Details for: C1QC

Gene ID: 714

Symbol: C1QC

Ensembl ID: ENSG00000159189

Description: complement C1q C chain

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 154.0704
    Cell Significance Index: 406.4300
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 118.4864
    Cell Significance Index: -18.4300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 43.6546
    Cell Significance Index: -17.7400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 40.2226
    Cell Significance Index: -18.9900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 14.9397
    Cell Significance Index: -18.4200
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 10.7185
    Cell Significance Index: 44.6100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 4.9685
    Cell Significance Index: 76.8700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 3.1416
    Cell Significance Index: 84.0400
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.2790
    Cell Significance Index: 10.3600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.8548
    Cell Significance Index: 6.9700
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.1653
    Cell Significance Index: 1.7700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.1411
    Cell Significance Index: 14.4100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0639
    Cell Significance Index: 12.6900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0435
    Cell Significance Index: 27.1500
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.0068
    Cell Significance Index: 0.1000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0013
    Cell Significance Index: -0.9700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0022
    Cell Significance Index: -0.4700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0030
    Cell Significance Index: -2.2400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0089
    Cell Significance Index: -5.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0089
    Cell Significance Index: -16.8500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0171
    Cell Significance Index: -31.5100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0205
    Cell Significance Index: -31.5100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0232
    Cell Significance Index: -31.5100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0234
    Cell Significance Index: -14.8400
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0245
    Cell Significance Index: -0.2500
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0301
    Cell Significance Index: -0.4000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0381
    Cell Significance Index: -6.5100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0383
    Cell Significance Index: -11.0100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0412
    Cell Significance Index: -14.7800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0418
    Cell Significance Index: -18.9600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0691
    Cell Significance Index: -12.4500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0857
    Cell Significance Index: -12.4600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0917
    Cell Significance Index: -18.4000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0991
    Cell Significance Index: -5.0100
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.1180
    Cell Significance Index: -1.0800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1288
    Cell Significance Index: -15.8400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1293
    Cell Significance Index: -16.7000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1296
    Cell Significance Index: -16.6100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1331
    Cell Significance Index: -15.1900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1457
    Cell Significance Index: -5.9700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1494
    Cell Significance Index: -7.0200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1520
    Cell Significance Index: -17.9200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1525
    Cell Significance Index: -20.9400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1807
    Cell Significance Index: -18.8200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1912
    Cell Significance Index: -9.9300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1913
    Cell Significance Index: -21.9200
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.1946
    Cell Significance Index: -1.6500
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1964
    Cell Significance Index: -1.7300
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.2139
    Cell Significance Index: -1.8700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2187
    Cell Significance Index: -17.3200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2190
    Cell Significance Index: -16.8100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2294
    Cell Significance Index: -17.1000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2302
    Cell Significance Index: -14.1500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2378
    Cell Significance Index: -6.3500
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2385
    Cell Significance Index: -4.0500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2598
    Cell Significance Index: -7.2600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2809
    Cell Significance Index: -18.8900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2954
    Cell Significance Index: -19.0600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2983
    Cell Significance Index: -15.5400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3089
    Cell Significance Index: -19.4700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3318
    Cell Significance Index: -20.3400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3790
    Cell Significance Index: -17.6700
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.3924
    Cell Significance Index: -4.7100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3929
    Cell Significance Index: -22.0500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4031
    Cell Significance Index: -10.8000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4358
    Cell Significance Index: -22.8800
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.4899
    Cell Significance Index: -6.0600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5410
    Cell Significance Index: -23.9300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5466
    Cell Significance Index: -19.1500
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.5534
    Cell Significance Index: -5.7300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5660
    Cell Significance Index: -18.1300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5707
    Cell Significance Index: -20.9500
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.5834
    Cell Significance Index: -8.3600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5988
    Cell Significance Index: -19.6100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6009
    Cell Significance Index: -17.7000
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: -0.6089
    Cell Significance Index: -6.6500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6261
    Cell Significance Index: -23.7100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.6378
    Cell Significance Index: -15.4500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6429
    Cell Significance Index: -18.4300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6493
    Cell Significance Index: -20.6800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.6498
    Cell Significance Index: -12.0100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.6517
    Cell Significance Index: -19.1400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.6567
    Cell Significance Index: -18.7400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.6660
    Cell Significance Index: -9.8300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6882
    Cell Significance Index: -17.6900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.6936
    Cell Significance Index: -30.1600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.6964
    Cell Significance Index: -24.4700
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.7218
    Cell Significance Index: -10.4800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.7218
    Cell Significance Index: -18.9800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.7256
    Cell Significance Index: -18.1000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.7418
    Cell Significance Index: -12.4200
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.7491
    Cell Significance Index: -12.8700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.7502
    Cell Significance Index: -19.1700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.7807
    Cell Significance Index: -19.8900
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.7898
    Cell Significance Index: -7.1400
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.8035
    Cell Significance Index: -16.3500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.8104
    Cell Significance Index: -13.6300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.8142
    Cell Significance Index: -20.3100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.8195
    Cell Significance Index: -13.8100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.8206
    Cell Significance Index: -17.5400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The C1QC gene is a single-exon gene that codes for a 216-amino acid protein. The protein is a subunit of the C1q complex, which is composed of three subunits (C1qA, C1qB, and C1qC). The C1q complex recognizes and binds to specific ligands, such as antibodies and pathogens, triggering the classical complement activation pathway. The C1QC subunit is essential for the formation of the C1q complex and the subsequent activation of the complement cascade. **Pathways and Functions:** The C1QC gene is involved in several key pathways, including: 1. **Classical Complement Activation Pathway:** The C1QC gene is a critical component of the classical complement activation pathway, which is triggered by the recognition of pathogens or foreign particles by the C1q complex. 2. **Immune Response:** The C1QC gene is significantly expressed in immune cells, including macrophages and dendritic cells, which are essential for the recognition and phagocytosis of pathogens. 3. **Innate Immunity:** The C1QC gene plays a role in the innate immune response, which provides the first line of defense against pathogens. 4. **Extracellular Matrix:** The C1QC gene is also involved in the regulation of the extracellular matrix, particularly in the context of collagen trimer formation. **Clinical Significance:** Dysregulation of the C1QC gene has been implicated in several diseases, including: 1. **Autoimmune Disorders:** The C1QC gene has been linked to autoimmune disorders, such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). 2. **Inflammatory Conditions:** The C1QC gene has been implicated in inflammatory conditions, such as atherosclerosis and cancer. 3. **Neurological Disorders:** The C1QC gene has been linked to neurological disorders, such as Alzheimer's disease and multiple sclerosis. In conclusion, the C1QC gene plays a crucial role in the classical complement activation pathway and is significantly expressed in immune cells. Dysregulation of the C1QC gene has been implicated in several diseases, highlighting the importance of this gene in maintaining immune homeostasis and preventing disease. Further research is needed to fully understand the mechanisms by which the C1QC gene regulates the complement cascade and to explore its potential as a therapeutic target for the treatment of autoimmune and inflammatory disorders.

