Details for: C1R

Gene ID: 715

Symbol: C1R

Ensembl ID: ENSG00000159403

Description: complement C1r

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 162.3322
    Cell Significance Index: -25.2500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 98.4453
    Cell Significance Index: -24.9700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 46.6828
    Cell Significance Index: -22.0400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 20.4792
    Cell Significance Index: -25.2500
  • Cell Name: theca cell (CL0000503)
    Fold Change: 15.7710
    Cell Significance Index: 92.6600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 14.7471
    Cell Significance Index: 217.6700
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 10.6823
    Cell Significance Index: 61.2500
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 8.3398
    Cell Significance Index: 22.0000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 7.1817
    Cell Significance Index: 48.6600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 6.3958
    Cell Significance Index: 183.3400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 5.8029
    Cell Significance Index: 796.9000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 4.6934
    Cell Significance Index: 79.0600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 4.5438
    Cell Significance Index: 582.4900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 3.9104
    Cell Significance Index: 76.3200
  • Cell Name: fibroblast of the aortic adventitia (CL0002547)
    Fold Change: 2.2811
    Cell Significance Index: 23.0200
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.9645
    Cell Significance Index: 24.7400
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.1465
    Cell Significance Index: 5.4600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.8991
    Cell Significance Index: 45.4400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.8615
    Cell Significance Index: 40.4900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.7193
    Cell Significance Index: 10.3300
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.7140
    Cell Significance Index: 4.4900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6808
    Cell Significance Index: 30.8600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.6497
    Cell Significance Index: 13.6000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5890
    Cell Significance Index: 112.0900
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.4677
    Cell Significance Index: 1.0800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.4208
    Cell Significance Index: 6.5100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3896
    Cell Significance Index: 172.2600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3895
    Cell Significance Index: 38.5300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3330
    Cell Significance Index: 300.6500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.3293
    Cell Significance Index: 5.8200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3206
    Cell Significance Index: 8.9600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.3049
    Cell Significance Index: 3.9100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.2893
    Cell Significance Index: 2.4300
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.2849
    Cell Significance Index: 3.1100
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.2572
    Cell Significance Index: 2.4800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2368
    Cell Significance Index: 47.0000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.2253
    Cell Significance Index: 2.5600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1936
    Cell Significance Index: 31.4900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1500
    Cell Significance Index: 113.5400
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.0900
    Cell Significance Index: 0.9400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0557
    Cell Significance Index: 6.0600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0421
    Cell Significance Index: 26.3200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0373
    Cell Significance Index: 0.6300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0310
    Cell Significance Index: 1.0900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0089
    Cell Significance Index: 16.7900
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.0045
    Cell Significance Index: 0.0500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0014
    Cell Significance Index: 0.9000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0007
    Cell Significance Index: -0.1300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0075
    Cell Significance Index: -0.9700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0144
    Cell Significance Index: -10.6800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0144
    Cell Significance Index: -26.4900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0170
    Cell Significance Index: -26.2000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0191
    Cell Significance Index: -1.3500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0214
    Cell Significance Index: -29.1500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0215
    Cell Significance Index: -12.1400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0246
    Cell Significance Index: -13.4500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0271
    Cell Significance Index: -19.8500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0284
    Cell Significance Index: -12.9000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0290
    Cell Significance Index: -4.9600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0307
    Cell Significance Index: -3.5800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0423
    Cell Significance Index: -5.2100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0437
    Cell Significance Index: -1.2600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0460
    Cell Significance Index: -9.2400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0496
    Cell Significance Index: -1.2400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0519
