Details for: C1R

Gene ID: 715

Symbol: C1R

Ensembl ID: ENSG00000159403

Description: complement C1r

Associated with

Other Information

Genular Protein ID: 642947284

Symbol: C1R_HUMAN

Name: Complement C1r subcomponent

UniProtKB Accession Codes:

P00736 A6NJQ8 Q68D77 Q8J012

Database IDs:

AGR 1 AlphaFoldDB 1 BRENDA 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 4 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 9 DrugCentral 1 EC 2 EMBL 7 EPD 1 EvolutionaryTrace 1 GO 13 Gene3D 4 GeneCards 1 GeneReviews 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 InParanoid 1 IntAct 1 InterPro 13 KEGG 1 MEROPS 1 MIM 4 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 15 PDBsum 9 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 7 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 SABIO-RK 1 SASBDB 1 SIGNOR 1 SMART 5 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 TreeFam 1 UCSC 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3021205

Title: Nucleotide sequence of the cDNA coding for human complement C1r.

PubMed ID: 3021205

DOI: 10.1021/bi00365a020

PubMed ID: 3030286

Title: Cloning and sequencing of full-length cDNA encoding the precursor of human complement component C1r.

PubMed ID: 3030286

DOI: 10.1042/bj2400783

PubMed ID: 12914573

Title: The human complement component C1R gene: the exon-intron structure and the molecular basis of allelic diversity.

PubMed ID: 12914573

DOI: 10.1046/j.1469-1809.2003.00019.x

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3036070

Title: Complete amino acid sequence of the A chain of human complement-classical-pathway enzyme C1r.

PubMed ID: 3036070

DOI: 10.1042/bj2410711

PubMed ID: 6303394

Title: Complete amino acid sequence of the catalytic chain of human complement subcomponent C1-r.

PubMed ID: 6303394

DOI: 10.1021/bi00277a003

PubMed ID: 2820791

Title: Identification of erythro-beta-hydroxyasparagine in the EGF-like domain of human C1r.

PubMed ID: 2820791

DOI: 10.1016/0014-5793(87)80205-3

PubMed ID: 8635594

Title: Identification of a cryptic protein kinase CK2 phosphorylation site in human complement protease Clr, and its use to probe intramolecular interaction.

PubMed ID: 8635594

DOI: 10.1016/0014-5793(96)00403-6

PubMed ID: 2831944

Title: Complete cDNA sequence of human complement Cls and close physical linkage of the homologous genes Cls and Clr.

PubMed ID: 2831944

DOI: 10.1021/bi00400a004

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27745832

Title: Periodontal Ehlers-Danlos syndrome is caused by mutations in C1R and C1S, which encode subcomponents C1r and C1s of complement.

PubMed ID: 27745832

DOI: 10.1016/j.ajhg.2016.08.019

PubMed ID: 9477945

Title: Solution structure of the epidermal growth factor (EGF)-like module of human complement protease C1r, an atypical member of the EGF family.

PubMed ID: 9477945

DOI: 10.1021/bi971851v

PubMed ID: 11823416

Title: The crystal structure of the zymogen catalytic domain of complement protease C1r reveals that a disruptive mechanical stress is required to trigger activation of the C1 complex.

PubMed ID: 11823416

DOI: 10.1093/emboj/21.3.231

PubMed ID: 12429092

Title: Monomeric structures of the zymogen and active catalytic domain of complement protease c1r: further insights into the c1 activation mechanism.

PubMed ID: 12429092

DOI: 10.1016/s0969-2126(02)00881-x

PubMed ID: 8162045

Title: A common amino acid polymorphism in complement component C1R.

PubMed ID: 8162045

DOI: 10.1093/hmg/3.1.217-a

PubMed ID: 22028381

Title: Quantitative detection of single amino acid polymorphisms by targeted proteomics.

PubMed ID: 22028381

DOI: 10.1093/jmcb/mjr024

Sequence Information:

  • Length: 705
  • Mass: 80119
  • Checksum: B45D120201061462
  • Sequence:
    • MWLLYLLVPA LFCRAGGSIP IPQKLFGEVT SPLFPKPYPN NFETTTVITV PTGYRVKLVF 
QQFDLEPSEG CFYDYVKISA DKKSLGRFCG QLGSPLGNPP GKKEFMSQGN KMLLTFHTDF 
SNEENGTIMF YKGFLAYYQA VDLDECASRS KSGEEDPQPQ CQHLCHNYVG GYFCSCRPGY 
ELQEDTHSCQ AECSSELYTE ASGYISSLEY PRSYPPDLRC NYSIRVERGL TLHLKFLEPF 
DIDDHQQVHC PYDQLQIYAN GKNIGEFCGK QRPPDLDTSS NAVDLLFFTD ESGDSRGWKL 
RYTTEIIKCP QPKTLDEFTI IQNLQPQYQF RDYFIATCKQ GYQLIEGNQV LHSFTAVCQD 
DGTWHRAMPR CKIKDCGQPR NLPNGDFRYT TTMGVNTYKA RIQYYCHEPY YKMQTRAGSR 
ESEQGVYTCT AQGIWKNEQK GEKIPRCLPV CGKPVNPVEQ RQRIIGGQKA KMGNFPWQVF 
TNIHGRGGGA LLGDRWILTA AHTLYPKEHE AQSNASLDVF LGHTNVEELM KLGNHPIRRV 
SVHPDYRQDE SYNFEGDIAL LELENSVTLG PNLLPICLPD NDTFYDLGLM GYVSGFGVME 
EKIAHDLRFV RLPVANPQAC ENWLRGKNRM DVFSQNMFCA GHPSLKQDAC QGDSGGVFAV 
RDPNTDRWVA TGIVSWGIGC SRGYGFYTKV LNYVDWIKKE MEEED

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.