C4B | ENSG00000224389 | NCBI 721

Details for: C4B

Gene ID: 721

Symbol: C4B

Ensembl ID: ENSG00000224389

Description: complement C4B (Chido/Rodgers blood group)

Associated with

Activation of c3 and c5
(R-HSA-174577)
Complement cascade
(R-HSA-166658)
Immune system
(R-HSA-168256)
Initial triggering of complement
(R-HSA-166663)
Innate immune system
(R-HSA-168249)
Regulation of complement cascade
(R-HSA-977606)
Axon
(GO:0030424)
Blood microparticle
(GO:0072562)
Carbohydrate binding
(GO:0030246)
Complement activation
(GO:0006956)
Complement activation, classical pathway
(GO:0006958)
Complement binding
(GO:0001848)
Dendrite
(GO:0030425)
Detection of molecule of bacterial origin
(GO:0032490)
Endopeptidase inhibitor activity
(GO:0004866)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Inflammatory response
(GO:0006954)
Innate immune response
(GO:0045087)
Opsonization
(GO:0008228)
Plasma membrane
(GO:0005886)
Positive regulation of apoptotic cell clearance
(GO:2000427)
Protein binding
(GO:0005515)
Symbiont cell surface
(GO:0106139)
Synapse
(GO:0045202)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 3.1088
Cell Significance Index: 64.4900
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 1.8083
Cell Significance Index: 63.5400
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.5575
Cell Significance Index: 49.8900
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 1.4886
Cell Significance Index: 37.2100
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 1.2814
Cell Significance Index: 19.3100
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.0496
Cell Significance Index: 30.2400
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.7355
Cell Significance Index: 45.0900
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 0.7131
Cell Significance Index: 7.8000
Cell Name: keratocyte (CL0002363)
Fold Change: 0.5673
Cell Significance Index: 9.0000
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 0.4283
Cell Significance Index: 3.6400
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3468
Cell Significance Index: 66.0000
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.2910
Cell Significance Index: 13.1900
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.2868
Cell Significance Index: 17.2200
Cell Name: helper T cell (CL0000912)
Fold Change: 0.1598
Cell Significance Index: 2.2700
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.1579
Cell Significance Index: 17.1800
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 0.1453
Cell Significance Index: 2.1500
Cell Name: decidual cell (CL2000002)
Fold Change: 0.1359
Cell Significance Index: 2.1800
Cell Name: intrahepatic cholangiocyte (CL0002538)
Fold Change: 0.0982
Cell Significance Index: 0.3700
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0876
Cell Significance Index: 1.8700
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.0755
Cell Significance Index: 5.2200
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.0715
Cell Significance Index: 64.6000
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.0673
Cell Significance Index: 6.6600
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.0523
Cell Significance Index: 8.5100
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.0176
Cell Significance Index: 0.1400
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.0125
Cell Significance Index: 0.2700
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0006
Cell Significance Index: 0.1100
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.0003
Cell Significance Index: 0.0400
Cell Name: odontoblast (CL0000060)
Fold Change: -0.0009
Cell Significance Index: -0.1100
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0009
Cell Significance Index: -0.6500
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0011
Cell Significance Index: -0.6400
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0011
Cell Significance Index: -0.0500
Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0012
Cell Significance Index: -0.6500
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0014
Cell Significance Index: -2.7100
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0017
Cell Significance Index: -3.1000
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0023
Cell Significance Index: -3.5300
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0028
Cell Significance Index: -0.3900
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0030
Cell Significance Index: -0.1400
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0034
Cell Significance Index: -4.6800
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0038
Cell Significance Index: -2.4000
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0038
Cell Significance Index: -2.8700
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0042
Cell Significance Index: -0.2200
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.0044
Cell Significance Index: -0.1100
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0064
Cell Significance Index: -2.8900
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0076
Cell Significance Index: -2.7400
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0093
Cell Significance Index: -1.9600
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0119
Cell Significance Index: -1.7300
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0126
Cell Significance Index: -2.5000
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0143
Cell Significance Index: -2.8700
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0155
Cell Significance Index: -2.7900
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -0.0190
Cell Significance Index: -0.1600
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0228
Cell Significance Index: -2.8000
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0267
Cell Significance Index: -2.7300
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.0319
Cell Significance Index: -0.9400
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0319
Cell Significance Index: -4.1200
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0324
Cell Significance Index: -3.8200
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0345
Cell Significance Index: -0.9200
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: -0.0373
Cell Significance Index: -0.4700
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: -0.0434
Cell Significance Index: -0.4500
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0453
Cell Significance Index: -3.4800
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0484
Cell Significance Index: -3.6100
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.0551
Cell Significance Index: -1.4500
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0626
Cell Significance Index: -1.3100
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: -0.0637
Cell Significance Index: -0.6100
Cell Name: early T lineage precursor (CL0002425)
Fold Change: -0.0651
Cell Significance Index: -0.9500
Cell Name: pulmonary capillary endothelial cell (CL4028001)
Fold Change: -0.0665
Cell Significance Index: -0.9100
Cell Name: preadipocyte (CL0002334)
Fold Change: -0.0697
Cell Significance Index: -1.3600
Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: -0.0728
Cell Significance Index: -0.7800
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0757
Cell Significance Index: -3.5600
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0773
Cell Significance Index: -3.4200
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0828
Cell Significance Index: -2.7100
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.0858
Cell Significance Index: -1.4500
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.0874
Cell Significance Index: -3.2100
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0882
Cell Significance Index: -2.8100
Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: -0.0894
Cell Significance Index: -1.0000
Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
Fold Change: -0.0900
Cell Significance Index: -1.2000
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0903
Cell Significance Index: -3.4200
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0915
Cell Significance Index: -2.4900
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0916
Cell Significance Index: -3.2100
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.0957
Cell Significance Index: -2.5600
Cell Name: neuroplacodal cell (CL0000032)
Fold Change: -0.0958
Cell Significance Index: -1.1800
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: -0.0965
Cell Significance Index: -1.0200
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: -0.0996
Cell Significance Index: -1.0300
Cell Name: immature NK T cell (CL0000914)
Fold Change: -0.1016
Cell Significance Index: -1.3000
Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.1079
Cell Significance Index: -0.8800
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.1083
Cell Significance Index: -3.1800
Cell Name: erythrocyte (CL0000232)
Fold Change: -0.1091
Cell Significance Index: -2.7800
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.1161
Cell Significance Index: -2.9000
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: -0.1164
Cell Significance Index: -1.5000
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.1203
Cell Significance Index: -2.0800
Cell Name: neural progenitor cell (CL0011020)
Fold Change: -0.1223
Cell Significance Index: -1.2100
Cell Name: ciliated cell (CL0000064)
Fold Change: -0.1247
Cell Significance Index: -1.3500
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.1255
Cell Significance Index: -3.0400
Cell Name: PP cell (CL0000696)
Fold Change: -0.1291
Cell Significance Index: -1.3100
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.1301
Cell Significance Index: -2.8100
Cell Name: leukocyte (CL0000738)
Fold Change: -0.1360
Cell Significance Index: -2.3100
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.1371
Cell Significance Index: -3.9300
Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -0.1376
Cell Significance Index: -2.0900
Cell Name: retinal astrocyte (CL4033015)
Fold Change: -0.1400
Cell Significance Index: -1.3700
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.1402
Cell Significance Index: -2.9800
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.1405
Cell Significance Index: -3.5100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Other Information

