Details for: C5

Gene ID: 727

Symbol: C5

Ensembl ID: ENSG00000106804

Description: complement C5

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 3.6
    Marker Score: 11,792
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 2.31
    Marker Score: 12,397
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.94
    Marker Score: 12,494
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.88
    Marker Score: 8,120
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.61
    Marker Score: 2,486
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.29
    Marker Score: 5,361
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.07
    Marker Score: 1,142
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.05
    Marker Score: 397
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1
    Marker Score: 2,040
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,816
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,041
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.98
    Marker Score: 672
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 501
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 454
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,412
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 367
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,736
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5,184
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 319
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,296
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.86
    Marker Score: 1,389
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 579
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 390
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 683
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.75
    Marker Score: 11,667
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.71
    Marker Score: 4,263
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.71
    Marker Score: 15,138
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2,890
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.64
    Marker Score: 800
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.64
    Marker Score: 351
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.63
    Marker Score: 381
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.6
    Marker Score: 517
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.59
    Marker Score: 954
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.59
    Marker Score: 591
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.58
    Marker Score: 1,217
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.55
    Marker Score: 353
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.54
    Marker Score: 2,246
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.52
    Marker Score: 162
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.52
    Marker Score: 341
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.51
    Marker Score: 213
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.49
    Marker Score: 235
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.49
    Marker Score: 344
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.48
    Marker Score: 147
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.48
    Marker Score: 3,114
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.48
    Marker Score: 198
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.47
    Marker Score: 434
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.47
    Marker Score: 262
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.46
    Marker Score: 205
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.46
    Marker Score: 796
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.45
    Marker Score: 168
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.45
    Marker Score: 2,347
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.45
    Marker Score: 16,916
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.43
    Marker Score: 223
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.42
    Marker Score: 123
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.42
    Marker Score: 244
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.41
    Marker Score: 6,600
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.4
    Marker Score: 109
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.39
    Marker Score: 97
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.39
    Marker Score: 524
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.39
    Marker Score: 749
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.38
    Marker Score: 461
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.37
    Marker Score: 366
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.36
    Marker Score: 847
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.36
    Marker Score: 113
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.35
    Marker Score: 195
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.35
    Marker Score: 2,666
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.35
    Marker Score: 145
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.34
    Marker Score: 415
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.34
    Marker Score: 21,052
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.33
    Marker Score: 1,290
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.33
    Marker Score: 152
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.32
    Marker Score: 4,828
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.32
    Marker Score: 143
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.31
    Marker Score: 106
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.31
    Marker Score: 1,258
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.31
    Marker Score: 125
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3
    Marker Score: 206
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.3
    Marker Score: 80
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 0.3
    Marker Score: 167
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.29
    Marker Score: 192
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.29
    Marker Score: 141
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.29
    Marker Score: 107
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.29
    Marker Score: 332
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.28
    Marker Score: 306
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.28
    Marker Score: 347
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.28
    Marker Score: 426
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.27
    Marker Score: 86
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.27
    Marker Score: 159
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.26
    Marker Score: 2,507
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.26
    Marker Score: 2,250
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.26
    Marker Score: 376
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.26
    Marker Score: 414
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.25
    Marker Score: 9,345
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.25
    Marker Score: 601
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.25
    Marker Score: 551
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.25
    Marker Score: 888
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.25
    Marker Score: 66

