Details for: C5

Gene ID: 727

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: C5

Ensembl ID: ENSG00000106804

Description: complement C5

Cell Significance Landscape

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • midzonal region hepatocyte CL0019028
    CSI 8.44
    rCSI 19.81%
    PRS 97.4
  • hepatic stellate cell CL0000632
    CSI 7.48
    rCSI 28.04%
    PRS 98.19
  • hepatocyte CL0000182
    CSI 7.16
    rCSI 12.81%
    PRS 97.75
  • Kupffer cell CL0000091
    CSI 6.22
    rCSI 14.23%
    PRS 99.01
  • centrilobular region hepatocyte CL0019029
    CSI 5.27
    rCSI 13.76%
    PRS 96.99
  • epithelial cell of lung CL0000082
    CSI 3.65
    rCSI 3.02%
    PRS 99.34
  • epithelial cell of lower respiratory tract CL0002632
    CSI 3.63
    rCSI 2.81%
    PRS 99.44
  • cholangiocyte CL1000488
    CSI 3.54
    rCSI 21.18%
    PRS 97.55
  • intrahepatic cholangiocyte CL0002538
    CSI 3.49
    rCSI 8.38%
    PRS 98.6
  • periportal region hepatocyte CL0019026
    CSI 3.47
    rCSI 13.51%
    PRS 97.24
  • pulmonary alveolar type 2 cell CL0002063
    CSI 3.3
    rCSI 5.12%
    PRS 98.73
  • astrocyte of the cerebral cortex CL0002605
    CSI 3.16
    rCSI 7.1%
    PRS 96.13
  • cardiac neuron CL0010022
    CSI 3.12
    rCSI 9.99%
    PRS 98.54
  • lung secretory cell CL1000272
    CSI 2.92
    rCSI 7.23%
    PRS 99.32
  • choroid plexus epithelial cell CL0000706
    CSI 2.88
    rCSI 4.72%
    PRS 97.4
  • chondrocyte CL0000138
    CSI 2.41
    rCSI 3.84%
    PRS 97.44
  • parietal epithelial cell CL1000452
    CSI 1.67
    rCSI 4.46%
    PRS 97.85
  • indirect pathway medium spiny neuron CL4023029
    CSI 0.34
    rCSI 8.19%
    PRS 94.08
  • direct pathway medium spiny neuron CL4023026
    CSI 0.34
    rCSI 8.06%
    PRS 94.37

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

Loading network (please wait)...

Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [C5](/details-gene/727), or complement C5, is a protein-coding gene located on chromosome 9q33.2 that encodes a critical component of the innate immune system's complement cascade. As a central protein in this pathway, [C5](/details-gene/727) is cleaved into the potent anaphylatoxin C5a and the C5b fragment. C5a is a powerful chemoattractant involved in the [inflammatory response](/details-ontologies/GO:0006954), while C5b initiates the assembly of the [membrane attack complex](/details-ontologies/GO:0005579), leading to the lysis of target cells. Expression data indicates that **Overall**, [C5](/details-gene/727) is predominantly synthesized by liver cells, particularly [midzonal region hepatocyte](/details-cell/CL0019028)s and [hepatic stellate cell](/details-cell/CL0000632)s, consistent with the liver being the primary source of circulating complement proteins. Deficiencies in [C5](/details-gene/727) are associated with susceptibility to recurrent infections, as documented in OMIM ([120900](https://omim.org/entry/120900)). ## Cellular Roles and Expression Landscape The expression profile of [C5](/details-gene/727) underscores its central role as a secreted immune protein primarily produced by the liver. **Overall**, the gene shows the highest significance in various liver cell populations, including [midzonal region hepatocyte](/details-cell/CL0019028) (CSI: 8.44), [hepatic stellate cell](/details-cell/CL0000632) (CSI: 7.48), and [hepatocyte](/details-cell/CL0000182) (CSI: 7.16). This pattern extends to liver-resident macrophages, known as [Kupffer cell](/details-cell/CL0000091)s (CSI: 6.22), solidifying the liver as the principal site of systemic [C5](/details-gene/727) synthesis. Beyond the liver, the data suggests notable extrahepatic sites of [C5](/details-gene/727) expression, which may contribute to local immune surveillance and tissue-specific inflammation. Significant expression is observed in respiratory cells, such as [epithelial cell of lung](/details-cell/CL0000082) (CSI: 3.65) and [pulmonary alveolar type 2 cell](/details-cell/CL0002063) (CSI: 3.30). Furthermore, expression is detected in specific cell types within the central nervous system, including [astrocyte of the cerebral cortex](/details-cell/CL0002605) (CSI: 3.16) and [choroid plexus epithelial cell](/details-cell/CL0000706) (CSI: 2.88). This suggests that while systemic levels are maintained by the liver, local production in tissues like the lung and brain may play a key role in orchestrating immediate, localized complement activation during injury or infection. ## Pathways and Molecular Function The functions of [C5](/details-gene/727) are intrinsically linked to its position as the lynchpin of the terminal complement pathway. Functional annotations confirm its role in the [Innate immune system](/details-pathways/R-HSA-168249), specifically within the [Complement cascade](/details-pathways/R-HSA-166658). Upon activation by C5 convertases from the classical or alternative pathways, [C5](/details-gene/727) is cleaved, initiating two distinct effector arms, a process detailed in the Reactome pathway [Activation of c3 and c5](/details-pathways/R-HSA-174577). The smaller C5a fragment acts as a potent pro-inflammatory mediator and chemoattractant, consistent with its annotated roles in [chemotaxis](/details-ontologies/GO:0006935) and [inflammatory response](/details-ontologies/GO:0006954). C5a exerts its effects by binding to G protein-coupled receptors, which is reflected in annotations such as [G alpha (i) signalling events](/details-pathways/R-HSA-418594) and [Signaling by gpcr](/details-pathways/R-HSA-372790). The larger C5b fragment initiates the [Terminal pathway of complement](/details-pathways/R-HSA-166665), where it sequentially recruits components C6, C7, C8, and multiple C9 molecules to form the cytolytic [membrane attack complex](/details-ontologies/GO:0005579) (MAC). This complex inserts into the membranes of target cells, such as bacteria, leading to their destruction, a function captured by the GO term [Killing of cells of another organism](/details-ontologies/GO:0031640). This dual functionality makes [C5](/details-gene/727) a critical regulator of both immune cell recruitment and direct pathogen elimination. ## Research Directions The established role of [C5](/details-gene/727) in immunity and its expression in specific extrahepatic tissues provide fertile ground for further investigation, particularly concerning the regulation and function of local complement synthesis. **Proposed Hypotheses:** 1. **Local Synthesis in Neuroinflammation:** The notable expression of [C5](/details-gene/727) in [astrocyte of the cerebral cortex](/details-cell/CL0002605) and [choroid plexus epithelial cell](/details-cell/CL0000706)s suggests that local, CNS-derived C5 contributes to neuroinflammatory processes. We hypothesize that astrocyte-derived C5 is a key driver of blood-brain barrier breakdown and microglial activation during CNS injury or infection, acting independently of systemic C5 levels. 2. **Zonal Regulation in Liver Homeostasis and Injury:** The observed expression differences across hepatocyte subtypes, with the highest CSI in [midzonal region hepatocyte](/details-cell/CL0019028)s, suggest zonal regulation within the liver lobule. We hypothesize that this spatial expression pattern is governed by metabolic and oxygen gradients and creates zonal susceptibility to complement-mediated damage during ischemia-reperfusion injury or toxic insults. **Proposed Key Experiment:** To test the hypothesis regarding the role of local [C5](/details-gene/727) synthesis in neuroinflammation, a conditional knockout mouse model could be employed. Specifically, generating mice with a floxed *C5* allele and crossing them with mice expressing Cre recombinase under an astrocyte-specific promoter (e.g., GFAP-Cre) would delete [C5](/details-gene/727) production specifically in astrocytes. These mice, along with liver-specific C5 knockout and wild-type controls, could be subjected to a model of neurotrauma or infection (e.g., focal stroke or intracerebral LPS injection). The contribution of astrocyte-derived C5 could be dissected by comparing outcomes such as immune cell infiltration, cytokine profiles in cerebrospinal fluid, and the extent of neuronal damage across the different genetic models. **Therapeutic Potential:** [C5](/details-gene/727) is a clinically validated and highly significant therapeutic target. Its central role in propagating inflammation and causing cell lysis makes it a prime candidate for inhibition in diseases characterized by excessive or inappropriate complement activation. The therapeutic strategy is exclusively focused on **inhibition** of [C5](/details-gene/727) cleavage or blockade of its products (C5a, C5b). Approved monoclonal antibodies that bind [C5](/details-gene/727) and prevent its cleavage into C5a and C5b are standard-of-care for conditions like paroxysmal nocturnal hemoglobinuria (PNH), atypical hemolytic uremic syndrome (aHUS), and myasthenia gravis, demonstrating its profound therapeutic relevance.