    Cell Significance Index: -5.9500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0549
    Cell Significance Index: -4.2100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0562
    Cell Significance Index: -20.1500
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.0650
    Cell Significance Index: -0.3000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0750
    Cell Significance Index: -15.8000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0786
    Cell Significance Index: -22.6200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0834
    Cell Significance Index: -8.5200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0847
    Cell Significance Index: -12.3100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0850
    Cell Significance Index: -5.8800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1069
    Cell Significance Index: -7.9700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1576
    Cell Significance Index: -3.4200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1707
    Cell Significance Index: -10.2500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1767
    Cell Significance Index: -5.6600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1816
    Cell Significance Index: -4.7800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1829
    Cell Significance Index: -20.8800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1896
    Cell Significance Index: -11.6300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1904
    Cell Significance Index: -3.0200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2097
    Cell Significance Index: -24.7400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2330
    Cell Significance Index: -24.2600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2787
    Cell Significance Index: -22.0700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2888
    Cell Significance Index: -3.9400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2963
    Cell Significance Index: -6.3100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3198
    Cell Significance Index: -14.9100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3735
    Cell Significance Index: -19.4600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3948
    Cell Significance Index: -25.4700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4113
    Cell Significance Index: -25.9200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4304
    Cell Significance Index: -22.6000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4330
    Cell Significance Index: -24.3000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4579
    Cell Significance Index: -10.5800
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: -0.4593
    Cell Significance Index: -2.6500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4677
    Cell Significance Index: -12.7300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5184
    Cell Significance Index: -19.0300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.5206
    Cell Significance Index: -7.8500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.5226
    Cell Significance Index: -27.1500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5429
    Cell Significance Index: -18.8700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5583
    Cell Significance Index: -14.3500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Serine protease activity**: C1r possesses serine protease activity, which enables it to cleave and activate other proteins, thereby initiating the complement cascade. 2. **Zymogen activation**: C1r is a zymogen, requiring activation by other proteins to become functional. 3. **Calcium ion binding**: C1r exhibits calcium ion binding capabilities, which are essential for its activation and subsequent interactions with other complement components. 4. **Molecular sequestering activity**: C1r can bind to other proteins, sequestering them and preventing their activation or degradation. **Pathways and Functions:** 1. **Classical pathway of complement activation**: C1r is a key component of the classical pathway, which is triggered by the binding of C1q to antibody-antigen complexes. C1r activates C1s, a serine protease that cleaves C4 and C2, leading to the formation of C4b2a, the C3 convertase. 2. **Regulation of complement cascade**: C1r can regulate the complement cascade by binding to and inhibiting C1s, thereby controlling the activity of the classical pathway. 3. **Immune response modulation**: C1r plays a role in modulating the immune response by influencing the activity of other immune cells and molecules. 4. **Extracellular matrix remodeling**: C1r can contribute to the remodeling of the extracellular matrix by binding to and activating other proteases. **Significantly Expressed Cells:** C1r is expressed in various cell types, including: 1. **Fibroblasts**: C1r is expressed in fibroblasts from lung, bronchus, prostate, mammary gland, and breast tissues. 2. **Decidual cells**: C1r is also expressed in decidual cells, which play a crucial role in implantation and pregnancy. 3. **Stromal cells**: C1r is expressed in stromal cells of the ovary and prostate. **Clinical Significance:** Dysregulation of the complement cascade, including the classical pathway, has been implicated in various diseases, including: 1. **Autoimmune disorders**: Dysregulation of the classical pathway has been linked to autoimmune disorders, such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). 2. **Inflammatory diseases**: Overactivation of the classical pathway has been implicated in inflammatory diseases, such as atherosclerosis and cancer. 3. **Infectious diseases**: Dysregulation of the complement cascade has been linked to infectious diseases, such as sepsis and meningitis. In conclusion, Complement C1r is a critical component of the classical pathway of the complement cascade, playing a pivotal role in the regulation of the immune response. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding the complex interactions between C1r and other immune molecules. Further research is needed to elucidate the mechanisms underlying C1r's functions and to explore its therapeutic potential in the treatment of immune-related diseases.

