Associated with
Other Information
Genular Protein ID: 1215384334
Symbol: CO3_HUMAN
Name: Complement C3
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2579379
Title: Human complement component C3: cDNA coding sequence and derived primary structure.
PubMed ID: 2579379
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8376604
Title: The adipsin-acylation stimulating protein system and regulation of intracellular triglyceride synthesis.
PubMed ID: 8376604
DOI: 10.1172/jci116733
PubMed ID: 1238393
Title: Human anaphylatoxin (C3a) from the third component of complement. Primary structure.
PubMed ID: 1238393
PubMed ID: 24367091
Title: Neisseria meningitidis NalP cleaves human complement C3, facilitating degradation of C3b and survival in human serum.
PubMed ID: 24367091
PubMed ID: 7539791
Title: Identification of angiotensinogen and complement C3dg as novel proteins binding the proform of eosinophil major basic protein in human pregnancy serum and plasma.
PubMed ID: 7539791
PubMed ID: 6175959
Title: Third component of human complement: localization of the internal thiolester bond.
PubMed ID: 6175959
PubMed ID: 2972794
Title: Identification of distinct C3b and C4b recognition sites in the human C3b/C4b receptor (CR1, CD35) by deletion mutagenesis.
PubMed ID: 2972794
PubMed ID: 3279119
Title: A 34-amino acid peptide of the third component of complement mediates properdin binding.
PubMed ID: 3279119
PubMed ID: 2849025
Title: Complement component C3b binds directly to purified glycoprotein C of herpes simplex virus types 1 and 2.
PubMed ID: 2849025
PubMed ID: 2909530
Title: Purification and characterization of acylation stimulating protein.
PubMed ID: 2909530
PubMed ID: 1577777
Title: Structural requirements for thioester bond formation in human complement component C3. Reassessment of the role of thioester bond integrity on the conformation of C3.
PubMed ID: 1577777
PubMed ID: 8416818
Title: Disulfide bridges in human complement component C3b.
PubMed ID: 8416818
PubMed ID: 8175757
Title: Analysis of the functional domains of complement receptor type 1 (C3b/C4b receptor; CD35) by substitution mutagenesis.
PubMed ID: 8175757
PubMed ID: 9059512
Title: Acylation-stimulating protein (ASP) regulates glucose transport in the rat L6 muscle cell line.
PubMed ID: 9059512
PubMed ID: 9555951
Title: Coordinated release of acylation stimulating protein (ASP) and triacylglycerol clearance by human adipose tissue in vivo in the postprandial period.
PubMed ID: 9555951
PubMed ID: 10432298
Title: Acylation-stimulating protein (ASP): structure-function determinants of cell surface binding and triacylglycerol synthetic activity.
PubMed ID: 10432298
DOI: 10.1042/bj3420041
PubMed ID: 11773063
Title: The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des Arg(74).
PubMed ID: 11773063
PubMed ID: 12540846
Title: The chemoattractant receptor-like protein C5L2 binds the C3a des-Arg77/acylation-stimulating protein.
PubMed ID: 12540846
PubMed ID: 12754519
Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.
PubMed ID: 12754519
DOI: 10.1038/nbt827
PubMed ID: 14760718
Title: Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.
PubMed ID: 14760718
PubMed ID: 15809665
Title: Acylation-stimulating protein: effect of acute exercise and endurance training.
PubMed ID: 15809665
PubMed ID: 15833747
Title: C5L2 is a functional receptor for acylation-stimulating protein.
PubMed ID: 15833747
PubMed ID: 16335952
Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.
PubMed ID: 16335952
DOI: 10.1021/pr0502065
PubMed ID: 16302015
Title: Relationships among acylation stimulating protein, adiponectin and complement C3 in lean vs obese type 2 diabetes.
PubMed ID: 16302015
PubMed ID: 16333141
Title: Targeting the signaling pathway of acylation stimulating protein.
PubMed ID: 16333141
PubMed ID: 16263699
Title: Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach.
PubMed ID: 16263699
PubMed ID: 18805911
Title: Acylation stimulating protein but not complement C3 associates with metabolic syndrome components in Chinese children and adolescents.
PubMed ID: 18805911
DOI: 10.1530/eje-08-0467
PubMed ID: 18160402
Title: Group A streptococcal cysteine protease degrades C3 (C3b) and contributes to evasion of innate immunity.
PubMed ID: 18160402
PubMed ID: 19112495
Title: The Staphylococcus aureus protein Sbi acts as a complement inhibitor and forms a tripartite complex with host complement Factor H and C3b.
PubMed ID: 19112495
PubMed ID: 19159218
Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
PubMed ID: 19159218
DOI: 10.1021/pr8008012
PubMed ID: 19615750
Title: C5a- and ASP-mediated C5L2 activation, endocytosis and recycling are lost in S323I-C5L2 mutation.
PubMed ID: 19615750
PubMed ID: 20083651
Title: Mutational analyses reveal that the staphylococcal immune evasion molecule Sbi and complement receptor 2 (CR2) share overlapping contact residues on C3d: implications for the controversy regarding the CR2/C3d cocrystal structure.