Genular Protein ID: 1685889785

Symbol: CO5_HUMAN

Name: Complement C5

UniProtKB Accession Codes:

P01031 Q14CJ0 Q27I61

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CPTAC 2 CTD 1 CarbonylDB 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 12 DrugCentral 1 EMBL 6 EMDB 16 Ensembl 1 EvolutionaryTrace 1 GO 17 Gene3D 10 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 19 KEGG 1 MANE-Select 1 MEROPS 1 MIM 4 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 36 PDBsum 36 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 11 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 5 RefSeq 2 SASBDB 1 SIGNOR 1 SMART 5 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1984448

Title: Complete cDNA sequence of human complement pro-C5. Evidence of truncated transcripts derived from a single copy gene.

PubMed ID: 1984448

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3365401

Title: Molecular analysis of human complement component C5: localization of the structural gene to chromosome 9.

PubMed ID: 3365401

DOI: 10.1021/bi00405a012

PubMed ID: 2579066

Title: Isolation and sequence analysis of a cDNA clone encoding the fifth complement component.

PubMed ID: 2579066

DOI: 10.1016/s0021-9258(18)89523-0

PubMed ID: 690134

Title: Primary structural analysis of the polypeptide portion of human C5a anaphylatoxin. Polypeptide sequence determination and assignment of the oligosaccharide attachment site in C5a.

PubMed ID: 690134

DOI: 10.1016/s0021-9258(17)38013-4

PubMed ID: 1996961

Title: Group B streptococci inactivate complement component C5a by enzymic cleavage at the C-terminus.

PubMed ID: 1996961

DOI: 10.1042/bj2730635

PubMed ID: 8182049

Title: The amino terminus of the human C5a receptor is required for high affinity C5a binding and for receptor activation by C5a but not C5a analogs.

PubMed ID: 8182049

DOI: 10.1016/s0021-9258(17)36643-7

PubMed ID: 9553099

Title: Residues 21-30 within the extracellular N-terminal region of the C5a receptor represent a binding domain for the C5a anaphylatoxin.

PubMed ID: 9553099

DOI: 10.1074/jbc.273.17.10411

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 3408713

Title: Sequence-specific assignments in the 1H NMR spectrum of the human inflammatory protein C5a.

PubMed ID: 3408713

DOI: 10.1021/bi00410a007

PubMed ID: 2784981

Title: Tertiary structure of human complement component C5a in solution from nuclear magnetic resonance data.

PubMed ID: 2784981

DOI: 10.1021/bi00427a025

PubMed ID: 2730871

Title: Heteronuclear three-dimensional NMR spectroscopy of the inflammatory protein C5a.

PubMed ID: 2730871

DOI: 10.1021/bi00432a008

PubMed ID: 9007977

Title: Solution structure of a unique C5a semi-synthetic antagonist: implications in receptor binding.

PubMed ID: 9007977

DOI: 10.1002/pro.5560060107

PubMed ID: 9188742

Title: Structural definition of the C5a C-terminus by two-dimensional nuclear magnetic resonance spectroscopy.

PubMed ID: 9188742

DOI: 10.1002/(sici)1097-0134(199706)28:2<261::aid-prot13>3.0.co;2-g

PubMed ID: 7730648

Title: Inherited human complement C5 deficiency. Nonsense mutations in exons 1 (Gln1 to Stop) and 36 (Arg1458 to Stop) and compound heterozygosity in three African-American families.

PubMed ID: 7730648

PubMed ID: 15778377

Title: Linking C5 deficiency to an exonic splicing enhancer mutation.

PubMed ID: 15778377

DOI: 10.4049/jimmunol.174.7.4172

PubMed ID: 15488949

Title: C5 complement deficiency in a Spanish family. Molecular characterization of the double mutation responsible for the defect.

PubMed ID: 15488949

DOI: 10.1016/j.molimm.2004.06.036

PubMed ID: 15995705

Title: Complement factor 5 is a quantitative trait gene that modifies liver fibrogenesis in mice and humans.

PubMed ID: 15995705

DOI: 10.1038/ng1599

PubMed ID: 15598652

Title: Functional insights from the structure of the multifunctional C345C domain of C5 of complement.

PubMed ID: 15598652

DOI: 10.1074/jbc.m413126200

PubMed ID: 18536718

Title: Structure of and influence of a tick complement inhibitor on human complement component 5.

