Details for: C3

Gene ID: 718

Symbol: C3

Ensembl ID: ENSG00000125730

Description: complement C3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 89.5041
    Cell Significance Index: 44.9500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 58.4728
    Cell Significance Index: -23.7600
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 53.5113
    Cell Significance Index: 141.1600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 24.7606
    Cell Significance Index: -23.6400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 17.6105
    Cell Significance Index: -54.0900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 16.4061
    Cell Significance Index: 276.3600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.6239
    Cell Significance Index: -28.4600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 7.4729
    Cell Significance Index: 145.8500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 7.0076
    Cell Significance Index: 47.4800
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 4.3200
    Cell Significance Index: 24.7700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.7732
    Cell Significance Index: 108.1600
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 3.4860
    Cell Significance Index: 20.0800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 3.2497
    Cell Significance Index: 75.0800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 3.1418
    Cell Significance Index: 623.5000
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 2.1600
    Cell Significance Index: 8.1400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 2.1368
    Cell Significance Index: 33.0600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.8191
    Cell Significance Index: 26.8500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.6538
    Cell Significance Index: 52.9700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 1.4430
    Cell Significance Index: 72.9300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.3750
    Cell Significance Index: 64.6300
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 1.2126
    Cell Significance Index: 11.6900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.8455
    Cell Significance Index: 116.1100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7758
    Cell Significance Index: 423.6700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7328
    Cell Significance Index: 139.4500
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.7167
    Cell Significance Index: 10.2700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.5997
    Cell Significance Index: 31.2400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.3847
    Cell Significance Index: 291.2200
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.3424
    Cell Significance Index: 3.7400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.2714
    Cell Significance Index: 31.0900
  • Cell Name: airway submucosal gland collecting duct epithelial cell (CL4033023)
    Fold Change: 0.2479
    Cell Significance Index: 1.7400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2318
    Cell Significance Index: 209.2800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2043
    Cell Significance Index: 20.2100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1133
    Cell Significance Index: 18.4300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.0696
    Cell Significance Index: 1.0000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0685
    Cell Significance Index: 8.8500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0199
    Cell Significance Index: 0.7000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0114
    Cell Significance Index: 1.2500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0005
    Cell Significance Index: -0.0900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0034
    Cell Significance Index: -0.6200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0109
    Cell Significance Index: -8.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0120
    Cell Significance Index: -22.5300
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0206
    Cell Significance Index: -0.1700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0208
    Cell Significance Index: -12.9900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0218
    Cell Significance Index: -40.2400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0260
    Cell Significance Index: -39.9500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0264
    Cell Significance Index: -14.9100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0299
    Cell Significance Index: -20.6500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0299
    Cell Significance Index: -40.6700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0339
    Cell Significance Index: -21.5100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0341
    Cell Significance Index: -25.0100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0420
    Cell Significance Index: -15.0700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0430
    Cell Significance Index: -1.2400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0486
    Cell Significance Index: -4.9600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0568
    Cell Significance Index: -1.4200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0593
    Cell Significance Index: -17.0700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0611
    Cell Significance Index: -27.7200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0825
    Cell Significance Index: -10.1500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0855
    Cell Significance Index: -37.8000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0875
    Cell Significance Index: -18.4300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0891
    Cell Significance Index: -5.4600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0941
    Cell Significance Index: -10.9700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0992
    Cell Significance Index: -19.9000
