Details for: C1QB

Gene ID: 713

Symbol: C1QB

Ensembl ID: ENSG00000173369

Description: complement C1q B chain

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 219.0830
    Cell Significance Index: 577.9300
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 129.9301
    Cell Significance Index: -20.2100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 62.0467
    Cell Significance Index: -25.5600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 41.1559
    Cell Significance Index: -21.1700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 16.3834
    Cell Significance Index: -20.2000
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 11.9919
    Cell Significance Index: 49.9100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 8.8946
    Cell Significance Index: 72.5300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 5.3931
    Cell Significance Index: 83.4400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 2.6877
    Cell Significance Index: 71.9000
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.0654
    Cell Significance Index: 8.6300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1935
    Cell Significance Index: 38.4000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.1267
    Cell Significance Index: 12.9400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0394
    Cell Significance Index: 24.5800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0210
    Cell Significance Index: 15.9000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0016
    Cell Significance Index: -1.1800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0026
    Cell Significance Index: -0.5400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0089
    Cell Significance Index: -5.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0095
    Cell Significance Index: -17.9800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0194
    Cell Significance Index: -35.8000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0229
    Cell Significance Index: -35.2900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0245
    Cell Significance Index: -7.0500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0276
    Cell Significance Index: -17.5300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0310
    Cell Significance Index: -5.3000
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0324
    Cell Significance Index: -0.4300
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0382
    Cell Significance Index: -0.3900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0454
    Cell Significance Index: -20.6300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0463
    Cell Significance Index: -16.5900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0529
    Cell Significance Index: -9.5300
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0841
    Cell Significance Index: -1.2300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0973
    Cell Significance Index: -19.5200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1128
    Cell Significance Index: -5.7000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1197
    Cell Significance Index: -14.7200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1289
    Cell Significance Index: -18.7300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1449
    Cell Significance Index: -18.7200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1565
    Cell Significance Index: -20.0600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1572
    Cell Significance Index: -17.9400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1716
    Cell Significance Index: -23.5700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1729
    Cell Significance Index: -8.1300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1753
    Cell Significance Index: -20.6700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1979
    Cell Significance Index: -20.6100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2164
    Cell Significance Index: -24.7900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2369
    Cell Significance Index: -14.5600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2397
    Cell Significance Index: -9.8200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2477
    Cell Significance Index: -19.0100
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.2480
    Cell Significance Index: -2.2700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2541
    Cell Significance Index: -18.9400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2574
    Cell Significance Index: -20.3900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2683
    Cell Significance Index: -12.5100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2707
    Cell Significance Index: -14.0600
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.2711
    Cell Significance Index: -2.3700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2730
    Cell Significance Index: -7.6300
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.2798
    Cell Significance Index: -2.3700
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2876
    Cell Significance Index: -4.8900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3145
    Cell Significance Index: -19.8200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3180
    Cell Significance Index: -21.3800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3236
    Cell Significance Index: -8.6400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3340
    Cell Significance Index: -21.5500
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.3382
    Cell Significance Index: -2.9800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3494
    Cell Significance Index: -21.4200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4256
    Cell Significance Index: -23.8800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.4717
    Cell Significance Index: -21.3800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4977
    Cell Significance Index: -26.1300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.5337
    Cell Significance Index: -14.3000
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.5368
    Cell Significance Index: -6.6400
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.5378
    Cell Significance Index: -6.4600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5953
    Cell Significance Index: -20.6900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6137
    Cell Significance Index: -21.5000
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: -0.6295
    Cell Significance Index: -6.8800
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.6408
    Cell Significance Index: -9.1800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6601
    Cell Significance Index: -24.2300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6648
    Cell Significance Index: -21.7700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.6676
    Cell Significance Index: -16.1700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6807
    Cell Significance Index: -21.6800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6831
    Cell Significance Index: -20.1200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.7039
    Cell Significance Index: -10.3900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.7228
    Cell Significance Index: -20.7200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.7411
    Cell Significance Index: -21.1500
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: -0.7446
    Cell Significance Index: -5.4000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.7450
    Cell Significance Index: -21.8800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.7666
    Cell Significance Index: -11.1300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.7710
    Cell Significance Index: -14.2500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.7820
    Cell Significance Index: -20.1000
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.8156
    Cell Significance Index: -9.5900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.8180
    Cell Significance Index: -13.6900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.8207
    Cell Significance Index: -21.5800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.8244
    Cell Significance Index: -28.9700
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.8471
    Cell Significance Index: -17.2400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.8484
    Cell Significance Index: -21.6800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.8509
    Cell Significance Index: -21.2200
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.8651
    Cell Significance Index: -22.0400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.8777
    Cell Significance Index: -14.7900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.8876
    Cell Significance Index: -22.1400
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.8979
    Cell Significance Index: -9.3000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.9145
    Cell Significance Index: -22.8600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.9165
    Cell Significance Index: -21.9800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.9394
    Cell Significance Index: -20.5700
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.9535
    Cell Significance Index: -8.6200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.9675
    Cell Significance Index: -20.6800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.9822
    Cell Significance Index: -20.5000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.9866
    Cell Significance Index: -42.9000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure:** The C1QB gene encodes a single-chain variable region (SCV) of the B subunit of the C1q complex, which is composed of three heavy chains (α, β, and γ) and three light chains (β, β, and β). 2. **Function:** The C1QB protein is a key component of the C1q complex, which recognizes and binds to antibody-coated pathogens, marking them for destruction. This process is crucial for eliminating pathogens and preventing tissue damage. 3. **Expression:** The C1QB gene is widely expressed in various cell types, including lung macrophages, Kupffer cells, alveolar macrophages, eurydendroid cells, Hofbauer cells, mature microglial cells, capillary endothelial cells, CD1c-positive myeloid dendritic cells, and central nervous system macrophages. 4. **Regulation:** The C1QB gene is subject to various regulatory mechanisms, including transcriptional and post-transcriptional control, which ensures its proper expression and function in different cell types and immune responses. **Pathways and Functions:** 1. **Classical Complement Activation:** The C1QB protein participates in the classical pathway of complement activation, which is triggered by the binding of C1q to antibody-coated pathogens. This pathway leads to the formation of the C3 convertase, which cleaves C3 and activates the complement cascade. 2. **Immune System Regulation:** The C1QB protein plays a critical role in regulating the immune response by modulating the activity of various immune cells, including macrophages, dendritic cells, and endothelial cells. 3. **Innate Immunity:** The C1QB gene is involved in the innate immune response, which provides the first line of defense against pathogens. The C1QB protein helps to eliminate pathogens and prevent tissue damage by activating the complement cascade and modulating the activity of immune cells. 4. **Tissue Homeostasis:** The C1QB gene is also involved in maintaining tissue homeostasis by regulating the activity of immune cells and preventing excessive inflammation. **Clinical Significance:** Dysregulation of the C1QB gene has been implicated in various diseases, including: 1. **Autoimmune Disorders:** Mutations in the C1QB gene have been associated with autoimmune disorders, such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). 2. **Inflammatory Diseases:** Dysregulation of the C1QB gene has been linked to inflammatory diseases, such as atherosclerosis and multiple sclerosis. 3. **Cancer:** The C1QB gene has been implicated in cancer progression, as it helps to regulate the activity of immune cells and prevent tumor growth. In conclusion, the C1QB gene plays a critical role in the innate immune system by participating in the classical pathway of complement activation and regulating the activity of immune cells. Dysregulation of this gene has been implicated in various diseases, highlighting the importance of understanding its functions and mechanisms of regulation.

