Details for: C4BPA
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: amacrine cell (CL0000561)
Fold Change: 8.86
Marker Score: 28,390 - Cell Name: Mueller cell (CL0000636)
Fold Change: 3.81
Marker Score: 5,288 - Cell Name: type II pneumocyte (CL0002063)
Fold Change: 3.02
Marker Score: 19,687 - Cell Name: pneumocyte (CL0000322)
Fold Change: 2.36
Marker Score: 3,786 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 2.18
Marker Score: 11,703 - Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 1.85
Marker Score: 7,980 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 1.85
Marker Score: 11,880 - Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 1.76
Marker Score: 788 - Cell Name: lactocyte (CL0002325)
Fold Change: 1.64
Marker Score: 26,337 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.6
Marker Score: 1,161 - Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 1.57
Marker Score: 3,868 - Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.36
Marker Score: 862 - Cell Name: type I pneumocyte (CL0002062)
Fold Change: 1.36
Marker Score: 1,634 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.31
Marker Score: 2,480 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.25
Marker Score: 847 - Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 1.24
Marker Score: 6,522 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.24
Marker Score: 2,521 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.16
Marker Score: 483 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.14
Marker Score: 4,799 - Cell Name: double negative thymocyte (CL0002489)
Fold Change: 1.11
Marker Score: 1,528 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.08
Marker Score: 6,560 - Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 1
Marker Score: 528 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,805 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48,029 - Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 0.98
Marker Score: 1,053 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,406 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.98
Marker Score: 505 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.97
Marker Score: 459 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,412 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5,315 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.93
Marker Score: 371 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2,739 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9
Marker Score: 324 - Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.88
Marker Score: 498 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.82
Marker Score: 626 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1,259 - Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 394 - Cell Name: monocyte (CL0000576)
Fold Change: 0.75
Marker Score: 980 - Cell Name: brush cell (CL0002204)
Fold Change: 0.75
Marker Score: 685 - Cell Name: hepatocyte (CL0000182)
Fold Change: 0.73
Marker Score: 502 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.72
Marker Score: 459 - Cell Name: epithelial cell (CL0000066)
Fold Change: 0.71
Marker Score: 1,132 - Cell Name: ionocyte (CL0005006)
Fold Change: 0.7
Marker Score: 214 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 178 - Cell Name: inflammatory macrophage (CL0000863)
Fold Change: 0.65
Marker Score: 201 - Cell Name: malignant cell (CL0001064)
Fold Change: 0.63
Marker Score: 8,399 - Cell Name: bronchial epithelial cell (CL0002328)
Fold Change: 0.59
Marker Score: 156 - Cell Name: precursor B cell (CL0000817)
Fold Change: 0.58
Marker Score: 386 - Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.57
Marker Score: 239 - Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 450 - Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 0.56
Marker Score: 211 - Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.55
Marker Score: 147 - Cell Name: cholangiocyte (CL1000488)
Fold Change: 0.53
Marker Score: 198 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.49
Marker Score: 7,672 - Cell Name: pro-B cell (CL0000826)
Fold Change: 0.49
Marker Score: 471 - Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 0.48
Marker Score: 237 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.46
Marker Score: 212 - Cell Name: mucus secreting cell (CL0000319)
Fold Change: 0.44
Marker Score: 113 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.44
Marker Score: 265 - Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 0.42
Marker Score: 122 - Cell Name: Kupffer cell (CL0000091)
Fold Change: 0.42
Marker Score: 422 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.41
Marker Score: 425 - Cell Name: ON-bipolar cell (CL0000749)
Fold Change: 0.41
Marker Score: 1,186 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: 0.39
Marker Score: 200 - Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
Fold Change: 0.37
Marker Score: 102 - Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.37
Marker Score: 369 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: 0.36
Marker Score: 158 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.32
Marker Score: 323 - Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 0.31
Marker Score: 598 - Cell Name: epithelial cell of exocrine pancreas (CL1001433)
Fold Change: 0.31
Marker Score: 175 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.31
Marker Score: 98 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.3
Marker Score: 179 - Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.29
Marker Score: 140 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.28
Marker Score: 163 - Cell Name: club cell (CL0000158)
Fold Change: 0.28
Marker Score: 322 - Cell Name: macrophage (CL0000235)
Fold Change: 0.28
Marker Score: 306 - Cell Name: mast cell (CL0000097)
Fold Change: 0.27
Marker Score: 158 - Cell Name: plasma cell (CL0000786)
Fold Change: 0.27
Marker Score: 297 - Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.27
Marker Score: 549 - Cell Name: T cell (CL0000084)
Fold Change: 0.27
Marker Score: 457 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.26
Marker Score: 89 - Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.25
Marker Score: 312 - Cell Name: neutrophil (CL0000775)
Fold Change: 0.25
Marker Score: 152 - Cell Name: endothelial cell (CL0000115)
Fold Change: 0.24
Marker Score: 217 - Cell Name: secretory cell (CL0000151)
Fold Change: 0.23
Marker Score: 418 - Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.23
Marker Score: 50 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.23
Marker Score: 223 - Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 0.23
Marker Score: 400 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.22
Marker Score: 64 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.22
Marker Score: 74 - Cell Name: lung microvascular endothelial cell (CL2000016)
Fold Change: 0.22
Marker Score: 46 - Cell Name: mesothelial cell (CL0000077)
Fold Change: 0.21
Marker Score: 85 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.21
Marker Score: 249 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.21
Marker Score: 860 - Cell Name: fibroblast (CL0000057)
Fold Change: 0.2
Marker Score: 198 - Cell Name: basal cell (CL0000646)
Fold Change: 0.2
Marker Score: 259 - Cell Name: neuroendocrine cell (CL0000165)
Fold Change: 0.2
Marker Score: 76 - Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.19
Marker Score: 85 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.19
Marker Score: 404 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.19
Marker Score: 186
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 629521722
Symbol: C4BPA_HUMAN
Name: C4b-binding protein alpha chain
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2590215
Title: Molecular cloning of the cDNA coding for proline-rich protein (PRP): identity of PRP as C4b-binding protein.
