Details for: C5

Gene ID: 727

Symbol: C5

Ensembl ID: ENSG00000106804

Description: complement C5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 59.3397
    Cell Significance Index: -9.2300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 35.0492
    Cell Significance Index: -8.8900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 20.5535
    Cell Significance Index: -8.3500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 9.8020
    Cell Significance Index: 165.1200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 8.7563
    Cell Significance Index: -8.3600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 7.4699
    Cell Significance Index: -9.2100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 4.2532
    Cell Significance Index: 63.7300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.8557
    Cell Significance Index: -6.2500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.3644
    Cell Significance Index: -9.3300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.2434
    Cell Significance Index: 445.2100
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 1.9250
    Cell Significance Index: 7.2500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.5925
    Cell Significance Index: 72.1900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.3788
    Cell Significance Index: 262.4000
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.2503
    Cell Significance Index: 7.2000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7786
    Cell Significance Index: 46.7400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7166
    Cell Significance Index: 70.8900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5925
    Cell Significance Index: 535.0100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.5840
    Cell Significance Index: 8.6200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5629
    Cell Significance Index: 61.2300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3611
    Cell Significance Index: 10.4100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3391
    Cell Significance Index: 55.1600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.3174
    Cell Significance Index: 14.0400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3161
    Cell Significance Index: 11.9700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2729
    Cell Significance Index: 18.8800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2266
    Cell Significance Index: 4.9100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1993
    Cell Significance Index: 11.1900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1795
    Cell Significance Index: 36.0000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1390
    Cell Significance Index: 49.8700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1277
    Cell Significance Index: 3.5700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0922
    Cell Significance Index: 1.8000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0711
    Cell Significance Index: 12.1400
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0570
    Cell Significance Index: 0.8000
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.0508
    Cell Significance Index: 0.7300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0426
    Cell Significance Index: 1.0700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0396
    Cell Significance Index: 74.5500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0274
    Cell Significance Index: 17.4200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0225
    Cell Significance Index: 0.4800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0225
    Cell Significance Index: 34.5900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0219
    Cell Significance Index: 40.3300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0156
    Cell Significance Index: 11.8000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0105
    Cell Significance Index: 4.6600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0064
    Cell Significance Index: 0.8800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0035
    Cell Significance Index: 4.8100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0007
    Cell Significance Index: 0.3300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0007
    Cell Significance Index: -0.1200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0031
    Cell Significance Index: -0.1100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0040
    Cell Significance Index: -2.4800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0041
    Cell Significance Index: -0.2500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0051
    Cell Significance Index: -2.8000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0062
    Cell Significance Index: -4.6100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0064
    Cell Significance Index: -0.1100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0086
    Cell Significance Index: -4.8700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0091
    Cell Significance Index: -6.6800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0101
    Cell Significance Index: -1.4700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0115
    Cell Significance Index: -2.4300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0159
    Cell Significance Index: -1.8200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0161
    Cell Significance Index: -4.6200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0181
    Cell Significance Index: -1.1100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0216
    Cell Significance Index: -2.5200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0364
    Cell Significance Index: -4.2900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0365
    Cell Significance Index: -1.1700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0403
