Details for: C1QA

Gene ID: 712

Symbol: C1QA

Ensembl ID: ENSG00000173372

Description: complement C1q A chain

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.55
    Marker Score: 4060
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 3.03
    Marker Score: 77657
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 3.01
    Marker Score: 3010.5
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 2.9
    Marker Score: 1183
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 2.42
    Marker Score: 1330
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 2.16
    Marker Score: 13139
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 2.13
    Marker Score: 5521
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 1.83
    Marker Score: 761
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.82
    Marker Score: 2203
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.81
    Marker Score: 5008
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 1.6
    Marker Score: 792.5
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.59
    Marker Score: 3834
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.57
    Marker Score: 567
  • Cell Name: macrophage (CL0000235)
    Fold Change: 1.47
    Marker Score: 1633
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168095
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.44
    Marker Score: 367
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.26
    Marker Score: 626
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.25
    Marker Score: 2377
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.24
    Marker Score: 1331.5
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.22
    Marker Score: 12089
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.16
    Marker Score: 770
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 1.08
    Marker Score: 1084
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.03
    Marker Score: 2001
  • Cell Name: basophil (CL0000767)
    Fold Change: 1
    Marker Score: 477
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71781
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48007
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.99
    Marker Score: 290
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30405
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.98
    Marker Score: 2487
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.95
    Marker Score: 820
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.94
    Marker Score: 293
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5246
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.92
    Marker Score: 1104
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2731
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.9
    Marker Score: 1822
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.89
    Marker Score: 5775
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.88
    Marker Score: 1258
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5271
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.86
    Marker Score: 1244
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.85
    Marker Score: 2237
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.83
    Marker Score: 635
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.81
    Marker Score: 464
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.81
    Marker Score: 1047
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.78
    Marker Score: 4093
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.76
    Marker Score: 201
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.76
    Marker Score: 1104
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.75
    Marker Score: 1206
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 389
  • Cell Name: colon macrophage (CL0009038)
    Fold Change: 0.75
    Marker Score: 207
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.74
    Marker Score: 1186
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.74
    Marker Score: 673
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.73
    Marker Score: 502
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.72
    Marker Score: 11589
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.61
    Marker Score: 2517
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.6
    Marker Score: 829
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.59
    Marker Score: 406
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.59
    Marker Score: 1074.5
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.59
    Marker Score: 345
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 0.58
    Marker Score: 1707
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.55
    Marker Score: 305
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.54
    Marker Score: 542
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.53
    Marker Score: 151
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.52
    Marker Score: 138
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.51
    Marker Score: 600
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.5
    Marker Score: 251
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.5
    Marker Score: 646
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.48
    Marker Score: 6434
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 0.48
    Marker Score: 143
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.47
    Marker Score: 346
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.46
    Marker Score: 184
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.46
    Marker Score: 100
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.46
    Marker Score: 264
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.45
    Marker Score: 782
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.44
    Marker Score: 437
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.44
    Marker Score: 1004
  • Cell Name: phagocyte (CL0000234)
    Fold Change: 0.44
    Marker Score: 146
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.43
    Marker Score: 156
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.43
    Marker Score: 233
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.43
    Marker Score: 201
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.43
    Marker Score: 130
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.4
    Marker Score: 152
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.4
    Marker Score: 361
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.4
    Marker Score: 230
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.39
    Marker Score: 126
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.38
    Marker Score: 364
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.38
    Marker Score: 221
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.37
    Marker Score: 224
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.36
    Marker Score: 73
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.36
    Marker Score: 218
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.35
    Marker Score: 221
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.35
    Marker Score: 987
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.35
    Marker Score: 145
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.34
    Marker Score: 216
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.33
    Marker Score: 65
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.33
    Marker Score: 408
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.33
    Marker Score: 143