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Structure**: Complement C5 is a transmembrane protein consisting of a large subunit and a smaller subunit, which are linked by a disulfide bond. 2. **Function**: C5 is involved in the terminal pathway of complement activation, where it is cleaved into C5a and C5b, leading to the formation of the MAC and the recruitment of inflammatory cells. 3. **Expression**: C5 is widely expressed in various tissues, including the liver, colon, lung, and brain, where it is produced by hepatocytes, enterocytes, epithelial cells, endothelial cells, and hepatic stellate cells. 4. **Regulation**: C5 is negatively regulated by the protein C5a-inhibitory factor (C5i), which prevents excessive activation of the complement system. **Pathways and Functions** 1. **Complement Activation**: C5 is involved in the terminal pathway of complement activation, where it is cleaved into C5a and C5b, leading to the formation of the MAC. 2. **Cell Chemotaxis**: C5a is a potent chemotactic agent that recruits inflammatory cells to the site of inflammation. 3. **Cell Surface Receptor Signaling**: C5 binds to specific receptors on the surface of immune cells, triggering signaling cascades that facilitate the activation of immune responses. 4. **G Protein-Coupled Receptor Signaling**: C5 interacts with G protein-coupled receptors, which leads to the activation of downstream signaling pathways involved in inflammation and immune responses. **Clinical Significance** 1. **Complement Dysregulation**: Dysregulation of the complement system, including C5, has been implicated in various diseases, such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and age-related macular degeneration (AMD). 2. **Inflammatory Disorders**: C5 is involved in the pathogenesis of inflammatory disorders, including asthma, chronic obstructive pulmonary disease (COPD), and inflammatory bowel disease (IBD). 3. **Neurological Disorders**: C5 has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 4. **Cancer**: C5 has been shown to play a role in cancer progression, particularly in the recruitment of inflammatory cells to tumor sites. In conclusion, complement C5 is a critical component of the innate immune system, playing a key role in the defense against pathogens and damaged cells. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its mechanisms of action and regulation.

Genular Protein ID: 1685889785

Symbol: CO5_HUMAN

Name: Complement C5

UniProtKB Accession Codes:

P01031 Q14CJ0 Q27I61

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CPTAC 2 CTD 1 CarbonylDB 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 10 DrugCentral 1 EMBL 6 EMDB 12 EPD 1 Ensembl 1 EvolutionaryTrace 1 GO 17 Gene3D 10 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 18 KEGG 1 MANE-Select 1 MEROPS 1 MIM 4 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 56 PDBsum 33 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 11 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 5 RefSeq 2 SASBDB 1 SIGNOR 1 SMART 5 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1984448

Title: Complete cDNA sequence of human complement pro-C5. Evidence of truncated transcripts derived from a single copy gene.

PubMed ID: 1984448

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3365401

Title: Molecular analysis of human complement component C5: localization of the structural gene to chromosome 9.

PubMed ID: 3365401

DOI: 10.1021/bi00405a012

PubMed ID: 2579066

Title: Isolation and sequence analysis of a cDNA clone encoding the fifth complement component.

PubMed ID: 2579066

DOI: 10.1016/s0021-9258(18)89523-0

PubMed ID: 690134

Title: Primary structural analysis of the polypeptide portion of human C5a anaphylatoxin. Polypeptide sequence determination and assignment of the oligosaccharide attachment site in C5a.

PubMed ID: 690134

DOI: 10.1016/s0021-9258(17)38013-4

PubMed ID: 1996961

Title: Group B streptococci inactivate complement component C5a by enzymic cleavage at the C-terminus.

PubMed ID: 1996961

DOI: 10.1042/bj2730635

PubMed ID: 8182049

Title: The amino terminus of the human C5a receptor is required for high affinity C5a binding and for receptor activation by C5a but not C5a analogs.

PubMed ID: 8182049

DOI: 10.1016/s0021-9258(17)36643-7

PubMed ID: 9553099

Title: Residues 21-30 within the extracellular N-terminal region of the C5a receptor represent a binding domain for the C5a anaphylatoxin.

PubMed ID: 9553099

DOI: 10.1074/jbc.273.17.10411

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 3408713

Title: Sequence-specific assignments in the 1H NMR spectrum of the human inflammatory protein C5a.

PubMed ID: 3408713

DOI: 10.1021/bi00410a007

PubMed ID: 2784981

Title: Tertiary structure of human complement component C5a in solution from nuclear magnetic resonance data.

PubMed ID: 2784981

DOI: 10.1021/bi00427a025

PubMed ID: 2730871

Title: Heteronuclear three-dimensional NMR spectroscopy of the inflammatory protein C5a.

