Details for: C4BPB

Gene ID: 725

Symbol: C4BPB

Ensembl ID: ENSG00000123843

Description: complement component 4 binding protein beta

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 3.78
    Marker Score: 12,111
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 2.1
    Marker Score: 11,313
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.85
    Marker Score: 11,883
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.84
    Marker Score: 7,919
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.14
    Marker Score: 6,896
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 1.01
    Marker Score: 660
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,827
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,052
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.99
    Marker Score: 710
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 508
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.99
    Marker Score: 625
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,409
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.98
    Marker Score: 15,346
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 461
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,326
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.92
    Marker Score: 3,024
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,739
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.91
    Marker Score: 615
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,261
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 691
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 576
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.75
    Marker Score: 511
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.74
    Marker Score: 297
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7
    Marker Score: 2,934
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.67
    Marker Score: 714
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.56
    Marker Score: 356
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 147
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.51
    Marker Score: 1,032
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.5
    Marker Score: 190
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.5
    Marker Score: 187
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.49
    Marker Score: 678
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 276
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.45
    Marker Score: 858
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 0.44
    Marker Score: 250
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.39
    Marker Score: 222
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.37
    Marker Score: 384
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.36
    Marker Score: 111
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.35
    Marker Score: 348
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.32
    Marker Score: 81
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.29
    Marker Score: 1,372
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.26
    Marker Score: 81
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.25
    Marker Score: 304
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.25
    Marker Score: 94
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.24
    Marker Score: 118
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.23
    Marker Score: 140
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.23
    Marker Score: 97
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.23
    Marker Score: 78
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.22
    Marker Score: 130
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.22
    Marker Score: 1,404
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.21
    Marker Score: 91
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.2
    Marker Score: 477
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.19
    Marker Score: 201
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.19
    Marker Score: 83
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.18
    Marker Score: 179
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.18
    Marker Score: 370
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.18
    Marker Score: 174
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.17
    Marker Score: 47
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.17
    Marker Score: 54
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.17
    Marker Score: 162
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.16
    Marker Score: 40
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.16
    Marker Score: 69
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.16
    Marker Score: 47
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.16
    Marker Score: 39
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.16
    Marker Score: 59
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.15
    Marker Score: 152
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.15
    Marker Score: 70
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.14
    Marker Score: 36
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.13
    Marker Score: 74
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.13
    Marker Score: 238
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.13
    Marker Score: 129
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.13
    Marker Score: 73
  • Cell Name: parietal cell (CL0000162)
    Fold Change: 0.13
    Marker Score: 35
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.12
    Marker Score: 350
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.12
    Marker Score: 422
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.12
    Marker Score: 86
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.12
    Marker Score: 50
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.12
    Marker Score: 770
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.11
    Marker Score: 361
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.11
    Marker Score: 33
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.11
    Marker Score: 23
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.11
    Marker Score: 53
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.11
    Marker Score: 752
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.11
    Marker Score: 100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.11
    Marker Score: 1,793
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.11
    Marker Score: 236
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.11
    Marker Score: 130
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.11
    Marker Score: 24
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.11
    Marker Score: 205
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.11
    Marker Score: 108
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.11
    Marker Score: 36
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1
    Marker Score: 47
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.1
    Marker Score: 113
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.1
    Marker Score: 54

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure**: C4BPB is a beta chain of the C4b-binding protein complex, consisting of two identical subunits linked by a disulfide bond. 2. **Function**: C4BPB regulates the activity of C4b, a key component of the classical pathway of complement activation, by binding to it and inhibiting its ability to bind to C4a. 3. **Cellular Expression**: C4BPB is expressed in various cell types, including hematopoietic cells, neurons, and epithelial cells, suggesting its widespread involvement in immune and homeostatic processes. 4. **Pathway Involvement**: C4BPB is integral to the regulation of the classical pathway of complement activation, which is a key component of the innate immune response. **Pathways and Functions:** 1. **Complement Activation**: C4BPB regulates the classical pathway of complement activation by binding to C4b and inhibiting its ability to bind to C4a. 2. **Negative Regulation of Complement Activation**: C4BPB's regulatory function on the classical pathway prevents excessive complement activation, which can lead to tissue damage and inflammation. 3. **Immune System Regulation**: C4BPB plays a role in regulating immune responses by modulating the activity of complement components and influencing the function of immune cells, such as T-helper 17 cells. 4. **Coagulation Regulation**: C4BPB's interaction with coagulation factors and platelets suggests its involvement in regulating coagulation processes and maintaining tissue homeostasis. **Clinical Significance:** Dysregulation of the complement system, including C4BPB, has been implicated in various diseases, including: 1. **Autoimmune Disorders**: Abnormal regulation of the complement system can contribute to autoimmune diseases, such as systemic lupus erythematosus (SLE). 2. **Inflammatory Disorders**: Dysregulation of C4BPB can lead to excessive complement activation, resulting in inflammatory conditions, such as atherosclerosis and rheumatoid arthritis. 3. **Coagulation Disorders**: Alterations in C4BPB expression or function can contribute to coagulation disorders, such as thrombosis and hemostasis defects. In conclusion, C4BPB is a critical regulator of the complement system, with significant implications for immune response, coagulation, and tissue homeostasis. Further research on this protein will shed light on its intricate mechanisms of action and its role in various diseases, enabling the development of novel therapeutic strategies.

Genular Protein ID: 267066831

Symbol: C4BPB_HUMAN

Name: C4b-binding protein beta chain

UniProtKB Accession Codes:

P20851 A5JYP8 D3DT81 Q5VVR0 Q9BS25

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 EMBL 8 Ensembl 4 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 6 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8325877

Title: The human C4b-binding protein beta-chain gene.

PubMed ID: 8325877

DOI: 10.1016/s0021-9258(18)82432-2

PubMed ID: 2300577

Title: Cloning of cDNA coding for the beta chain of human complement component C4b-binding protein: sequence homology with the alpha chain.

PubMed ID: 2300577

DOI: 10.1073/pnas.87.3.1183

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14760718

Title: Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.

PubMed ID: 14760718

DOI: 10.1002/pmic.200300556

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

Sequence Information:

  • Length: 252
  • Mass: 28357
  • Checksum: 0F6CC64067C5E2E7
  • Sequence:
    • MFFWCACCLM VAWRVSASDA EHCPELPPVD NSIFVAKEVE GQILGTYVCI KGYHLVGKKT 
LFCNASKEWD NTTTECRLGH CPDPVLVNGE FSSSGPVNVS DKITFMCNDH YILKGSNRSQ 
CLEDHTWAPP FPICKSRDCD PPGNPVHGYF EGNNFTLGST ISYYCEDRYY LVGVQEQQCV 
DGEWSSALPV CKLIQEAPKP ECEKALLAFQ ESKNLCEAME NFMQQLKESG MTMEELKYSL 
ELKKAELKAK LL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.