Genular Protein ID: 1102049999

Symbol: C1QB_HUMAN

Name: Complement C1q subcomponent subunit B

UniProtKB Accession Codes:

P02746 Q5T959 Q96H17

Database IDs:

AGR 1 AlphaFoldDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CORUM 1 CPTAC 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 9 EMBL 4 EMDB 1 EvolutionaryTrace 1 GO 12 Gene3D 1 GeneCards 1 GenomeRNAi 1 HGNC 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 9 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 2 SASBDB 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3000358

Title: Molecular cloning and characterization of the complementary DNA and gene coding for the B-chain of subcomponent C1q of the human complement system.

PubMed ID: 3000358

DOI: 10.1042/bj2310729

PubMed ID: 708376

Title: Amino acid sequence of the N-terminal 108 amino acid residues of the B chain of subcomponent C1q of the first component of human complement.

PubMed ID: 708376

DOI: 10.1042/bj1730863

PubMed ID: 486087

Title: Complete amino acid sequences of the three collagen-like regions present in subcomponent C1q of the first component of human complement.

PubMed ID: 486087

DOI: 10.1042/bj1790367

PubMed ID: 6981411

Title: Completion of the amino acid sequences of the A and B chains of subcomponent C1q of the first component of human complement.

PubMed ID: 6981411

DOI: 10.1042/bj2030559

PubMed ID: 6208566

Title: Cloning and characterization of the complementary DNA for the B chain of normal human serum C1q.

PubMed ID: 6208566

DOI: 10.1098/rstb.1984.0095

PubMed ID: 12847249

Title: Modular organization of the carboxyl-terminal, globular head region of human C1q A, B, and C chains.

PubMed ID: 12847249

DOI: 10.4049/jimmunol.171.2.812

PubMed ID: 19006321

Title: Interaction of human C1q with IgG and IgM: revisited.

PubMed ID: 19006321

DOI: 10.1021/bi801131h

PubMed ID: 6286235

Title: Comparable content of hydroxylysine-linked glycosides in subcomponents C1q of the first component of human, bovine and mouse complement.

PubMed ID: 6286235

DOI: 10.1016/s0174-173x(81)80015-5

PubMed ID: 12960167

Title: The crystal structure of the globular head of complement protein C1q provides a basis for its versatile recognition properties.

PubMed ID: 12960167

DOI: 10.1074/jbc.m307764200

PubMed ID: 9777412

Title: Molecular basis of hereditary C1q deficiency.

PubMed ID: 9777412

DOI: 10.1016/s0171-2985(98)80033-8

PubMed ID: 9476130

Title: Molecular basis of a new type of C1q-deficiency associated with a non-functional low molecular weight (LMW) C1q: parallels and differences to other known genetic C1q-defects.

PubMed ID: 9476130

DOI: 10.1016/s0162-3109(97)00065-9

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 253
  • Mass: 26722
  • Checksum: D80C753C0D430EDC
  • Sequence:
    • MMMKIPWGSI PVLMLLLLLG LIDISQAQLS CTGPPAIPGI PGIPGTPGPD GQPGTPGIKG 
EKGLPGLAGD HGEFGEKGDP GIPGNPGKVG PKGPMGPKGG PGAPGAPGPK GESGDYKATQ 
KIAFSATRTI NVPLRRDQTI RFDHVITNMN NNYEPRSGKF TCKVPGLYYF TYHASSRGNL 
CVNLMRGRER AQKVVTFCDY AYNTFQVTTG GMVLKLEQGE NVFLQATDKN SLLGMEGANS 
IFSGFLLFPD MEA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.