Details for: C4A
Associated with
Other Information
Genular Protein ID: 3429880887
Symbol: CO4A_HUMAN
Name: Complement C4-A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 6546707
Title: The structural basis of the multiple forms of human complement component C4.
PubMed ID: 6546707
PubMed ID: 1988494
Title: The complete exon-intron structure of a human complement component C4A gene. DNA sequences, polymorphism, and linkage to the 21-hydroxylase gene.
PubMed ID: 1988494
PubMed ID: 14574404
Title: The DNA sequence and analysis of human chromosome 6.
PubMed ID: 14574404
DOI: 10.1038/nature02055
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 3838531
PubMed ID: 8012361
Title: Characterisation of the novel gene G11 lying adjacent to the complement C4A gene in the human major histocompatibility complex.
PubMed ID: 8012361
DOI: 10.1093/hmg/3.3.481
PubMed ID: 6167582
Title: Complete primary structure of human C4a anaphylatoxin.
PubMed ID: 6167582
PubMed ID: 1699796
Title: Importance of the alpha 3-fragment of complement C4 for the binding with C4b-binding protein.
PubMed ID: 1699796
PubMed ID: 6978711
Title: Amino acid sequence around the thiol and reactive acyl groups of human complement component C4.
PubMed ID: 6978711
DOI: 10.1042/bj1990359
PubMed ID: 3696167
Title: The chemical structure of the C4d fragment of the human complement component C4.
PubMed ID: 3696167
PubMed ID: 6950384
Title: Sequence determination of the thiolester site of the fourth component of human complement.
PubMed ID: 6950384
PubMed ID: 9759862
Title: C4d DNA sequences of two infrequent human allotypes (C4A13 and C4B12) and the presence of signal sequences enhancing recombination.
PubMed ID: 9759862
PubMed ID: 6572000
Title: Cloning of a human complement component C4 gene.
PubMed ID: 6572000
PubMed ID: 6832377
Title: Amino acid sequence of a polymorphic segment from fragment C4d of human complement component C4.
PubMed ID: 6832377
PubMed ID: 3944109
Title: Identification of the site of sulfation of the fourth component of human complement.
PubMed ID: 3944109
PubMed ID: 6577433
Title: Use of a cDNA clone for the fourth component of human complement (C4) for analysis of a genetic deficiency of C4 in guinea pig.
PubMed ID: 6577433
PubMed ID: 2395880
Title: Substitution of a single amino acid (aspartic acid for histidine) converts the functional activity of human complement C4B to C4A.
PubMed ID: 2395880
PubMed ID: 8473511
Title: Genetic basis of human complement C4A deficiency. Detection of a point mutation leading to nonexpression.
PubMed ID: 8473511
DOI: 10.1172/jci116377
PubMed ID: 8538770
Title: The reaction mechanism of the internal thioester in the human complement component C4.
PubMed ID: 8538770
DOI: 10.1038/379177a0
PubMed ID: 10092831
Title: Deficiency of human complement protein C4 due to identical frameshift mutations in the C4A and C4B genes.
PubMed ID: 10092831
PubMed ID: 11367523
Title: Genetic, structural and functional diversities of human complement components C4A and C4B and their mouse homologues, Slp and C4.
PubMed ID: 11367523
PubMed ID: 12754519
Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.
PubMed ID: 12754519
DOI: 10.1038/nbt827
PubMed ID: 14760718
Title: Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.
PubMed ID: 14760718
PubMed ID: 2431902
Title: Structural basis of the polymorphism of human complement components C4A and C4B: gene size, reactivity and antigenicity.
PubMed ID: 2431902
PubMed ID: 16335952
Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.
PubMed ID: 16335952
DOI: 10.1021/pr0502065
PubMed ID: 17503323
Title: Gene copy-number variation and associated polymorphisms of complement component C4 in human systemic lupus erythematosus (SLE): low copy number is a risk factor for and high copy number is a protective factor against SLE susceptibility in European Americans.
PubMed ID: 17503323
DOI: 10.1086/518257
PubMed ID: 18780401
Title: Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry.
PubMed ID: 18780401
PubMed ID: 19159218
Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
PubMed ID: 19159218
DOI: 10.1021/pr8008012
PubMed ID: 19139490
Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.
PubMed ID: 19139490
PubMed ID: 19838169
Title: Enrichment of glycopeptides for glycan structure and attachment site identification.
PubMed ID: 19838169
DOI: 10.1038/nmeth.1392
PubMed ID: 23234360
Title: LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins.
PubMed ID: 23234360
DOI: 10.1021/pr300963h
PubMed ID: 26091039
Title: A single kinase generates the majority of the secreted phosphoproteome.
PubMed ID: 26091039
PubMed ID: 26814963
Title: Schizophrenia risk from complex variation of complement component 4.
