Details for: C1QC

Gene ID: 714

Symbol: C1QC

Ensembl ID: ENSG00000159189

Description: complement C1q C chain

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 4.22
    Marker Score: 4217
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.27
    Marker Score: 3740
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 3.06
    Marker Score: 1251
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.9
    Marker Score: 74176
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 2.42
    Marker Score: 1333
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 2.16
    Marker Score: 781
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 2.1
    Marker Score: 12752
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 2.03
    Marker Score: 1009
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.95
    Marker Score: 5042
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 1.87
    Marker Score: 778
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.46
    Marker Score: 1758
  • Cell Name: macrophage (CL0000235)
    Fold Change: 1.39
    Marker Score: 1548
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.21
    Marker Score: 803
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 1.2
    Marker Score: 591
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.17
    Marker Score: 1256
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.1
    Marker Score: 3032
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.06
    Marker Score: 1939
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.03
    Marker Score: 786
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71798
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48023
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.98
    Marker Score: 9698
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.97
    Marker Score: 1974
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5283
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2732
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.89
    Marker Score: 227
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5278
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.83
    Marker Score: 829
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1263
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.76
    Marker Score: 236
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 390
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.75
    Marker Score: 1197
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.74
    Marker Score: 678
  • Cell Name: colon macrophage (CL0009038)
    Fold Change: 0.72
    Marker Score: 200
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.71
    Marker Score: 406
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.65
    Marker Score: 2502
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.63
    Marker Score: 314
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.61
    Marker Score: 792
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.54
    Marker Score: 1313
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.54
    Marker Score: 488
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.5
    Marker Score: 133
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.5
    Marker Score: 1267
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.49
    Marker Score: 360
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.49
    Marker Score: 338
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.48
    Marker Score: 919
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.45
    Marker Score: 284
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.44
    Marker Score: 643
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.44
    Marker Score: 862
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.43
    Marker Score: 127
  • Cell Name: basophil (CL0000767)
    Fold Change: 0.43
    Marker Score: 204
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.43
    Marker Score: 2792
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.42
    Marker Score: 135
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.41
    Marker Score: 355
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.41
    Marker Score: 218
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.4
    Marker Score: 572
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 0.39
    Marker Score: 118
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.37
    Marker Score: 601
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.37
    Marker Score: 1151
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.37
    Marker Score: 215
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.37
    Marker Score: 482
  • Cell Name: phagocyte (CL0000234)
    Fold Change: 0.37
    Marker Score: 121
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.36
    Marker Score: 249
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.34
    Marker Score: 903
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.33
    Marker Score: 1721
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.32
    Marker Score: 201
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.32
    Marker Score: 547
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.31
    Marker Score: 121
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.31
    Marker Score: 134
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.3
    Marker Score: 441
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.29
    Marker Score: 296
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.29
    Marker Score: 279
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.29
    Marker Score: 349
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.29
    Marker Score: 256.5
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.28
    Marker Score: 4533
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.28
    Marker Score: 116
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.28
    Marker Score: 169
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.27
    Marker Score: 307
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.27
    Marker Score: 162
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.27
    Marker Score: 261
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.27
    Marker Score: 452
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.26
    Marker Score: 4123
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.26
    Marker Score: 190
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.26
    Marker Score: 152
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 89
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.26
    Marker Score: 160
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.26
    Marker Score: 1065
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.25
    Marker Score: 106.5
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 0.25
    Marker Score: 115
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.25
    Marker Score: 66
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.25
    Marker Score: 49
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 0.25
    Marker Score: 728
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.25
    Marker Score: 291
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.25
    Marker Score: 50
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.25
    Marker Score: 136
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.24
    Marker Score: 336
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.24
    Marker Score: 69
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.24
    Marker Score: 171