Description

**Key Characteristics:** 1. **Structural Features:** The C4B protein is a serine protease that is part of the complement system, which is a group of proteins that play a key role in the immune response. 2. **Blood Group Antigen:** The C4B protein is also known as the Chido/Rodgers blood group antigen, which is a carbohydrate-binding protein that can be found on the surface of certain cells. 3. **Significant Expression:** C4B is significantly expressed in various immune cells, including conventional dendritic cells, T cells, granulocytes, and epithelial cells. 4. **Regulation of Complement Cascade:** The C4B protein plays a critical role in the activation of the classical complement pathway, which is essential for the elimination of pathogens and the regulation of inflammation. **Pathways and Functions:** 1. **Complement Activation:** The C4B protein is involved in the activation of the classical complement pathway, which is a crucial step in the elimination of pathogens. 2. **Inflammatory Response:** C4B regulates the inflammatory response by modulating the activation of immune cells and the release of pro-inflammatory cytokines. 3. **Apoptotic Cell Clearance:** The C4B protein is involved in the regulation of apoptotic cell clearance, which is essential for maintaining tissue homeostasis. 4. **Immune System Regulation:** C4B plays a critical role in regulating the immune system by modulating the activity of immune cells and the activation of the complement cascade. **Clinical Significance:** 1. **Autoimmune Diseases:** Dysregulation of the C4B protein has been implicated in various autoimmune diseases, including systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). 2. **Infectious Diseases:** The C4B protein is essential for the elimination of pathogens, and its dysregulation can lead to increased susceptibility to infections. 3. **Cancer:** C4B has been implicated in the regulation of cancer progression, and its dysregulation can contribute to tumor growth and metastasis. 4. **Transplantation:** The C4B protein is involved in the regulation of immune responses in transplantation, and its dysregulation can lead to rejection of transplanted tissues. In conclusion, the C4B gene plays a critical role in the regulation of the complement cascade and the immune response. Its dysregulation has been implicated in various diseases, including autoimmune and infectious diseases, and cancer. Further research is needed to fully understand the mechanisms by which C4B regulates the immune response and to develop therapeutic strategies for the treatment of diseases associated with C4B dysregulation.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.