Details for: C3AR1

Gene ID: 719

Symbol: C3AR1

Ensembl ID: ENSG00000171860

Description: complement C3a receptor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 61.6541
    Cell Significance Index: -9.5900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 38.4792
    Cell Significance Index: -9.7600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 23.9750
    Cell Significance Index: -9.7400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 20.5294
    Cell Significance Index: -10.5600
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 11.4900
    Cell Significance Index: 30.3100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 10.4583
    Cell Significance Index: -9.9900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 7.7699
    Cell Significance Index: -9.5800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 4.4407
    Cell Significance Index: 68.7100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 4.3863
    Cell Significance Index: 109.6500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.3116
    Cell Significance Index: -7.1000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.7993
    Cell Significance Index: -4.8200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.5101
    Cell Significance Index: 68.4500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.4918
    Cell Significance Index: 32.3200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0667
    Cell Significance Index: 203.0000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.7628
    Cell Significance Index: 6.2200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7604
    Cell Significance Index: 75.2200
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.7321
    Cell Significance Index: 5.9300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6776
    Cell Significance Index: 611.8000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.4665
    Cell Significance Index: 7.0300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3491
    Cell Significance Index: 56.7800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.3360
    Cell Significance Index: 6.2100
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.3078
    Cell Significance Index: 4.3200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2878
    Cell Significance Index: 31.3000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2202
    Cell Significance Index: 4.6900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1422
    Cell Significance Index: 9.8400
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.0601
    Cell Significance Index: 0.2500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0033
    Cell Significance Index: 0.2000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0004
    Cell Significance Index: 0.0800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0002
    Cell Significance Index: 0.0200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0028
    Cell Significance Index: -0.1000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0029
    Cell Significance Index: -5.5300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0045
    Cell Significance Index: -0.1300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0060
    Cell Significance Index: -9.2300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0061
    Cell Significance Index: -11.3100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0085
    Cell Significance Index: -11.5300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0100
    Cell Significance Index: -2.8700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0110
    Cell Significance Index: -8.3200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0122
    Cell Significance Index: -9.0200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0125
    Cell Significance Index: -7.9400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0125
    Cell Significance Index: -2.5100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0132
    Cell Significance Index: -9.6900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0149
    Cell Significance Index: -8.3800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0172
    Cell Significance Index: -6.1600
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0205
    Cell Significance Index: -0.3000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0206
    Cell Significance Index: -9.3300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0285
    Cell Significance Index: -5.1400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0453
    Cell Significance Index: -9.5400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0495
    Cell Significance Index: -7.2000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0519
    Cell Significance Index: -8.8600
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0692
    Cell Significance Index: -0.9200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0699
    Cell Significance Index: -9.6100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0720
    Cell Significance Index: -8.8500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0735
    Cell Significance Index: -9.4200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0737
    Cell Significance Index: -4.5200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0738
    Cell Significance Index: -8.4600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0816
    Cell Significance Index: -10.5400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0853
    Cell Significance Index: -9.9400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0904
    Cell Significance Index: -10.6600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0913
    Cell Significance Index: -9.5100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1119
    Cell Significance Index: -5.8300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1131
    Cell Significance Index: -5.3200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1159
    Cell Significance Index: -7.4800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1225
    Cell Significance Index: -6.1900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1227
    Cell Significance Index: -3.4300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1229
    Cell Significance Index: -9.4300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1256
    Cell Significance Index: -5.4600
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1284
    Cell Significance Index: -2.1800
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1361
    Cell Significance Index: -1.3900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1377
    Cell Significance Index: -4.4100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1405
    Cell Significance Index: -10.4700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1410
    Cell Significance Index: -9.4800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1485
    Cell Significance Index: -9.1300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1525
    Cell Significance Index: -7.9200
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.1550
    Cell Significance Index: -1.3100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1591
    Cell Significance Index: -7.4200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1597
    Cell Significance Index: -4.2800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1620
    Cell Significance Index: -10.2100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1878
    Cell Significance Index: -10.5400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1960
    Cell Significance Index: -8.0300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2030
    Cell Significance Index: -5.4200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2066
    Cell Significance Index: -4.0400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2093
    Cell Significance Index: -5.3800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2152
    Cell Significance Index: -6.3200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2204
    Cell Significance Index: -7.7200
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.2276
    Cell Significance Index: -1.9900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.2314
    Cell Significance Index: -3.3600
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.2349
    Cell Significance Index: -2.0700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2438
    Cell Significance Index: -7.7700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2453
    Cell Significance Index: -10.8500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2494
    Cell Significance Index: -6.0400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2703
    Cell Significance Index: -8.8500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2709
    Cell Significance Index: -6.9200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2863
    Cell Significance Index: -10.8400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2877
    Cell Significance Index: -4.9300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3040
    Cell Significance Index: -11.1600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3131
    Cell Significance Index: -7.8100
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.3145
    Cell Significance Index: -3.8900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3335
    Cell Significance Index: -8.9200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3341
    Cell Significance Index: -9.8400
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.3355
    Cell Significance Index: -3.0700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Receptor Function:** C3AR1 is a G-protein-coupled receptor (GPCR) that recognizes and binds to C3a, an anaphylatoxin derived from the complement component C3. 2. **Signaling Pathways:** The activation of C3AR1 triggers a complex signaling cascade that involves the activation of phospholipase C, increase in intracellular calcium concentrations, and the production of pro-inflammatory cytokines. 3. **Cell Recruitment:** C3AR1 is involved in the recruitment of myeloid leukocytes, including macrophages and neutrophils, to sites of inflammation, where they contribute to the clearance of pathogens and the promotion of tissue repair. 4. **Disease Association:** Alterations in C3AR1 expression or function have been implicated in various inflammatory and autoimmune diseases, including Leishmania infection, atherosclerosis, and rheumatoid arthritis. **Pathways and Functions:** 1. **Complement Cascade:** C3AR1 is part of the complement cascade, a complex network of proteins that play a crucial role in the innate immune response. 2. **Chemotaxis:** The activation of C3AR1 promotes chemotaxis, the movement of cells in response to chemical stimuli, which is essential for the recruitment of immune cells to sites of inflammation. 3. **Angiogenesis:** C3AR1 is involved in the regulation of angiogenesis, the process of new blood vessel formation, which is critical for tissue repair and inflammation resolution. 4. **Inflammatory Response:** C3AR1 plays a key role in the regulation of the inflammatory response, promoting the production of pro-inflammatory cytokines and the recruitment of immune cells to sites of inflammation. **Clinical Significance:** 1. **Inflammatory Diseases:** Alterations in C3AR1 expression or function have been implicated in various inflammatory diseases, including Leishmania infection, atherosclerosis, and rheumatoid arthritis. 2. **Immunotherapy:** Targeting C3AR1 may provide a novel therapeutic strategy for the treatment of inflammatory diseases. 3. **Vaccine Development:** Understanding the role of C3AR1 in the immune response may lead to the development of vaccines that target this receptor, potentially enhancing immune protection against infectious diseases. 4. **Cancer Research:** C3AR1 has been implicated in cancer progression and metastasis, suggesting that targeting this receptor may provide a novel therapeutic strategy for cancer treatment. In conclusion, C3AR1 is a crucial component of the innate immune system, playing a pivotal role in the regulation of inflammation and immune responses. Further research on this gene may lead to the development of novel therapeutic strategies for the treatment of inflammatory diseases and cancer.

