Details for: C4BPA

Gene ID: 722

Symbol: C4BPA

Ensembl ID: ENSG00000123838

Description: complement component 4 binding protein alpha

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 8.86
    Marker Score: 28,390
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 3.81
    Marker Score: 5,288
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 3.02
    Marker Score: 19,687
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.36
    Marker Score: 3,786
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 2.18
    Marker Score: 11,703
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.85
    Marker Score: 7,980
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.85
    Marker Score: 11,880
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.76
    Marker Score: 788
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.64
    Marker Score: 26,337
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1,161
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.57
    Marker Score: 3,868
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 862
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.36
    Marker Score: 1,634
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.31
    Marker Score: 2,480
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.25
    Marker Score: 847
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.24
    Marker Score: 6,522
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.24
    Marker Score: 2,521
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.16
    Marker Score: 483
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4,799
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.11
    Marker Score: 1,528
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.08
    Marker Score: 6,560
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1
    Marker Score: 528
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,805
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,029
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.98
    Marker Score: 1,053
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,406
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 505
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,315
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 371
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,739
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.88
    Marker Score: 498
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.82
    Marker Score: 626
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,259
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.75
    Marker Score: 980
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 685
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.73
    Marker Score: 502
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 459
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.71
    Marker Score: 1,132
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.7
    Marker Score: 214
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.65
    Marker Score: 201
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.63
    Marker Score: 8,399
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.59
    Marker Score: 156
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.58
    Marker Score: 386
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.57
    Marker Score: 239
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 450
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.56
    Marker Score: 211
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 147
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.53
    Marker Score: 198
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.49
    Marker Score: 7,672
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 471
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.48
    Marker Score: 237
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.46
    Marker Score: 212
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.44
    Marker Score: 113
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.44
    Marker Score: 265
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.42
    Marker Score: 122
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.42
    Marker Score: 422
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.41
    Marker Score: 425
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.41
    Marker Score: 1,186
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.39
    Marker Score: 200
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.37
    Marker Score: 102
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 369
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.36
    Marker Score: 158
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.32
    Marker Score: 323
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.31
    Marker Score: 598
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 0.31
    Marker Score: 175
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.31
    Marker Score: 98
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.3
    Marker Score: 179
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.29
    Marker Score: 140
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.28
    Marker Score: 163
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.28
    Marker Score: 322
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.28
    Marker Score: 306
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.27
    Marker Score: 158
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.27
    Marker Score: 297
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.27
    Marker Score: 549
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.27
    Marker Score: 457
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 89
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.25
    Marker Score: 312
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.25
    Marker Score: 152
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.24
    Marker Score: 217
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.23
    Marker Score: 418
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.23
    Marker Score: 50
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.23
    Marker Score: 223
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.23
    Marker Score: 400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.22
    Marker Score: 46
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.21
    Marker Score: 85
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.21
    Marker Score: 249
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.21
    Marker Score: 860
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.2
    Marker Score: 198
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.2
    Marker Score: 259
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.2
    Marker Score: 76
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.19
    Marker Score: 85
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.19
    Marker Score: 404
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.19
    Marker Score: 186

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure:** C4BPA is a protein composed of 4 alpha chains, each with a molecular weight of approximately 40 kDa. It binds to C4b, a fragment of the complement component 4 (C4), and regulates its activity. 2. **Function:** C4BPA acts as a negative regulator of the classical pathway complement activation, which is a crucial step in the elimination of pathogens. It also regulates opsonization, a process that enhances the recognition and phagocytosis of pathogens by immune cells. 3. **Expression:** C4BPA is expressed in various tissues, including liver, lung, and immune cells, such as amacrine cells, Mueller cells, and hepatocytes. 4. **Cellular localization:** C4BPA is primarily found on the plasma membrane, where it regulates complement activation and opsonization. **Pathways and Functions:** 1. **Complement activation:** C4BPA regulates classical pathway complement activation by binding to C4b and inhibiting its activity. 2. **Opsonization:** C4BPA enhances the recognition and phagocytosis of pathogens by binding to C4b and facilitating its interaction with pattern recognition receptors on immune cells. 3. **Negative regulation of complement cascade:** C4BPA negatively regulates the complement cascade by inhibiting the activation of C4b, thereby preventing excessive complement activation and tissue damage. 4. **Protein binding:** C4BPA binds to various proteins, including C4b, C3b, and factor B, regulating their activity and function. **Clinical Significance:** 1. **Complement dysregulation:** Abnormal expression or function of C4BPA has been implicated in various diseases, including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and glomerulonephritis. 2. **Infectious diseases:** C4BPA plays a crucial role in the regulation of the complement cascade, and its dysregulation can contribute to the pathogenesis of infectious diseases, such as sepsis and pneumonia. 3. **Cancer:** C4BPA expression has been found to be altered in various types of cancer, suggesting its potential role in cancer progression and metastasis. 4. **Immunological disorders:** C4BPA is involved in the regulation of T cell-mediated immunity, and its dysregulation can contribute to immunological disorders, such as autoimmune diseases and transplant rejection. In conclusion, C4BPA is a critical component of the innate immune system, playing a pivotal role in the regulation of the complement cascade, opsonization, and negative regulation of complement activation. Its dysregulation has been implicated in various diseases, including infectious diseases, autoimmune disorders, and cancer. Further research is necessary to fully understand the role of C4BPA in immune regulation and disease pathogenesis.