Genular Protein ID: 642947284

Symbol: C1R_HUMAN

Name: Complement C1r subcomponent

UniProtKB Accession Codes:

P00736 A6NJQ8 Q68D77 Q8J012

Database IDs:

AGR 1 AlphaFoldDB 1 BRENDA 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 4 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 9 DrugCentral 1 EC 2 EMBL 7 EvolutionaryTrace 1 GO 13 Gene3D 4 GeneCards 1 GeneReviews 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 InParanoid 1 IntAct 1 InterPro 13 KEGG 1 MEROPS 1 MIM 4 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 9 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 7 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 SABIO-RK 1 SASBDB 1 SIGNOR 1 SMART 5 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 TreeFam 1 UCSC 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3021205

Title: Nucleotide sequence of the cDNA coding for human complement C1r.

PubMed ID: 3021205

DOI: 10.1021/bi00365a020

PubMed ID: 3030286

Title: Cloning and sequencing of full-length cDNA encoding the precursor of human complement component C1r.

PubMed ID: 3030286

DOI: 10.1042/bj2400783

PubMed ID: 12914573

Title: The human complement component C1R gene: the exon-intron structure and the molecular basis of allelic diversity.

PubMed ID: 12914573

DOI: 10.1046/j.1469-1809.2003.00019.x

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3036070

Title: Complete amino acid sequence of the A chain of human complement-classical-pathway enzyme C1r.

PubMed ID: 3036070

DOI: 10.1042/bj2410711

PubMed ID: 6303394

Title: Complete amino acid sequence of the catalytic chain of human complement subcomponent C1-r.

PubMed ID: 6303394

DOI: 10.1021/bi00277a003

PubMed ID: 2820791

Title: Identification of erythro-beta-hydroxyasparagine in the EGF-like domain of human C1r.

PubMed ID: 2820791

DOI: 10.1016/0014-5793(87)80205-3

PubMed ID: 8635594

Title: Identification of a cryptic protein kinase CK2 phosphorylation site in human complement protease Clr, and its use to probe intramolecular interaction.

PubMed ID: 8635594

DOI: 10.1016/0014-5793(96)00403-6

PubMed ID: 2831944

Title: Complete cDNA sequence of human complement Cls and close physical linkage of the homologous genes Cls and Clr.

PubMed ID: 2831944

DOI: 10.1021/bi00400a004

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27745832

Title: Periodontal Ehlers-Danlos syndrome is caused by mutations in C1R and C1S, which encode subcomponents C1r and C1s of complement.

PubMed ID: 27745832

DOI: 10.1016/j.ajhg.2016.08.019

PubMed ID: 9477945

Title: Solution structure of the epidermal growth factor (EGF)-like module of human complement protease C1r, an atypical member of the EGF family.

PubMed ID: 9477945

DOI: 10.1021/bi971851v

PubMed ID: 11823416

Title: The crystal structure of the zymogen catalytic domain of complement protease C1r reveals that a disruptive mechanical stress is required to trigger activation of the C1 complex.

PubMed ID: 11823416

DOI: 10.1093/emboj/21.3.231

PubMed ID: 12429092

Title: Monomeric structures of the zymogen and active catalytic domain of complement protease c1r: further insights into the c1 activation mechanism.

PubMed ID: 12429092

DOI: 10.1016/s0969-2126(02)00881-x

PubMed ID: 8162045

Title: A common amino acid polymorphism in complement component C1R.

PubMed ID: 8162045

DOI: 10.1093/hmg/3.1.217-a

PubMed ID: 22028381

Title: Quantitative detection of single amino acid polymorphisms by targeted proteomics.

PubMed ID: 22028381

DOI: 10.1093/jmcb/mjr024

Sequence Information:

  • Length: 705
  • Mass: 80119
  • Checksum: B45D120201061462
  • Sequence:
    • MWLLYLLVPA LFCRAGGSIP IPQKLFGEVT SPLFPKPYPN NFETTTVITV PTGYRVKLVF 
QQFDLEPSEG CFYDYVKISA DKKSLGRFCG QLGSPLGNPP GKKEFMSQGN KMLLTFHTDF 
SNEENGTIMF YKGFLAYYQA VDLDECASRS KSGEEDPQPQ CQHLCHNYVG GYFCSCRPGY 
ELQEDTHSCQ AECSSELYTE ASGYISSLEY PRSYPPDLRC NYSIRVERGL TLHLKFLEPF 
DIDDHQQVHC PYDQLQIYAN GKNIGEFCGK QRPPDLDTSS NAVDLLFFTD ESGDSRGWKL 
RYTTEIIKCP QPKTLDEFTI IQNLQPQYQF RDYFIATCKQ GYQLIEGNQV LHSFTAVCQD 
DGTWHRAMPR CKIKDCGQPR NLPNGDFRYT TTMGVNTYKA RIQYYCHEPY YKMQTRAGSR 
ESEQGVYTCT AQGIWKNEQK GEKIPRCLPV CGKPVNPVEQ RQRIIGGQKA KMGNFPWQVF 
TNIHGRGGGA LLGDRWILTA AHTLYPKEHE AQSNASLDVF LGHTNVEELM KLGNHPIRRV 
SVHPDYRQDE SYNFEGDIAL LELENSVTLG PNLLPICLPD NDTFYDLGLM GYVSGFGVME 
EKIAHDLRFV RLPVANPQAC ENWLRGKNRM DVFSQNMFCA GHPSLKQDAC QGDSGGVFAV 
RDPNTDRWVA TGIVSWGIGC SRGYGFYTKV LNYVDWIKKE MEEED

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.