C4BPA | ENSG00000123838 | NCBI 722

Details for: C4BPA

Gene ID: 722

Symbol: C4BPA

Ensembl ID: ENSG00000123838

Description: complement component 4 binding protein alpha

Associated with

Complement cascade
(R-HSA-166658)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Regulation of complement cascade
(R-HSA-977606)
Blood microparticle
(GO:0072562)
Complement activation, classical pathway
(GO:0006958)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Innate immune response
(GO:0045087)
Negative regulation of complement activation, classical pathway
(GO:0045959)
Plasma membrane
(GO:0005886)
Positive regulation of protein catabolic process
(GO:0045732)
Protein binding
(GO:0005515)
Regulation of opsonization
(GO:1903027)
Response to symbiotic bacterium
(GO:0009609)
Rna binding
(GO:0003723)
T cell mediated immunity
(GO:0002456)

Other Information

Proteins

C4b-binding protein alpha chain

Genular Protein ID: 629521722

Symbol: C4BPA_HUMAN

Name: C4b-binding protein alpha chain

UniProtKB Accession Codes:

P04003 Q5VVQ8

Database IDs:

Citations:

PubMed ID: 2590215

Title: Molecular cloning of the cDNA coding for proline-rich protein (PRP): identity of PRP as C4b-binding protein.

PubMed ID: 2590215

DOI: 10.1016/0006-291x(89)91045-0

PubMed ID: 1989602

Title: Genomic organization of the alpha chain of the human C4b-binding protein gene.

PubMed ID: 1989602

DOI: 10.1016/0006-291x(91)90509-6

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3378624

Title: Derivation of the sequence of the signal peptide in human C4b-binding protein and interspecies cross-hybridisation of the C4bp cDNA sequence.

PubMed ID: 3378624

DOI: 10.1016/0014-5793(88)80763-4

PubMed ID: 3017751

Title: Studies on the structure of the human C4b-binding protein gene.

PubMed ID: 3017751

DOI: 10.1016/0014-5793(86)81390-4

PubMed ID: 3840370

Title: Molecular cloning and characterization of the cDNA coding for C4b-binding protein, a regulatory protein of the classical pathway of the human complement system.

PubMed ID: 3840370

DOI: 10.1042/bj2300133

PubMed ID: 4033666

Title: Amino acid sequence studies of human C4b-binding protein: N-terminal sequence analysis and alignment of the fragments produced by limited proteolysis with chymotrypsin and the peptides produced by cyanogen bromide treatment.

PubMed ID: 4033666

DOI: 10.1016/0161-5890(85)90127-0

PubMed ID: 14760718

Title: Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.

PubMed ID: 14760718

DOI: 10.1002/pmic.200300556

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24600566

Title: Complement regulator C4BP binds to Staphylococcus aureus surface proteins SdrE and Bbp inhibiting bacterial opsonization and killing.

PubMed ID: 24600566

DOI: 10.1016/j.rinim.2013.10.004

PubMed ID: 6222381

Title: Visualization of human C4b-binding protein and its complexes with vitamin K-dependent protein S and complement protein C4b.

PubMed ID: 6222381

DOI: 10.1073/pnas.80.11.3461

PubMed ID: 16330538

Title: Human C4b-binding protein, structural basis for interaction with streptococcal M protein, a major bacterial virulence factor.

PubMed ID: 16330538

DOI: 10.1074/jbc.m511563200

Sequence Information:

Length: 597
Mass: 67033
Checksum: 67E03F2EA85A16DD
Sequence:

MHPPKTPSGA LHRKRKMAAW PFSRLWKVSD PILFQMTLIA ALLPAVLGNC GPPPTLSFAA 
PMDITLTETR FKTGTTLKYT CLPGYVRSHS TQTLTCNSDG EWVYNTFCIY KRCRHPGELR 
NGQVEIKTDL SFGSQIEFSC SEGFFLIGST TSRCEVQDRG VGWSHPLPQC EIVKCKPPPD 
IRNGRHSGEE NFYAYGFSVT YSCDPRFSLL GHASISCTVE NETIGVWRPS PPTCEKITCR 
KPDVSHGEMV SGFGPIYNYK DTIVFKCQKG FVLRGSSVIH CDADSKWNPS PPACEPNSCI 
NLPDIPHASW ETYPRPTKED VYVVGTVLRY RCHPGYKPTT DEPTTVICQK NLRWTPYQGC 
EALCCPEPKL NNGEITQHRK SRPANHCVYF YGDEISFSCH ETSRFSAICQ GDGTWSPRTP 
SCGDICNFPP KIAHGHYKQS SSYSFFKEEI IYECDKGYIL VGQAKLSCSY SHWSAPAPQC 
KALCRKPELV NGRLSVDKDQ YVEPENVTIQ CDSGYGVVGP QSITCSGNRT WYPEVPKCEW 
ETPEGCEQVL TGKRLMQCLP NPEDVKMALE VYKLSLEIEQ LELQRDSARQ STLDKEL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: C4BPA

Associated with

Other Information

Molecular cloning of the cDNA coding for proline-rich protein (PRP): identity of PRP as C4b-binding protein. PubMed ID: 2590215

Genomic organization of the alpha chain of the human C4b-binding protein gene. PubMed ID: 1989602

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Derivation of the sequence of the signal peptide in human C4b-binding protein and interspecies cross-hybridisation of the C4bp cDNA sequence. PubMed ID: 3378624

Studies on the structure of the human C4b-binding protein gene. PubMed ID: 3017751

Molecular cloning and characterization of the cDNA coding for C4b-binding protein, a regulatory protein of the classical pathway of the human complement system. PubMed ID: 3840370

Amino acid sequence studies of human C4b-binding protein: N-terminal sequence analysis and alignment of the fragments produced by limited proteolysis with chymotrypsin and the peptides produced by cyanogen bromide treatment. PubMed ID: 4033666

Screening for N-glycosylated proteins by liquid chromatography mass spectrometry. PubMed ID: 14760718

Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. PubMed ID: 16335952

Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. PubMed ID: 19159218

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Complement regulator C4BP binds to Staphylococcus aureus surface proteins SdrE and Bbp inhibiting bacterial opsonization and killing. PubMed ID: 24600566

Visualization of human C4b-binding protein and its complexes with vitamin K-dependent protein S and complement protein C4b. PubMed ID: 6222381

Human C4b-binding protein, structural basis for interaction with streptococcal M protein, a major bacterial virulence factor. PubMed ID: 16330538