Details for: C4BPB

Gene ID: 725

Symbol: C4BPB

Ensembl ID: ENSG00000123843

Description: complement component 4 binding protein beta

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 20.8300
    Cell Significance Index: -3.2400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 12.8921
    Cell Significance Index: -3.2700
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 10.2945
    Cell Significance Index: 5.1700
  • Cell Name: theca cell (CL0000503)
    Fold Change: 5.7821
    Cell Significance Index: 33.9700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 4.8285
    Cell Significance Index: -3.2400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 4.7640
    Cell Significance Index: 80.2500
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 3.4762
    Cell Significance Index: 9.1700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 3.4355
    Cell Significance Index: -3.2800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.5120
    Cell Significance Index: 287.7400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.3908
    Cell Significance Index: 276.0100
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 1.1488
    Cell Significance Index: 4.9400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8359
    Cell Significance Index: 82.6900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8233
    Cell Significance Index: 133.9000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.7228
    Cell Significance Index: 10.8300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6771
    Cell Significance Index: 40.6500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6043
    Cell Significance Index: 65.7300
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.5800
    Cell Significance Index: 3.3400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5696
    Cell Significance Index: 12.3400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4876
    Cell Significance Index: 14.0500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.4566
    Cell Significance Index: 6.7400
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.3646
    Cell Significance Index: 2.7700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3505
    Cell Significance Index: 24.2400
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.3021
    Cell Significance Index: 1.8100
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.2735
    Cell Significance Index: 1.0300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.2628
    Cell Significance Index: 4.4200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1788
    Cell Significance Index: 3.7100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1657
    Cell Significance Index: 7.5100
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.1581
    Cell Significance Index: 1.5600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1517
    Cell Significance Index: 3.2300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1283
    Cell Significance Index: 6.0300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0661
    Cell Significance Index: 0.8400
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.0571
    Cell Significance Index: 0.6800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0510
    Cell Significance Index: 8.7100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0319
    Cell Significance Index: 1.1200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0303
    Cell Significance Index: 3.5300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0224
    Cell Significance Index: 2.9000
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.0215
    Cell Significance Index: 0.1400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0184
    Cell Significance Index: 0.4600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0112
    Cell Significance Index: 0.3300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0084
    Cell Significance Index: 0.2700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0043
    Cell Significance Index: 0.4900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0002
    Cell Significance Index: 0.3500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0009
    Cell Significance Index: -0.5600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0012
    Cell Significance Index: -0.9200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0017
    Cell Significance Index: -0.3000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0020
    Cell Significance Index: -3.7700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0023
    Cell Significance Index: -3.4800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0024
    Cell Significance Index: -1.8100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0027
    Cell Significance Index: -1.4900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0029
    Cell Significance Index: -3.9800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0031
    Cell Significance Index: -1.7300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0032
    Cell Significance Index: -1.1300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0037
    Cell Significance Index: -0.0300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0039
    Cell Significance Index: -0.1800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0048
    Cell Significance Index: -3.0600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0050
    Cell Significance Index: -1.0000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0081
    Cell Significance Index: -0.8300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0091
    Cell Significance Index: -4.1200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0095
    Cell Significance Index: -2.0000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0112
    Cell Significance Index: -3.2100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0139
    Cell Significance Index: -1.5900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0170
    Cell Significance Index: -2.4700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0172
    Cell Significance Index: -2.3600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0232
    Cell Significance Index: -2.8500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0273
    Cell Significance Index: -1.6800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0286
    Cell Significance Index: -3.3700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0307
    Cell Significance Index: -3.2000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0378
    Cell Significance Index: -0.5700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0401
    Cell Significance Index: -2.0300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0435
    Cell Significance Index: -0.7500
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.0436
    Cell Significance Index: -0.3300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0439
    Cell Significance Index: -2.9500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0447
    Cell Significance Index: -3.3300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0461
    Cell Significance Index: -3.5400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0536
    Cell Significance Index: -2.3300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0608
    Cell Significance Index: -1.6300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0610
    Cell Significance Index: -3.1800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0613
    Cell Significance Index: -3.7700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0616
    Cell Significance Index: -2.5200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0618
    Cell Significance Index: -3.9900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0656
    Cell Significance Index: -3.4100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0677
    Cell Significance Index: -3.8000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0683
    Cell Significance Index: -1.6600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0700
    Cell Significance Index: -1.9600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0712
    Cell Significance Index: -1.8300
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0741
    Cell Significance Index: -0.4600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0742
    Cell Significance Index: -2.6000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0791
    Cell Significance Index: -2.5900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0816
    Cell Significance Index: -1.1600
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0822
    Cell Significance Index: -1.1400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0823
    Cell Significance Index: -2.6200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0845
    Cell Significance Index: -2.2600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0889
    Cell Significance Index: -1.8600
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0894
    Cell Significance Index: -0.6500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0929
    Cell Significance Index: -1.3300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0934
    Cell Significance Index: -4.1300
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0937
    Cell Significance Index: -0.8900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0948
    Cell Significance Index: -2.5800
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0986
    Cell Significance Index: -1.2200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure**: C4BPB is a beta chain of the C4b-binding protein complex, consisting of two identical subunits linked by a disulfide bond. 2. **Function**: C4BPB regulates the activity of C4b, a key component of the classical pathway of complement activation, by binding to it and inhibiting its ability to bind to C4a. 3. **Cellular Expression**: C4BPB is expressed in various cell types, including hematopoietic cells, neurons, and epithelial cells, suggesting its widespread involvement in immune and homeostatic processes. 4. **Pathway Involvement**: C4BPB is integral to the regulation of the classical pathway of complement activation, which is a key component of the innate immune response. **Pathways and Functions:** 1. **Complement Activation**: C4BPB regulates the classical pathway of complement activation by binding to C4b and inhibiting its ability to bind to C4a. 2. **Negative Regulation of Complement Activation**: C4BPB's regulatory function on the classical pathway prevents excessive complement activation, which can lead to tissue damage and inflammation. 3. **Immune System Regulation**: C4BPB plays a role in regulating immune responses by modulating the activity of complement components and influencing the function of immune cells, such as T-helper 17 cells. 4. **Coagulation Regulation**: C4BPB's interaction with coagulation factors and platelets suggests its involvement in regulating coagulation processes and maintaining tissue homeostasis. **Clinical Significance:** Dysregulation of the complement system, including C4BPB, has been implicated in various diseases, including: 1. **Autoimmune Disorders**: Abnormal regulation of the complement system can contribute to autoimmune diseases, such as systemic lupus erythematosus (SLE). 2. **Inflammatory Disorders**: Dysregulation of C4BPB can lead to excessive complement activation, resulting in inflammatory conditions, such as atherosclerosis and rheumatoid arthritis. 3. **Coagulation Disorders**: Alterations in C4BPB expression or function can contribute to coagulation disorders, such as thrombosis and hemostasis defects. In conclusion, C4BPB is a critical regulator of the complement system, with significant implications for immune response, coagulation, and tissue homeostasis. Further research on this protein will shed light on its intricate mechanisms of action and its role in various diseases, enabling the development of novel therapeutic strategies.

