion, C1QA is a crucial component of the classical complement pathway, playing a pivotal role in the regulation of the immune response and the clearance of pathogens and damaged cells. Its dysregulation has been implicated in various diseases, highlighting the importance of this protein in maintaining immune homeostasis. Further research is necessary to fully understand the mechanisms of C1QA and its role in human disease.

Genular Protein ID: 3125227765

Symbol: C1QA_HUMAN

Name: Complement C1q subcomponent subunit A

UniProtKB Accession Codes:

P02745 B2R4X2 Q5T963

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 EMBL 8 EMDB 1 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 9 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 3 SASBDB 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1706597

Title: Characterization and organization of the genes encoding the A-, B- and C-chains of human complement subcomponent C1q. The complete derived amino acid sequence of human C1q.

PubMed ID: 1706597

DOI: 10.1042/bj2740481

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 486087

Title: Complete amino acid sequences of the three collagen-like regions present in subcomponent C1q of the first component of human complement.

PubMed ID: 486087

DOI: 10.1042/bj1790367

PubMed ID: 6981411

Title: Completion of the amino acid sequences of the A and B chains of subcomponent C1q of the first component of human complement.

PubMed ID: 6981411

DOI: 10.1042/bj2030559

PubMed ID: 9324355

Title: Complement receptor type 1 (CR1, CD35) is a receptor for C1q.

PubMed ID: 9324355

DOI: 10.1016/s1074-7613(00)80356-8

PubMed ID: 12847249

Title: Modular organization of the carboxyl-terminal, globular head region of human C1q A, B, and C chains.

PubMed ID: 12847249

DOI: 10.4049/jimmunol.171.2.812

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19006321

Title: Interaction of human C1q with IgG and IgM: revisited.

PubMed ID: 19006321

DOI: 10.1021/bi801131h

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 9777412

Title: Molecular basis of hereditary C1q deficiency.

PubMed ID: 9777412

DOI: 10.1016/s0171-2985(98)80033-8

PubMed ID: 23720782

Title: Collagen-binding microbial surface components recognizing adhesive matrix molecule (MSCRAMM) of Gram-positive bacteria inhibit complement activation via the classical pathway.

PubMed ID: 23720782

DOI: 10.1074/jbc.m113.454462

PubMed ID: 28325905

Title: Evidence for C1q-mediated crosslinking of CD33/LAIR-1 inhibitory immunoreceptors and biological control of CD33/LAIR-1 expression.

PubMed ID: 28325905

DOI: 10.1038/s41598-017-00290-w

PubMed ID: 29563915

Title: C1q and Mannose-Binding Lectin Interact with CR1 in the Same Region on CCP24-25 Modules.

PubMed ID: 29563915

DOI: 10.3389/fimmu.2018.00453

PubMed ID: 12960167

Title: The crystal structure of the globular head of complement protein C1q provides a basis for its versatile recognition properties.

PubMed ID: 12960167

DOI: 10.1074/jbc.m307764200

Sequence Information:

  • Length: 245
  • Mass: 26017
  • Checksum: 8FF6B6AE02D49C4C
  • Sequence:
    • MEGPRGWLVL CVLAISLASM VTEDLCRAPD GKKGEAGRPG RRGRPGLKGE QGEPGAPGIR 
TGIQGLKGDQ GEPGPSGNPG KVGYPGPSGP LGARGIPGIK GTKGSPGNIK DQPRPAFSAI 
RRNPPMGGNV VIFDTVITNQ EEPYQNHSGR FVCTVPGYYY FTFQVLSQWE ICLSIVSSSR 
GQVRRSLGFC DTTNKGLFQV VSGGMVLQLQ QGDQVWVEKD PKKGHIYQGS EADSVFSGFL 
IFPSA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.