Gene C3AR1 - ENSG00000171860 | NCBI Gene ID: 719

Details for: C3AR1

Gene ID: 719

Symbol: C3AR1

Ensembl ID: ENSG00000171860

Description: complement C3a receptor 1

Associated with

Cell recruitment (pro-inflammatory response)
(R-HSA-9664424)
Class a/1 (rhodopsin-like receptors)
(R-HSA-373076)
Complement cascade
(R-HSA-166658)
Disease
(R-HSA-1643685)
G alpha (i) signalling events
(R-HSA-418594)
Gpcr downstream signalling
(R-HSA-388396)
Gpcr ligand binding
(R-HSA-500792)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Leishmania infection
(R-HSA-9658195)
Neutrophil degranulation
(R-HSA-6798695)
Parasitic infection pathways
(R-HSA-9824443)
Peptide ligand-binding receptors
(R-HSA-375276)
Purinergic signaling in leishmaniasis infection
(R-HSA-9660826)
Regulation of complement cascade
(R-HSA-977606)
Signaling by gpcr
(R-HSA-372790)
Signal transduction
(R-HSA-162582)
Azurophil granule membrane
(GO:0035577)
Blood circulation
(GO:0008015)
Calcium-mediated signaling
(GO:0019722)
Chemotaxis
(GO:0006935)
Complement component c3a receptor activity
(GO:0004876)
Complement component c5a receptor activity
(GO:0004878)
Complement component c5a signaling pathway
(GO:0038178)
Complement receptor mediated signaling pathway
(GO:0002430)
G protein-coupled receptor activity
(GO:0004930)
G protein-coupled receptor signaling pathway
(GO:0007186)
Inflammatory response
(GO:0006954)
Phospholipase c-activating g protein-coupled receptor signaling pathway
(GO:0007200)
Plasma membrane
(GO:0005886)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of cytosolic calcium ion concentration
(GO:0007204)
Positive regulation of macrophage chemotaxis
(GO:0010759)
Positive regulation of neutrophil chemotaxis
(GO:0090023)
Positive regulation of vascular endothelial growth factor production
(GO:0010575)
Specific granule membrane
(GO:0035579)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 2.95
Marker Score: 3565
Cell Name: lung macrophage (CL1001603)
Fold Change: 2.51
Marker Score: 2869.5
Cell Name: Kupffer cell (CL0000091)
Fold Change: 2.11
Marker Score: 2113.5
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.99
Marker Score: 1982
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 1.73
Marker Score: 953
Cell Name: eurydendroid cell (CL0000253)
Fold Change: 1.72
Marker Score: 703
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.59
Marker Score: 1159
Cell Name: mural cell (CL0008034)
Fold Change: 1.48
Marker Score: 170013
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 1.4
Marker Score: 35979
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 1.36
Marker Score: 2646
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 1.28
Marker Score: 3080
Cell Name: elicited macrophage (CL0000861)
Fold Change: 1.26
Marker Score: 7673
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.16
Marker Score: 480
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.14
Marker Score: 4800
Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: 1.04
Marker Score: 433
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 1.03
Marker Score: 788
Cell Name: microglial cell (CL0000129)
Fold Change: 1.02
Marker Score: 1865
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 1.02
Marker Score: 2642
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71809
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48033
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.99
Marker Score: 667.5
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30406
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.97
Marker Score: 501
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.96
Marker Score: 455
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2411
Cell Name: basophil (CL0000767)
Fold Change: 0.95
Marker Score: 450
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5302
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 0.92
Marker Score: 2288
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.92
Marker Score: 367
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2736
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.9
Marker Score: 1838
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.89
Marker Score: 320
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5281
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.87
Marker Score: 398
Cell Name: amacrine cell (CL0000561)
Fold Change: 0.84
Marker Score: 2702
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 0.83
Marker Score: 412
Cell Name: macrophage (CL0000235)
Fold Change: 0.81
Marker Score: 897
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.77
Marker Score: 1258
Cell Name: brush cell (CL0002204)
Fold Change: 0.76