PubMed ID: 2590215
PubMed ID: 1989602
Title: Genomic organization of the alpha chain of the human C4b-binding protein gene.
PubMed ID: 1989602
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 3378624
Title: Derivation of the sequence of the signal peptide in human C4b-binding protein and interspecies cross-hybridisation of the C4bp cDNA sequence.
PubMed ID: 3378624
PubMed ID: 3017751
Title: Studies on the structure of the human C4b-binding protein gene.
PubMed ID: 3017751
PubMed ID: 3840370
Title: Molecular cloning and characterization of the cDNA coding for C4b-binding protein, a regulatory protein of the classical pathway of the human complement system.
PubMed ID: 3840370
DOI: 10.1042/bj2300133
PubMed ID: 4033666
Title: Amino acid sequence studies of human C4b-binding protein: N-terminal sequence analysis and alignment of the fragments produced by limited proteolysis with chymotrypsin and the peptides produced by cyanogen bromide treatment.
PubMed ID: 4033666
PubMed ID: 14760718
Title: Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.
PubMed ID: 14760718
PubMed ID: 16335952
Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.
PubMed ID: 16335952
DOI: 10.1021/pr0502065
PubMed ID: 19159218
Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
PubMed ID: 19159218
DOI: 10.1021/pr8008012
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 24600566
Title: Complement regulator C4BP binds to Staphylococcus aureus surface proteins SdrE and Bbp inhibiting bacterial opsonization and killing.
PubMed ID: 24600566
PubMed ID: 6222381
Title: Visualization of human C4b-binding protein and its complexes with vitamin K-dependent protein S and complement protein C4b.
PubMed ID: 6222381
PubMed ID: 16330538
Title: Human C4b-binding protein, structural basis for interaction with streptococcal M protein, a major bacterial virulence factor.
PubMed ID: 16330538
Sequence Information:
- Length: 597
- Mass: 67033
- Checksum: 67E03F2EA85A16DD
- Sequence:
MHPPKTPSGA LHRKRKMAAW PFSRLWKVSD PILFQMTLIA ALLPAVLGNC GPPPTLSFAA PMDITLTETR FKTGTTLKYT CLPGYVRSHS TQTLTCNSDG EWVYNTFCIY KRCRHPGELR NGQVEIKTDL SFGSQIEFSC SEGFFLIGST TSRCEVQDRG VGWSHPLPQC EIVKCKPPPD IRNGRHSGEE NFYAYGFSVT YSCDPRFSLL GHASISCTVE NETIGVWRPS PPTCEKITCR KPDVSHGEMV SGFGPIYNYK DTIVFKCQKG FVLRGSSVIH CDADSKWNPS PPACEPNSCI NLPDIPHASW ETYPRPTKED VYVVGTVLRY RCHPGYKPTT DEPTTVICQK NLRWTPYQGC EALCCPEPKL NNGEITQHRK SRPANHCVYF YGDEISFSCH ETSRFSAICQ GDGTWSPRTP SCGDICNFPP KIAHGHYKQS SSYSFFKEEI IYECDKGYIL VGQAKLSCSY SHWSAPAPQC KALCRKPELV NGRLSVDKDQ YVEPENVTIQ CDSGYGVVGP QSITCSGNRT WYPEVPKCEW ETPEGCEQVL TGKRLMQCLP NPEDVKMALE VYKLSLEIEQ LELQRDSARQ STLDKEL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.