Genular Protein ID: 4214348737

Symbol: C1QC_HUMAN

Name: Complement C1q subcomponent subunit C

UniProtKB Accession Codes:

P02747 Q7Z502 Q96DL2 Q96H05

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CPTAC 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 10 EMBL 4 EMDB 1 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 9 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 3 SASBDB 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1706597

Title: Characterization and organization of the genes encoding the A-, B- and C-chains of human complement subcomponent C1q. The complete derived amino acid sequence of human C1q.

PubMed ID: 1706597

DOI: 10.1042/bj2740481

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 486087

Title: Complete amino acid sequences of the three collagen-like regions present in subcomponent C1q of the first component of human complement.

PubMed ID: 486087

DOI: 10.1042/bj1790367

PubMed ID: 12847249

Title: Modular organization of the carboxyl-terminal, globular head region of human C1q A, B, and C chains.

PubMed ID: 12847249

DOI: 10.4049/jimmunol.171.2.812

PubMed ID: 19006321

Title: Interaction of human C1q with IgG and IgM: revisited.

PubMed ID: 19006321

DOI: 10.1021/bi801131h

PubMed ID: 12960167

Title: The crystal structure of the globular head of complement protein C1q provides a basis for its versatile recognition properties.

PubMed ID: 12960167

DOI: 10.1074/jbc.m307764200

PubMed ID: 9777412

Title: Molecular basis of hereditary C1q deficiency.

PubMed ID: 9777412

DOI: 10.1016/s0171-2985(98)80033-8

PubMed ID: 8630118

Title: Homozygous hereditary C1q deficiency and systemic lupus erythematosus. A new family and the molecular basis of C1q deficiency in three families.

PubMed ID: 8630118

DOI: 10.1002/art.1780390419

Sequence Information:

  • Length: 245
  • Mass: 25774
  • Checksum: FA17117EB7ABFC12
  • Sequence:
    • MDVGPSSLPH LGLKLLLLLL LLPLRGQANT GCYGIPGMPG LPGAPGKDGY DGLPGPKGEP 
GIPAIPGIRG PKGQKGEPGL PGHPGKNGPM GPPGMPGVPG PMGIPGEPGE EGRYKQKFQS 
VFTVTRQTHQ PPAPNSLIRF NAVLTNPQGD YDTSTGKFTC KVPGLYYFVY HASHTANLCV 
LLYRSGVKVV TFCGHTSKTN QVNSGGVLLR LQVGEEVWLA VNDYYDMVGI QGSDSVFSGF 
LLFPD

Genular Protein ID: 2315305355

Symbol: A0A8Q3SIZ0_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A8Q3SIZ0

Database IDs:

CTD 1 DisGeNET 1 EMBL 1 Ensembl 3 Gene3D 1 GeneTree 1 HGNC 1 InterPro 3 NCBI Taxonomy 1 PANTHER 2 PRINTS 1 PROSITE 2 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 156
  • Mass: 16994
  • Checksum: 01E42D3509B7278C
  • Sequence:
    • MGPPGMPGVP GPMGIPGEPG EEGRYKQKFQ SVFTVTRQTH QPPAPNSLIR FNAVLTNPQG 
DYDTSTGKFT CKVPGLYYFV YHASHTANLC VLLYRSGVKV VTFCGHTSKT NQVNSGGVLL 
RLQVGEEVWL AVNDYYDMVG IQGSDSVFSG FLLFPD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.