    Cell Significance Index: -5.1600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0406
    Cell Significance Index: -4.9900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0534
    Cell Significance Index: -3.5900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0535
    Cell Significance Index: -5.4700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0560
    Cell Significance Index: -6.4100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0566
    Cell Significance Index: -1.1800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0584
    Cell Significance Index: -3.0400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0601
    Cell Significance Index: -3.8800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0653
    Cell Significance Index: -6.8000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0704
    Cell Significance Index: -9.0900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0759
    Cell Significance Index: -5.3700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0820
    Cell Significance Index: -5.1700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0831
    Cell Significance Index: -6.3800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0957
    Cell Significance Index: -7.1300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1026
    Cell Significance Index: -1.4700
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1027
    Cell Significance Index: -1.2700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1029
    Cell Significance Index: -1.7800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1054
    Cell Significance Index: -2.8200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1107
    Cell Significance Index: -5.1600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1125
    Cell Significance Index: -8.9100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1347
    Cell Significance Index: -6.3300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1350
    Cell Significance Index: -7.0900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1357
    Cell Significance Index: -7.0500
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.1485
    Cell Significance Index: -1.8700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1571
    Cell Significance Index: -2.6300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1734
    Cell Significance Index: -4.6500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1765
    Cell Significance Index: -5.6200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1861
    Cell Significance Index: -3.1300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1967
    Cell Significance Index: -6.8900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1971
    Cell Significance Index: -6.8500
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.2010
    Cell Significance Index: -2.8100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2017
    Cell Significance Index: -10.1900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2053
    Cell Significance Index: -6.7200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2060
    Cell Significance Index: -4.4500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2071
    Cell Significance Index: -6.1000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2074
    Cell Significance Index: -6.5600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2117
    Cell Significance Index: -4.2500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2189
    Cell Significance Index: -5.2500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2252
    Cell Significance Index: -4.7800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Structure**: Complement C5 is a transmembrane protein consisting of a large subunit and a smaller subunit, which are linked by a disulfide bond. 2. **Function**: C5 is involved in the terminal pathway of complement activation, where it is cleaved into C5a and C5b, leading to the formation of the MAC and the recruitment of inflammatory cells. 3. **Expression**: C5 is widely expressed in various tissues, including the liver, colon, lung, and brain, where it is produced by hepatocytes, enterocytes, epithelial cells, endothelial cells, and hepatic stellate cells. 4. **Regulation**: C5 is negatively regulated by the protein C5a-inhibitory factor (C5i), which prevents excessive activation of the complement system. **Pathways and Functions** 1. **Complement Activation**: C5 is involved in the terminal pathway of complement activation, where it is cleaved into C5a and C5b, leading to the formation of the MAC. 2. **Cell Chemotaxis**: C5a is a potent chemotactic agent that recruits inflammatory cells to the site of inflammation. 3. **Cell Surface Receptor Signaling**: C5 binds to specific receptors on the surface of immune cells, triggering signaling cascades that facilitate the activation of immune responses. 4. **G Protein-Coupled Receptor Signaling**: C5 interacts with G protein-coupled receptors, which leads to the activation of downstream signaling pathways involved in inflammation and immune responses. **Clinical Significance** 1. **Complement Dysregulation**: Dysregulation of the complement system, including C5, has been implicated in various diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and age-related macular degeneration (AMD). 2. **Inflammatory Disorders**: C5 is involved in the pathogenesis of inflammatory disorders, including asthma, chronic obstructive pulmonary disease (COPD), and inflammatory bowel disease (IBD). 3. **Neurological Disorders**: C5 has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 4. **Cancer**: C5 has been shown to play a role in cancer progression, particularly in the recruitment of inflammatory cells to tumor sites. In conclusion, complement C5 is a critical component of the innate immune system, playing a key role in the defense against pathogens and damaged cells. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its mechanisms of action and regulation.

