Details for: C4A

Gene ID: 720

Symbol: C4A

Ensembl ID: ENSG00000244731

Description: complement C4A (Chido/Rodgers blood group)

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 6.8940
    Cell Significance Index: 242.2500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 3.9694
    Cell Significance Index: 114.3700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 3.4326
    Cell Significance Index: 85.8100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 2.9939
    Cell Significance Index: 183.5600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 2.7733
    Cell Significance Index: 57.5300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.8579
    Cell Significance Index: 40.2500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.0920
    Cell Significance Index: 34.9800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.9934
    Cell Significance Index: 14.9700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8402
    Cell Significance Index: 159.9000
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.7460
    Cell Significance Index: 8.1600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5927
    Cell Significance Index: 58.6300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4858
    Cell Significance Index: 438.6200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4658
    Cell Significance Index: 9.9200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3257
    Cell Significance Index: 35.4300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3103
    Cell Significance Index: 50.4700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2320
    Cell Significance Index: 13.9300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1802
    Cell Significance Index: 12.4600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.1206
    Cell Significance Index: 1.7800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.1178
    Cell Significance Index: 1.8900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0914
    Cell Significance Index: 1.4500
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.0870
    Cell Significance Index: 0.9400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.0774
    Cell Significance Index: 0.6500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0660
    Cell Significance Index: 4.1600
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.0398
    Cell Significance Index: 0.4500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.0238
    Cell Significance Index: 0.7000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0169
    Cell Significance Index: 0.2400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0108
    Cell Significance Index: 1.4800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0071
    Cell Significance Index: 0.3200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0032
    Cell Significance Index: 0.4700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0028
    Cell Significance Index: 0.0700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0018
    Cell Significance Index: 1.0100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0006
    Cell Significance Index: 0.1000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0004
    Cell Significance Index: 0.7800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0004
    Cell Significance Index: -0.6600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0005
    Cell Significance Index: -0.7600
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0009
    Cell Significance Index: -0.0100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0009
    Cell Significance Index: -1.2700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0015
    Cell Significance Index: -0.3000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0016
    Cell Significance Index: -1.0000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0016
    Cell Significance Index: -1.1900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0018
    Cell Significance Index: -0.6400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0018
    Cell Significance Index: -1.0300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0022
    Cell Significance Index: -1.6100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0026
    Cell Significance Index: -1.1800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0052
    Cell Significance Index: -1.0400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0053
    Cell Significance Index: -0.6100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0075
    Cell Significance Index: -0.1300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0076
    Cell Significance Index: -0.7800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0084
    Cell Significance Index: -0.6500
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0101
    Cell Significance Index: -0.1400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0107
    Cell Significance Index: -1.3800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0112
    Cell Significance Index: -0.5200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0113
    Cell Significance Index: -1.3300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0133
    Cell Significance Index: -0.9900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0144
    Cell Significance Index: -0.7500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0145
    Cell Significance Index: -0.3800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0201
    Cell Significance Index: -1.6000
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.0214
    Cell Significance Index: -0.1700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0255
    Cell Significance Index: -0.4300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0255
    Cell Significance Index: -1.4300
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: -0.0266
    Cell Significance Index: -0.1000
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.0266
    Cell Significance Index: -0.2200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0312
    Cell Significance Index: -1.3800
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0331
    Cell Significance Index: -0.3200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0337
    Cell Significance Index: -1.5900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0338
    Cell Significance Index: -1.1100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0367
    Cell Significance Index: -1.1700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0367
    Cell Significance Index: -1.3900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0370
    Cell Significance Index: -0.5300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0383
    Cell Significance Index: -0.9800
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.0397
    Cell Significance Index: -0.5000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0419
    Cell Significance Index: -1.1200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0435
    Cell Significance Index: -1.0900
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0441
    Cell Significance Index: -0.4600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0443
    Cell Significance Index: -1.2100
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: -0.0449
    Cell Significance Index: -0.4300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0452
    Cell Significance Index: -1.1300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0495
    Cell Significance Index: -1.4200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0516
    Cell Significance Index: -1.0800
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0518
    Cell Significance Index: -0.4400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0518
    Cell Significance Index: -1.1200
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -0.0525
    Cell Significance Index: -0.3300
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0534
    Cell Significance Index: -0.7400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0537
    Cell Significance Index: -1.3100
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0542
    Cell Significance Index: -0.7900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0547
    Cell Significance Index: -1.1600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0553
    Cell Significance Index: -1.1100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0565
    Cell Significance Index: -1.6600
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0568
    Cell Significance Index: -0.8500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0584
    Cell Significance Index: -1.1600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0585
    Cell Significance Index: -0.8500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0593
    Cell Significance Index: -1.3700
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.0603
    Cell Significance Index: -0.8200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0604
    Cell Significance Index: -1.2600
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0605
    Cell Significance Index: -1.1900
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.0624
    Cell Significance Index: -0.7900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0627
    Cell Significance Index: -1.2500
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0629
    Cell Significance Index: -0.8100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0669
    Cell Significance Index: -1.6200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0673
    Cell Significance Index: -1.0900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The C4A protein is a 75-amino acid fragment that is released from the complement component C4 during the activation of the classical and alternative complement pathways. C4A is a potent anaphylatoxin, which means it can induce the release of histamine from mast cells, leading to increased vascular permeability and inflammation. C4A also has anti-inflammatory properties, as it can inhibit the production of pro-inflammatory cytokines. The protein is highly conserved across different species, suggesting its importance in the evolution of the complement system. **Pathways and Functions** The C4A protein is involved in various cellular processes, including: 1. **Activation of C3 and C5**: C4A is released during the activation of the classical and alternative complement pathways, which leads to the activation of C3 and C5, resulting in the formation of the membrane attack complex (MAC) and the release of pro-inflammatory cytokines. 2. **Immune response**: C4A plays a crucial role in the immune response by inducing the activation of immune cells, such as dendritic cells and granulocytes, and by regulating the production of pro-inflammatory cytokines. 3. **Apoptosis**: C4A has anti-inflammatory properties, as it can inhibit the production of pro-inflammatory cytokines and promote apoptosis (programmed cell death) in infected cells. 4. **Regulation of the complement cascade**: C4A regulates the complement cascade by inhibiting the production of pro-inflammatory cytokines and promoting the activation of anti-inflammatory cytokines. **Clinical Significance** Dysregulation of the complement system, including the C4A gene, has been implicated in various diseases, including: 1. **Autoimmune diseases**: Dysregulation of the complement system has been linked to autoimmune diseases, such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). 2. **Inflammatory disorders**: C4A has anti-inflammatory properties, and its dysregulation may contribute to the development of inflammatory disorders, such as asthma and inflammatory bowel disease (IBD). 3. **Cancer**: The complement system, including C4A, has been implicated in cancer progression and metastasis. 4. **Neurological disorders**: Dysregulation of the complement system has been linked to neurological disorders, such as Alzheimer's disease and multiple sclerosis. In conclusion, the C4A gene plays a crucial role in the immune response, apoptosis, and regulation of the complement cascade. Dysregulation of the C4A gene has been implicated in various diseases, highlighting the importance of this protein in human health and disease.