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: -0.1024
    Cell Significance Index: -1.0100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1037
    Cell Significance Index: -4.7000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1072
    Cell Significance Index: -7.4200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1077
    Cell Significance Index: -15.6500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1248
    Cell Significance Index: -7.4900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1542
    Cell Significance Index: -3.3400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1591
    Cell Significance Index: -3.3000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1680
    Cell Significance Index: -19.1800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1767
    Cell Significance Index: -8.2400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1893
    Cell Significance Index: -14.5300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2404
    Cell Significance Index: -28.3500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2652
    Cell Significance Index: -27.6100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.2783
    Cell Significance Index: -4.6800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3052
    Cell Significance Index: -22.7500
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.3401
    Cell Significance Index: -5.4000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3434
    Cell Significance Index: -27.2000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3911
    Cell Significance Index: -26.3000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.4052
    Cell Significance Index: -21.0500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.4213
    Cell Significance Index: -54.0100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4220
    Cell Significance Index: -25.9400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4235
    Cell Significance Index: -9.0200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4508
    Cell Significance Index: -28.4100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.4559
    Cell Significance Index: -6.8700
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.4604
    Cell Significance Index: -5.5300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4613
    Cell Significance Index: -29.7600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4866
    Cell Significance Index: -13.6000
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.5153
    Cell Significance Index: -4.2600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5410
    Cell Significance Index: -30.3600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5629
    Cell Significance Index: -7.6800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5955
    Cell Significance Index: -26.3400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.6194
    Cell Significance Index: -43.8100
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.6204
    Cell Significance Index: -6.4000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6364
    Cell Significance Index: -23.3600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6469
    Cell Significance Index: -33.9600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6611
    Cell Significance Index: -17.6900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.6652
    Cell Significance Index: -18.1100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6858
    Cell Significance Index: -25.9700
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -0.7188
    Cell Significance Index: -4.5200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** Complement C3 is a large glycoprotein, consisting of three domains: C3a, C3b, and C3c. The C3a domain is a potent anaphylatoxin, which stimulates the production of pro-inflammatory cytokines and chemokines. The C3b domain is involved in the opsonization of pathogens, marking them for destruction by phagocytic cells. The C3c domain is involved in the regulation of the complement cascade, inhibiting the formation of the membrane attack complex (MAC). **Pathways and Functions** C3 is involved in various signaling pathways, including: 1. **Complement cascade**: C3 is the central protein in the complement cascade, which is activated by the binding of pathogens to the surface of host cells. The activation of C3 leads to the production of C3a and C3b, which stimulate the production of pro-inflammatory cytokines and chemokines. 2. **Adaptive immune system**: C3 is involved in the regulation of T-cell activation and the production of cytokines, which are essential for the adaptive immune response. 3. **Inflammatory response**: C3 is a key regulator of the inflammatory response, stimulating the production of pro-inflammatory cytokines and chemokines. 4. **Immune system regulation**: C3 is involved in the regulation of immune cell function, including the activation and proliferation of T-cells and B-cells. **Clinical Significance** C3 has significant clinical implications in various diseases, including: 1. **Systemic lupus erythematosus (SLE)**: Elevated levels of C3 are a hallmark of SLE, a chronic autoimmune disorder characterized by inflammation and tissue damage. 2. **Leishmaniasis**: C3 is involved in the regulation of the immune response to Leishmania parasites, which cause this infectious disease. 3. **Infectious diseases**: C3 is involved in the regulation of the immune response to various pathogens, including bacteria, viruses, and fungi. 4. **Autoimmune disorders**: C3 is involved in the regulation of immune cell function, which is essential for the development of autoimmune disorders, such as rheumatoid arthritis and multiple sclerosis. In conclusion, Complement C3 is a critical protein in the innate immune system, playing a central role in the regulation of inflammation, cell signaling, and immune responses. Its dysregulation is implicated in various diseases, highlighting the importance of C3 in maintaining immune homeostasis.