PubMed ID: 18536718

DOI: 10.1038/ni.1625

PubMed ID: 20133685

Title: Structural basis for inhibition of complement C5 by the SSL7 protein from Staphylococcus aureus.

PubMed ID: 20133685

DOI: 10.1073/pnas.0910565107

PubMed ID: 21217642

Title: Substrate recognition by complement convertases revealed in the C5-cobra venom factor complex.

PubMed ID: 21217642

DOI: 10.1038/emboj.2010.341

PubMed ID: 27018802

Title: Structural basis for therapeutic inhibition of complement C5.

PubMed ID: 27018802

DOI: 10.1038/nsmb.3196

PubMed ID: 31871188

Title: An inhibitor of complement C5 provides structural insights into activation.

PubMed ID: 31871188

DOI: 10.1073/pnas.1909973116

PubMed ID: 22028381

Title: Quantitative detection of single amino acid polymorphisms by targeted proteomics.

PubMed ID: 22028381

DOI: 10.1093/jmcb/mjr024

PubMed ID: 24521109

Title: Genetic variants in C5 and poor response to eculizumab.

PubMed ID: 24521109

DOI: 10.1056/nejmoa1311084

Sequence Information:

  • Length: 1676
  • Mass: 188305
  • Checksum: A7589E352F74672A
  • Sequence:
    • MGLLGILCFL IFLGKTWGQE QTYVISAPKI FRVGASENIV IQVYGYTEAF DATISIKSYP 
DKKFSYSSGH VHLSSENKFQ NSAILTIQPK QLPGGQNPVS YVYLEVVSKH FSKSKRMPIT 
YDNGFLFIHT DKPVYTPDQS VKVRVYSLND DLKPAKRETV LTFIDPEGSE VDMVEEIDHI 
GIISFPDFKI PSNPRYGMWT IKAKYKEDFS TTGTAYFEVK EYVLPHFSVS IEPEYNFIGY 
KNFKNFEITI KARYFYNKVV TEADVYITFG IREDLKDDQK EMMQTAMQNT MLINGIAQVT 
FDSETAVKEL SYYSLEDLNN KYLYIAVTVI ESTGGFSEEA EIPGIKYVLS PYKLNLVATP 
LFLKPGIPYP IKVQVKDSLD QLVGGVPVTL NAQTIDVNQE TSDLDPSKSV TRVDDGVASF 
VLNLPSGVTV LEFNVKTDAP DLPEENQARE GYRAIAYSSL SQSYLYIDWT DNHKALLVGE 
HLNIIVTPKS PYIDKITHYN YLILSKGKII HFGTREKFSD ASYQSINIPV TQNMVPSSRL 
LVYYIVTGEQ TAELVSDSVW LNIEEKCGNQ LQVHLSPDAD AYSPGQTVSL NMATGMDSWV 
ALAAVDSAVY GVQRGAKKPL ERVFQFLEKS DLGCGAGGGL NNANVFHLAG LTFLTNANAD 
DSQENDEPCK EILRPRRTLQ KKIEEIAAKY KHSVVKKCCY DGACVNNDET CEQRAARISL 
GPRCIKAFTE CCVVASQLRA NISHKDMQLG RLHMKTLLPV SKPEIRSYFP ESWLWEVHLV 
PRRKQLQFAL PDSLTTWEIQ GVGISNTGIC VADTVKAKVF KDVFLEMNIP YSVVRGEQIQ 
LKGTVYNYRT SGMQFCVKMS AVEGICTSES PVIDHQGTKS SKCVRQKVEG SSSHLVTFTV 
LPLEIGLHNI NFSLETWFGK EILVKTLRVV PEGVKRESYS GVTLDPRGIY GTISRRKEFP 
YRIPLDLVPK TEIKRILSVK GLLVGEILSA VLSQEGINIL THLPKGSAEA ELMSVVPVFY 
VFHYLETGNH WNIFHSDPLI EKQKLKKKLK EGMLSIMSYR NADYSYSVWK GGSASTWLTA 
FALRVLGQVN KYVEQNQNSI CNSLLWLVEN YQLDNGSFKE NSQYQPIKLQ GTLPVEAREN 
SLYLTAFTVI GIRKAFDICP LVKIDTALIK ADNFLLENTL PAQSTFTLAI SAYALSLGDK 
THPQFRSIVS ALKREALVKG NPPIYRFWKD NLQHKDSSVP NTGTARMVET TAYALLTSLN 
LKDINYVNPV IKWLSEEQRY GGGFYSTQDT INAIEGLTEY SLLVKQLRLS MDIDVSYKHK 
GALHNYKMTD KNFLGRPVEV LLNDDLIVST GFGSGLATVH VTTVVHKTST SEEVCSFYLK 
IDTQDIEASH YRGYGNSDYK RIVACASYKP SREESSSGSS HAVMDISLPT GISANEEDLK 
ALVEGVDQLF TDYQIKDGHV ILQLNSIPSS DFLCVRFRIF ELFEVGFLSP ATFTVYEYHR 
PDKQCTMFYS TSNIKIQKVC EGAACKCVEA DCGQMQEELD LTISAETRKQ TACKPEIAYA 
YKVSITSITV ENVFVKYKAT LLDIYKTGEA VAEKDSEITF IKKVTCTNAE LVKGRQYLIM 
GKEALQIKYN FSFRYIYPLD SLTWIEYWPR DTTCSSCQAF LANLDEFAED IFLNGC