Marker Score: 693
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.75
Marker Score: 390
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.71
Marker Score: 455
Cell Name: myeloid cell (CL0000763)
Fold Change: 0.71
Marker Score: 1138
Cell Name: mature microglial cell (CL0002629)
Fold Change: 0.7
Marker Score: 254.5
Cell Name: classical monocyte (CL0000860)
Fold Change: 0.7
Marker Score: 2887
Cell Name: thymocyte (CL0000893)
Fold Change: 0.68
Marker Score: 716
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.68
Marker Score: 175
Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: 0.68
Marker Score: 352
Cell Name: monocyte (CL0000576)
Fold Change: 0.6
Marker Score: 776
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.59
Marker Score: 33055
Cell Name: blood cell (CL0000081)
Fold Change: 0.58
Marker Score: 6698
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 444
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.54
Marker Score: 170
Cell Name: mature T cell (CL0002419)
Fold Change: 0.48
Marker Score: 4775
Cell Name: mononuclear phagocyte (CL0000113)
Fold Change: 0.45
Marker Score: 452
Cell Name: intraepithelial lymphocyte (CL0002496)
Fold Change: 0.45
Marker Score: 500
Cell Name: neutrophil (CL0000775)
Fold Change: 0.45
Marker Score: 274
Cell Name: colon macrophage (CL0009038)
Fold Change: 0.45
Marker Score: 123
Cell Name: promyelocyte (CL0000836)
Fold Change: 0.41
Marker Score: 203
Cell Name: myelocyte (CL0002193)
Fold Change: 0.4
Marker Score: 172
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.4
Marker Score: 128
Cell Name: leukocyte (CL0000738)
Fold Change: 0.38
Marker Score: 218
Cell Name: Unknown (CL0000003)
Fold Change: 0.38
Marker Score: 1171
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 0.38
Marker Score: 372
Cell Name: mast cell (CL0000097)
Fold Change: 0.38
Marker Score: 218
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.38
Marker Score: 362
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 0.33
Marker Score: 220
Cell Name: promonocyte (CL0000559)
Fold Change: 0.32
Marker Score: 208
Cell Name: IgG memory B cell (CL0000979)
Fold Change: 0.3
Marker Score: 180
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.29
Marker Score: 78
Cell Name: inflammatory macrophage (CL0000863)
Fold Change: 0.27
Marker Score: 84
Cell Name: dendritic cell, human (CL0001056)
Fold Change: 0.26
Marker Score: 265
Cell Name: intermediate monocyte (CL0002393)
Fold Change: 0.26
Marker Score: 89
Cell Name: dendritic cell (CL0000451)
Fold Change: 0.25
Marker Score: 174
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.25
Marker Score: 151
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.24
Marker Score: 146
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 0.24
Marker Score: 142
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.24
Marker Score: 99
Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 0.23
Marker Score: 159
Cell Name: retinal pigment epithelial cell (CL0002586)
Fold Change: 0.23
Marker Score: 67
Cell Name: granulocyte (CL0000094)
Fold Change: 0.23
Marker Score: 101
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.22
Marker Score: 64
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.22
Marker Score: 148
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.22
Marker Score: 418
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.22
Marker Score: 138
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 0.22
Marker Score: 599
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.22
Marker Score: 73
Cell Name: papillary tips cell (CL1000597)
Fold Change: 0.21
Marker Score: 43
Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
Fold Change: 0.21
Marker Score: 46
Cell Name: phagocyte (CL0000234)
Fold Change: 0.21
Marker Score: 68
Cell Name: eosinophil (CL0000771)
Fold Change: 0.2
Marker Score: 65
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 0.2
Marker Score: 144
Cell Name: T-helper 1 cell (CL0000545)
Fold Change: 0.2
Marker Score: 77
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 0.19
Marker Score: 141
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 0.19
Marker Score: 59
Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 0.19
Marker Score: 550
Cell Name: lung microvascular endothelial cell (CL2000016)
Fold Change: 0.19
Marker Score: 40
Cell Name: peritubular capillary endothelial cell (CL1001033)
Fold Change: 0.18
Marker Score: 43
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.18
Marker Score: 40
Cell Name: common dendritic progenitor (CL0001029)
Fold Change: 0.18
Marker Score: 63
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 0.18
Marker Score: 161

