Associated with
Other Information
Genular Protein ID: 1685889785
Symbol: CO5_HUMAN
Name: Complement C5
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1984448
Title: Complete cDNA sequence of human complement pro-C5. Evidence of truncated transcripts derived from a single copy gene.
PubMed ID: 1984448
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 3365401
Title: Molecular analysis of human complement component C5: localization of the structural gene to chromosome 9.
PubMed ID: 3365401
DOI: 10.1021/bi00405a012
PubMed ID: 2579066
Title: Isolation and sequence analysis of a cDNA clone encoding the fifth complement component.
PubMed ID: 2579066
PubMed ID: 690134
Title: Primary structural analysis of the polypeptide portion of human C5a anaphylatoxin. Polypeptide sequence determination and assignment of the oligosaccharide attachment site in C5a.
PubMed ID: 690134
PubMed ID: 1996961
Title: Group B streptococci inactivate complement component C5a by enzymic cleavage at the C-terminus.
PubMed ID: 1996961
DOI: 10.1042/bj2730635
PubMed ID: 8182049
Title: The amino terminus of the human C5a receptor is required for high affinity C5a binding and for receptor activation by C5a but not C5a analogs.
PubMed ID: 8182049
PubMed ID: 9553099
Title: Residues 21-30 within the extracellular N-terminal region of the C5a receptor represent a binding domain for the C5a anaphylatoxin.
PubMed ID: 9553099
PubMed ID: 16335952
Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.
PubMed ID: 16335952
DOI: 10.1021/pr0502065
PubMed ID: 3408713
Title: Sequence-specific assignments in the 1H NMR spectrum of the human inflammatory protein C5a.
PubMed ID: 3408713
DOI: 10.1021/bi00410a007
PubMed ID: 2784981
Title: Tertiary structure of human complement component C5a in solution from nuclear magnetic resonance data.
PubMed ID: 2784981
DOI: 10.1021/bi00427a025
PubMed ID: 2730871
Title: Heteronuclear three-dimensional NMR spectroscopy of the inflammatory protein C5a.
PubMed ID: 2730871
DOI: 10.1021/bi00432a008
PubMed ID: 9007977
Title: Solution structure of a unique C5a semi-synthetic antagonist: implications in receptor binding.
PubMed ID: 9007977
PubMed ID: 9188742
Title: Structural definition of the C5a C-terminus by two-dimensional nuclear magnetic resonance spectroscopy.
PubMed ID: 9188742
DOI: 10.1002/(sici)1097-0134(199706)28:2<261::aid-prot13>3.0.co;2-g
PubMed ID: 7730648
Title: Inherited human complement C5 deficiency. Nonsense mutations in exons 1 (Gln1 to Stop) and 36 (Arg1458 to Stop) and compound heterozygosity in three African-American families.
PubMed ID: 7730648
PubMed ID: 15778377
Title: Linking C5 deficiency to an exonic splicing enhancer mutation.
PubMed ID: 15778377
PubMed ID: 15488949
Title: C5 complement deficiency in a Spanish family. Molecular characterization of the double mutation responsible for the defect.
PubMed ID: 15488949
PubMed ID: 15995705
Title: Complement factor 5 is a quantitative trait gene that modifies liver fibrogenesis in mice and humans.
PubMed ID: 15995705
DOI: 10.1038/ng1599
PubMed ID: 15598652
Title: Functional insights from the structure of the multifunctional C345C domain of C5 of complement.
PubMed ID: 15598652
PubMed ID: 18536718
Title: Structure of and influence of a tick complement inhibitor on human complement component 5.
PubMed ID: 18536718
DOI: 10.1038/ni.1625
PubMed ID: 20133685
Title: Structural basis for inhibition of complement C5 by the SSL7 protein from Staphylococcus aureus.
PubMed ID: 20133685
PubMed ID: 21217642
Title: Substrate recognition by complement convertases revealed in the C5-cobra venom factor complex.