Genular Protein ID: 2362153213

Symbol: Q59GS8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59GS8

Database IDs:

ARBA 9 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 5 Gene3D 7 InterPro 11 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 7 RefSeq 1 SMART 3 SUPFAM 1

Sequence Information:

  • Length: 1106
  • Mass: 123351
  • Checksum: F0CC415C9FAE2D6A
  • Sequence:
    • GRAGEVRALS SGAQRRGSHF VVLCRLPRGR ARVVGASLSH APLPLRYCWK GRGGVSRLFC 
SQRARMPGSL GREASGRAGP TGCGAFAFGL RCRYVISAPK IFRVGASENI VIQVYGYTEA 
FDATISIKSY PDKKFSYSSG HVHLSSENKF QNSAILTIQP KQLPGGQNPV SYVYLEVVSK 
HFSKSKRMPI TYDNGFLFIH TDKPVYTPDQ SVKVRVYSLN DDLKPAKRET VLTFIDPEGS 
EVDMVEEIDH IGIISFPDFK IPSNPRYGMW TIKAKYKEDF STTGTAYFEV KEYVLPHFSV 
SIEPEYNFIG YKNFKNFEIT IKARYFYNKV VTEADVYITF GIREDLKDDQ KEMMQTAMQN 
TMLINGIAQV TFDSETAVKE LSYYSLEDLN NKYLYIAVTV IESTGGFSEE AEIPGIKYVL 
SPYKLNLVAT PLFLKPGIPY PIKVQVKDSL DQLVGGVPVT LNAQTIDVNQ ETSDLDPSKS 
VTRVDDGVAS FVLNLPSGVT VLEFNVKTDA PDLPEENQAR EGYRAIAYSS LSQSYLYIDW 
TDNHKALLVG EHLNIIVTPK SPYIDKITHY NYLILSKGKI IHFGTREKFS DASYQSINIP 
VTQNMVPSSR LLVYYIVTGE QTAELVSDSV WLNIEEKCGN QLQVHLSPDA DAYSPGQTVS 
LNMATGMDSW VALAAVDSAV YGVQRGAKKP LERVFQFLEK SDLGCGAGGG LNNANVFHLA 
GLTFLTNANA DDSQENDEPC KEILRPRRTL QKKIEEIAAK YKHSVVKKCC YDGACVNNDE 
TCEQRAARIS LGPRCIKAFT ECCVVASQLR ANISHKDMQL GRLHMKTLLP VSKPEIRSYF 
PESWLWEVHL VPRRKQLQFA LPDSLTTWEI QGVGISNTGI CVADTVKAKV FKDVFLEMNI 
PYSVVRGEQI QLKGTVYNYR TSGMQFCVKM SAVEGICTSE SPVIDHQGTK SSKCVRQKVE 
GSSSHLVTFT VLPLEIGLHN INFSLETWFG KEILVKTLRV VPEGVKRESY SGVTLDPRGI 
YGTISRRKEF PYRIPLDLVP KTEIKRILSV KGLLVGEILS AVLSQEGINI LTHLPKGSAE 
AELMSVVPVF YVFLPGNRKS LEHFSF

Genular Protein ID: 3667407407

Symbol: A0A8Q3SID6_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A8Q3SID6

Database IDs:

