Details for: C4BPA

Gene ID: 722

Symbol: C4BPA

Ensembl ID: ENSG00000123838

Description: complement component 4 binding protein alpha

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 8.86
    Marker Score: 28390
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 3.81
    Marker Score: 5288
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 3.02
    Marker Score: 19687
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.36
    Marker Score: 3786
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 2.18
    Marker Score: 11703
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.85
    Marker Score: 7980
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.85
    Marker Score: 11880
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.76
    Marker Score: 788
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.64
    Marker Score: 26337
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1161
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.57
    Marker Score: 3868
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 862
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.36
    Marker Score: 1634
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.31
    Marker Score: 2480
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.25
    Marker Score: 847
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.24
    Marker Score: 6522
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.24
    Marker Score: 2521
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.16
    Marker Score: 483
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4799
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.11
    Marker Score: 1528
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.08
    Marker Score: 6560
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1
    Marker Score: 528
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71805
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48029
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.98
    Marker Score: 1053
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 505
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5315
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 371
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2739
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.88
    Marker Score: 497.5
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.82
    Marker Score: 626
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1259
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.75
    Marker Score: 980
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 685
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.73
    Marker Score: 501.5
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 459
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.71
    Marker Score: 1132
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.7
    Marker Score: 214
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.65
    Marker Score: 200.5
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.63
    Marker Score: 8399
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.59
    Marker Score: 156
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.58
    Marker Score: 386
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.57
    Marker Score: 239
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 450
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.56
    Marker Score: 211
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 147
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.53
    Marker Score: 197.5
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.49
    Marker Score: 7672
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 471
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.48
    Marker Score: 237
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.46
    Marker Score: 212
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.44
    Marker Score: 113
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.44
    Marker Score: 265
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.42
    Marker Score: 122
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.42
    Marker Score: 422
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.41
    Marker Score: 425
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.41
    Marker Score: 1186
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.39
    Marker Score: 199.5
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.37
    Marker Score: 101.5
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 369
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.36
    Marker Score: 158
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.32
    Marker Score: 323
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.31
    Marker Score: 598
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 0.31
    Marker Score: 175
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.31
    Marker Score: 98
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.3
    Marker Score: 179
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.29
    Marker Score: 140
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.28
    Marker Score: 163
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.28
    Marker Score: 322
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.28
    Marker Score: 306
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.27
    Marker Score: 158
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.27
    Marker Score: 297
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.27
    Marker Score: 549
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.27
    Marker Score: 457
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 89
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.25
    Marker Score: 312
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.25
    Marker Score: 152
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.24
    Marker Score: 217
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.23
    Marker Score: 418
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.23
    Marker Score: 50
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.23
    Marker Score: 223
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.23
    Marker Score: 400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.22
    Marker Score: 46
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.21
    Marker Score: 85
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.21
    Marker Score: 249
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.21
    Marker Score: 860
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.2
    Marker Score: 198
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.2
    Marker Score: 259
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.2
    Marker Score: 76
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.19
    Marker Score: 85
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.19
    Marker Score: 404
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.19
    Marker Score: 186

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Other Information

**Key characteristics:** - C4BPA is a glycoprotein with a molecular weight of approximately 120 kDa. - It is a transmembrane protein that is expressed on the surface of immune cells, such as macrophages, neutrophils, and dendritic cells. - C4BPA is a key regulator of the classical pathway of the complement system. - It binds to complement proteins C1q and C3, which are necessary for the activation of the pathway. - When C4BPA binds to C1q and C3, it recruits them to the surface of the immune cell, where they can activate the complement cascade. **Pathways and functions:** - C4BPA is involved in the classical pathway of the complement system, a pathway that is activated by the binding of antibodies to antigens on the surface of invading pathogens. - The classical pathway is responsible for the opsonization of invading pathogens, which is the process by which they are coated with a protein called serum albumin. - C4BPA is also involved in the regulation of opsonization. - It helps to control the inflammatory response by inhibiting the activation of the complement system in non-infected cells. **Clinical significance:** - Mutations in the C4BPA gene have been linked to a number of human diseases, including complement deficiencies and autoimmune disorders. - C4BPA is a potential target for therapeutic intervention in these diseases. - C4BPA is a promising target for the development of new treatments for complement deficiencies and autoimmune disorders.