PubMed ID: 21217642
PubMed ID: 27018802
Title: Structural basis for therapeutic inhibition of complement C5.
PubMed ID: 27018802
DOI: 10.1038/nsmb.3196
PubMed ID: 31871188
Title: An inhibitor of complement C5 provides structural insights into activation.
PubMed ID: 31871188
PubMed ID: 22028381
Title: Quantitative detection of single amino acid polymorphisms by targeted proteomics.
PubMed ID: 22028381
DOI: 10.1093/jmcb/mjr024
PubMed ID: 24521109
Title: Genetic variants in C5 and poor response to eculizumab.
PubMed ID: 24521109
Sequence Information:
- Length: 1676
- Mass: 188305
- Checksum: A7589E352F74672A
- Sequence:
MGLLGILCFL IFLGKTWGQE QTYVISAPKI FRVGASENIV IQVYGYTEAF DATISIKSYP DKKFSYSSGH VHLSSENKFQ NSAILTIQPK QLPGGQNPVS YVYLEVVSKH FSKSKRMPIT YDNGFLFIHT DKPVYTPDQS VKVRVYSLND DLKPAKRETV LTFIDPEGSE VDMVEEIDHI GIISFPDFKI PSNPRYGMWT IKAKYKEDFS TTGTAYFEVK EYVLPHFSVS IEPEYNFIGY KNFKNFEITI KARYFYNKVV TEADVYITFG IREDLKDDQK EMMQTAMQNT MLINGIAQVT FDSETAVKEL SYYSLEDLNN KYLYIAVTVI ESTGGFSEEA EIPGIKYVLS PYKLNLVATP LFLKPGIPYP IKVQVKDSLD QLVGGVPVTL NAQTIDVNQE TSDLDPSKSV TRVDDGVASF VLNLPSGVTV LEFNVKTDAP DLPEENQARE GYRAIAYSSL SQSYLYIDWT DNHKALLVGE HLNIIVTPKS PYIDKITHYN YLILSKGKII HFGTREKFSD ASYQSINIPV TQNMVPSSRL LVYYIVTGEQ TAELVSDSVW LNIEEKCGNQ LQVHLSPDAD AYSPGQTVSL NMATGMDSWV ALAAVDSAVY GVQRGAKKPL ERVFQFLEKS DLGCGAGGGL NNANVFHLAG LTFLTNANAD DSQENDEPCK EILRPRRTLQ KKIEEIAAKY KHSVVKKCCY DGACVNNDET CEQRAARISL GPRCIKAFTE CCVVASQLRA NISHKDMQLG RLHMKTLLPV SKPEIRSYFP ESWLWEVHLV PRRKQLQFAL PDSLTTWEIQ GVGISNTGIC VADTVKAKVF KDVFLEMNIP YSVVRGEQIQ LKGTVYNYRT SGMQFCVKMS AVEGICTSES PVIDHQGTKS SKCVRQKVEG SSSHLVTFTV LPLEIGLHNI NFSLETWFGK EILVKTLRVV PEGVKRESYS GVTLDPRGIY GTISRRKEFP YRIPLDLVPK TEIKRILSVK GLLVGEILSA VLSQEGINIL THLPKGSAEA ELMSVVPVFY VFHYLETGNH WNIFHSDPLI EKQKLKKKLK EGMLSIMSYR NADYSYSVWK GGSASTWLTA FALRVLGQVN KYVEQNQNSI CNSLLWLVEN YQLDNGSFKE NSQYQPIKLQ GTLPVEAREN SLYLTAFTVI GIRKAFDICP LVKIDTALIK ADNFLLENTL PAQSTFTLAI SAYALSLGDK THPQFRSIVS ALKREALVKG NPPIYRFWKD NLQHKDSSVP NTGTARMVET TAYALLTSLN