Genular Protein ID: 1215384334

Symbol: CO3_HUMAN

Name: Complement C3

UniProtKB Accession Codes:

P01024 A7E236

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CORUM 1 CPTAC 4 CTD 1 CarbonylDB 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 9 DrugCentral 1 EMBL 5 EMDB 15 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 43 Gene3D 10 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 23 KEGG 1 MANE-Select 1 MEROPS 1 MIM 7 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 66 PDBsum 66 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 12 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 10 RefSeq 1 SABIO-RK 1 SFLD 1 SIGNOR 1 SMART 6 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 TreeFam 1 UniProtKB 4 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2579379

Title: Human complement component C3: cDNA coding sequence and derived primary structure.

PubMed ID: 2579379

DOI: 10.1073/pnas.82.3.708

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8376604

Title: The adipsin-acylation stimulating protein system and regulation of intracellular triglyceride synthesis.

PubMed ID: 8376604

DOI: 10.1172/jci116733

PubMed ID: 1238393

Title: Human anaphylatoxin (C3a) from the third component of complement. Primary structure.

PubMed ID: 1238393

DOI: 10.1016/s0021-9258(19)40758-8

PubMed ID: 24367091

Title: Neisseria meningitidis NalP cleaves human complement C3, facilitating degradation of C3b and survival in human serum.

PubMed ID: 24367091

DOI: 10.1073/pnas.1321556111

PubMed ID: 7539791

Title: Identification of angiotensinogen and complement C3dg as novel proteins binding the proform of eosinophil major basic protein in human pregnancy serum and plasma.

PubMed ID: 7539791

DOI: 10.1074/jbc.270.23.13645

PubMed ID: 6175959

Title: Third component of human complement: localization of the internal thiolester bond.

PubMed ID: 6175959

DOI: 10.1073/pnas.79.4.1054

PubMed ID: 2972794

Title: Identification of distinct C3b and C4b recognition sites in the human C3b/C4b receptor (CR1, CD35) by deletion mutagenesis.

PubMed ID: 2972794

DOI: 10.1084/jem.168.5.1699

PubMed ID: 3279119

Title: A 34-amino acid peptide of the third component of complement mediates properdin binding.

PubMed ID: 3279119

PubMed ID: 2849025

Title: Complement component C3b binds directly to purified glycoprotein C of herpes simplex virus types 1 and 2.

PubMed ID: 2849025

DOI: 10.1016/0882-4010(87)90012-x

PubMed ID: 2909530

Title: Purification and characterization of acylation stimulating protein.

PubMed ID: 2909530

DOI: 10.1016/s0021-9258(17)31275-9

PubMed ID: 1577777

Title: Structural requirements for thioester bond formation in human complement component C3. Reassessment of the role of thioester bond integrity on the conformation of C3.

PubMed ID: 1577777

DOI: 10.1016/s0021-9258(19)50200-9

PubMed ID: 8416818

Title: Disulfide bridges in human complement component C3b.

PubMed ID: 8416818

DOI: 10.1016/0014-5793(93)81139-q

PubMed ID: 8175757

Title: Analysis of the functional domains of complement receptor type 1 (C3b/C4b receptor; CD35) by substitution mutagenesis.

PubMed ID: 8175757

DOI: 10.1016/s0021-9258(17)36829-1

PubMed ID: 9059512

Title: Acylation-stimulating protein (ASP) regulates glucose transport in the rat L6 muscle cell line.

PubMed ID: 9059512

DOI: 10.1016/s0005-2760(96)00144-0

PubMed ID: 9555951

Title: Coordinated release of acylation stimulating protein (ASP) and triacylglycerol clearance by human adipose tissue in vivo in the postprandial period.

PubMed ID: 9555951

PubMed ID: 10432298

Title: Acylation-stimulating protein (ASP): structure-function determinants of cell surface binding and triacylglycerol synthetic activity.

PubMed ID: 10432298

DOI: 10.1042/bj3420041

PubMed ID: 11773063

Title: The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des Arg(74).

PubMed ID: 11773063

DOI: 10.1074/jbc.c100714200

PubMed ID: 12540846

Title: The chemoattractant receptor-like protein C5L2 binds the C3a des-Arg77/acylation-stimulating protein.

PubMed ID: 12540846

DOI: 10.1074/jbc.m206169200

PubMed ID: 12754519

Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.

PubMed ID: 12754519

DOI: 10.1038/nbt827

PubMed ID: 14760718

Title: Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.

PubMed ID: 14760718

DOI: 10.1002/pmic.200300556

PubMed ID: 15809665

Title: Acylation-stimulating protein: effect of acute exercise and endurance training.

PubMed ID: 15809665

DOI: 10.1038/sj.ijo.0802949

PubMed ID: 15833747

Title: C5L2 is a functional receptor for acylation-stimulating protein.

PubMed ID: 15833747

DOI: 10.1074/jbc.m406921200

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 16302015

Title: Relationships among acylation stimulating protein, adiponectin and complement C3 in lean vs obese type 2 diabetes.

PubMed ID: 16302015

DOI: 10.1038/sj.ijo.0803173

PubMed ID: 16333141

Title: Targeting the signaling pathway of acylation stimulating protein.