Genular Protein ID: 3429880887

Symbol: CO4A_HUMAN

Name: Complement C4-A

UniProtKB Accession Codes:

P0C0L4 A6H8M8 A6NHJ5 A7E2V2 B0QZR6 B0V2C8 B2RUT6 B7ZVZ6 P01028 P78445 Q13160 Q13906 Q14033 Q14835 Q4LE82 Q5JNX2 Q5JQM8 Q6P4R1 Q6U2E5 Q6U2E8 Q6U2F0 Q6U2F3 Q6U2F4 Q6U2F6 Q6U2F8 Q6U2G0 Q96EG2 Q96SA8 Q9NPK5 Q9UIP5

Database IDs:

AGR 2 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 2 BioGRID-ORCS 2 BioMuta 1 CCDS 2 CDD 3 CPTAC 2 CTD 2 CarbonylDB 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 2 DrugBank 1 EMBL 38 EMDB 4 Ensembl 4 EvolutionaryTrace 1 GO 17 Gene3D 10 GeneCards 1 GeneTree 1 GeneWiki 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 20 KEGG 2 MANE-Select 1 MEROPS 1 MIM 7 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NIAGADS 1 OMA 1 OpenTargets 1 Orphanet 4 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 2 PRIDE 1 PRINTS 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 11 PharmGKB 2 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 5 RefSeq 3 SABIO-RK 1 SFLD 1 SIGNOR 1 SMART 6 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 6546707

Title: The structural basis of the multiple forms of human complement component C4.

PubMed ID: 6546707

DOI: 10.1016/0092-8674(84)90040-0

PubMed ID: 1988494

Title: The complete exon-intron structure of a human complement component C4A gene. DNA sequences, polymorphism, and linkage to the 21-hydroxylase gene.

PubMed ID: 1988494

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3838531

Title: Polymorphism of human complement component C4.

PubMed ID: 3838531

DOI: 10.1007/bf00364869

PubMed ID: 8012361

Title: Characterisation of the novel gene G11 lying adjacent to the complement C4A gene in the human major histocompatibility complex.

PubMed ID: 8012361

DOI: 10.1093/hmg/3.3.481

PubMed ID: 6167582

Title: Complete primary structure of human C4a anaphylatoxin.