Genular Protein ID: 2105727185

Symbol: C3AR_HUMAN

Name: C3a anaphylatoxin chemotactic receptor

UniProtKB Accession Codes:

Q16581 O43771 Q92868

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EMDB 10 Ensembl 1 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 10 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 5 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8605247

Title: cDNA cloning of a novel G protein-coupled receptor with a large extracellular loop structure.

PubMed ID: 8605247

DOI: 10.1016/0167-4781(95)00209-x

PubMed ID: 8765043

Title: Expression cloning of the human C3a anaphylatoxin receptor (C3aR) from differentiated U-937 cells.

PubMed ID: 8765043

DOI: 10.1002/eji.1830260840

PubMed ID: 8702752

Title: Molecular cloning and characterization of the human anaphylatoxin C3a receptor.

PubMed ID: 8702752

DOI: 10.1074/jbc.271.34.20231

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12871936

Title: Sulfation of tyrosine 174 in the human C3a receptor is essential for binding of C3a anaphylatoxin.

PubMed ID: 12871936

DOI: 10.1074/jbc.m306061200

PubMed ID: 23234360

Title: LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins.

PubMed ID: 23234360

DOI: 10.1021/pr300963h

Sequence Information:

  • Length: 482
  • Mass: 53864
  • Checksum: 287E219D98CED203
  • Sequence:
    • MASFSAETNS TDLLSQPWNE PPVILSMVIL SLTFLLGLPG NGLVLWVAGL KMQRTVNTIW 
FLHLTLADLL CCLSLPFSLA HLALQGQWPY GRFLCKLIPS IIVLNMFASV FLLTAISLDR 
CLVVFKPIWC QNHRNVGMAC SICGCIWVVA FVMCIPVFVY REIFTTDNHN RCGYKFGLSS 
SLDYPDFYGD PLENRSLENI VQPPGEMNDR LDPSSFQTND HPWTVPTVFQ PQTFQRPSAD 
SLPRGSARLT SQNLYSNVFK PADVVSPKIP SGFPIEDHET SPLDNSDAFL STHLKLFPSA 
SSNSFYESEL PQGFQDYYNL GQFTDDDQVP TPLVAITITR LVVGFLLPSV IMIACYSFIV 
FRMQRGRFAK SQSKTFRVAV VVVAVFLVCW TPYHIFGVLS LLTDPETPLG KTLMSWDHVC 
IALASANSCF NPFLYALLGK DFRKKARQSI QGILEAAFSE ELTRSTHCPS NNVISERNST 
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Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.