Genular Protein ID: 1685889785

Symbol: CO5_HUMAN

Name: Complement C5

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1984448

Title: Complete cDNA sequence of human complement pro-C5. Evidence of truncated transcripts derived from a single copy gene.

PubMed ID: 1984448

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3365401

Title: Molecular analysis of human complement component C5: localization of the structural gene to chromosome 9.

PubMed ID: 3365401

DOI: 10.1021/bi00405a012

PubMed ID: 2579066

Title: Isolation and sequence analysis of a cDNA clone encoding the fifth complement component.

PubMed ID: 2579066

DOI: 10.1016/s0021-9258(18)89523-0

PubMed ID: 690134

Title: Primary structural analysis of the polypeptide portion of human C5a anaphylatoxin. Polypeptide sequence determination and assignment of the oligosaccharide attachment site in C5a.

PubMed ID: 690134

DOI: 10.1016/s0021-9258(17)38013-4

PubMed ID: 1996961

Title: Group B streptococci inactivate complement component C5a by enzymic cleavage at the C-terminus.

PubMed ID: 1996961

DOI: 10.1042/bj2730635

PubMed ID: 8182049

Title: The amino terminus of the human C5a receptor is required for high affinity C5a binding and for receptor activation by C5a but not C5a analogs.

PubMed ID: 8182049

DOI: 10.1016/s0021-9258(17)36643-7

PubMed ID: 9553099

Title: Residues 21-30 within the extracellular N-terminal region of the C5a receptor represent a binding domain for the C5a anaphylatoxin.

PubMed ID: 9553099

DOI: 10.1074/jbc.273.17.10411

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 3408713

Title: Sequence-specific assignments in the 1H NMR spectrum of the human inflammatory protein C5a.

PubMed ID: 3408713

DOI: 10.1021/bi00410a007

PubMed ID: 2784981

Title: Tertiary structure of human complement component C5a in solution from nuclear magnetic resonance data.

PubMed ID: 2784981

DOI: 10.1021/bi00427a025

PubMed ID: 2730871

Title: Heteronuclear three-dimensional NMR spectroscopy of the inflammatory protein C5a.

PubMed ID: 2730871

DOI: 10.1021/bi00432a008

PubMed ID: 9007977

Title: Solution structure of a unique C5a semi-synthetic antagonist: implications in receptor binding.

PubMed ID: 9007977

DOI: 10.1002/pro.5560060107

PubMed ID: 9188742

Title: Structural definition of the C5a C-terminus by two-dimensional nuclear magnetic resonance spectroscopy.

PubMed ID: 9188742

DOI: 10.1002/(sici)1097-0134(199706)28:2<261::aid-prot13>3.0.co;2-g

PubMed ID: 7730648

Title: Inherited human complement C5 deficiency. Nonsense mutations in exons 1 (Gln1 to Stop) and 36 (Arg1458 to Stop) and compound heterozygosity in three African-American families.

PubMed ID: 7730648

PubMed ID: 15778377

Title: Linking C5 deficiency to an exonic splicing enhancer mutation.

PubMed ID: 15778377

DOI: 10.4049/jimmunol.174.7.4172

PubMed ID: 15488949

Title: C5 complement deficiency in a Spanish family. Molecular characterization of the double mutation responsible for the defect.

PubMed ID: 15488949

DOI: 10.1016/j.molimm.2004.06.036

PubMed ID: 15995705

Title: Complement factor 5 is a quantitative trait gene that modifies liver fibrogenesis in mice and humans.

PubMed ID: 15995705

DOI: 10.1038/ng1599

PubMed ID: 15598652

Title: Functional insights from the structure of the multifunctional C345C domain of C5 of complement.

PubMed ID: 15598652

DOI: 10.1074/jbc.m413126200

PubMed ID: 18536718

Title: Structure of and influence of a tick complement inhibitor on human complement component 5.

PubMed ID: 18536718

DOI: 10.1038/ni.1625

PubMed ID: 20133685

Title: Structural basis for inhibition of complement C5 by the SSL7 protein from Staphylococcus aureus.

PubMed ID: 20133685

DOI: 10.1073/pnas.0910565107

PubMed ID: 21217642

Title: Substrate recognition by complement convertases revealed in the C5-cobra venom factor complex.

PubMed ID: 21217642

DOI: 10.1038/emboj.2010.341

PubMed ID: 27018802

Title: Structural basis for therapeutic inhibition of complement C5.

PubMed ID: 27018802

DOI: 10.1038/nsmb.3196

PubMed ID: 31871188

Title: An inhibitor of complement C5 provides structural insights into activation.

PubMed ID: 31871188

DOI: 10.1073/pnas.1909973116

PubMed ID: 22028381

Title: Quantitative detection of single amino acid polymorphisms by targeted proteomics.

PubMed ID: 22028381

DOI: 10.1093/jmcb/mjr024

PubMed ID: 24521109

Title: Genetic variants in C5 and poor response to eculizumab.