ARBA 10 CDD 3 CTD 1 DisGeNET 1 EMBL 1 Ensembl 2 GO 5 Gene3D 10 GeneTree 1 HGNC 1 InterPro 19 NCBI Taxonomy 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 11 Proteomes 2 RefSeq 1 SMART 5 SMR 1 SUPFAM 4

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 1682
  • Mass: 188619
  • Checksum: 9A59940315D0DD38
  • Sequence:
    • MPGSLGREAS GRAGPTGCGA FAFGLRCRYV ISAPKIFRVG ASENIVIQVY GYTEAFDATI 
SIKSYPDKKF SYSSGHVHLS SENKFQNSAI LTIQPKQLPG GQNPVSYVYL EVVSKHFSKS 
KRMPITYDNG FLFIHTDKPV YTPDQSVKVR VYSLNDDLKP AKRETVLTFI DPEGSEVDMV 
EEIDHIGIIS FPDFKIPSNP RYGMWTIKAK YKEDFSTTGT AYFEVKEYVL PHFSVSIEPE 
YNFIGYKNFK NFEITIKARY FYNKVVTEAD VYITFGIRED LKDDQKEMMQ TAMQNTMLIN 
GIAQVTFDSE TAVKELSYYS LEDLNNKYLY IAVTVIESTG GFSEEAEIPG IKYVLSPYKL 
NLVATPLFLK PGIPYPIKVQ VKDSLDQLVG GVPVTLNAQT IDVNQETSDL DPSKSVTRVD 
DGVASFVLNL PSGVTVLEFN VKTDAPDLPE ENQAREGYRA IAYSSLSQSY LYIDWTDNHK 
ALLVGEHLNI IVTPKSPYID KITHYNYLIL SKGKIIHFGT REKFSDASYQ SINIPVTQNM 
VPSSRLLVYY IVTGEQTAEL VSDSVWLNIE EKCGNQLQVH LSPDADAYSP GQTVSLNMAT 
GMDSWVALAA VDSAVYGVQR GAKKPLERVF QFLEKSDLGC GAGGGLNNAN VFHLAGLTFL 
TNANADDSQE NDEPCKEILR PRRTLQKKIE EIAAKYKHSV VKKCCYDGAC VNNDETCEQR 
AARISLGPRC IKAFTECCVV ASQLRANISH KDMQLGRLHM KTLLPVSKPE IRSYFPESWL 
WEVHLVPRRK QLQFALPDSL TTWEIQGVGI SNTGICVADT VKAKVFKDVF LEMNIPYSVV 
RGEQIQLKGT VYNYRTSGMQ FCVKMSAVEG ICTSESPVID HQGTKSSKCV RQKVEGSSSH 
LVTFTVLPLE IGLHNINFSL ETWFGKEILV KTLRVVPEGV KRESYSGVTL DPRGIYGTIS 
RRKEFPYRIP LDLVPKTEIK RILSVKGLLV GEILSAVLSQ EGINILTHLP KGSAEAELMS 
VVPVFYVFHY LETGNHWNIF HSDPLIEKQK LKKKLKEGML SIMSYRNADY SYSVWKGGSA 
STWLTAFALR VLGQVNKYVE QNQNSICNSL LWLVENYQLD NGSFKENSQY QPIKLQGTLP 
VEARENSLYL TAFTVIGIRK AFDICPLVKI DTALIKADNF LLENTLPAQS TFTLAISAYA 
LSLGDKTHPQ FRSIVSALKR EALVKGNPPI YRFWKDNLQH KDSSVPNTGT ARMVETTAYA 
LLTSLNLKDI NYVNPVIKWL SEEQRYGGGF YSTQDTINAI EGLTEYSLLV KQLRLSMDID 
VSYKHKGALH NYKMTDKNFL GRPVEVLLND DLIVSTGFGS GLATVHVTTV VHKTSTSEEV 
CSFYLKIDTQ DIEASHYRGY GNSDYKRIVA CASYKPSREE SSSGSSHAVM DISLPTGISA 
NEEDLKALVE GVDQLFTDYQ IKDGHVILQL NSIPSSDFLC VRFRIFELFE VGFLSPATFT 
VYEYHRPDKQ CTMFYSTSNI KIQKVCEGAA CKCVEADCGQ MQEELDLTIS AETRKQTACK 
PEIAYAYKVS ITSITVENVF VKYKATLLDI YKTGEAVAEK DSEITFIKKV TCTNAELVKG 
RQYLIMGKEA LQIKYNFSFR YIYPLDSLTW IEYWPRDTTC SSCQAFLANL DEFAEDIFLN 
GC