Ifih1 | ENSMUSG00000026896 | NCBI 71586

Details for: Ifih1

Gene ID: 71586

Symbol: Ifih1

Ensembl ID: ENSMUSG00000026896

Description: interferon induced with helicase C domain 1

Associated with

Deubiquitination
(R-MMU-5688426)
Metabolism of proteins
(R-MMU-392499)
Post-translational protein modification
(R-MMU-597592)
Ub-specific processing proteases
(R-MMU-5689880)
Antiviral innate immune response
(GO:0140374)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Cellular response to exogenous dsrna
(GO:0071360)
Cellular response to virus
(GO:0098586)
Cytoplasm
(GO:0005737)
Defense response to virus
(GO:0051607)
Dna binding
(GO:0003677)
Double-stranded rna binding
(GO:0003725)
Identical protein binding
(GO:0042802)
Innate immune response
(GO:0045087)
Interferon-beta production
(GO:0032608)
Mda-5 signaling pathway
(GO:0039530)
Mitochondrion
(GO:0005739)
Negative regulation of viral genome replication
(GO:0045071)
Nucleus
(GO:0005634)
Pattern recognition receptor activity
(GO:0038187)
Positive regulation of interferon-alpha production
(GO:0032727)
Positive regulation of interferon-beta production
(GO:0032728)
Positive regulation of interleukin-6 production
(GO:0032755)
Positive regulation of response to cytokine stimulus
(GO:0060760)
Positive regulation of tumor necrosis factor production
(GO:0032760)
Protein binding
(GO:0005515)
Protein complex oligomerization
(GO:0051259)
Protein domain specific binding
(GO:0019904)
Protein sumoylation
(GO:0016925)
Response to virus
(GO:0009615)
Ribonucleoprotein complex binding
(GO:0043021)
Rna binding
(GO:0003723)
Rna helicase activity
(GO:0003724)
Single-stranded rna binding
(GO:0003727)
Type i interferon-mediated signaling pathway
(GO:0060337)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Interferon-induced helicase C domain-containing protein 1

Genular Protein ID: 656380068

Symbol: IFIH1_MOUSE

Name: Interferon-induced helicase C domain-containing protein 1

UniProtKB Accession Codes:

Q8R5F7 A2AUY7 Q3U6S2 Q68EM4 Q8BYC9 Q8BZ01 Q8K5C7 Q8R144 Q8VE79 Q99KS4 Q9D2Z5

Database IDs:

Citations:

PubMed ID: 12015121

Title: Overexpression of Helicard, a CARD-containing helicase cleaved during apoptosis, accelerates DNA degradation.

PubMed ID: 12015121

DOI: 10.1016/s0960-9822(02)00842-4

PubMed ID: 11805321

Title: mda-5: an interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties.

PubMed ID: 11805321

DOI: 10.1073/pnas.022637199

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16625202

Title: Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses.

PubMed ID: 16625202

DOI: 10.1038/nature04734

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 17942531

Title: Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity.

PubMed ID: 17942531

DOI: 10.1128/jvi.01080-07

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 19656871

Title: Activation of MDA5 requires higher-order RNA structures generated during virus infection.

PubMed ID: 19656871

DOI: 10.1128/jvi.00770-09

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21616437

Title: Immune signaling by RIG-I-like receptors.

PubMed ID: 21616437

DOI: 10.1016/j.immuni.2011.05.003

PubMed ID: 21884169

Title: RIG-I-like receptors: cytoplasmic sensors for non-self RNA.

PubMed ID: 21884169

DOI: 10.1111/j.1600-065x.2011.01052.x

PubMed ID: 20950133

Title: Retinoic acid-inducible gene-I-like receptors.

PubMed ID: 20950133

DOI: 10.1089/jir.2010.0057

PubMed ID: 21245900

Title: 2 methylate or not 2 methylate: viral evasion of the type I interferon response.

PubMed ID: 21245900

DOI: 10.1038/ni0211-114

PubMed ID: 21217758

Title: Ribose 2'-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5.