PubMed ID: 16333141

DOI: 10.1194/jlr.m500500-jlr200

PubMed ID: 16263699

Title: Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach.

PubMed ID: 16263699

DOI: 10.1074/mcp.m500324-mcp200

PubMed ID: 18805911

Title: Acylation stimulating protein but not complement C3 associates with metabolic syndrome components in Chinese children and adolescents.

PubMed ID: 18805911

DOI: 10.1530/eje-08-0467

PubMed ID: 18160402

Title: Group A streptococcal cysteine protease degrades C3 (C3b) and contributes to evasion of innate immunity.

PubMed ID: 18160402

DOI: 10.1074/jbc.m704821200

PubMed ID: 19112495

Title: The Staphylococcus aureus protein Sbi acts as a complement inhibitor and forms a tripartite complex with host complement Factor H and C3b.

PubMed ID: 19112495

DOI: 10.1371/journal.ppat.1000250

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19615750

Title: C5a- and ASP-mediated C5L2 activation, endocytosis and recycling are lost in S323I-C5L2 mutation.

PubMed ID: 19615750

DOI: 10.1016/j.molimm.2009.06.007

PubMed ID: 20083651

Title: Mutational analyses reveal that the staphylococcal immune evasion molecule Sbi and complement receptor 2 (CR2) share overlapping contact residues on C3d: implications for the controversy regarding the CR2/C3d cocrystal structure.

PubMed ID: 20083651

DOI: 10.4049/jimmunol.0902919

PubMed ID: 20951140

Title: Delineation of the complement receptor type 2-C3d complex by site-directed mutagenesis and molecular docking.

PubMed ID: 20951140

DOI: 10.1016/j.jmb.2010.10.005

PubMed ID: 19913840

Title: Serum complement C3: a determinant of cardiometabolic risk, additive to the metabolic syndrome, in middle-aged population.

PubMed ID: 19913840

DOI: 10.1016/j.metabol.2009.09.006

PubMed ID: 21502375

Title: Staphylococcus aureus metalloprotease aureolysin cleaves complement C3 to mediate immune evasion.

PubMed ID: 21502375

DOI: 10.4049/jimmunol.1002948

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

PubMed ID: 3260670

Title: Secondary structure of complement component C3a anaphylatoxin in solution as determined by NMR spectroscopy: differences between crystal and solution conformations.

PubMed ID: 3260670

DOI: 10.1073/pnas.85.14.5036

PubMed ID: 9596584

Title: X-ray crystal structure of C3d: a C3 fragment and ligand for complement receptor 2.

PubMed ID: 9596584

DOI: 10.1126/science.280.5367.1277

PubMed ID: 11387479

Title: Structure of complement receptor 2 in complex with its C3d ligand.

PubMed ID: 11387479

DOI: 10.1126/science.1059118

PubMed ID: 15713468

Title: Solution structure of the complex between CR2 SCR 1-2 and C3d of human complement: an X-ray scattering and sedimentation modelling study.

PubMed ID: 15713468

DOI: 10.1016/j.jmb.2004.12.006

PubMed ID: 16177781

Title: Structures of complement component C3 provide insights into the function and evolution of immunity.

PubMed ID: 16177781

DOI: 10.1038/nature04005

PubMed ID: 17051160

Title: Structure of C3b reveals conformational changes that underlie complement activity.

PubMed ID: 17051160

DOI: 10.1038/nature05172

PubMed ID: 17051150

Title: Structure of C3b in complex with CRIg gives insights into regulation of complement activation.

PubMed ID: 17051150

DOI: 10.1038/nature05263

PubMed ID: 17684013

Title: Structure of compstatin in complex with complement component C3c reveals a new mechanism of complement inhibition.

PubMed ID: 17684013

DOI: 10.1074/jbc.m704587200

PubMed ID: 17351618

Title: A structural basis for complement inhibition by Staphylococcus aureus.

PubMed ID: 17351618

DOI: 10.1038/ni1450

PubMed ID: 21055811

Title: A structural basis for Staphylococcal complement subversion: X-ray structure of the complement-binding domain of Staphylococcus aureus protein Sbi in complex with ligand C3d.

