Details for: C4BPA

Gene ID: 722

Symbol: C4BPA

Ensembl ID: ENSG00000123838

Description: complement component 4 binding protein alpha

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 11.0844
    Cell Significance Index: 29.2400
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 8.5641
    Cell Significance Index: 79.4800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 5.1710
    Cell Significance Index: 87.1100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 3.3181
    Cell Significance Index: 71.8900
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 2.1704
    Cell Significance Index: 1.0900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.6381
    Cell Significance Index: 311.7500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.4076
    Cell Significance Index: 279.3400
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 1.1139
    Cell Significance Index: 2.4500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0733
    Cell Significance Index: 106.1800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.7737
    Cell Significance Index: 11.4200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.7339
    Cell Significance Index: 15.6300
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.7068
    Cell Significance Index: 4.0700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5670
    Cell Significance Index: 61.6800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5666
    Cell Significance Index: 92.1500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3819
    Cell Significance Index: 22.9300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3245
    Cell Significance Index: 22.4400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2780
    Cell Significance Index: 7.4500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.2711
    Cell Significance Index: 205.1900
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.2416
    Cell Significance Index: 0.9100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.1889
    Cell Significance Index: 2.8300
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.1095
    Cell Significance Index: 1.1300
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.0836
    Cell Significance Index: 1.1600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0802
    Cell Significance Index: 10.3600
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.0679
    Cell Significance Index: 0.6700
  • Cell Name: chorionic trophoblast cell (CL0011101)
    Fold Change: 0.0677
    Cell Significance Index: 0.2100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0604
    Cell Significance Index: 10.3100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0440
    Cell Significance Index: 24.0200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0271
    Cell Significance Index: 1.2800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0232
    Cell Significance Index: 0.3500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0213
    Cell Significance Index: 4.2700
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.0201
    Cell Significance Index: 0.1600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0145
    Cell Significance Index: 5.2100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0140
    Cell Significance Index: 1.6000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0118
    Cell Significance Index: 18.1300
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.0105
    Cell Significance Index: 0.1000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0099
    Cell Significance Index: 18.6800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0081
    Cell Significance Index: 11.0200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0053
    Cell Significance Index: 9.7800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0040
    Cell Significance Index: 1.1500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0013
    Cell Significance Index: 0.1800
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: 0.0012
    Cell Significance Index: 0.0100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0002
    Cell Significance Index: -0.1000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0004
    Cell Significance Index: -0.3300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0005
    Cell Significance Index: -0.1100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0024
    Cell Significance Index: -1.3400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0038
    Cell Significance Index: -0.1100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0039
    Cell Significance Index: -0.0600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0057
    Cell Significance Index: -0.2000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0065
    Cell Significance Index: -4.1300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0092
    Cell Significance Index: -1.0500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0102
    Cell Significance Index: -4.6300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0116
    Cell Significance Index: -0.2900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0135
    Cell Significance Index: -0.6100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0143
    Cell Significance Index: -2.0800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0156
    Cell Significance Index: -0.9600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0172
    Cell Significance Index: -0.8700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0213
    Cell Significance Index: -3.8400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0277
    Cell Significance Index: -1.2900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0291
    Cell Significance Index: -2.2300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0298
    Cell Significance Index: -0.5100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0315
    Cell Significance Index: -2.1200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0331
    Cell Significance Index: -0.4100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0369
    Cell Significance Index: -1.6000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0385
    Cell Significance Index: -4.0100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0425
    Cell Significance Index: -4.9500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0447
    Cell Significance Index: -5.5000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0449
    Cell Significance Index: -1.4200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0467
    Cell Significance Index: -0.7900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0480
    Cell Significance Index: -1.9700
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0515
    Cell Significance Index: -0.7700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0527
    Cell Significance Index: -3.2300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0614
    Cell Significance Index: -0.8800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0626
    Cell Significance Index: -3.5100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0630
    Cell Significance Index: -6.4400
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0679
    Cell Significance Index: -1.1600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0712
    Cell Significance Index: -1.8300
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0725
    Cell Significance Index: -0.7700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0726
    Cell Significance Index: -5.4100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0744
    Cell Significance Index: -1.1300
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0752
    Cell Significance Index: -0.9900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0848
    Cell Significance Index: -2.9700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0925
    Cell Significance Index: -4.0900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0969
    Cell Significance Index: -5.0400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1005
    Cell Significance Index: -3.8100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1008
    Cell Significance Index: -2.1400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1090
    Cell Significance Index: -3.4700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1109
    Cell Significance Index: -3.6300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1142
    Cell Significance Index: -3.1900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1155
    Cell Significance Index: -2.8800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1156
    Cell Significance Index: -2.3200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1171
    Cell Significance Index: -4.3000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1172
    Cell Significance Index: -2.8100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1247
    Cell Significance Index: -2.6100
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1276
    Cell Significance Index: -1.8600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1294
    Cell Significance Index: -2.5300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1324
    Cell Significance Index: -4.2400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1366
    Cell Significance Index: -2.9900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1382
    Cell Significance Index: -3.9500
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.1387
    Cell Significance Index: -1.1000
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.1467
    Cell Significance Index: -1.9800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure:** C4BPA is a protein composed of 4 alpha chains, each with a molecular weight of approximately 40 kDa. It binds to C4b, a fragment of the complement component 4 (C4), and regulates its activity. 2. **Function:** C4BPA acts as a negative regulator of the classical pathway complement activation, which is a crucial step in the elimination of pathogens. It also regulates opsonization, a process that enhances the recognition and phagocytosis of pathogens by immune cells. 3. **Expression:** C4BPA is expressed in various tissues, including liver, lung, and immune cells, such as amacrine cells, Mueller cells, and hepatocytes. 4. **Cellular localization:** C4BPA is primarily found on the plasma membrane, where it regulates complement activation and opsonization. **Pathways and Functions:** 1. **Complement activation:** C4BPA regulates classical pathway complement activation by binding to C4b and inhibiting its activity. 2. **Opsonization:** C4BPA enhances the recognition and phagocytosis of pathogens by binding to C4b and facilitating its interaction with pattern recognition receptors on immune cells. 3. **Negative regulation of complement cascade:** C4BPA negatively regulates the complement cascade by inhibiting the activation of C4b, thereby preventing excessive complement activation and tissue damage. 4. **Protein binding:** C4BPA binds to various proteins, including C4b, C3b, and factor B, regulating their activity and function. **Clinical Significance:** 1. **Complement dysregulation:** Abnormal expression or function of C4BPA has been implicated in various diseases, including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and glomerulonephritis. 2. **Infectious diseases:** C4BPA plays a crucial role in the regulation of the complement cascade, and its dysregulation can contribute to the pathogenesis of infectious diseases, such as sepsis and pneumonia. 3. **Cancer:** C4BPA expression has been found to be altered in various types of cancer, suggesting its potential role in cancer progression and metastasis. 4. **Immunological disorders:** C4BPA is involved in the regulation of T cell-mediated immunity, and its dysregulation can contribute to immunological disorders, such as autoimmune diseases and transplant rejection. In conclusion, C4BPA is a critical component of the innate immune system, playing a pivotal role in the regulation of the complement cascade, opsonization, and negative regulation of complement activation. Its dysregulation has been implicated in various diseases, including infectious diseases, autoimmune disorders, and cancer. Further research is necessary to fully understand the role of C4BPA in immune regulation and disease pathogenesis.

