Details for: C1R

Gene ID: 715

Symbol: C1R

Ensembl ID: ENSG00000159403

Description: complement C1r

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 3.66
    Marker Score: 9,576
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 3.62
    Marker Score: 4,983
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.51
    Marker Score: 2,996
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.34
    Marker Score: 113,781
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 3.03
    Marker Score: 1,263
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 2.93
    Marker Score: 1,926
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.92
    Marker Score: 12,601
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.88
    Marker Score: 32,421
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.74
    Marker Score: 1,962
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.7
    Marker Score: 1,543
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 2.53
    Marker Score: 1,087
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 2.52
    Marker Score: 13,550
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 2.42
    Marker Score: 557
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 2.41
    Marker Score: 601
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 2.39
    Marker Score: 601
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.38
    Marker Score: 765
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 2.34
    Marker Score: 608
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 2.2
    Marker Score: 495
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 2.09
    Marker Score: 2,018
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 2
    Marker Score: 565
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.95
    Marker Score: 3,127
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.93
    Marker Score: 8,338
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.91
    Marker Score: 12,311
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.82
    Marker Score: 1,147
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.77
    Marker Score: 3,323
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.74
    Marker Score: 1,857
  • Cell Name: adipose microvascular endothelial cell (CL2000072)
    Fold Change: 1.73
    Marker Score: 515
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.68
    Marker Score: 416
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.52
    Marker Score: 7,489
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.52
    Marker Score: 847
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168,704
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.41
    Marker Score: 1,626
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.36
    Marker Score: 1,353
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.35
    Marker Score: 2,597
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 1.32
    Marker Score: 529
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.31
    Marker Score: 1,615
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.28
    Marker Score: 325
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.27
    Marker Score: 835
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.19
    Marker Score: 4,403
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.18
    Marker Score: 1,262
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 1.15
    Marker Score: 1,501
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.15
    Marker Score: 834
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.13
    Marker Score: 7,339
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.12
    Marker Score: 18,030
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 1.11
    Marker Score: 249
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.06
    Marker Score: 725
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.04
    Marker Score: 1,602
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,756
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.03
    Marker Score: 367
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.02
    Marker Score: 495
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 1.01
    Marker Score: 267
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,774
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,999
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.99
    Marker Score: 13,294
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,404
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 496
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 451
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,408
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.95
    Marker Score: 2,311
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.92
    Marker Score: 476
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.92
    Marker Score: 5,959
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,737
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.91
    Marker Score: 364
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 318
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.88
    Marker Score: 884
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.88
    Marker Score: 912
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5,011
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,270
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.86
    Marker Score: 501
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.85
    Marker Score: 311
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.85
    Marker Score: 241
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.85
    Marker Score: 11,169
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.84
    Marker Score: 291
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.83
    Marker Score: 1,650
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.82
    Marker Score: 213
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.82
    Marker Score: 240
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.81
    Marker Score: 302
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.8
    Marker Score: 193
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.8
    Marker Score: 706
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 590
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.76
    Marker Score: 1,240
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.75
    Marker Score: 283
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 386
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.74
    Marker Score: 183
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.74
    Marker Score: 1,170
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.73
    Marker Score: 667
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.73
    Marker Score: 1,199
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.73
    Marker Score: 3,064
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 0.72
    Marker Score: 404
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.72
    Marker Score: 197
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.71
    Marker Score: 507
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.68
    Marker Score: 799
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.68
    Marker Score: 207
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.68
    Marker Score: 586
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.66
    Marker Score: 595
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.66
    Marker Score: 3,444
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.65
    Marker Score: 226
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.65
    Marker Score: 220

