Details for: ACTG2
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 30.0730
Cell Significance Index: 158.2500 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 19.8465
Cell Significance Index: -9.3700 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 11.0396
Cell Significance Index: -10.5400 - Cell Name: decidual cell (CL2000002)
Fold Change: 2.2810
Cell Significance Index: 36.6000 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 1.9934
Cell Significance Index: 49.8300 - Cell Name: germ cell (CL0000586)
Fold Change: 1.0185
Cell Significance Index: 7.6900 - Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 0.9789
Cell Significance Index: 11.3300 - Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
Fold Change: 0.6699
Cell Significance Index: 4.9600 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 0.6226
Cell Significance Index: 15.0800 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.4974
Cell Significance Index: 94.6700 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.3350
Cell Significance Index: 33.1400 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.2971
Cell Significance Index: 268.3000 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.2337
Cell Significance Index: 4.1300 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.1790
Cell Significance Index: 32.2700 - Cell Name: myoepithelial cell (CL0000185)
Fold Change: 0.1666
Cell Significance Index: 1.8900 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.1591
Cell Significance Index: 25.8800 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.1396
Cell Significance Index: 63.3400 - Cell Name: perivascular cell (CL4033054)
Fold Change: 0.1299
Cell Significance Index: 0.6000 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 0.1066
Cell Significance Index: 0.9000 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.1049
Cell Significance Index: 5.4500 - Cell Name: theca cell (CL0000503)
Fold Change: 0.0817
Cell Significance Index: 0.4800 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0748
Cell Significance Index: 51.7000 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.0664
Cell Significance Index: 7.2300 - Cell Name: embryonic fibroblast (CL2000042)
Fold Change: 0.0439
Cell Significance Index: 0.2100 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.0261
Cell Significance Index: 0.7300 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0197
Cell Significance Index: 0.3300 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0129
Cell Significance Index: 1.7700 - Cell Name: enteric neuron (CL0007011)
Fold Change: 0.0124
Cell Significance Index: 0.0900 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.0082
Cell Significance Index: 0.5700 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.0065
Cell Significance Index: 0.1000 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0031
Cell Significance Index: -0.1100 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.0045
Cell Significance Index: -0.1300 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0050
Cell Significance Index: -9.4800 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0070
Cell Significance Index: -12.9600 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0079
Cell Significance Index: -3.5000 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0080
Cell Significance Index: -0.4900 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0086
Cell Significance Index: -13.3100 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0098
Cell Significance Index: -13.3100 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0138
Cell Significance Index: -8.7700 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0162
Cell Significance Index: -11.8700 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0163
Cell Significance Index: -12.3200 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0181
Cell Significance Index: -13.4000 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0183
Cell Significance Index: -0.8300 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0200
Cell Significance Index: -10.9400 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0210
Cell Significance Index: -13.1400 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0211
Cell Significance Index: -2.7100 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0238
Cell Significance Index: -13.4100 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.0263
Cell Significance Index: -0.5700 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0281
Cell Significance Index: -2.9300 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0323
Cell Significance Index: -4.1700 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0325
Cell Significance Index: -11.6600 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0329
Cell Significance Index: -9.4600 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0443
Cell Significance Index: -5.4500 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0501
Cell Significance Index: -10.0400 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0569
Cell Significance Index: -11.2900 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0640
Cell Significance Index: -13.4700 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0659
Cell Significance Index: -1.3800 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0678
Cell Significance Index: -9.8600 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0724
Cell Significance Index: -12.3600 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0840
Cell Significance Index: -3.9500 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.0976
Cell Significance Index: -5.8600 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0982
Cell Significance Index: -10.0300 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1040
Cell Significance Index: -7.7500 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1061
Cell Significance Index: -12.3600 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.1070
Cell Significance Index: -2.7500 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.1101
Cell Significance Index: -12.9900 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1160
Cell Significance Index: -13.2900 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.1226
Cell Significance Index: -5.7200 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.1509
Cell Significance Index: -1.6400 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.1605
Cell Significance Index: -8.3600 - Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: -0.1692
Cell Significance Index: -1.6200 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1775
Cell Significance Index: -13.6200 - Cell Name: muscle cell (CL0000187)
Fold Change: -0.1892
Cell Significance Index: -1.8100 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.1963
Cell Significance Index: -2.2300 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.2000
Cell Significance Index: -13.4500 - Cell Name: tendon cell (CL0000388)
Fold Change: -0.2022
Cell Significance Index: -2.7500 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.2165
Cell Significance Index: -13.3100 - Cell Name: slow muscle cell (CL0000189)
Fold Change: -0.2199
Cell Significance Index: -3.2900 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.2259
Cell Significance Index: -4.8100 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.2277
Cell Significance Index: -11.5100 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: -0.2328
Cell Significance Index: -2.3500 - Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
Fold Change: -0.2336
Cell Significance Index: -2.5600 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.2345
Cell Significance Index: -7.5100 - Cell Name: stromal cell of endometrium (CL0002255)
Fold Change: -0.2418
Cell Significance Index: -3.4400 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.2526
Cell Significance Index: -2.6200 - Cell Name: ependymal cell (CL0000065)
Fold Change: -0.2563
Cell Significance Index: -3.0200 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.2563
Cell Significance Index: -14.3800 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.2637
Cell Significance Index: -5.4700 - Cell Name: osteoblast (CL0000062)
Fold Change: -0.2721
Cell Significance Index: -2.6400 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.2734
Cell Significance Index: -4.1200 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.2764
Cell Significance Index: -14.5100 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.2802
Cell Significance Index: -2.5800 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.2851
Cell Significance Index: -12.6100 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.3072
Cell Significance Index: -12.5900 - Cell Name: keratinocyte (CL0000312)
Fold Change: -0.3083
Cell Significance Index: -7.7000 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.3187
Cell Significance Index: -8.5100 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.3207
Cell Significance Index: -6.8600 - Cell Name: mesodermal cell (CL0000222)
Fold Change: -0.3323
Cell Significance Index: -2.0800 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.3330
Cell Significance Index: -12.6100 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.3380
Cell Significance Index: -11.8400
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1564387319
Symbol: ACTH_HUMAN
Name: Actin, gamma-enteric smooth muscle
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2377475
Title: The nucleotide sequence of a human smooth muscle (enteric type) gamma-actin cDNA.