LKDINYVNPV IKWLSEEQRY GGGFYSTQDT INAIEGLTEY SLLVKQLRLS MDIDVSYKHK GALHNYKMTD KNFLGRPVEV LLNDDLIVST GFGSGLATVH VTTVVHKTST SEEVCSFYLK IDTQDIEASH YRGYGNSDYK RIVACASYKP SREESSSGSS HAVMDISLPT GISANEEDLK ALVEGVDQLF TDYQIKDGHV ILQLNSIPSS DFLCVRFRIF ELFEVGFLSP ATFTVYEYHR PDKQCTMFYS TSNIKIQKVC EGAACKCVEA DCGQMQEELD LTISAETRKQ TACKPEIAYA YKVSITSITV ENVFVKYKAT LLDIYKTGEA VAEKDSEITF IKKVTCTNAE LVKGRQYLIM GKEALQIKYN FSFRYIYPLD SLTWIEYWPR DTTCSSCQAF LANLDEFAED IFLNGC
Genular Protein ID: 2362153213
Symbol: Q59GS8_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 1106
- Mass: 123351
- Checksum: F0CC415C9FAE2D6A
- Sequence:
GRAGEVRALS SGAQRRGSHF VVLCRLPRGR ARVVGASLSH APLPLRYCWK GRGGVSRLFC SQRARMPGSL GREASGRAGP TGCGAFAFGL RCRYVISAPK IFRVGASENI VIQVYGYTEA FDATISIKSY PDKKFSYSSG HVHLSSENKF QNSAILTIQP KQLPGGQNPV SYVYLEVVSK HFSKSKRMPI TYDNGFLFIH TDKPVYTPDQ SVKVRVYSLN DDLKPAKRET VLTFIDPEGS EVDMVEEIDH IGIISFPDFK IPSNPRYGMW TIKAKYKEDF STTGTAYFEV KEYVLPHFSV SIEPEYNFIG YKNFKNFEIT IKARYFYNKV VTEADVYITF GIREDLKDDQ KEMMQTAMQN TMLINGIAQV TFDSETAVKE LSYYSLEDLN NKYLYIAVTV IESTGGFSEE AEIPGIKYVL SPYKLNLVAT PLFLKPGIPY PIKVQVKDSL DQLVGGVPVT LNAQTIDVNQ ETSDLDPSKS VTRVDDGVAS FVLNLPSGVT VLEFNVKTDA PDLPEENQAR EGYRAIAYSS LSQSYLYIDW TDNHKALLVG EHLNIIVTPK SPYIDKITHY NYLILSKGKI IHFGTREKFS DASYQSINIP VTQNMVPSSR LLVYYIVTGE QTAELVSDSV WLNIEEKCGN QLQVHLSPDA DAYSPGQTVS LNMATGMDSW VALAAVDSAV YGVQRGAKKP LERVFQFLEK SDLGCGAGGG LNNANVFHLA GLTFLTNANA DDSQENDEPC KEILRPRRTL QKKIEEIAAK YKHSVVKKCC YDGACVNNDE TCEQRAARIS LGPRCIKAFT ECCVVASQLR ANISHKDMQL GRLHMKTLLP VSKPEIRSYF PESWLWEVHL VPRRKQLQFA LPDSLTTWEI QGVGISNTGI CVADTVKAKV FKDVFLEMNI PYSVVRGEQI QLKGTVYNYR TSGMQFCVKM SAVEGICTSE SPVIDHQGTK SSKCVRQKVE GSSSHLVTFT VLPLEIGLHN INFSLETWFG KEILVKTLRV VPEGVKRESY SGVTLDPRGI YGTISRRKEF PYRIPLDLVP KTEIKRILSV KGLLVGEILS AVLSQEGINI LTHLPKGSAE AELMSVVPVF YVFLPGNRKS LEHFSF
Genular Protein ID: 3667407407
Symbol: A0A8Q3SID6_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15164053
Title: DNA sequence and analysis of human chromosome 9.