Genular Protein ID: 629521722

Symbol: C4BPA_HUMAN

Name: C4b-binding protein alpha chain

UniProtKB Accession Codes:

P04003 Q5VVQ8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 CarbonylDB 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 EMBL 20 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2590215

Title: Molecular cloning of the cDNA coding for proline-rich protein (PRP): identity of PRP as C4b-binding protein.

PubMed ID: 2590215

DOI: 10.1016/0006-291x(89)91045-0

PubMed ID: 1989602

Title: Genomic organization of the alpha chain of the human C4b-binding protein gene.

PubMed ID: 1989602

DOI: 10.1016/0006-291x(91)90509-6

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3378624

Title: Derivation of the sequence of the signal peptide in human C4b-binding protein and interspecies cross-hybridisation of the C4bp cDNA sequence.

PubMed ID: 3378624

DOI: 10.1016/0014-5793(88)80763-4

PubMed ID: 3017751

Title: Studies on the structure of the human C4b-binding protein gene.

PubMed ID: 3017751

DOI: 10.1016/0014-5793(86)81390-4

PubMed ID: 3840370

Title: Molecular cloning and characterization of the cDNA coding for C4b-binding protein, a regulatory protein of the classical pathway of the human complement system.

PubMed ID: 3840370

DOI: 10.1042/bj2300133

PubMed ID: 4033666

Title: Amino acid sequence studies of human C4b-binding protein: N-terminal sequence analysis and alignment of the fragments produced by limited proteolysis with chymotrypsin and the peptides produced by cyanogen bromide treatment.

PubMed ID: 4033666

DOI: 10.1016/0161-5890(85)90127-0

PubMed ID: 14760718

Title: Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.

PubMed ID: 14760718

DOI: 10.1002/pmic.200300556

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24600566

Title: Complement regulator C4BP binds to Staphylococcus aureus surface proteins SdrE and Bbp inhibiting bacterial opsonization and killing.

PubMed ID: 24600566

DOI: 10.1016/j.rinim.2013.10.004

PubMed ID: 6222381

Title: Visualization of human C4b-binding protein and its complexes with vitamin K-dependent protein S and complement protein C4b.

PubMed ID: 6222381

DOI: 10.1073/pnas.80.11.3461

PubMed ID: 16330538

Title: Human C4b-binding protein, structural basis for interaction with streptococcal M protein, a major bacterial virulence factor.

PubMed ID: 16330538

DOI: 10.1074/jbc.m511563200

Sequence Information:

  • Length: 597
  • Mass: 67033
  • Checksum: 67E03F2EA85A16DD
  • Sequence:
    • MHPPKTPSGA LHRKRKMAAW PFSRLWKVSD PILFQMTLIA ALLPAVLGNC GPPPTLSFAA 
PMDITLTETR FKTGTTLKYT CLPGYVRSHS TQTLTCNSDG EWVYNTFCIY KRCRHPGELR 
NGQVEIKTDL SFGSQIEFSC SEGFFLIGST TSRCEVQDRG VGWSHPLPQC EIVKCKPPPD 
IRNGRHSGEE NFYAYGFSVT YSCDPRFSLL GHASISCTVE NETIGVWRPS PPTCEKITCR 
KPDVSHGEMV SGFGPIYNYK DTIVFKCQKG FVLRGSSVIH CDADSKWNPS PPACEPNSCI 
NLPDIPHASW ETYPRPTKED VYVVGTVLRY RCHPGYKPTT DEPTTVICQK NLRWTPYQGC 
EALCCPEPKL NNGEITQHRK SRPANHCVYF YGDEISFSCH ETSRFSAICQ GDGTWSPRTP 
SCGDICNFPP KIAHGHYKQS SSYSFFKEEI IYECDKGYIL VGQAKLSCSY SHWSAPAPQC 
KALCRKPELV NGRLSVDKDQ YVEPENVTIQ CDSGYGVVGP QSITCSGNRT WYPEVPKCEW 
ETPEGCEQVL TGKRLMQCLP NPEDVKMALE VYKLSLEIEQ LELQRDSARQ STLDKEL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.