C3AR1 | ENSG00000171860 | NCBI 719

Details for: C3AR1

Gene ID: 719

Symbol: C3AR1

Ensembl ID: ENSG00000171860

Description: complement C3a receptor 1

Associated with

Cell recruitment (pro-inflammatory response)
(R-HSA-9664424)
Class a/1 (rhodopsin-like receptors)
(R-HSA-373076)
Complement cascade
(R-HSA-166658)
Disease
(R-HSA-1643685)
G alpha (i) signalling events
(R-HSA-418594)
Gpcr downstream signalling
(R-HSA-388396)
Gpcr ligand binding
(R-HSA-500792)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Neutrophil degranulation
(R-HSA-6798695)
Parasitic infection pathways
(R-HSA-9824443)
Peptide ligand-binding receptors
(R-HSA-375276)
Purinergic signaling in leishmaniasis infection
(R-HSA-9660826)
Regulation of complement cascade
(R-HSA-977606)
Signaling by gpcr
(R-HSA-372790)
Signal transduction
(R-HSA-162582)
Azurophil granule membrane
(GO:0035577)
Blood circulation
(GO:0008015)
Calcium-mediated signaling
(GO:0019722)
Chemotaxis
(GO:0006935)
Complement component c3a receptor activity
(GO:0004876)
Complement component c5a receptor activity
(GO:0004878)
Complement component c5a signaling pathway
(GO:0038178)
Complement receptor mediated signaling pathway
(GO:0002430)
G protein-coupled receptor activity
(GO:0004930)
G protein-coupled receptor signaling pathway
(GO:0007186)
Inflammatory response
(GO:0006954)
Phospholipase c-activating g protein-coupled receptor signaling pathway
(GO:0007200)
Plasma membrane
(GO:0005886)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of cytosolic calcium ion concentration
(GO:0007204)
Positive regulation of macrophage chemotaxis
(GO:0010759)
Positive regulation of neutrophil chemotaxis
(GO:0090023)
Positive regulation of vascular endothelial growth factor production
(GO:0010575)
Specific granule membrane
(GO:0035579)

Other Information

Proteins

C3a anaphylatoxin chemotactic receptor

Genular Protein ID: 2105727185

Symbol: C3AR_HUMAN

Name: C3a anaphylatoxin chemotactic receptor

UniProtKB Accession Codes:

Q16581 O43771 Q92868

Database IDs:

Citations:

PubMed ID: 8605247

Title: cDNA cloning of a novel G protein-coupled receptor with a large extracellular loop structure.

PubMed ID: 8605247

DOI: 10.1016/0167-4781(95)00209-x

PubMed ID: 8765043

Title: Expression cloning of the human C3a anaphylatoxin receptor (C3aR) from differentiated U-937 cells.

PubMed ID: 8765043

DOI: 10.1002/eji.1830260840

PubMed ID: 8702752

Title: Molecular cloning and characterization of the human anaphylatoxin C3a receptor.

PubMed ID: 8702752

DOI: 10.1074/jbc.271.34.20231

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12871936

Title: Sulfation of tyrosine 174 in the human C3a receptor is essential for binding of C3a anaphylatoxin.

PubMed ID: 12871936

DOI: 10.1074/jbc.m306061200

PubMed ID: 23234360

Title: LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins.

PubMed ID: 23234360

DOI: 10.1021/pr300963h

Sequence Information:

Length: 482
Mass: 53864
Checksum: 287E219D98CED203
Sequence:

MASFSAETNS TDLLSQPWNE PPVILSMVIL SLTFLLGLPG NGLVLWVAGL KMQRTVNTIW 
FLHLTLADLL CCLSLPFSLA HLALQGQWPY GRFLCKLIPS IIVLNMFASV FLLTAISLDR 
CLVVFKPIWC QNHRNVGMAC SICGCIWVVA FVMCIPVFVY REIFTTDNHN RCGYKFGLSS 
SLDYPDFYGD PLENRSLENI VQPPGEMNDR LDPSSFQTND HPWTVPTVFQ PQTFQRPSAD 
SLPRGSARLT SQNLYSNVFK PADVVSPKIP SGFPIEDHET SPLDNSDAFL STHLKLFPSA 
SSNSFYESEL PQGFQDYYNL GQFTDDDQVP TPLVAITITR LVVGFLLPSV IMIACYSFIV 
FRMQRGRFAK SQSKTFRVAV VVVAVFLVCW TPYHIFGVLS LLTDPETPLG KTLMSWDHVC 
IALASANSCF NPFLYALLGK DFRKKARQSI QGILEAAFSE ELTRSTHCPS NNVISERNST 
TV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: C3AR1

Associated with

Other Information

cDNA cloning of a novel G protein-coupled receptor with a large extracellular loop structure. PubMed ID: 8605247

Expression cloning of the human C3a anaphylatoxin receptor (C3aR) from differentiated U-937 cells. PubMed ID: 8765043

Molecular cloning and characterization of the human anaphylatoxin C3a receptor. PubMed ID: 8702752

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Sulfation of tyrosine 174 in the human C3a receptor is essential for binding of C3a anaphylatoxin. PubMed ID: 12871936