PubMed ID: 6167582

DOI: 10.1016/s0021-9258(19)68898-8

PubMed ID: 1699796

Title: Importance of the alpha 3-fragment of complement C4 for the binding with C4b-binding protein.

PubMed ID: 1699796

DOI: 10.1016/0014-5793(90)80389-z

PubMed ID: 6978711

Title: Amino acid sequence around the thiol and reactive acyl groups of human complement component C4.

PubMed ID: 6978711

DOI: 10.1042/bj1990359

PubMed ID: 3696167

Title: The chemical structure of the C4d fragment of the human complement component C4.

PubMed ID: 3696167

DOI: 10.1016/0161-5890(87)90165-9

PubMed ID: 6950384

Title: Sequence determination of the thiolester site of the fourth component of human complement.

PubMed ID: 6950384

DOI: 10.1073/pnas.78.12.7388

PubMed ID: 9759862

Title: C4d DNA sequences of two infrequent human allotypes (C4A13 and C4B12) and the presence of signal sequences enhancing recombination.

PubMed ID: 9759862

PubMed ID: 6572000

Title: Cloning of a human complement component C4 gene.

PubMed ID: 6572000

DOI: 10.1073/pnas.80.1.264

PubMed ID: 6832377

Title: Amino acid sequence of a polymorphic segment from fragment C4d of human complement component C4.

PubMed ID: 6832377

DOI: 10.1016/0014-5793(83)80188-4

PubMed ID: 3944109

Title: Identification of the site of sulfation of the fourth component of human complement.

PubMed ID: 3944109

DOI: 10.1016/s0021-9258(17)36009-x

PubMed ID: 6577433

Title: Use of a cDNA clone for the fourth component of human complement (C4) for analysis of a genetic deficiency of C4 in guinea pig.

PubMed ID: 6577433

DOI: 10.1073/pnas.80.17.5387

PubMed ID: 2395880

Title: Substitution of a single amino acid (aspartic acid for histidine) converts the functional activity of human complement C4B to C4A.

PubMed ID: 2395880

DOI: 10.1073/pnas.87.17.6868

PubMed ID: 8473511

Title: Genetic basis of human complement C4A deficiency. Detection of a point mutation leading to nonexpression.

PubMed ID: 8473511

DOI: 10.1172/jci116377

PubMed ID: 8538770

Title: The reaction mechanism of the internal thioester in the human complement component C4.

PubMed ID: 8538770

DOI: 10.1038/379177a0

PubMed ID: 10092831

Title: Deficiency of human complement protein C4 due to identical frameshift mutations in the C4A and C4B genes.

PubMed ID: 10092831

PubMed ID: 11367523

Title: Genetic, structural and functional diversities of human complement components C4A and C4B and their mouse homologues, Slp and C4.

PubMed ID: 11367523

DOI: 10.1016/s1567-5769(01)00019-4

PubMed ID: 12754519

Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.

PubMed ID: 12754519

DOI: 10.1038/nbt827

PubMed ID: 14760718

Title: Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.

PubMed ID: 14760718

DOI: 10.1002/pmic.200300556

PubMed ID: 2431902

Title: Structural basis of the polymorphism of human complement components C4A and C4B: gene size, reactivity and antigenicity.

PubMed ID: 2431902

DOI: 10.1002/j.1460-2075.1986.tb04582.x

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 17503323

Title: Gene copy-number variation and associated polymorphisms of complement component C4 in human systemic lupus erythematosus (SLE): low copy number is a risk factor for and high copy number is a protective factor against SLE susceptibility in European Americans.

PubMed ID: 17503323

DOI: 10.1086/518257

PubMed ID: 18780401

Title: Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry.

PubMed ID: 18780401

DOI: 10.1002/pmic.200701057

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19139490

Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.

PubMed ID: 19139490

DOI: 10.1074/mcp.m800504-mcp200

PubMed ID: 19838169

Title: Enrichment of glycopeptides for glycan structure and attachment site identification.

PubMed ID: 19838169

DOI: 10.1038/nmeth.1392

PubMed ID: 23234360

Title: LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins.

PubMed ID: 23234360

DOI: 10.1021/pr300963h

PubMed ID: 26091039

Title: A single kinase generates the majority of the secreted phosphoproteome.

PubMed ID: 26091039

DOI: 10.1016/j.cell.2015.05.028

PubMed ID: 26814963

Title: Schizophrenia risk from complex variation of complement component 4.

PubMed ID: 26814963

DOI: 10.1038/nature16549

PubMed ID: 12367531

Title: X-ray crystal structure of the C4d fragment of human complement component C4.