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**Key characteristics:** - C3AR1 is a type of complement receptor that is expressed on myeloid cells. - It is a part of the classical complement cascade, which is a complex network of proteins that is involved in the immune response. - C3AR1 is a key regulator of the classical complement cascade. - It can inhibit the activation of the cascade by binding to complement proteins and blocking their interaction with their receptors. **Pathways and functions:** - C3AR1 is involved in the regulation of inflammation. - It is expressed on myeloid cells, which are the first cells to respond to infection. - When C3AR1 is activated by complement proteins, it inhibits the activation of the classical complement cascade. - This prevents the release of inflammatory cytokines and chemokines, which can help to promote inflammation. **Clinical significance:** - Mutations in C3AR1 have been linked to a number of human diseases, including leishmaniasis, rheumatoid arthritis, and asthma. - C3AR1 is a potential target for new therapies for these diseases. **Additional information:** - C3AR1 is a member of the immunoglobulin superfamily. - It is expressed in high levels in healthy individuals. - In patients with diseases that are characterized by inflammation, such as leishmaniasis, C3AR1 expression is often increased.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

C3a anaphylatoxin chemotactic receptor

Genular Protein ID: 2105727185

Symbol: C3AR_HUMAN

Name: C3a anaphylatoxin chemotactic receptor

UniProtKB Accession Codes:

Q16581 O43771 Q92868

Database IDs:

Citations:

PubMed ID: 8605247

Title: cDNA cloning of a novel G protein-coupled receptor with a large extracellular loop structure.

PubMed ID: 8605247

DOI: 10.1016/0167-4781(95)00209-x

PubMed ID: 8765043

Title: Expression cloning of the human C3a anaphylatoxin receptor (C3aR) from differentiated U-937 cells.

PubMed ID: 8765043

DOI: 10.1002/eji.1830260840

PubMed ID: 8702752

Title: Molecular cloning and characterization of the human anaphylatoxin C3a receptor.

PubMed ID: 8702752

DOI: 10.1074/jbc.271.34.20231

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12871936

Title: Sulfation of tyrosine 174 in the human C3a receptor is essential for binding of C3a anaphylatoxin.

PubMed ID: 12871936

DOI: 10.1074/jbc.m306061200

PubMed ID: 23234360

Title: LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins.

PubMed ID: 23234360

DOI: 10.1021/pr300963h

Sequence Information:

Length: 482
Mass: 53864
Checksum: 287E219D98CED203
Sequence:

MASFSAETNS TDLLSQPWNE PPVILSMVIL SLTFLLGLPG NGLVLWVAGL KMQRTVNTIW 
FLHLTLADLL CCLSLPFSLA HLALQGQWPY GRFLCKLIPS IIVLNMFASV FLLTAISLDR 
CLVVFKPIWC QNHRNVGMAC SICGCIWVVA FVMCIPVFVY REIFTTDNHN RCGYKFGLSS 
SLDYPDFYGD PLENRSLENI VQPPGEMNDR LDPSSFQTND HPWTVPTVFQ PQTFQRPSAD 
SLPRGSARLT SQNLYSNVFK PADVVSPKIP SGFPIEDHET SPLDNSDAFL STHLKLFPSA 
SSNSFYESEL PQGFQDYYNL GQFTDDDQVP TPLVAITITR LVVGFLLPSV IMIACYSFIV 
FRMQRGRFAK SQSKTFRVAV VVVAVFLVCW TPYHIFGVLS LLTDPETPLG KTLMSWDHVC 
IALASANSCF NPFLYALLGK DFRKKARQSI QGILEAAFSE ELTRSTHCPS NNVISERNST 
TV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: C3AR1

Associated with

Cells (max top 100)

Other Information

cDNA cloning of a novel G protein-coupled receptor with a large extracellular loop structure. PubMed ID: 8605247

Expression cloning of the human C3a anaphylatoxin receptor (C3aR) from differentiated U-937 cells. PubMed ID: 8765043

Molecular cloning and characterization of the human anaphylatoxin C3a receptor. PubMed ID: 8702752

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Sulfation of tyrosine 174 in the human C3a receptor is essential for binding of C3a anaphylatoxin. PubMed ID: 12871936