Genular Protein ID: 267066831

Symbol: C4BPB_HUMAN

Name: C4b-binding protein beta chain

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8325877

Title: The human C4b-binding protein beta-chain gene.

PubMed ID: 8325877

DOI: 10.1016/s0021-9258(18)82432-2

PubMed ID: 2300577

Title: Cloning of cDNA coding for the beta chain of human complement component C4b-binding protein: sequence homology with the alpha chain.

PubMed ID: 2300577

DOI: 10.1073/pnas.87.3.1183

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14760718

Title: Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.

PubMed ID: 14760718

DOI: 10.1002/pmic.200300556

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

Sequence Information:

  • Length: 252
  • Mass: 28357
  • Checksum: 0F6CC64067C5E2E7
  • Sequence:
  • MFFWCACCLM VAWRVSASDA EHCPELPPVD NSIFVAKEVE GQILGTYVCI KGYHLVGKKT 
    LFCNASKEWD NTTTECRLGH CPDPVLVNGE FSSSGPVNVS DKITFMCNDH YILKGSNRSQ 
    CLEDHTWAPP FPICKSRDCD PPGNPVHGYF EGNNFTLGST ISYYCEDRYY LVGVQEQQCV 
    DGEWSSALPV CKLIQEAPKP ECEKALLAFQ ESKNLCEAME NFMQQLKESG MTMEELKYSL 
    ELKKAELKAK LL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.