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** - C1QC is a protein of the immunoglobulin superfamily. - It is a transmembrane protein with a molecular weight of approximately 120 kDa. - It is expressed in a cell surface membrane. - It is a key regulator of the classical pathway of the complement system. **Pathways and functions:** - C1QC is involved in the classical antibody-mediated complement activation pathway. - It is a central component of the classical pathway, which is activated by antibodies binding to antigens. - Upon activation, C1QC forms the C1q complex, which is a central intermediate in the pathway. - The C1q complex mediates the conversion of C1r and C1s to C1q and C1s, respectively. - These cleaved fragments of C1r and C1s then bind to C2, initiating the complement cascade. **Clinical significance:** - Mutations in the C1QC gene have been linked to several human diseases, including recurrent infections, autoimmune disorders, and cancer. - C1QC is a potential therapeutic target for diseases characterized by complement overactivity, such as sepsis and autoimmune diseases. - C1QC inhibitors are being investigated as potential treatments for these conditions. **Additional notes:** - C1QC is also expressed in low levels in healthy individuals. - Its expression is upregulated in response to inflammation and infection. - It is a key regulator of inflammation and tissue damage.

Genular Protein ID: 4214348737

Symbol: C1QC_HUMAN

Name: Complement C1q subcomponent subunit C

UniProtKB Accession Codes:

P02747 Q7Z502 Q96DL2 Q96H05

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CPTAC 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 10 EMBL 4 EMDB 1 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 9 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 3 SAM 1 SASBDB 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1706597

Title: Characterization and organization of the genes encoding the A-, B- and C-chains of human complement subcomponent C1q. The complete derived amino acid sequence of human C1q.

PubMed ID: 1706597

DOI: 10.1042/bj2740481

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 486087

Title: Complete amino acid sequences of the three collagen-like regions present in subcomponent C1q of the first component of human complement.

PubMed ID: 486087

DOI: 10.1042/bj1790367

PubMed ID: 12847249

Title: Modular organization of the carboxyl-terminal, globular head region of human C1q A, B, and C chains.

PubMed ID: 12847249

DOI: 10.4049/jimmunol.171.2.812

PubMed ID: 19006321

Title: Interaction of human C1q with IgG and IgM: revisited.

PubMed ID: 19006321

DOI: 10.1021/bi801131h

PubMed ID: 12960167

Title: The crystal structure of the globular head of complement protein C1q provides a basis for its versatile recognition properties.

PubMed ID: 12960167

DOI: 10.1074/jbc.m307764200

PubMed ID: 9777412

Title: Molecular basis of hereditary C1q deficiency.

PubMed ID: 9777412

DOI: 10.1016/s0171-2985(98)80033-8

PubMed ID: 8630118

Title: Homozygous hereditary C1q deficiency and systemic lupus erythematosus. A new family and the molecular basis of C1q deficiency in three families.

PubMed ID: 8630118

DOI: 10.1002/art.1780390419

Sequence Information:

  • Length: 245
  • Mass: 25774
  • Checksum: FA17117EB7ABFC12
  • Sequence:
    • MDVGPSSLPH LGLKLLLLLL LLPLRGQANT GCYGIPGMPG LPGAPGKDGY DGLPGPKGEP 
GIPAIPGIRG PKGQKGEPGL PGHPGKNGPM GPPGMPGVPG PMGIPGEPGE EGRYKQKFQS 
VFTVTRQTHQ PPAPNSLIRF NAVLTNPQGD YDTSTGKFTC KVPGLYYFVY HASHTANLCV 
LLYRSGVKVV TFCGHTSKTN QVNSGGVLLR LQVGEEVWLA VNDYYDMVGI QGSDSVFSGF 
LLFPD

Genular Protein ID: 2315305355

Symbol: A0A8Q3SIZ0_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A8Q3SIZ0

Database IDs:

CTD 1 EMBL 1 Ensembl 3 Gene3D 1 GeneTree 1 HGNC 1 InterPro 2 MaxQB 1 NCBI Taxonomy 1 PANTHER 2 PRINTS 1 PROSITE 2 PeptideAtlas 1 Pfam 1 Proteomes 2 RefSeq 1 SAM 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 156
  • Mass: 16994
  • Checksum: 01E42D3509B7278C
  • Sequence:
    • MGPPGMPGVP GPMGIPGEPG EEGRYKQKFQ SVFTVTRQTH QPPAPNSLIR FNAVLTNPQG 
DYDTSTGKFT CKVPGLYYFV YHASHTANLC VLLYRSGVKV VTFCGHTSKT NQVNSGGVLL 
RLQVGEEVWL AVNDYYDMVG IQGSDSVFSG FLLFPD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.