Genular Protein ID: 629521722

Symbol: C4BPA_HUMAN

Name: C4b-binding protein alpha chain

UniProtKB Accession Codes:

P04003 Q5VVQ8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 CarbonylDB 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 EMBL 20 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 7 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2590215

Title: Molecular cloning of the cDNA coding for proline-rich protein (PRP): identity of PRP as C4b-binding protein.

PubMed ID: 2590215

DOI: 10.1016/0006-291x(89)91045-0

PubMed ID: 1989602

Title: Genomic organization of the alpha chain of the human C4b-binding protein gene.

PubMed ID: 1989602

DOI: 10.1016/0006-291x(91)90509-6

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3378624

Title: Derivation of the sequence of the signal peptide in human C4b-binding protein and interspecies cross-hybridisation of the C4bp cDNA sequence.

PubMed ID: 3378624

DOI: 10.1016/0014-5793(88)80763-4

PubMed ID: 3017751

Title: Studies on the structure of the human C4b-binding protein gene.

PubMed ID: 3017751

DOI: 10.1016/0014-5793(86)81390-4

PubMed ID: 3840370

Title: Molecular cloning and characterization of the cDNA coding for C4b-binding protein, a regulatory protein of the classical pathway of the human complement system.

PubMed ID: 3840370

DOI: 10.1042/bj2300133

PubMed ID: 4033666

Title: Amino acid sequence studies of human C4b-binding protein: N-terminal sequence analysis and alignment of the fragments produced by limited proteolysis with chymotrypsin and the peptides produced by cyanogen bromide treatment.

PubMed ID: 4033666

DOI: 10.1016/0161-5890(85)90127-0

PubMed ID: 14760718

Title: Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.

PubMed ID: 14760718

DOI: 10.1002/pmic.200300556

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24600566

Title: Complement regulator C4BP binds to Staphylococcus aureus surface proteins SdrE and Bbp inhibiting bacterial opsonization and killing.

PubMed ID: 24600566

DOI: 10.1016/j.rinim.2013.10.004

PubMed ID: 6222381

Title: Visualization of human C4b-binding protein and its complexes with vitamin K-dependent protein S and complement protein C4b.

PubMed ID: 6222381

DOI: 10.1073/pnas.80.11.3461

PubMed ID: 16330538

Title: Human C4b-binding protein, structural basis for interaction with streptococcal M protein, a major bacterial virulence factor.

PubMed ID: 16330538

DOI: 10.1074/jbc.m511563200

Sequence Information:

  • Length: 597
  • Mass: 67033
  • Checksum: 67E03F2EA85A16DD
  • Sequence:
    • MHPPKTPSGA LHRKRKMAAW PFSRLWKVSD PILFQMTLIA ALLPAVLGNC GPPPTLSFAA 
PMDITLTETR FKTGTTLKYT CLPGYVRSHS TQTLTCNSDG EWVYNTFCIY KRCRHPGELR 
NGQVEIKTDL SFGSQIEFSC SEGFFLIGST TSRCEVQDRG VGWSHPLPQC EIVKCKPPPD 
IRNGRHSGEE NFYAYGFSVT YSCDPRFSLL GHASISCTVE NETIGVWRPS PPTCEKITCR 
KPDVSHGEMV SGFGPIYNYK DTIVFKCQKG FVLRGSSVIH CDADSKWNPS PPACEPNSCI 
NLPDIPHASW ETYPRPTKED VYVVGTVLRY RCHPGYKPTT DEPTTVICQK NLRWTPYQGC 
EALCCPEPKL NNGEITQHRK SRPANHCVYF YGDEISFSCH ETSRFSAICQ GDGTWSPRTP 
SCGDICNFPP KIAHGHYKQS SSYSFFKEEI IYECDKGYIL VGQAKLSCSY SHWSAPAPQC 
KALCRKPELV NGRLSVDKDQ YVEPENVTIQ CDSGYGVVGP QSITCSGNRT WYPEVPKCEW 
ETPEGCEQVL TGKRLMQCLP NPEDVKMALE VYKLSLEIEQ LELQRDSARQ STLDKEL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.