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Serine protease activity**: C1r possesses serine protease activity, which enables it to cleave and activate other proteins, thereby initiating the complement cascade. 2. **Zymogen activation**: C1r is a zymogen, requiring activation by other proteins to become functional. 3. **Calcium ion binding**: C1r exhibits calcium ion binding capabilities, which are essential for its activation and subsequent interactions with other complement components. 4. **Molecular sequestering activity**: C1r can bind to other proteins, sequestering them and preventing their activation or degradation. **Pathways and Functions:** 1. **Classical pathway of complement activation**: C1r is a key component of the classical pathway, which is triggered by the binding of C1q to antibody-antigen complexes. C1r activates C1s, a serine protease that cleaves C4 and C2, leading to the formation of C4b2a, the C3 convertase. 2. **Regulation of complement cascade**: C1r can regulate the complement cascade by binding to and inhibiting C1s, thereby controlling the activity of the classical pathway. 3. **Immune response modulation**: C1r plays a role in modulating the immune response by influencing the activity of other immune cells and molecules. 4. **Extracellular matrix remodeling**: C1r can contribute to the remodeling of the extracellular matrix by binding to and activating other proteases. **Significantly Expressed Cells:** C1r is expressed in various cell types, including: 1. **Fibroblasts**: C1r is expressed in fibroblasts from lung, bronchus, prostate, mammary gland, and breast tissues. 2. **Decidual cells**: C1r is also expressed in decidual cells, which play a crucial role in implantation and pregnancy. 3. **Stromal cells**: C1r is expressed in stromal cells of the ovary and prostate. **Clinical Significance:** Dysregulation of the complement cascade, including the classical pathway, has been implicated in various diseases, including: 1. **Autoimmune disorders**: Dysregulation of the classical pathway has been linked to autoimmune disorders, such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). 2. **Inflammatory diseases**: Overactivation of the classical pathway has been implicated in inflammatory diseases, such as atherosclerosis and cancer. 3. **Infectious diseases**: Dysregulation of the complement cascade has been linked to infectious diseases, such as sepsis and meningitis. In conclusion, Complement C1r is a critical component of the classical pathway of the complement cascade, playing a pivotal role in the regulation of the immune response. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding the complex interactions between C1r and other immune molecules. Further research is needed to elucidate the mechanisms underlying C1r's functions and to explore its therapeutic potential in the treatment of immune-related diseases.

Genular Protein ID: 642947284

Symbol: C1R_HUMAN

Name: Complement C1r subcomponent

UniProtKB Accession Codes:

P00736 A6NJQ8 Q68D77 Q8J012

Database IDs:

AGR 1 AlphaFoldDB 1 BRENDA 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 4 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 9 DrugCentral 1 EC 2 EMBL 7 EPD 1 EvolutionaryTrace 1 GO 13 Gene3D 4 GeneCards 1 GeneReviews 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 InParanoid 1 IntAct 1 InterPro 13 KEGG 1 MEROPS 1 MIM 4 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 15 PDBsum 9 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 7 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 SABIO-RK 1 SASBDB 1 SIGNOR 1 SMART 5 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 TreeFam 1 UCSC 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3021205

Title: Nucleotide sequence of the cDNA coding for human complement C1r.

PubMed ID: 3021205

DOI: 10.1021/bi00365a020

PubMed ID: 3030286

Title: Cloning and sequencing of full-length cDNA encoding the precursor of human complement component C1r.

PubMed ID: 3030286

DOI: 10.1042/bj2400783

PubMed ID: 12914573

Title: The human complement component C1R gene: the exon-intron structure and the molecular basis of allelic diversity.

PubMed ID: 12914573

DOI: 10.1046/j.1469-1809.2003.00019.x

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3036070

Title: Complete amino acid sequence of the A chain of human complement-classical-pathway enzyme C1r.

PubMed ID: 3036070

DOI: 10.1042/bj2410711

PubMed ID: 6303394

Title: Complete amino acid sequence of the catalytic chain of human complement subcomponent C1-r.

PubMed ID: 6303394

DOI: 10.1021/bi00277a003

PubMed ID: 2820791

Title: Identification of erythro-beta-hydroxyasparagine in the EGF-like domain of human C1r.