PubMed ID: 20083651
PubMed ID: 20951140
Title: Delineation of the complement receptor type 2-C3d complex by site-directed mutagenesis and molecular docking.
PubMed ID: 20951140
PubMed ID: 19913840
Title: Serum complement C3: a determinant of cardiometabolic risk, additive to the metabolic syndrome, in middle-aged population.
PubMed ID: 19913840
PubMed ID: 21502375
Title: Staphylococcus aureus metalloprotease aureolysin cleaves complement C3 to mediate immune evasion.
PubMed ID: 21502375
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 26091039
Title: A single kinase generates the majority of the secreted phosphoproteome.
PubMed ID: 26091039
PubMed ID: 3260670
Title: Secondary structure of complement component C3a anaphylatoxin in solution as determined by NMR spectroscopy: differences between crystal and solution conformations.
PubMed ID: 3260670
PubMed ID: 9596584
Title: X-ray crystal structure of C3d: a C3 fragment and ligand for complement receptor 2.
PubMed ID: 9596584
PubMed ID: 11387479
Title: Structure of complement receptor 2 in complex with its C3d ligand.
PubMed ID: 11387479
PubMed ID: 15713468
Title: Solution structure of the complex between CR2 SCR 1-2 and C3d of human complement: an X-ray scattering and sedimentation modelling study.
PubMed ID: 15713468
PubMed ID: 16177781
Title: Structures of complement component C3 provide insights into the function and evolution of immunity.
PubMed ID: 16177781
DOI: 10.1038/nature04005
PubMed ID: 17051160
Title: Structure of C3b reveals conformational changes that underlie complement activity.
PubMed ID: 17051160
DOI: 10.1038/nature05172
PubMed ID: 17051150
Title: Structure of C3b in complex with CRIg gives insights into regulation of complement activation.
PubMed ID: 17051150
DOI: 10.1038/nature05263
PubMed ID: 17684013
Title: Structure of compstatin in complex with complement component C3c reveals a new mechanism of complement inhibition.
PubMed ID: 17684013
PubMed ID: 17351618
Title: A structural basis for complement inhibition by Staphylococcus aureus.
PubMed ID: 17351618
DOI: 10.1038/ni1450
PubMed ID: 21055811
Title: A structural basis for Staphylococcal complement subversion: X-ray structure of the complement-binding domain of Staphylococcus aureus protein Sbi in complex with ligand C3d.
PubMed ID: 21055811
PubMed ID: 21527715
Title: A crystal structure of the complex between human complement receptor 2 and its ligand C3d.
PubMed ID: 21527715
PubMed ID: 28264884
Title: Functional and structural insight into properdin control of complement alternative pathway amplification.
PubMed ID: 28264884
PubMed ID: 31507604
Title: Structural Basis for Properdin Oligomerization and Convertase Stimulation in the Human Complement System.
PubMed ID: 31507604
PubMed ID: 2473125
Title: The difference between human C3F and C3S results from a single amino acid change from an asparagine to an aspartate residue at position 1216 on the alpha-chain of the complement component, C3.
PubMed ID: 2473125
PubMed ID: 2584723
Title:
PubMed ID: 2584723
PubMed ID: 1976733
Title: Molecular basis of polymorphisms of human complement component C3.
PubMed ID: 1976733
PubMed ID: 7961791
Title: Inherited human complement C3 deficiency. An amino acid substitution in the beta-chain (Asp549 to Asn) impairs C3 secretion.
PubMed ID: 7961791
PubMed ID: 17634448
Title: Complement C3 variant and the risk of age-related macular degeneration.
PubMed ID: 17634448
DOI: 10.1056/nejmoa072618
PubMed ID: 18796626
Title: Mutations in complement C3 predispose to development of atypical hemolytic uremic syndrome.
PubMed ID: 18796626
PubMed ID: 20513133
Title: Mutations in alternative pathway complement proteins in American patients with atypical hemolytic uremic syndrome.
PubMed ID: 20513133
DOI: 10.1002/humu.21256
PubMed ID: 22028381
Title: Quantitative detection of single amino acid polymorphisms by targeted proteomics.
PubMed ID: 22028381
DOI: 10.1093/jmcb/mjr024
PubMed ID: 21555552
Title: Common polymorphisms in C3, factor B, and factor H collaborate to determine systemic complement activity and disease risk.
PubMed ID: 21555552
PubMed ID: 21285368
Title: Dual interaction of factor H with C3d and glycosaminoglycans in host-nonhost discrimination by complement.
PubMed ID: 21285368
PubMed ID: 21317894
Title: Structural basis for engagement by complement factor H of C3b on a self surface.
PubMed ID: 21317894
DOI: 10.1038/nsmb.2018
PubMed ID: 24036952
Title: Rare variants in CFI, C3 and C9 are associated with high risk of advanced age-related macular degeneration.
