Details for: CAPN5

Gene ID: 726

Symbol: CAPN5

Ensembl ID: ENSG00000149260

Description: calpain 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 62.2970
    Cell Significance Index: -9.6900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 40.3322
    Cell Significance Index: -10.2300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 24.5903
    Cell Significance Index: -9.9900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 17.4659
    Cell Significance Index: -11.7200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 10.4531
    Cell Significance Index: -9.9800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.1511
    Cell Significance Index: -10.0500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.6587
    Cell Significance Index: -12.4800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.6331
    Cell Significance Index: 251.2500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 3.2352
    Cell Significance Index: 146.6400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.7881
    Cell Significance Index: 38.0400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.4860
    Cell Significance Index: 129.1400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.2712
    Cell Significance Index: 20.9200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.9442
    Cell Significance Index: 116.7200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.8573
    Cell Significance Index: 27.8300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.5518
    Cell Significance Index: 22.0900
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 1.3102
    Cell Significance Index: 14.2000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.2339
    Cell Significance Index: 35.5500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1815
    Cell Significance Index: 1066.8500
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.7730
    Cell Significance Index: 5.0400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.6096
    Cell Significance Index: 19.5300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5409
    Cell Significance Index: 97.5100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5331
    Cell Significance Index: 52.7400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4710
    Cell Significance Index: 10.0300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.4270
    Cell Significance Index: 6.8500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3866
    Cell Significance Index: 62.8800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3360
    Cell Significance Index: 8.4000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.2452
    Cell Significance Index: 4.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2368
    Cell Significance Index: 47.5000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2021
    Cell Significance Index: 21.9800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1997
    Cell Significance Index: 138.0900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1565
    Cell Significance Index: 19.2500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1560
    Cell Significance Index: 5.4800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1036
    Cell Significance Index: 37.1500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1033
    Cell Significance Index: 19.6500
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.0931
    Cell Significance Index: 0.9600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0772
    Cell Significance Index: 15.3300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0763
    Cell Significance Index: 41.6900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0715
    Cell Significance Index: 0.7400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0689
    Cell Significance Index: 9.4600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0617
    Cell Significance Index: 116.1800
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.0570
    Cell Significance Index: 0.8000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0452
    Cell Significance Index: 2.7800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0363
    Cell Significance Index: 0.6100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0203
    Cell Significance Index: 0.3400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0200
    Cell Significance Index: 2.5600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0189
    Cell Significance Index: 2.1700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0168
    Cell Significance Index: 25.8600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0089
    Cell Significance Index: 16.3900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0015
    Cell Significance Index: 0.9600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0071
    Cell Significance Index: -1.0400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0074
    Cell Significance Index: -10.1100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0119
    Cell Significance Index: -9.0100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0129
    Cell Significance Index: -5.8400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0132
    Cell Significance Index: -9.6700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0137
    Cell Significance Index: -6.0400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0157
    Cell Significance Index: -11.6500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0188
    Cell Significance Index: -11.7300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0196
    Cell Significance Index: -11.0600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0388
    Cell Significance Index: -11.1600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0410
    Cell Significance Index: -4.7800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0426
    Cell Significance Index: -1.1900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0430
    Cell Significance Index: -0.9000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0478
    Cell Significance Index: -8.1600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0550
    Cell Significance Index: -11.5900
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -0.0615
    Cell Significance Index: -0.6200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0637
    Cell Significance Index: -1.3800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0647
    Cell Significance Index: -1.7000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0649
    Cell Significance Index: -0.9300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0682
    Cell Significance Index: -6.9700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0699
    Cell Significance Index: -7.2800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0965
    Cell Significance Index: -12.4700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0977
    Cell Significance Index: -1.5500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0990
    Cell Significance Index: -11.6800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1018
    Cell Significance Index: -5.7100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1034
    Cell Significance Index: -5.4300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1138
    Cell Significance Index: -7.1700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1230
    Cell Significance Index: -8.2700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1269
    Cell Significance Index: -9.7400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1315
    Cell Significance Index: -6.8500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1341
    Cell Significance Index: -10.6200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1443
    Cell Significance Index: -3.4600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1454
    Cell Significance Index: -9.3800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1455
    Cell Significance Index: -2.8400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1501
    Cell Significance Index: -9.2000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1510
    Cell Significance Index: -4.1100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1518
    Cell Significance Index: -4.4700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1562
    Cell Significance Index: -7.8900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1620
    Cell Significance Index: -12.0800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1643
    Cell Significance Index: -7.6600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1658
    Cell Significance Index: -3.4400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1708
    Cell Significance Index: -3.4300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1809
    Cell Significance Index: -3.8700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1823
    Cell Significance Index: -3.8700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1827
    Cell Significance Index: -6.3500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1840
    Cell Significance Index: -5.2500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1842
    Cell Significance Index: -3.9800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1924
    Cell Significance Index: -8.5100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2098
    Cell Significance Index: -3.6000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2098
    Cell Significance Index: -7.3500
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.2112
    Cell Significance Index: -1.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CAPN5 exhibits the following key characteristics: * Calcium-dependent cysteine-type endopeptidase activity, which enables it to cleave specific protein substrates. * High expression levels in epithelial cells, immune cells, and neural tissues. * Involved in degradation of the extracellular matrix, cell adhesion, and signal transduction pathways. * Secreted as an exosome, allowing it to interact with distant cells and tissues. * Exhibits tissue-specific expression patterns, suggesting its role in maintaining tissue homeostasis. **Pathways and Functions:** CAPN5 is implicated in various cellular processes, including: * **Cell surface and cytoplasmic signaling**: CAPN5 interacts with signaling molecules, modulating cell surface receptor activity and cytoplasmic signaling pathways. * **Proteolysis and degradation**: CAPN5 cleaves specific protein substrates, regulating the degradation of extracellular matrix components and cell adhesion molecules. * **Extracellular matrix organization**: CAPN5 influences the structure and organization of the extracellular matrix, affecting cell migration, differentiation, and tissue development. * **Synapse and neural function**: CAPN5 is expressed in neural tissues, suggesting its involvement in synaptic plasticity and neural function. **Clinical Significance:** Dysregulation of CAPN5 has been implicated in various diseases, including: * **Neurodegenerative disorders**: Alterations in CAPN5 expression have been linked to neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease. * **Cancer**: CAPN5 has been shown to regulate cell adhesion, migration, and invasion in cancer cells, suggesting its potential as a therapeutic target. * **Inflammatory diseases**: CAPN5 has been implicated in the pathogenesis of inflammatory diseases, such as rheumatoid arthritis and asthma, where it regulates cell surface signaling and proteolysis. * **Tissue injury and fibrosis**: CAPN5 has been shown to regulate extracellular matrix degradation and fibrosis in various tissues, including the liver, kidney, and lung. In conclusion, CAPN5 is a multifunctional protein that plays a critical role in maintaining tissue homeostasis and regulating various cellular processes. Its dysregulation has been implicated in various diseases, highlighting the need for further research into its molecular mechanisms and therapeutic potential.