PubMed ID: 2820791

DOI: 10.1016/0014-5793(87)80205-3

PubMed ID: 8635594

Title: Identification of a cryptic protein kinase CK2 phosphorylation site in human complement protease Clr, and its use to probe intramolecular interaction.

PubMed ID: 8635594

DOI: 10.1016/0014-5793(96)00403-6

PubMed ID: 2831944

Title: Complete cDNA sequence of human complement Cls and close physical linkage of the homologous genes Cls and Clr.

PubMed ID: 2831944

DOI: 10.1021/bi00400a004

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27745832

Title: Periodontal Ehlers-Danlos syndrome is caused by mutations in C1R and C1S, which encode subcomponents C1r and C1s of complement.

PubMed ID: 27745832

DOI: 10.1016/j.ajhg.2016.08.019

PubMed ID: 9477945

Title: Solution structure of the epidermal growth factor (EGF)-like module of human complement protease C1r, an atypical member of the EGF family.

PubMed ID: 9477945

DOI: 10.1021/bi971851v

PubMed ID: 11823416

Title: The crystal structure of the zymogen catalytic domain of complement protease C1r reveals that a disruptive mechanical stress is required to trigger activation of the C1 complex.

PubMed ID: 11823416

DOI: 10.1093/emboj/21.3.231

PubMed ID: 12429092

Title: Monomeric structures of the zymogen and active catalytic domain of complement protease c1r: further insights into the c1 activation mechanism.

PubMed ID: 12429092

DOI: 10.1016/s0969-2126(02)00881-x

PubMed ID: 8162045

Title: A common amino acid polymorphism in complement component C1R.

PubMed ID: 8162045

DOI: 10.1093/hmg/3.1.217-a

PubMed ID: 22028381

Title: Quantitative detection of single amino acid polymorphisms by targeted proteomics.

PubMed ID: 22028381

DOI: 10.1093/jmcb/mjr024

Sequence Information:

  • Length: 705
  • Mass: 80119
  • Checksum: B45D120201061462
  • Sequence:
    • MWLLYLLVPA LFCRAGGSIP IPQKLFGEVT SPLFPKPYPN NFETTTVITV PTGYRVKLVF 
QQFDLEPSEG CFYDYVKISA DKKSLGRFCG QLGSPLGNPP GKKEFMSQGN KMLLTFHTDF 
SNEENGTIMF YKGFLAYYQA VDLDECASRS KSGEEDPQPQ CQHLCHNYVG GYFCSCRPGY 
ELQEDTHSCQ AECSSELYTE ASGYISSLEY PRSYPPDLRC NYSIRVERGL TLHLKFLEPF 
DIDDHQQVHC PYDQLQIYAN GKNIGEFCGK QRPPDLDTSS NAVDLLFFTD ESGDSRGWKL 
RYTTEIIKCP QPKTLDEFTI IQNLQPQYQF RDYFIATCKQ GYQLIEGNQV LHSFTAVCQD 
DGTWHRAMPR CKIKDCGQPR NLPNGDFRYT TTMGVNTYKA RIQYYCHEPY YKMQTRAGSR 
ESEQGVYTCT AQGIWKNEQK GEKIPRCLPV CGKPVNPVEQ RQRIIGGQKA KMGNFPWQVF 
TNIHGRGGGA LLGDRWILTA AHTLYPKEHE AQSNASLDVF LGHTNVEELM KLGNHPIRRV 
SVHPDYRQDE SYNFEGDIAL LELENSVTLG PNLLPICLPD NDTFYDLGLM GYVSGFGVME 
EKIAHDLRFV RLPVANPQAC ENWLRGKNRM DVFSQNMFCA GHPSLKQDAC QGDSGGVFAV 
RDPNTDRWVA TGIVSWGIGC SRGYGFYTKV LNYVDWIKKE MEEED

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.