PubMed ID: 21055811

DOI: 10.1016/j.molimm.2010.09.017

PubMed ID: 21527715

Title: A crystal structure of the complex between human complement receptor 2 and its ligand C3d.

PubMed ID: 21527715

DOI: 10.1126/science.1201954

PubMed ID: 28264884

Title: Functional and structural insight into properdin control of complement alternative pathway amplification.

PubMed ID: 28264884

DOI: 10.15252/embj.201696173

PubMed ID: 31507604

Title: Structural Basis for Properdin Oligomerization and Convertase Stimulation in the Human Complement System.

PubMed ID: 31507604

DOI: 10.3389/fimmu.2019.02007

PubMed ID: 2473125

Title: The difference between human C3F and C3S results from a single amino acid change from an asparagine to an aspartate residue at position 1216 on the alpha-chain of the complement component, C3.

PubMed ID: 2473125

PubMed ID: 2584723

Title:

PubMed ID: 2584723

PubMed ID: 1976733

Title: Molecular basis of polymorphisms of human complement component C3.

PubMed ID: 1976733

DOI: 10.1084/jem.172.4.1011

PubMed ID: 7961791

Title: Inherited human complement C3 deficiency. An amino acid substitution in the beta-chain (Asp549 to Asn) impairs C3 secretion.

PubMed ID: 7961791

DOI: 10.1016/s0021-9258(18)46954-2

PubMed ID: 17634448

Title: Complement C3 variant and the risk of age-related macular degeneration.

PubMed ID: 17634448

DOI: 10.1056/nejmoa072618

PubMed ID: 18796626

Title: Mutations in complement C3 predispose to development of atypical hemolytic uremic syndrome.

PubMed ID: 18796626

DOI: 10.1182/blood-2008-01-133702

PubMed ID: 20513133

Title: Mutations in alternative pathway complement proteins in American patients with atypical hemolytic uremic syndrome.

PubMed ID: 20513133

DOI: 10.1002/humu.21256

PubMed ID: 22028381

Title: Quantitative detection of single amino acid polymorphisms by targeted proteomics.

PubMed ID: 22028381

DOI: 10.1093/jmcb/mjr024

PubMed ID: 21555552

Title: Common polymorphisms in C3, factor B, and factor H collaborate to determine systemic complement activity and disease risk.

PubMed ID: 21555552

DOI: 10.1073/pnas.1019338108

PubMed ID: 21285368

Title: Dual interaction of factor H with C3d and glycosaminoglycans in host-nonhost discrimination by complement.

PubMed ID: 21285368

DOI: 10.1073/pnas.1017087108

PubMed ID: 21317894

Title: Structural basis for engagement by complement factor H of C3b on a self surface.

PubMed ID: 21317894

DOI: 10.1038/nsmb.2018

PubMed ID: 24036952

Title: Rare variants in CFI, C3 and C9 are associated with high risk of advanced age-related macular degeneration.

PubMed ID: 24036952

DOI: 10.1038/ng.2741

Sequence Information:

  • Length: 1663
  • Mass: 187148
  • Checksum: 30C2832A9E75FFC4
  • Sequence:
    • MGPTSGPSLL LLLLTHLPLA LGSPMYSIIT PNILRLESEE TMVLEAHDAQ GDVPVTVTVH 
DFPGKKLVLS SEKTVLTPAT NHMGNVTFTI PANREFKSEK GRNKFVTVQA TFGTQVVEKV 
VLVSLQSGYL FIQTDKTIYT PGSTVLYRIF TVNHKLLPVG RTVMVNIENP EGIPVKQDSL 
SSQNQLGVLP LSWDIPELVN MGQWKIRAYY ENSPQQVFST EFEVKEYVLP SFEVIVEPTE 
KFYYIYNEKG LEVTITARFL YGKKVEGTAF VIFGIQDGEQ RISLPESLKR IPIEDGSGEV 
VLSRKVLLDG VQNPRAEDLV GKSLYVSATV ILHSGSDMVQ AERSGIPIVT SPYQIHFTKT 
PKYFKPGMPF DLMVFVTNPD GSPAYRVPVA VQGEDTVQSL TQGDGVAKLS INTHPSQKPL 
SITVRTKKQE LSEAEQATRT MQALPYSTVG NSNNYLHLSV LRTELRPGET LNVNFLLRMD 
RAHEAKIRYY TYLIMNKGRL LKAGRQVREP GQDLVVLPLS ITTDFIPSFR LVAYYTLIGA 
SGQREVVADS VWVDVKDSCV GSLVVKSGQS EDRQPVPGQQ MTLKIEGDHG ARVVLVAVDK 
GVFVLNKKNK LTQSKIWDVV EKADIGCTPG SGKDYAGVFS DAGLTFTSSS GQQTAQRAEL 
QCPQPAARRR RSVQLTEKRM DKVGKYPKEL RKCCEDGMRE NPMRFSCQRR TRFISLGEAC 
KKVFLDCCNY ITELRRQHAR ASHLGLARSN LDEDIIAEEN IVSRSEFPES WLWNVEDLKE 
PPKNGISTKL MNIFLKDSIT TWEILAVSMS DKKGICVADP FEVTVMQDFF IDLRLPYSVV 
RNEQVEIRAV LYNYRQNQEL KVRVELLHNP AFCSLATTKR RHQQTVTIPP KSSLSVPYVI 
VPLKTGLQEV EVKAAVYHHF ISDGVRKSLK VVPEGIRMNK TVAVRTLDPE RLGREGVQKE 
DIPPADLSDQ VPDTESETRI LLQGTPVAQM TEDAVDAERL KHLIVTPSGC GEQNMIGMTP 
TVIAVHYLDE TEQWEKFGLE KRQGALELIK KGYTQQLAFR QPSSAFAAFV KRAPSTWLTA 
YVVKVFSLAV NLIAIDSQVL CGAVKWLILE KQKPDGVFQE DAPVIHQEMI GGLRNNNEKD 
MALTAFVLIS LQEAKDICEE QVNSLPGSIT KAGDFLEANY MNLQRSYTVA IAGYALAQMG 
RLKGPLLNKF LTTAKDKNRW EDPGKQLYNV EATSYALLAL LQLKDFDFVP PVVRWLNEQR 
YYGGGYGSTQ ATFMVFQALA QYQKDAPDHQ ELNLDVSLQL PSRSSKITHR IHWESASLLR 
SEETKENEGF TVTAEGKGQG TLSVVTMYHA KAKDQLTCNK FDLKVTIKPA PETEKRPQDA 
KNTMILEICT RYRGDQDATM SILDISMMTG FAPDTDDLKQ LANGVDRYIS KYELDKAFSD 
RNTLIIYLDK VSHSEDDCLA FKVHQYFNVE LIQPGAVKVY AYYNLEESCT RFYHPEKEDG 
KLNKLCRDEL CRCAEENCFI QKSDDKVTLE ERLDKACEPG VDYVYKTRLV KVQLSNDFDE 
YIMAIEQTIK SGSDEVQVGQ QRTFISPIKC REALKLEEKK HYLMWGLSSD FWGEKPNLSY 
IIGKDTWVEH WPEEDECQDE ENQKQCQDLG AFTESMVVFG CPN

Genular Protein ID: 1271765858

Symbol: B4DR57_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DR57

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 1 Gene3D 1 InterPro 3 KEGG 1 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 Pfam 4 RefSeq 1 SAM 1 SMR 1

Sequence Information:

  • Length: 235
  • Mass: 26082
  • Checksum: 96A083386384C0CB
  • Sequence:
    • MGPTSGPSLL LLLLTHLPLA LGSPMYSIIT PNILRLESEE TMVQEAHDAQ GDVPVTVTVH 
DFPGKKLVLS SEKTVLTPAT NHMGNVTFTI PANREFKSEK GRNKFVTVQA TFGTQVVEKV 
VLVSLQSGYL LIQTDKTIYT PGSTVLYRIF TVNHKLLPVG RTVMVNIENP EGIPVKQDSL 
SSQNQLGVLP LSWDIPELVN MGQWKIRAYY ENSPQQVFST EFEVKEYVLP SFEVI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.