PubMed ID: 24521109

DOI: 10.1056/nejmoa1311084

Sequence Information:

  • Length: 1676
  • Mass: 188305
  • Checksum: A7589E352F74672A
  • Sequence:
  • MGLLGILCFL IFLGKTWGQE QTYVISAPKI FRVGASENIV IQVYGYTEAF DATISIKSYP 
    DKKFSYSSGH VHLSSENKFQ NSAILTIQPK QLPGGQNPVS YVYLEVVSKH FSKSKRMPIT 
    YDNGFLFIHT DKPVYTPDQS VKVRVYSLND DLKPAKRETV LTFIDPEGSE VDMVEEIDHI 
    GIISFPDFKI PSNPRYGMWT IKAKYKEDFS TTGTAYFEVK EYVLPHFSVS IEPEYNFIGY 
    KNFKNFEITI KARYFYNKVV TEADVYITFG IREDLKDDQK EMMQTAMQNT MLINGIAQVT 
    FDSETAVKEL SYYSLEDLNN KYLYIAVTVI ESTGGFSEEA EIPGIKYVLS PYKLNLVATP 
    LFLKPGIPYP IKVQVKDSLD QLVGGVPVTL NAQTIDVNQE TSDLDPSKSV TRVDDGVASF 
    VLNLPSGVTV LEFNVKTDAP DLPEENQARE GYRAIAYSSL SQSYLYIDWT DNHKALLVGE 
    HLNIIVTPKS PYIDKITHYN YLILSKGKII HFGTREKFSD ASYQSINIPV TQNMVPSSRL 
    LVYYIVTGEQ TAELVSDSVW LNIEEKCGNQ LQVHLSPDAD AYSPGQTVSL NMATGMDSWV 
    ALAAVDSAVY GVQRGAKKPL ERVFQFLEKS DLGCGAGGGL NNANVFHLAG LTFLTNANAD 
    DSQENDEPCK EILRPRRTLQ KKIEEIAAKY KHSVVKKCCY DGACVNNDET CEQRAARISL 
    GPRCIKAFTE CCVVASQLRA NISHKDMQLG RLHMKTLLPV SKPEIRSYFP ESWLWEVHLV 
    PRRKQLQFAL PDSLTTWEIQ GVGISNTGIC VADTVKAKVF KDVFLEMNIP YSVVRGEQIQ 
    LKGTVYNYRT SGMQFCVKMS AVEGICTSES PVIDHQGTKS SKCVRQKVEG SSSHLVTFTV 
    LPLEIGLHNI NFSLETWFGK EILVKTLRVV PEGVKRESYS GVTLDPRGIY GTISRRKEFP 
    YRIPLDLVPK TEIKRILSVK GLLVGEILSA VLSQEGINIL THLPKGSAEA ELMSVVPVFY 
    VFHYLETGNH WNIFHSDPLI EKQKLKKKLK EGMLSIMSYR NADYSYSVWK GGSASTWLTA 
    FALRVLGQVN KYVEQNQNSI CNSLLWLVEN YQLDNGSFKE NSQYQPIKLQ GTLPVEAREN 
    SLYLTAFTVI GIRKAFDICP LVKIDTALIK ADNFLLENTL PAQSTFTLAI SAYALSLGDK 
    THPQFRSIVS ALKREALVKG NPPIYRFWKD NLQHKDSSVP NTGTARMVET TAYALLTSLN 
    LKDINYVNPV IKWLSEEQRY GGGFYSTQDT INAIEGLTEY SLLVKQLRLS MDIDVSYKHK 
    GALHNYKMTD KNFLGRPVEV LLNDDLIVST GFGSGLATVH VTTVVHKTST SEEVCSFYLK 
    IDTQDIEASH YRGYGNSDYK RIVACASYKP SREESSSGSS HAVMDISLPT GISANEEDLK 
    ALVEGVDQLF TDYQIKDGHV ILQLNSIPSS DFLCVRFRIF ELFEVGFLSP ATFTVYEYHR 
    PDKQCTMFYS TSNIKIQKVC EGAACKCVEA DCGQMQEELD LTISAETRKQ TACKPEIAYA 
    YKVSITSITV ENVFVKYKAT LLDIYKTGEA VAEKDSEITF IKKVTCTNAE LVKGRQYLIM 
    GKEALQIKYN FSFRYIYPLD SLTWIEYWPR DTTCSSCQAF LANLDEFAED IFLNGC