Genular Protein ID: 1447427887

Symbol: CAN5_HUMAN

Name: Calpain-5

UniProtKB Accession Codes:

O15484 O00263

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 3 Ensembl 3 ExpressionAtlas 1 GO 8 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 12 KEGG 1 MANE-Select 1 MEROPS 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9367857

Title: Identification of a novel, tissue-specific calpain htra-3; a human homologue of the Caenorhabditis elegans sex determination gene.

PubMed ID: 9367857

DOI: 10.1006/bbrc.1997.7571

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9339374

Title: A new subfamily of vertebrate calpains lacking a calmodulin-like domain: implications for calpain regulation and evolution.

PubMed ID: 9339374

DOI: 10.1006/geno.1997.4870

PubMed ID: 23055945

Title: Calpain-5 mutations cause autoimmune uveitis, retinal neovascularization, and photoreceptor degeneration.

PubMed ID: 23055945

DOI: 10.1371/journal.pgen.1003001

Sequence Information:

  • Length: 640
  • Mass: 73169
  • Checksum: 7A3A9A1A920410BC
  • Sequence:
    • MFSCVKPYED QNYSALRRDC RRRKVLFEDP LFPATDDSLY YKGTPGPAVR WKRPKGICED 
PRLFVDGISS HDLHQGQVGN CWFVAACSSL ASRESLWQKV IPDWKEQEWD PEKPNAYAGI 
FHFHFWRFGE WVDVVIDDRL PTVNNQLIYC HSNSRNEFWC ALVEKAYAKL AGCYQALDGG 
NTADALVDFT GGVSEPIDLT EGDFANDETK RNQLFERMLK VHSRGGLISA SIKAVTAADM 
EARLACGLVK GHAYAVTDVR KVRLGHGLLA FFKSEKLDMI RLRNPWGERE WNGPWSDTSE 
EWQKVSKSER EKMGVTVQDD GEFWMTFEDV CRYFTDIIKC RVINTSHLSI HKTWEEARLH 
GAWTLHEDPR QNRGGGCINH KDTFFQNPQY IFEVKKPEDE VLICIQQRPK RSTRREGKGE 
NLAIGFDIYK VEENRQYRMH SLQHKAASSI YINSRSVFLR TDQPEGRYVI IPTTFEPGHT 
GEFLLRVFTD VPSNCRELRL DEPPHTCWSS LCGYPQLVTQ VHVLGAAGLK DSPTGANSYV 
IIKCEGDKVR SAVQKGTSTP EYNVKGIFYR KKLSQPITVQ VWNHRVLKDE FLGQVHLKAD 
PDNLQALHTL HLRDRNSRQP SNLPGTVAVH ILSSTSLMAV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.