Genular Protein ID: 629521722

Symbol: C4BPA_HUMAN

Name: C4b-binding protein alpha chain

UniProtKB Accession Codes:

P04003 Q5VVQ8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 CarbonylDB 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 EMBL 20 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 7 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2590215

Title: Molecular cloning of the cDNA coding for proline-rich protein (PRP): identity of PRP as C4b-binding protein.

PubMed ID: 2590215

DOI: 10.1016/0006-291x(89)91045-0

PubMed ID: 1989602

Title: Genomic organization of the alpha chain of the human C4b-binding protein gene.

PubMed ID: 1989602

DOI: 10.1016/0006-291x(91)90509-6

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3378624

Title: Derivation of the sequence of the signal peptide in human C4b-binding protein and interspecies cross-hybridisation of the C4bp cDNA sequence.

PubMed ID: 3378624

DOI: 10.1016/0014-5793(88)80763-4

PubMed ID: 3017751

Title: Studies on the structure of the human C4b-binding protein gene.

PubMed ID: 3017751

DOI: 10.1016/0014-5793(86)81390-4

PubMed ID: 3840370

Title: Molecular cloning and characterization of the cDNA coding for C4b-binding protein, a regulatory protein of the classical pathway of the human complement system.

PubMed ID: 3840370

DOI: 10.1042/bj2300133

PubMed ID: 4033666

Title: Amino acid sequence studies of human C4b-binding protein: N-terminal sequence analysis and alignment of the fragments produced by limited proteolysis with chymotrypsin and the peptides produced by cyanogen bromide treatment.

PubMed ID: 4033666

DOI: 10.1016/0161-5890(85)90127-0

PubMed ID: 14760718

Title: Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.

PubMed ID: 14760718

DOI: 10.1002/pmic.200300556

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24600566

Title: Complement regulator C4BP binds to Staphylococcus aureus surface proteins SdrE and Bbp inhibiting bacterial opsonization and killing.

PubMed ID: 24600566

DOI: 10.1016/j.rinim.2013.10.004

PubMed ID: 6222381

Title: Visualization of human C4b-binding protein and its complexes with vitamin K-dependent protein S and complement protein C4b.

PubMed ID: 6222381

DOI: 10.1073/pnas.80.11.3461

PubMed ID: 16330538

Title: Human C4b-binding protein, structural basis for interaction with streptococcal M protein, a major bacterial virulence factor.

PubMed ID: 16330538

DOI: 10.1074/jbc.m511563200

Sequence Information:

  • Length: 597
  • Mass: 67033
  • Checksum: 67E03F2EA85A16DD
  • Sequence:
    • MHPPKTPSGA LHRKRKMAAW PFSRLWKVSD PILFQMTLIA ALLPAVLGNC GPPPTLSFAA 
PMDITLTETR FKTGTTLKYT CLPGYVRSHS TQTLTCNSDG EWVYNTFCIY KRCRHPGELR 
NGQVEIKTDL SFGSQIEFSC SEGFFLIGST TSRCEVQDRG VGWSHPLPQC EIVKCKPPPD 
IRNGRHSGEE NFYAYGFSVT YSCDPRFSLL GHASISCTVE NETIGVWRPS PPTCEKITCR 
KPDVSHGEMV SGFGPIYNYK DTIVFKCQKG FVLRGSSVIH CDADSKWNPS PPACEPNSCI 
NLPDIPHASW ETYPRPTKED VYVVGTVLRY RCHPGYKPTT DEPTTVICQK NLRWTPYQGC 
EALCCPEPKL NNGEITQHRK SRPANHCVYF YGDEISFSCH ETSRFSAICQ GDGTWSPRTP 
SCGDICNFPP KIAHGHYKQS SSYSFFKEEI IYECDKGYIL VGQAKLSCSY SHWSAPAPQC 
KALCRKPELV NGRLSVDKDQ YVEPENVTIQ CDSGYGVVGP QSITCSGNRT WYPEVPKCEW 
ETPEGCEQVL TGKRLMQCLP NPEDVKMALE VYKLSLEIEQ LELQRDSARQ STLDKEL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.