Genular Protein ID: 2362153213

Symbol: Q59GS8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 1106
  • Mass: 123351
  • Checksum: F0CC415C9FAE2D6A
  • Sequence:
  • GRAGEVRALS SGAQRRGSHF VVLCRLPRGR ARVVGASLSH APLPLRYCWK GRGGVSRLFC 
    SQRARMPGSL GREASGRAGP TGCGAFAFGL RCRYVISAPK IFRVGASENI VIQVYGYTEA 
    FDATISIKSY PDKKFSYSSG HVHLSSENKF QNSAILTIQP KQLPGGQNPV SYVYLEVVSK 
    HFSKSKRMPI TYDNGFLFIH TDKPVYTPDQ SVKVRVYSLN DDLKPAKRET VLTFIDPEGS 
    EVDMVEEIDH IGIISFPDFK IPSNPRYGMW TIKAKYKEDF STTGTAYFEV KEYVLPHFSV 
    SIEPEYNFIG YKNFKNFEIT IKARYFYNKV VTEADVYITF GIREDLKDDQ KEMMQTAMQN 
    TMLINGIAQV TFDSETAVKE LSYYSLEDLN NKYLYIAVTV IESTGGFSEE AEIPGIKYVL 
    SPYKLNLVAT PLFLKPGIPY PIKVQVKDSL DQLVGGVPVT LNAQTIDVNQ ETSDLDPSKS 
    VTRVDDGVAS FVLNLPSGVT VLEFNVKTDA PDLPEENQAR EGYRAIAYSS LSQSYLYIDW 
    TDNHKALLVG EHLNIIVTPK SPYIDKITHY NYLILSKGKI IHFGTREKFS DASYQSINIP 
    VTQNMVPSSR LLVYYIVTGE QTAELVSDSV WLNIEEKCGN QLQVHLSPDA DAYSPGQTVS 
    LNMATGMDSW VALAAVDSAV YGVQRGAKKP LERVFQFLEK SDLGCGAGGG LNNANVFHLA 
    GLTFLTNANA DDSQENDEPC KEILRPRRTL QKKIEEIAAK YKHSVVKKCC YDGACVNNDE 
    TCEQRAARIS LGPRCIKAFT ECCVVASQLR ANISHKDMQL GRLHMKTLLP VSKPEIRSYF 
    PESWLWEVHL VPRRKQLQFA LPDSLTTWEI QGVGISNTGI CVADTVKAKV FKDVFLEMNI 
    PYSVVRGEQI QLKGTVYNYR TSGMQFCVKM SAVEGICTSE SPVIDHQGTK SSKCVRQKVE 
    GSSSHLVTFT VLPLEIGLHN INFSLETWFG KEILVKTLRV VPEGVKRESY SGVTLDPRGI 
    YGTISRRKEF PYRIPLDLVP KTEIKRILSV KGLLVGEILS AVLSQEGINI LTHLPKGSAE 
    AELMSVVPVF YVFLPGNRKS LEHFSF

