C1QA | ENSG00000173372 | NCBI 712

Details for: C1QA

Gene ID: 712

Symbol: C1QA

Ensembl ID: ENSG00000173372

Description: complement C1q A chain

Associated with

Classical antibody-mediated complement activation
(R-HSA-173623)
Complement cascade
(R-HSA-166658)
Creation of c4 and c2 activators
(R-HSA-166786)
Immune system
(R-HSA-168256)
Initial triggering of complement
(R-HSA-166663)
Innate immune system
(R-HSA-168249)
Regulation of complement cascade
(R-HSA-977606)
Amyloid-beta binding
(GO:0001540)
Astrocyte activation
(GO:0048143)
Cell-cell signaling
(GO:0007267)
Collagen-containing extracellular matrix
(GO:0062023)
Collagen trimer
(GO:0005581)
Complement-mediated synapse pruning
(GO:0150062)
Complement activation
(GO:0006956)
Complement activation, classical pathway
(GO:0006958)
Complement component c1 complex
(GO:0005602)
Complement component c1q complex
(GO:0062167)
Extracellular region
(GO:0005576)
Innate immune response
(GO:0045087)
Microglial cell activation
(GO:0001774)
Neuron remodeling
(GO:0016322)
Postsynapse
(GO:0098794)
Protein binding
(GO:0005515)
Synapse
(GO:0045202)
Synapse organization
(GO:0050808)
Synapse pruning
(GO:0098883)
Vertebrate eye-specific patterning
(GO:0150064)

Other Information

Proteins

Complement C1q subcomponent subunit A

Genular Protein ID: 3125227765

Symbol: C1QA_HUMAN

Name: Complement C1q subcomponent subunit A

UniProtKB Accession Codes:

P02745 B2R4X2 Q5T963

Database IDs:

Citations:

PubMed ID: 1706597

Title: Characterization and organization of the genes encoding the A-, B- and C-chains of human complement subcomponent C1q. The complete derived amino acid sequence of human C1q.

PubMed ID: 1706597

DOI: 10.1042/bj2740481

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 486087

Title: Complete amino acid sequences of the three collagen-like regions present in subcomponent C1q of the first component of human complement.

PubMed ID: 486087

DOI: 10.1042/bj1790367

PubMed ID: 6981411

Title: Completion of the amino acid sequences of the A and B chains of subcomponent C1q of the first component of human complement.

PubMed ID: 6981411

DOI: 10.1042/bj2030559

PubMed ID: 9324355

Title: Complement receptor type 1 (CR1, CD35) is a receptor for C1q.

PubMed ID: 9324355

DOI: 10.1016/s1074-7613(00)80356-8

PubMed ID: 12847249

Title: Modular organization of the carboxyl-terminal, globular head region of human C1q A, B, and C chains.

PubMed ID: 12847249

DOI: 10.4049/jimmunol.171.2.812

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19006321

Title: Interaction of human C1q with IgG and IgM: revisited.

PubMed ID: 19006321

DOI: 10.1021/bi801131h

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 9777412

Title: Molecular basis of hereditary C1q deficiency.

PubMed ID: 9777412

DOI: 10.1016/s0171-2985(98)80033-8

PubMed ID: 23720782

Title: Collagen-binding microbial surface components recognizing adhesive matrix molecule (MSCRAMM) of Gram-positive bacteria inhibit complement activation via the classical pathway.

PubMed ID: 23720782

DOI: 10.1074/jbc.m113.454462

PubMed ID: 28325905

Title: Evidence for C1q-mediated crosslinking of CD33/LAIR-1 inhibitory immunoreceptors and biological control of CD33/LAIR-1 expression.

PubMed ID: 28325905

DOI: 10.1038/s41598-017-00290-w

PubMed ID: 29563915

Title: C1q and Mannose-Binding Lectin Interact with CR1 in the Same Region on CCP24-25 Modules.

PubMed ID: 29563915

DOI: 10.3389/fimmu.2018.00453

PubMed ID: 12960167

Title: The crystal structure of the globular head of complement protein C1q provides a basis for its versatile recognition properties.

PubMed ID: 12960167

DOI: 10.1074/jbc.m307764200

Sequence Information:

Length: 245
Mass: 26017
Checksum: 8FF6B6AE02D49C4C
Sequence:

MEGPRGWLVL CVLAISLASM VTEDLCRAPD GKKGEAGRPG RRGRPGLKGE QGEPGAPGIR 
TGIQGLKGDQ GEPGPSGNPG KVGYPGPSGP LGARGIPGIK GTKGSPGNIK DQPRPAFSAI 
RRNPPMGGNV VIFDTVITNQ EEPYQNHSGR FVCTVPGYYY FTFQVLSQWE ICLSIVSSSR 
GQVRRSLGFC DTTNKGLFQV VSGGMVLQLQ QGDQVWVEKD PKKGHIYQGS EADSVFSGFL 
IFPSA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: C1QA

Associated with

Other Information

Characterization and organization of the genes encoding the A-, B- and C-chains of human complement subcomponent C1q. The complete derived amino acid sequence of human C1q. PubMed ID: 1706597

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Complete amino acid sequences of the three collagen-like regions present in subcomponent C1q of the first component of human complement. PubMed ID: 486087

Completion of the amino acid sequences of the A and B chains of subcomponent C1q of the first component of human complement. PubMed ID: 6981411

Complement receptor type 1 (CR1, CD35) is a receptor for C1q. PubMed ID: 9324355

Modular organization of the carboxyl-terminal, globular head region of human C1q A, B, and C chains. PubMed ID: 12847249

Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. PubMed ID: 16335952

Interaction of human C1q with IgG and IgM: revisited. PubMed ID: 19006321

Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. PubMed ID: 19159218

Molecular basis of hereditary C1q deficiency. PubMed ID: 9777412

Collagen-binding microbial surface components recognizing adhesive matrix molecule (MSCRAMM) of Gram-positive bacteria inhibit complement activation via the classical pathway. PubMed ID: 23720782

Evidence for C1q-mediated crosslinking of CD33/LAIR-1 inhibitory immunoreceptors and biological control of CD33/LAIR-1 expression. PubMed ID: 28325905

C1q and Mannose-Binding Lectin Interact with CR1 in the Same Region on CCP24-25 Modules. PubMed ID: 29563915

The crystal structure of the globular head of complement protein C1q provides a basis for its versatile recognition properties. PubMed ID: 12960167