PubMed ID: 12367531

DOI: 10.1016/s0022-2836(02)00854-9

PubMed ID: 1573268

Title: The coding sequence of the hemolytically inactive C4A6 allotype of human complement component C4 reveals that a single arginine to tryptophan substitution at beta-chain residue 458 is the likely cause of the defect.

PubMed ID: 1573268

Sequence Information:

  • Length: 1744
  • Mass: 192785
  • Checksum: 9396A4CC4DA3602C
  • Sequence:
    • MRLLWGLIWA SSFFTLSLQK PRLLLFSPSV VHLGVPLSVG VQLQDVPRGQ VVKGSVFLRN 
PSRNNVPCSP KVDFTLSSER DFALLSLQVP LKDAKSCGLH QLLRGPEVQL VAHSPWLKDS 
LSRTTNIQGI NLLFSSRRGH LFLQTDQPIY NPGQRVRYRV FALDQKMRPS TDTITVMVEN 
SHGLRVRKKE VYMPSSIFQD DFVIPDISEP GTWKISARFS DGLESNSSTQ FEVKKYVLPN 
FEVKITPGKP YILTVPGHLD EMQLDIQARY IYGKPVQGVA YVRFGLLDED GKKTFFRGLE 
SQTKLVNGQS HISLSKAEFQ DALEKLNMGI TDLQGLRLYV AAAIIESPGG EMEEAELTSW 
YFVSSPFSLD LSKTKRHLVP GAPFLLQALV REMSGSPASG IPVKVSATVS SPGSVPEVQD 
IQQNTDGSGQ VSIPIIIPQT ISELQLSVSA GSPHPAIARL TVAAPPSGGP GFLSIERPDS 
RPPRVGDTLN LNLRAVGSGA TFSHYYYMIL SRGQIVFMNR EPKRTLTSVS VFVDHHLAPS 
FYFVAFYYHG DHPVANSLRV DVQAGACEGK LELSVDGAKQ YRNGESVKLH LETDSLALVA 
LGALDTALYA AGSKSHKPLN MGKVFEAMNS YDLGCGPGGG DSALQVFQAA GLAFSDGDQW 
TLSRKRLSCP KEKTTRKKRN VNFQKAINEK LGQYASPTAK RCCQDGVTRL PMMRSCEQRA 
ARVQQPDCRE PFLSCCQFAE SLRKKSRDKG QAGLQRALEI LQEEDLIDED DIPVRSFFPE 
NWLWRVETVD RFQILTLWLP DSLTTWEIHG LSLSKTKGLC VATPVQLRVF REFHLHLRLP 
MSVRRFEQLE LRPVLYNYLD KNLTVSVHVS PVEGLCLAGG GGLAQQVLVP AGSARPVAFS 
VVPTAAAAVS LKVVARGSFE FPVGDAVSKV LQIEKEGAIH REELVYELNP LDHRGRTLEI 
PGNSDPNMIP DGDFNSYVRV TASDPLDTLG SEGALSPGGV ASLLRLPRGC GEQTMIYLAP 
TLAASRYLDK TEQWSTLPPE TKDHAVDLIQ KGYMRIQQFR KADGSYAAWL SRDSSTWLTA 
FVLKVLSLAQ EQVGGSPEKL QETSNWLLSQ QQADGSFQDP CPVLDRSMQG GLVGNDETVA 
LTAFVTIALH HGLAVFQDEG AEPLKQRVEA SISKANSFLG EKASAGLLGA HAAAITAYAL 
TLTKAPVDLL GVAHNNLMAM AQETGDNLYW GSVTGSQSNA VSPTPAPRNP SDPMPQAPAL 
WIETTAYALL HLLLHEGKAE MADQASAWLT RQGSFQGGFR STQDTVIALD ALSAYWIASH 
TTEERGLNVT LSSTGRNGFK SHALQLNNRQ IRGLEEELQF SLGSKINVKV GGNSKGTLKV 
LRTYNVLDMK NTTCQDLQIE VTVKGHVEYT MEANEDYEDY EYDELPAKDD PDAPLQPVTP 
LQLFEGRRNR RRREAPKVVE EQESRVHYTV CIWRNGKVGL SGMAIADVTL LSGFHALRAD 
LEKLTSLSDR YVSHFETEGP HVLLYFDSVP TSRECVGFEA VQEVPVGLVQ PASATLYDYY 
NPERRCSVFY GAPSKSRLLA TLCSAEVCQC AEGKCPRQRR ALERGLQDED GYRMKFACYY 
PRVEYGFQVK VLREDSRAAF RLFETKITQV LHFTKDVKAA ANQMRNFLVR ASCRLRLEPG 
KEYLIMGLDG ATYDLEGHPQ YLLDSNSWIE EMPSERLCRS TRQRAACAQL NDFLQEYGTQ 
GCQV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.