PubMed ID: 15164053
DOI: 10.1038/nature02465
Sequence Information:
- Length: 1682
- Mass: 188619
- Checksum: 9A59940315D0DD38
- Sequence:
MPGSLGREAS GRAGPTGCGA FAFGLRCRYV ISAPKIFRVG ASENIVIQVY GYTEAFDATI SIKSYPDKKF SYSSGHVHLS SENKFQNSAI LTIQPKQLPG GQNPVSYVYL EVVSKHFSKS KRMPITYDNG FLFIHTDKPV YTPDQSVKVR VYSLNDDLKP AKRETVLTFI DPEGSEVDMV EEIDHIGIIS FPDFKIPSNP RYGMWTIKAK YKEDFSTTGT AYFEVKEYVL PHFSVSIEPE YNFIGYKNFK NFEITIKARY FYNKVVTEAD VYITFGIRED LKDDQKEMMQ TAMQNTMLIN GIAQVTFDSE TAVKELSYYS LEDLNNKYLY IAVTVIESTG GFSEEAEIPG IKYVLSPYKL NLVATPLFLK PGIPYPIKVQ VKDSLDQLVG GVPVTLNAQT IDVNQETSDL DPSKSVTRVD DGVASFVLNL PSGVTVLEFN VKTDAPDLPE ENQAREGYRA IAYSSLSQSY LYIDWTDNHK ALLVGEHLNI IVTPKSPYID KITHYNYLIL SKGKIIHFGT REKFSDASYQ SINIPVTQNM VPSSRLLVYY IVTGEQTAEL VSDSVWLNIE EKCGNQLQVH LSPDADAYSP GQTVSLNMAT GMDSWVALAA VDSAVYGVQR GAKKPLERVF QFLEKSDLGC GAGGGLNNAN VFHLAGLTFL TNANADDSQE NDEPCKEILR PRRTLQKKIE EIAAKYKHSV VKKCCYDGAC VNNDETCEQR AARISLGPRC IKAFTECCVV ASQLRANISH KDMQLGRLHM KTLLPVSKPE IRSYFPESWL WEVHLVPRRK QLQFALPDSL TTWEIQGVGI SNTGICVADT VKAKVFKDVF LEMNIPYSVV RGEQIQLKGT VYNYRTSGMQ FCVKMSAVEG ICTSESPVID HQGTKSSKCV RQKVEGSSSH LVTFTVLPLE IGLHNINFSL ETWFGKEILV KTLRVVPEGV KRESYSGVTL DPRGIYGTIS RRKEFPYRIP LDLVPKTEIK RILSVKGLLV GEILSAVLSQ EGINILTHLP KGSAEAELMS VVPVFYVFHY LETGNHWNIF HSDPLIEKQK LKKKLKEGML SIMSYRNADY SYSVWKGGSA STWLTAFALR VLGQVNKYVE QNQNSICNSL LWLVENYQLD NGSFKENSQY QPIKLQGTLP VEARENSLYL TAFTVIGIRK AFDICPLVKI DTALIKADNF LLENTLPAQS TFTLAISAYA LSLGDKTHPQ FRSIVSALKR EALVKGNPPI YRFWKDNLQH KDSSVPNTGT ARMVETTAYA LLTSLNLKDI NYVNPVIKWL SEEQRYGGGF YSTQDTINAI EGLTEYSLLV KQLRLSMDID VSYKHKGALH NYKMTDKNFL GRPVEVLLND DLIVSTGFGS GLATVHVTTV VHKTSTSEEV CSFYLKIDTQ DIEASHYRGY GNSDYKRIVA CASYKPSREE SSSGSSHAVM DISLPTGISA NEEDLKALVE GVDQLFTDYQ IKDGHVILQL NSIPSSDFLC VRFRIFELFE VGFLSPATFT VYEYHRPDKQ CTMFYSTSNI KIQKVCEGAA CKCVEADCGQ MQEELDLTIS AETRKQTACK PEIAYAYKVS ITSITVENVF VKYKATLLDI YKTGEAVAEK DSEITFIKKV TCTNAELVKG RQYLIMGKEA LQIKYNFSFR YIYPLDSLTW IEYWPRDTTC SSCQAFLANL DEFAEDIFLN GC
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.