Details for: CAPN5

Gene ID: 726

Symbol: CAPN5

Ensembl ID: ENSG00000149260

Description: calpain 5

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.9
    Marker Score: 2099
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.72
    Marker Score: 5393
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.45
    Marker Score: 9225
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.44
    Marker Score: 6898
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.43
    Marker Score: 1375
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.43
    Marker Score: 973
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.33
    Marker Score: 888
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.25
    Marker Score: 2934
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.06
    Marker Score: 2158
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.03
    Marker Score: 789
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.02
    Marker Score: 1926
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1
    Marker Score: 998
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.99
    Marker Score: 15543
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.99
    Marker Score: 1041
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 504
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 458
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5331
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2735
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.91
    Marker Score: 1477
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.89
    Marker Score: 1318
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5281
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.85
    Marker Score: 417
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.8
    Marker Score: 373
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.8
    Marker Score: 198
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.79
    Marker Score: 1869
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.78
    Marker Score: 245
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.76
    Marker Score: 285
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.75
    Marker Score: 299
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.74
    Marker Score: 3115
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.74
    Marker Score: 679
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.73
    Marker Score: 234
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.72
    Marker Score: 435
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.71
    Marker Score: 765
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.7
    Marker Score: 870.5
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.7
    Marker Score: 1072
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.69
    Marker Score: 1576
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.69
    Marker Score: 869
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.69
    Marker Score: 441
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.69
    Marker Score: 2846
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.68
    Marker Score: 4538
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.67
    Marker Score: 192
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.66
    Marker Score: 2766.5
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.66
    Marker Score: 313
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.65
    Marker Score: 188
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.65
    Marker Score: 3904
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.65
    Marker Score: 157
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.62
    Marker Score: 958
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.61
    Marker Score: 23189
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.58
    Marker Score: 256
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 439
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.54
    Marker Score: 5470
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.53
    Marker Score: 540
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.52
    Marker Score: 194
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.51
    Marker Score: 103
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.51
    Marker Score: 147
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.48
    Marker Score: 2838
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.48
    Marker Score: 29277
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.47
    Marker Score: 755
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.47
    Marker Score: 4057
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.45
    Marker Score: 378
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.45
    Marker Score: 1952
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.44
    Marker Score: 115
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.41
    Marker Score: 3509
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.41
    Marker Score: 295
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.41
    Marker Score: 1103
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.4
    Marker Score: 435
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.4
    Marker Score: 234
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.4
    Marker Score: 14685
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.4
    Marker Score: 1001
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.39
    Marker Score: 2527
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.39
    Marker Score: 103
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.39
    Marker Score: 76
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.39
    Marker Score: 5777
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.38
    Marker Score: 100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.38
    Marker Score: 145
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.38
    Marker Score: 518
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.37
    Marker Score: 2016
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.37
    Marker Score: 704
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.36
    Marker Score: 3084
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.36
    Marker Score: 121
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.35
    Marker Score: 245
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.35
    Marker Score: 374
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.35
    Marker Score: 348
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.35
    Marker Score: 1246
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.35
    Marker Score: 366.5
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.34
    Marker Score: 228
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.34
    Marker Score: 417
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.34
    Marker Score: 661
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.34
    Marker Score: 128
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.34
    Marker Score: 107
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.34
    Marker Score: 155
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.33
    Marker Score: 258
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.33
    Marker Score: 158
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.33
    Marker Score: 85
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.33
    Marker Score: 218
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.32
    Marker Score: 93

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Other Information

**Key characteristics:** - Capn5 is a large protein (126 kDa) with 11 transmembrane domains. - It is expressed in a variety of cell types, including corneal epithelial cells, colon epithelial cells, foveolar cells of the stomach, enterocytes, intestine goblet cells, squamous epithelial cells, nasal mucosa goblet cells, kidney proximal straight tubule epithelial cells, and immature innate lymphoid cells. - It is a key regulator of cell migration, adhesion, and signaling. **Pathways and functions:** - Capn5 is a key regulator of cell surface signaling. It is expressed on the cell surface of various cell types and is involved in cell-cell adhesion, cell migration, and cell signaling. - It is also involved in the degradation of the extracellular matrix (ECM) and the remodeling of the tissue microenvironment. - It is involved in the regulation of inflammation and wound healing. **Clinical significance:** - Mutations in the CAPN5 gene have been linked to a number of human diseases, including corneal dystrophy, inflammatory bowel disease, and cancer. - Capn5 inhibitors are being investigated as potential therapeutic agents for these diseases.

Genular Protein ID: 1447427887

Symbol: CAN5_HUMAN

Name: Calpain-5

UniProtKB Accession Codes:

O15484 O00263

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 3 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 8 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MEROPS 1 MIM 3 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9367857

Title: Identification of a novel, tissue-specific calpain htra-3; a human homologue of the Caenorhabditis elegans sex determination gene.

PubMed ID: 9367857

DOI: 10.1006/bbrc.1997.7571

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9339374

Title: A new subfamily of vertebrate calpains lacking a calmodulin-like domain: implications for calpain regulation and evolution.

PubMed ID: 9339374

DOI: 10.1006/geno.1997.4870

PubMed ID: 23055945

Title: Calpain-5 mutations cause autoimmune uveitis, retinal neovascularization, and photoreceptor degeneration.

PubMed ID: 23055945

DOI: 10.1371/journal.pgen.1003001

Sequence Information:

  • Length: 640
  • Mass: 73169
  • Checksum: 7A3A9A1A920410BC
  • Sequence:
    • MFSCVKPYED QNYSALRRDC RRRKVLFEDP LFPATDDSLY YKGTPGPAVR WKRPKGICED 
PRLFVDGISS HDLHQGQVGN CWFVAACSSL ASRESLWQKV IPDWKEQEWD PEKPNAYAGI 
FHFHFWRFGE WVDVVIDDRL PTVNNQLIYC HSNSRNEFWC ALVEKAYAKL AGCYQALDGG 
NTADALVDFT GGVSEPIDLT EGDFANDETK RNQLFERMLK VHSRGGLISA SIKAVTAADM 
EARLACGLVK GHAYAVTDVR KVRLGHGLLA FFKSEKLDMI RLRNPWGERE WNGPWSDTSE 
EWQKVSKSER EKMGVTVQDD GEFWMTFEDV CRYFTDIIKC RVINTSHLSI HKTWEEARLH 
GAWTLHEDPR QNRGGGCINH KDTFFQNPQY IFEVKKPEDE VLICIQQRPK RSTRREGKGE 
NLAIGFDIYK VEENRQYRMH SLQHKAASSI YINSRSVFLR TDQPEGRYVI IPTTFEPGHT 
GEFLLRVFTD VPSNCRELRL DEPPHTCWSS LCGYPQLVTQ VHVLGAAGLK DSPTGANSYV 
IIKCEGDKVR SAVQKGTSTP EYNVKGIFYR KKLSQPITVQ VWNHRVLKDE FLGQVHLKAD 
PDNLQALHTL HLRDRNSRQP SNLPGTVAVH ILSSTSLMAV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.