Genular Protein ID: 3667407407

Symbol: A0A8Q3SID6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 1682
  • Mass: 188619
  • Checksum: 9A59940315D0DD38
  • Sequence:
  • MPGSLGREAS GRAGPTGCGA FAFGLRCRYV ISAPKIFRVG ASENIVIQVY GYTEAFDATI 
    SIKSYPDKKF SYSSGHVHLS SENKFQNSAI LTIQPKQLPG GQNPVSYVYL EVVSKHFSKS 
    KRMPITYDNG FLFIHTDKPV YTPDQSVKVR VYSLNDDLKP AKRETVLTFI DPEGSEVDMV 
    EEIDHIGIIS FPDFKIPSNP RYGMWTIKAK YKEDFSTTGT AYFEVKEYVL PHFSVSIEPE 
    YNFIGYKNFK NFEITIKARY FYNKVVTEAD VYITFGIRED LKDDQKEMMQ TAMQNTMLIN 
    GIAQVTFDSE TAVKELSYYS LEDLNNKYLY IAVTVIESTG GFSEEAEIPG IKYVLSPYKL 
    NLVATPLFLK PGIPYPIKVQ VKDSLDQLVG GVPVTLNAQT IDVNQETSDL DPSKSVTRVD 
    DGVASFVLNL PSGVTVLEFN VKTDAPDLPE ENQAREGYRA IAYSSLSQSY LYIDWTDNHK 
    ALLVGEHLNI IVTPKSPYID KITHYNYLIL SKGKIIHFGT REKFSDASYQ SINIPVTQNM 
    VPSSRLLVYY IVTGEQTAEL VSDSVWLNIE EKCGNQLQVH LSPDADAYSP GQTVSLNMAT 
    GMDSWVALAA VDSAVYGVQR GAKKPLERVF QFLEKSDLGC GAGGGLNNAN VFHLAGLTFL 
    TNANADDSQE NDEPCKEILR PRRTLQKKIE EIAAKYKHSV VKKCCYDGAC VNNDETCEQR 
    AARISLGPRC IKAFTECCVV ASQLRANISH KDMQLGRLHM KTLLPVSKPE IRSYFPESWL 
    WEVHLVPRRK QLQFALPDSL TTWEIQGVGI SNTGICVADT VKAKVFKDVF LEMNIPYSVV 
    RGEQIQLKGT VYNYRTSGMQ FCVKMSAVEG ICTSESPVID HQGTKSSKCV RQKVEGSSSH 
    LVTFTVLPLE IGLHNINFSL ETWFGKEILV KTLRVVPEGV KRESYSGVTL DPRGIYGTIS 
    RRKEFPYRIP LDLVPKTEIK RILSVKGLLV GEILSAVLSQ EGINILTHLP KGSAEAELMS 
    VVPVFYVFHY LETGNHWNIF HSDPLIEKQK LKKKLKEGML SIMSYRNADY SYSVWKGGSA 
    STWLTAFALR VLGQVNKYVE QNQNSICNSL LWLVENYQLD NGSFKENSQY QPIKLQGTLP 
    VEARENSLYL TAFTVIGIRK AFDICPLVKI DTALIKADNF LLENTLPAQS TFTLAISAYA 
    LSLGDKTHPQ FRSIVSALKR EALVKGNPPI YRFWKDNLQH KDSSVPNTGT ARMVETTAYA 
    LLTSLNLKDI NYVNPVIKWL SEEQRYGGGF YSTQDTINAI EGLTEYSLLV KQLRLSMDID 
    VSYKHKGALH NYKMTDKNFL GRPVEVLLND DLIVSTGFGS GLATVHVTTV VHKTSTSEEV 
    CSFYLKIDTQ DIEASHYRGY GNSDYKRIVA CASYKPSREE SSSGSSHAVM DISLPTGISA 
    NEEDLKALVE GVDQLFTDYQ IKDGHVILQL NSIPSSDFLC VRFRIFELFE VGFLSPATFT 
    VYEYHRPDKQ CTMFYSTSNI KIQKVCEGAA CKCVEADCGQ MQEELDLTIS AETRKQTACK 
    PEIAYAYKVS ITSITVENVF VKYKATLLDI YKTGEAVAEK DSEITFIKKV TCTNAELVKG 
    RQYLIMGKEA LQIKYNFSFR YIYPLDSLTW IEYWPRDTTC SSCQAFLANL DEFAEDIFLN 
    GC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.