PubMed ID: 21217758

DOI: 10.1038/ni.1979

PubMed ID: 22314235

Title: MDA5 cooperatively forms dimers and ATP-sensitive filaments upon binding double-stranded RNA.

PubMed ID: 22314235

DOI: 10.1038/emboj.2012.19

Sequence Information:

Length: 1025
Mass: 115971
Checksum: 708FCAC690C9F6D8
Sequence:

MSIVCSAEDS FRNLILFFRP RLKMYIQVEP VLDHLIFLSA ETKEQILKKI NTCGNTSAAE 
LLLSTLEQGQ WPLGWTQMFV EALEHSGNPL AARYVKPTLT DLPSPSSETA HDECLHLLTL 
LQPTLVDKLL INDVLDTCFE KGLLTVEDRN RISAAGNSGN ESGVRELLRR IVQKENWFST 
FLDVLRQTGN DALFQELTGG GCPEDNTDLA NSSHRDGPAA NECLLPAVDE SSLETEAWNV 
DDILPEASCT DSSVTTESDT SLAEGSVSCF DESLGHNSNM GRDSGTMGSD SDESVIQTKR 
VSPEPELQLR PYQMEVAQPA LDGKNIIICL PTGSGKTRVA VYITKDHLDK KKQASESGKV 
IVLVNKVMLA EQLFRKEFNP YLKKWYRIIG LSGDTQLKIS FPEVVKSYDV IISTAQILEN 
SLLNLESGDD DGVQLSDFSL IIIDECHHTN KEAVYNNIMR RYLKQKLRNN DLKKQNKPAI 
PLPQILGLTA SPGVGAAKKQ SEAEKHILNI CANLDAFTIK TVKENLGQLK HQIKEPCKKF 
VIADDTRENP FKEKLLEIMA SIQTYCQKSP MSDFGTQHYE QWAIQMEKKA AKDGNRKDRV 
CAEHLRKYNE ALQINDTIRM IDAYSHLETF YTDEKEKKFA VLNDSDKSDD EASSCNDQLK 
GDVKKSLKLD ETDEFLMNLF FDNKKMLKKL AENPKYENEK LIKLRNTILE QFTRSEESSR 
GIIFTKTRQS TYALSQWIME NAKFAEVGVK AHHLIGAGHS SEVKPMTQTE QKEVISKFRT 
GEINLLIATT VAEEGLDIKE CNIVIRYGLV TNEIAMVQAR GRARADESTY VLVTSSGSGV 
TEREIVNDFR EKMMYKAINR VQNMKPEEYA HKILELQVQS ILEKKMKVKR SIAKQYNDNP 
SLITLLCKNC SMLVCSGENI HVIEKMHHVN MTPEFKGLYI VRENKALQKK FADYQTNGEI 
ICKCGQAWGT MMVHKGLDLP CLKIRNFVVN FKNNSPKKQY KKWVELPIRF PDLDYSEYCL 
YSDED

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ifih1

Associated with

Other Information

Overexpression of Helicard, a CARD-containing helicase cleaved during apoptosis, accelerates DNA degradation. PubMed ID: 12015121

mda-5: an interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties. PubMed ID: 11805321

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. PubMed ID: 16625202

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

Distinct RIG-I and MDA5 signaling by RNA viruses in innate immunity. PubMed ID: 17942531

The phagosomal proteome in interferon-gamma-activated macrophages. PubMed ID: 19144319

Activation of MDA5 requires higher-order RNA structures generated during virus infection. PubMed ID: 19656871

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Immune signaling by RIG-I-like receptors. PubMed ID: 21616437

RIG-I-like receptors: cytoplasmic sensors for non-self RNA. PubMed ID: 21884169

Retinoic acid-inducible gene-I-like receptors. PubMed ID: 20950133

2 methylate or not 2 methylate: viral evasion of the type I interferon response. PubMed ID: 21245900

Ribose 2'-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5. PubMed ID: 21217758

MDA5 cooperatively forms dimers and ATP-sensitive filaments upon binding double-stranded RNA. PubMed ID: 22314235