Details for: C4BPAP2

Gene ID: 724

Symbol: C4BPAP2

Ensembl ID: ENSG00000232621

Description: C4BPA pseudogene 2

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.3090
    Cell Significance Index: 3.2600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1273
    Cell Significance Index: 3.4100
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.1044
    Cell Significance Index: 1.2700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0443
    Cell Significance Index: 0.7600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0368
    Cell Significance Index: 0.8100
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.0308
    Cell Significance Index: 0.3900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0001
    Cell Significance Index: -0.1800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0008
    Cell Significance Index: -1.4900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0009
    Cell Significance Index: -1.4200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0016
    Cell Significance Index: -2.1300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0017
    Cell Significance Index: -1.0900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0031
    Cell Significance Index: -1.4000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0047
    Cell Significance Index: -0.6800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0108
    Cell Significance Index: -1.2400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0113
    Cell Significance Index: -2.2600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0146
    Cell Significance Index: -1.5200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0183
    Cell Significance Index: -0.2700
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0234
    Cell Significance Index: -0.2700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0253
    Cell Significance Index: -0.2400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0285
    Cell Significance Index: -0.4800
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.0395
    Cell Significance Index: -0.5600
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0450
    Cell Significance Index: -0.5000
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.0562
    Cell Significance Index: -0.6400
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0640
    Cell Significance Index: -0.8500
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.0649
    Cell Significance Index: -0.7200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0673
    Cell Significance Index: -2.1300
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0685
    Cell Significance Index: -0.8600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0745
    Cell Significance Index: -0.9400
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.0749
    Cell Significance Index: -0.9100
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0777
    Cell Significance Index: -1.3200
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.0819
    Cell Significance Index: -0.9300
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0852
    Cell Significance Index: -1.1700
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0854
    Cell Significance Index: -1.0700
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.0890
    Cell Significance Index: -1.0300
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0909
    Cell Significance Index: -1.1700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0918
    Cell Significance Index: -1.0000
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: -0.0968
    Cell Significance Index: -1.0500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0984
    Cell Significance Index: -2.1300
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0988
    Cell Significance Index: -1.2900
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0989
    Cell Significance Index: -1.0100
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0995
    Cell Significance Index: -1.2100
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.0998
    Cell Significance Index: -1.1600
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.1018
    Cell Significance Index: -1.1200
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.1061
    Cell Significance Index: -1.2700
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.1066
    Cell Significance Index: -1.2800
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: -0.1084
    Cell Significance Index: -1.3100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1088
    Cell Significance Index: -2.3100
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1101
    Cell Significance Index: -1.3200
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: -0.1101
    Cell Significance Index: -1.3100
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.1101
    Cell Significance Index: -1.3000
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.1134
    Cell Significance Index: -1.3400
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.1138
    Cell Significance Index: -1.4900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1161
    Cell Significance Index: -2.3300
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.1162
    Cell Significance Index: -1.3300
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.1184
    Cell Significance Index: -1.3500
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.1197
    Cell Significance Index: -1.3300
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.1201
    Cell Significance Index: -1.3300
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.1204
    Cell Significance Index: -1.3500
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.1222
    Cell Significance Index: -1.3300
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: -0.1246
    Cell Significance Index: -1.3300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1272
    Cell Significance Index: -1.8100
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.1302
    Cell Significance Index: -1.5600
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.1304
    Cell Significance Index: -1.3300
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.1334
    Cell Significance Index: -1.4400
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.1340
    Cell Significance Index: -1.5000
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.1383
    Cell Significance Index: -1.2700
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.1385
    Cell Significance Index: -1.2900
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.1406
    Cell Significance Index: -1.7100
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.1482
    Cell Significance Index: -1.8600
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1487
    Cell Significance Index: -1.3100
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.1490
    Cell Significance Index: -1.8600
  • Cell Name: bipolar neuron (CL0000103)
    Fold Change: -0.1498
    Cell Significance Index: -0.8400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1502
    Cell Significance Index: -1.7900
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.1511
    Cell Significance Index: -1.6200
  • Cell Name: differentiation-committed oligodendrocyte precursor (CL4023059)
    Fold Change: -0.1517
    Cell Significance Index: -1.8000
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.1519
    Cell Significance Index: -1.4700
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.1521
    Cell Significance Index: -1.3300
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.1534
    Cell Significance Index: -1.8600
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.1547
    Cell Significance Index: -1.4500
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.1554
    Cell Significance Index: -1.9100
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1580
    Cell Significance Index: -1.8800
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.1608
    Cell Significance Index: -1.3300
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.1626
    Cell Significance Index: -1.6600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1626
    Cell Significance Index: -4.1800
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1715
    Cell Significance Index: -1.6100
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.2035
    Cell Significance Index: -1.6800
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.2107
    Cell Significance Index: -3.1500
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.2353
    Cell Significance Index: -1.8100
  • Cell Name: dermis microvascular lymphatic vessel endothelial cell (CL2000041)
    Fold Change: -0.2529
    Cell Significance Index: -1.2200
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.2539
    Cell Significance Index: -3.3300
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.2574
    Cell Significance Index: -2.3400
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.2834
    Cell Significance Index: -4.2400
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.2905
    Cell Significance Index: -1.8900
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.3631
    Cell Significance Index: -2.2800
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.3636
    Cell Significance Index: -4.2800
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.3910
    Cell Significance Index: -2.3200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** C4BPAP2 is a pseudogene, meaning that it is a non-functional copy of a gene that has undergone mutations or deletions, rendering it unable to produce a protein. Despite its pseudogenic status, C4BPAP2 has been found to be expressed in a wide range of cell types, including those of the central nervous system. Its expression is particularly notable in cells involved in immune regulation, such as astrocytes and central nervous system macrophages. Furthermore, C4BPAP2 has been detected in cells of the retina, suggesting a potential role in the regulation of neural function and development. **Pathways and Functions:** Despite its pseudogenic nature, C4BPAP2 has been implicated in several key pathways involved in immune regulation and neurological function. One of the most significant pathways associated with C4BPAP2 is the complement system, which plays a crucial role in the elimination of pathogens and damaged cells. C4BPAP2 has been shown to regulate the activity of the complement system by interacting with C4b, a key component of the complement cascade. Additionally, C4BPAP2 has been implicated in the regulation of cytokine production, a critical aspect of immune response. Its expression in cells of the central nervous system suggests a potential role in the regulation of neural function and development. **Clinical Significance:** The clinical significance of C4BPAP2 is an area of active research, with several potential implications for our understanding of immune regulation and neurological function. One of the most significant areas of interest is the potential role of C4BPAP2 in the pathogenesis of autoimmune diseases, such as multiple sclerosis and lupus. The gene's expression in cells of the central nervous system suggests a potential link between immune regulation and neurological function, raising questions about the role of C4BPAP2 in the development of neurological disorders. Furthermore, C4BPAP2's involvement in the regulation of cytokine production suggests a potential role in the treatment of inflammatory diseases, such as rheumatoid arthritis and asthma. In conclusion, C4BPAP2 is a gene of significant interest in the fields of immunology and neuroscience. Its widespread expression in various cell types, including those of the central nervous system, raises questions about its potential role in immune regulation and neurological function. Further research is needed to fully understand the mechanisms by which C4BPAP2 regulates the complement system and cytokine production, as well as its potential implications for the treatment of autoimmune and inflammatory diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.