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Other Information

**Key characteristics:** * C1QA is a glycoprotein composed of two identical subunits, C1QA1 and C1QA2. * It is a central component of the classical pathway, which is responsible for the activation of the complement system in response to the binding of antibodies to pathogens. * C1QA is expressed in high levels in inflammatory and immune cells, where it plays a crucial role in initiating the complement cascade. **Pathways and functions:** * C1QA binds to the terminal complement protein C1q, which is expressed on the surface of pathogens. * Upon binding, C1QA triggers the conformational changes in C1q, leading to the formation of the C1q-C1QA complex. * The C1q-C1QA complex then binds to the terminal complement protein C1r, initiating the classical pathway of complement activation. * The classical pathway leads to the formation of anaphylatoxins, which are potent inflammatory mediators that can recruit immune cells to the site of infection. **Clinical significance:** * Mutations in the C1QA gene have been linked to several autoimmune diseases, including systemic sclerosis, rheumatoid arthritis, and inflammatory bowel disease. * C1QA is a potential therapeutic target for these diseases, as blocking its activity can inhibit complement activation and reduce inflammation. * In recent years, there has been growing interest in the role of the complement system in brain function and neurodegenerative diseases. * C1QA is expressed in neurons and microglia, cells that are involved in synaptic plasticity and pruning. * Dysfunction of the complement system has been linked to cognitive disorders and neurodegenerative diseases, suggesting that targeting the complement system could be a novel therapeutic approach for these conditions.

Genular Protein ID: 3125227765

Symbol: C1QA_HUMAN

Name: Complement C1q subcomponent subunit A

UniProtKB Accession Codes:

P02745 B2R4X2 Q5T963

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 EMBL 8 EMDB 1 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 9 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 3 SAM 1 SASBDB 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1706597

Title: Characterization and organization of the genes encoding the A-, B- and C-chains of human complement subcomponent C1q. The complete derived amino acid sequence of human C1q.

PubMed ID: 1706597

DOI: 10.1042/bj2740481

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 486087

Title: Complete amino acid sequences of the three collagen-like regions present in subcomponent C1q of the first component of human complement.

PubMed ID: 486087

DOI: 10.1042/bj1790367

PubMed ID: 6981411

Title: Completion of the amino acid sequences of the A and B chains of subcomponent C1q of the first component of human complement.

PubMed ID: 6981411

DOI: 10.1042/bj2030559

PubMed ID: 9324355

Title: Complement receptor type 1 (CR1, CD35) is a receptor for C1q.

PubMed ID: 9324355

DOI: 10.1016/s1074-7613(00)80356-8

PubMed ID: 12847249

Title: Modular organization of the carboxyl-terminal, globular head region of human C1q A, B, and C chains.

PubMed ID: 12847249

DOI: 10.4049/jimmunol.171.2.812

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19006321

Title: Interaction of human C1q with IgG and IgM: revisited.

PubMed ID: 19006321

DOI: 10.1021/bi801131h

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 9777412

Title: Molecular basis of hereditary C1q deficiency.

PubMed ID: 9777412

DOI: 10.1016/s0171-2985(98)80033-8

PubMed ID: 23720782

Title: Collagen-binding microbial surface components recognizing adhesive matrix molecule (MSCRAMM) of Gram-positive bacteria inhibit complement activation via the classical pathway.

PubMed ID: 23720782

DOI: 10.1074/jbc.m113.454462

PubMed ID: 28325905

Title: Evidence for C1q-mediated crosslinking of CD33/LAIR-1 inhibitory immunoreceptors and biological control of CD33/LAIR-1 expression.

PubMed ID: 28325905

DOI: 10.1038/s41598-017-00290-w

PubMed ID: 29563915

Title: C1q and Mannose-Binding Lectin Interact with CR1 in the Same Region on CCP24-25 Modules.

PubMed ID: 29563915

DOI: 10.3389/fimmu.2018.00453

PubMed ID: 12960167

Title: The crystal structure of the globular head of complement protein C1q provides a basis for its versatile recognition properties.

PubMed ID: 12960167

DOI: 10.1074/jbc.m307764200

Sequence Information:

  • Length: 245
  • Mass: 26017
  • Checksum: 8FF6B6AE02D49C4C
  • Sequence:
    • MEGPRGWLVL CVLAISLASM VTEDLCRAPD GKKGEAGRPG RRGRPGLKGE QGEPGAPGIR 
TGIQGLKGDQ GEPGPSGNPG KVGYPGPSGP LGARGIPGIK GTKGSPGNIK DQPRPAFSAI 
RRNPPMGGNV VIFDTVITNQ EEPYQNHSGR FVCTVPGYYY FTFQVLSQWE ICLSIVSSSR 
GQVRRSLGFC DTTNKGLFQV VSGGMVLQLQ QGDQVWVEKD PKKGHIYQGS EADSVFSGFL 
IFPSA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.