PubMed ID: 26814963
DOI: 10.1038/nature16549
PubMed ID: 12367531
Title: X-ray crystal structure of the C4d fragment of human complement component C4.
PubMed ID: 12367531
PubMed ID: 1573268
Title: The coding sequence of the hemolytically inactive C4A6 allotype of human complement component C4 reveals that a single arginine to tryptophan substitution at beta-chain residue 458 is the likely cause of the defect.
PubMed ID: 1573268
Sequence Information:
- Length: 1744
- Mass: 192785
- Checksum: 9396A4CC4DA3602C
- Sequence:
MRLLWGLIWA SSFFTLSLQK PRLLLFSPSV VHLGVPLSVG VQLQDVPRGQ VVKGSVFLRN PSRNNVPCSP KVDFTLSSER DFALLSLQVP LKDAKSCGLH QLLRGPEVQL VAHSPWLKDS LSRTTNIQGI NLLFSSRRGH LFLQTDQPIY NPGQRVRYRV FALDQKMRPS TDTITVMVEN SHGLRVRKKE VYMPSSIFQD DFVIPDISEP GTWKISARFS DGLESNSSTQ FEVKKYVLPN FEVKITPGKP YILTVPGHLD EMQLDIQARY IYGKPVQGVA YVRFGLLDED GKKTFFRGLE SQTKLVNGQS HISLSKAEFQ DALEKLNMGI TDLQGLRLYV AAAIIESPGG EMEEAELTSW YFVSSPFSLD LSKTKRHLVP GAPFLLQALV REMSGSPASG IPVKVSATVS SPGSVPEVQD IQQNTDGSGQ VSIPIIIPQT ISELQLSVSA GSPHPAIARL TVAAPPSGGP GFLSIERPDS RPPRVGDTLN LNLRAVGSGA TFSHYYYMIL SRGQIVFMNR EPKRTLTSVS VFVDHHLAPS FYFVAFYYHG DHPVANSLRV DVQAGACEGK LELSVDGAKQ YRNGESVKLH LETDSLALVA LGALDTALYA AGSKSHKPLN MGKVFEAMNS YDLGCGPGGG DSALQVFQAA GLAFSDGDQW TLSRKRLSCP KEKTTRKKRN VNFQKAINEK LGQYASPTAK RCCQDGVTRL PMMRSCEQRA ARVQQPDCRE PFLSCCQFAE SLRKKSRDKG QAGLQRALEI LQEEDLIDED DIPVRSFFPE NWLWRVETVD RFQILTLWLP DSLTTWEIHG LSLSKTKGLC VATPVQLRVF REFHLHLRLP MSVRRFEQLE LRPVLYNYLD KNLTVSVHVS PVEGLCLAGG GGLAQQVLVP AGSARPVAFS VVPTAAAAVS LKVVARGSFE FPVGDAVSKV LQIEKEGAIH REELVYELNP LDHRGRTLEI PGNSDPNMIP DGDFNSYVRV TASDPLDTLG SEGALSPGGV ASLLRLPRGC GEQTMIYLAP TLAASRYLDK TEQWSTLPPE TKDHAVDLIQ KGYMRIQQFR KADGSYAAWL SRDSSTWLTA FVLKVLSLAQ EQVGGSPEKL QETSNWLLSQ QQADGSFQDP CPVLDRSMQG GLVGNDETVA LTAFVTIALH HGLAVFQDEG AEPLKQRVEA SISKANSFLG EKASAGLLGA HAAAITAYAL TLTKAPVDLL GVAHNNLMAM AQETGDNLYW GSVTGSQSNA VSPTPAPRNP SDPMPQAPAL WIETTAYALL HLLLHEGKAE MADQASAWLT RQGSFQGGFR STQDTVIALD ALSAYWIASH TTEERGLNVT LSSTGRNGFK SHALQLNNRQ IRGLEEELQF SLGSKINVKV GGNSKGTLKV LRTYNVLDMK NTTCQDLQIE VTVKGHVEYT MEANEDYEDY EYDELPAKDD PDAPLQPVTP LQLFEGRRNR RRREAPKVVE EQESRVHYTV CIWRNGKVGL SGMAIADVTL LSGFHALRAD LEKLTSLSDR YVSHFETEGP HVLLYFDSVP TSRECVGFEA VQEVPVGLVQ PASATLYDYY NPERRCSVFY GAPSKSRLLA TLCSAEVCQC AEGKCPRQRR ALERGLQDED GYRMKFACYY PRVEYGFQVK VLREDSRAAF RLFETKITQV LHFTKDVKAA ANQMRNFLVR ASCRLRLEPG KEYLIMGLDG ATYDLEGHPQ YLLDSNSWIE EMPSERLCRS TRQRAACAQL NDFLQEYGTQ GCQV
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.