PubMed ID: 24036952
DOI: 10.1038/ng.2741
Sequence Information:
- Length: 1663
- Mass: 187148
- Checksum: 30C2832A9E75FFC4
- Sequence:
MGPTSGPSLL LLLLTHLPLA LGSPMYSIIT PNILRLESEE TMVLEAHDAQ GDVPVTVTVH DFPGKKLVLS SEKTVLTPAT NHMGNVTFTI PANREFKSEK GRNKFVTVQA TFGTQVVEKV VLVSLQSGYL FIQTDKTIYT PGSTVLYRIF TVNHKLLPVG RTVMVNIENP EGIPVKQDSL SSQNQLGVLP LSWDIPELVN MGQWKIRAYY ENSPQQVFST EFEVKEYVLP SFEVIVEPTE KFYYIYNEKG LEVTITARFL YGKKVEGTAF VIFGIQDGEQ RISLPESLKR IPIEDGSGEV VLSRKVLLDG VQNPRAEDLV GKSLYVSATV ILHSGSDMVQ AERSGIPIVT SPYQIHFTKT PKYFKPGMPF DLMVFVTNPD GSPAYRVPVA VQGEDTVQSL TQGDGVAKLS INTHPSQKPL SITVRTKKQE LSEAEQATRT MQALPYSTVG NSNNYLHLSV LRTELRPGET LNVNFLLRMD RAHEAKIRYY TYLIMNKGRL LKAGRQVREP GQDLVVLPLS ITTDFIPSFR LVAYYTLIGA SGQREVVADS VWVDVKDSCV GSLVVKSGQS EDRQPVPGQQ MTLKIEGDHG ARVVLVAVDK GVFVLNKKNK LTQSKIWDVV EKADIGCTPG SGKDYAGVFS DAGLTFTSSS GQQTAQRAEL QCPQPAARRR RSVQLTEKRM DKVGKYPKEL RKCCEDGMRE NPMRFSCQRR TRFISLGEAC KKVFLDCCNY ITELRRQHAR ASHLGLARSN LDEDIIAEEN IVSRSEFPES WLWNVEDLKE PPKNGISTKL MNIFLKDSIT TWEILAVSMS DKKGICVADP FEVTVMQDFF IDLRLPYSVV RNEQVEIRAV LYNYRQNQEL KVRVELLHNP AFCSLATTKR RHQQTVTIPP KSSLSVPYVI VPLKTGLQEV EVKAAVYHHF ISDGVRKSLK VVPEGIRMNK TVAVRTLDPE RLGREGVQKE DIPPADLSDQ VPDTESETRI LLQGTPVAQM TEDAVDAERL KHLIVTPSGC GEQNMIGMTP TVIAVHYLDE TEQWEKFGLE KRQGALELIK KGYTQQLAFR QPSSAFAAFV KRAPSTWLTA YVVKVFSLAV NLIAIDSQVL CGAVKWLILE KQKPDGVFQE DAPVIHQEMI GGLRNNNEKD MALTAFVLIS LQEAKDICEE QVNSLPGSIT KAGDFLEANY MNLQRSYTVA IAGYALAQMG RLKGPLLNKF LTTAKDKNRW EDPGKQLYNV EATSYALLAL LQLKDFDFVP PVVRWLNEQR YYGGGYGSTQ ATFMVFQALA QYQKDAPDHQ ELNLDVSLQL PSRSSKITHR IHWESASLLR SEETKENEGF TVTAEGKGQG TLSVVTMYHA KAKDQLTCNK FDLKVTIKPA PETEKRPQDA KNTMILEICT RYRGDQDATM SILDISMMTG FAPDTDDLKQ LANGVDRYIS KYELDKAFSD RNTLIIYLDK VSHSEDDCLA FKVHQYFNVE LIQPGAVKVY AYYNLEESCT RFYHPEKEDG KLNKLCRDEL CRCAEENCFI QKSDDKVTLE ERLDKACEPG VDYVYKTRLV KVQLSNDFDE YIMAIEQTIK SGSDEVQVGQ QRTFISPIKC REALKLEEKK HYLMWGLSSD FWGEKPNLSY IIGKDTWVEH WPEEDECQDE ENQKQCQDLG AFTESMVVFG CPN
Genular Protein ID: 1271765858
Symbol: B4DR57_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 235
- Mass: 26082
- Checksum: 96A083386384C0CB
- Sequence:
MGPTSGPSLL LLLLTHLPLA LGSPMYSIIT PNILRLESEE TMVQEAHDAQ GDVPVTVTVH DFPGKKLVLS SEKTVLTPAT NHMGNVTFTI PANREFKSEK GRNKFVTVQA TFGTQVVEKV VLVSLQSGYL LIQTDKTIYT PGSTVLYRIF TVNHKLLPVG RTVMVNIENP EGIPVKQDSL SSQNQLGVLP LSWDIPELVN MGQWKIRAYY ENSPQQVFST EFEVKEYVLP SFEVI
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.