PubMed ID: 2377475
PubMed ID: 1710027
Title: Structure, chromosome location, and expression of the human smooth muscle (enteric type) gamma-actin gene: evolution of six human actin genes.
PubMed ID: 1710027
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 19015515
Title: Connecting actin monomers by iso-peptide bond is a toxicity mechanism of the Vibrio cholerae MARTX toxin.
PubMed ID: 19015515
PubMed ID: 22223895
Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
PubMed ID: 22223895
PubMed ID: 26228148
Title: ACD toxin-produced actin oligomers poison formin-controlled actin polymerization.
PubMed ID: 26228148
PubMed ID: 30626964
Title: SETD3 is an actin histidine methyltransferase that prevents primary dystocia.
PubMed ID: 30626964
PubMed ID: 31993215
Title: Molecular basis for histidine N3-specific methylation of actin H73 by SETD3.
PubMed ID: 31993215
PubMed ID: 22960657
Title: Segregation of a missense variant in enteric smooth muscle actin gamma-2 with autosomal dominant familial visceral myopathy.
PubMed ID: 22960657
PubMed ID: 24777424
Title: Familial visceral myopathy diagnosed by exome sequencing of a patient with chronic intestinal pseudo-obstruction.
PubMed ID: 24777424
PubMed ID: 24337657
Title: De novo ACTG2 mutations cause congenital distended bladder, microcolon, and intestinal hypoperistalsis.
PubMed ID: 24337657
PubMed ID: 24676022
Title: Heterozygous de novo and inherited mutations in the smooth muscle actin (ACTG2) gene underlie megacystis-microcolon-intestinal hypoperistalsis syndrome.
PubMed ID: 24676022
PubMed ID: 27481187
Title: Visceral myopathy: Clinical and molecular survey of a cohort of seven new patients and state of the art of overlapping phenotypes.
PubMed ID: 27481187
DOI: 10.1002/ajmg.a.37857
PubMed ID: 26647307
Title: ACTG2 variants impair actin polymerization in sporadic Megacystis Microcolon Intestinal Hypoperistalsis Syndrome.
PubMed ID: 26647307
DOI: 10.1093/hmg/ddv497
PubMed ID: 28422808
Title: Diagnosis of chronic intestinal pseudo-obstruction and megacystis by sequencing the ACTG2 gene.
PubMed ID: 28422808
PubMed ID: 29781137
Title: Variants in ACTG2 underlie a substantial number of Australasian patients with primary chronic intestinal pseudo-obstruction.
PubMed ID: 29781137
DOI: 10.1111/nmo.13371
PubMed ID: 33294969
Title: Novel ACTG2 variants disclose allelic heterogeneity and bi-allelic inheritance in pediatric chronic intestinal pseudo-obstruction.
PubMed ID: 33294969
DOI: 10.1111/cge.13895
PubMed ID: 33880338
Title: Visceral myopathy diagnosed by a de novo ACTG2 mutation in a patient with chronic intestinal pseudo-obstruction-a case report.
PubMed ID: 33880338
DOI: 10.21037/tp-20-316
Sequence Information:
- Length: 376
- Mass: 41877
- Checksum: 6EC08CD5EEAD445E
- Sequence:
MCEEETTALV CDNGSGLCKA GFAGDDAPRA VFPSIVGRPR HQGVMVGMGQ KDSYVGDEAQ SKRGILTLKY PIEHGIITNW DDMEKIWHHS FYNELRVAPE EHPTLLTEAP LNPKANREKM TQIMFETFNV PAMYVAIQAV LSLYASGRTT GIVLDSGDGV THNVPIYEGY ALPHAIMRLD LAGRDLTDYL MKILTERGYS FVTTAEREIV RDIKEKLCYV ALDFENEMAT AASSSSLEKS YELPDGQVIT IGNERFRCPE TLFQPSFIGM ESAGIHETTY NSIMKCDIDI RKDLYANNVL SGGTTMYPGI ADRMQKEITA LAPSTMKIKI IAPPERKYSV WIGGSILASL STFQQMWISK PEYDEAGPSI VHRKCF
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.