PubMed ID: 2730871

DOI: 10.1021/bi00432a008

PubMed ID: 9007977

Title: Solution structure of a unique C5a semi-synthetic antagonist: implications in receptor binding.

PubMed ID: 9007977

DOI: 10.1002/pro.5560060107

PubMed ID: 9188742

Title: Structural definition of the C5a C-terminus by two-dimensional nuclear magnetic resonance spectroscopy.

PubMed ID: 9188742

DOI: 10.1002/(sici)1097-0134(199706)28:2<261::aid-prot13>3.0.co;2-g

PubMed ID: 7730648

Title: Inherited human complement C5 deficiency. Nonsense mutations in exons 1 (Gln1 to Stop) and 36 (Arg1458 to Stop) and compound heterozygosity in three African-American families.

PubMed ID: 7730648

PubMed ID: 15778377

Title: Linking C5 deficiency to an exonic splicing enhancer mutation.

PubMed ID: 15778377

DOI: 10.4049/jimmunol.174.7.4172

PubMed ID: 15488949

Title: C5 complement deficiency in a Spanish family. Molecular characterization of the double mutation responsible for the defect.

PubMed ID: 15488949

DOI: 10.1016/j.molimm.2004.06.036

PubMed ID: 15995705

Title: Complement factor 5 is a quantitative trait gene that modifies liver fibrogenesis in mice and humans.

PubMed ID: 15995705

DOI: 10.1038/ng1599

PubMed ID: 15598652

Title: Functional insights from the structure of the multifunctional C345C domain of C5 of complement.

PubMed ID: 15598652

DOI: 10.1074/jbc.m413126200

PubMed ID: 18536718

Title: Structure of and influence of a tick complement inhibitor on human complement component 5.

PubMed ID: 18536718

DOI: 10.1038/ni.1625

PubMed ID: 20133685

Title: Structural basis for inhibition of complement C5 by the SSL7 protein from Staphylococcus aureus.

PubMed ID: 20133685

DOI: 10.1073/pnas.0910565107

PubMed ID: 21217642

Title: Substrate recognition by complement convertases revealed in the C5-cobra venom factor complex.

PubMed ID: 21217642

DOI: 10.1038/emboj.2010.341

PubMed ID: 27018802

Title: Structural basis for therapeutic inhibition of complement C5.

PubMed ID: 27018802

DOI: 10.1038/nsmb.3196

PubMed ID: 31871188

Title: An inhibitor of complement C5 provides structural insights into activation.

PubMed ID: 31871188

DOI: 10.1073/pnas.1909973116

PubMed ID: 22028381

Title: Quantitative detection of single amino acid polymorphisms by targeted proteomics.

PubMed ID: 22028381

DOI: 10.1093/jmcb/mjr024

PubMed ID: 24521109

Title: Genetic variants in C5 and poor response to eculizumab.

PubMed ID: 24521109

DOI: 10.1056/nejmoa1311084

Sequence Information:

  • Length: 1676
  • Mass: 188305
  • Checksum: A7589E352F74672A
  • Sequence:
    • MGLLGILCFL IFLGKTWGQE QTYVISAPKI FRVGASENIV IQVYGYTEAF DATISIKSYP 
DKKFSYSSGH VHLSSENKFQ NSAILTIQPK QLPGGQNPVS YVYLEVVSKH FSKSKRMPIT 
YDNGFLFIHT DKPVYTPDQS VKVRVYSLND DLKPAKRETV LTFIDPEGSE VDMVEEIDHI 
GIISFPDFKI PSNPRYGMWT IKAKYKEDFS TTGTAYFEVK EYVLPHFSVS IEPEYNFIGY 
KNFKNFEITI KARYFYNKVV TEADVYITFG IREDLKDDQK EMMQTAMQNT MLINGIAQVT 
FDSETAVKEL SYYSLEDLNN KYLYIAVTVI ESTGGFSEEA EIPGIKYVLS PYKLNLVATP 
LFLKPGIPYP IKVQVKDSLD QLVGGVPVTL NAQTIDVNQE TSDLDPSKSV TRVDDGVASF 
VLNLPSGVTV LEFNVKTDAP DLPEENQARE GYRAIAYSSL SQSYLYIDWT DNHKALLVGE 
HLNIIVTPKS PYIDKITHYN YLILSKGKII HFGTREKFSD ASYQSINIPV TQNMVPSSRL 
LVYYIVTGEQ TAELVSDSVW LNIEEKCGNQ LQVHLSPDAD AYSPGQTVSL NMATGMDSWV 
ALAAVDSAVY GVQRGAKKPL ERVFQFLEKS DLGCGAGGGL NNANVFHLAG LTFLTNANAD 
DSQENDEPCK EILRPRRTLQ KKIEEIAAKY KHSVVKKCCY DGACVNNDET CEQRAARISL 
GPRCIKAFTE CCVVASQLRA NISHKDMQLG RLHMKTLLPV SKPEIRSYFP ESWLWEVHLV 
PRRKQLQFAL PDSLTTWEIQ GVGISNTGIC VADTVKAKVF KDVFLEMNIP YSVVRGEQIQ 
LKGTVYNYRT SGMQFCVKMS AVEGICTSES PVIDHQGTKS SKCVRQKVEG SSSHLVTFTV 
LPLEIGLHNI NFSLETWFGK EILVKTLRVV PEGVKRESYS GVTLDPRGIY GTISRRKEFP 
YRIPLDLVPK TEIKRILSVK GLLVGEILSA VLSQEGINIL THLPKGSAEA ELMSVVPVFY 
VFHYLETGNH WNIFHSDPLI EKQKLKKKLK EGMLSIMSYR NADYSYSVWK GGSASTWLTA 
FALRVLGQVN KYVEQNQNSI CNSLLWLVEN YQLDNGSFKE NSQYQPIKLQ GTLPVEAREN 
SLYLTAFTVI GIRKAFDICP LVKIDTALIK ADNFLLENTL PAQSTFTLAI SAYALSLGDK 
THPQFRSIVS ALKREALVKG NPPIYRFWKD NLQHKDSSVP NTGTARMVET TAYALLTSLN 
LKDINYVNPV IKWLSEEQRY GGGFYSTQDT INAIEGLTEY SLLVKQLRLS MDIDVSYKHK 
GALHNYKMTD KNFLGRPVEV LLNDDLIVST GFGSGLATVH VTTVVHKTST SEEVCSFYLK 
IDTQDIEASH YRGYGNSDYK RIVACASYKP SREESSSGSS HAVMDISLPT GISANEEDLK 
ALVEGVDQLF TDYQIKDGHV ILQLNSIPSS DFLCVRFRIF ELFEVGFLSP ATFTVYEYHR 
PDKQCTMFYS TSNIKIQKVC EGAACKCVEA DCGQMQEELD LTISAETRKQ TACKPEIAYA 
YKVSITSITV ENVFVKYKAT LLDIYKTGEA VAEKDSEITF IKKVTCTNAE LVKGRQYLIM 
GKEALQIKYN FSFRYIYPLD SLTWIEYWPR DTTCSSCQAF LANLDEFAED IFLNGC

Genular Protein ID: 2362153213

Symbol: Q59GS8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59GS8

Database IDs:

ARBA 9 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 5 Gene3D 7 GenomeRNAi 1 InterPro 10 MEROPS 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 7 RefSeq 1 SMART 3 SUPFAM 1

Sequence Information:

  • Length: 1106
  • Mass: 123351
  • Checksum: F0CC415C9FAE2D6A
  • Sequence:
    • GRAGEVRALS SGAQRRGSHF VVLCRLPRGR ARVVGASLSH APLPLRYCWK GRGGVSRLFC 
SQRARMPGSL GREASGRAGP TGCGAFAFGL RCRYVISAPK IFRVGASENI VIQVYGYTEA 
FDATISIKSY PDKKFSYSSG HVHLSSENKF QNSAILTIQP KQLPGGQNPV SYVYLEVVSK 
HFSKSKRMPI TYDNGFLFIH TDKPVYTPDQ SVKVRVYSLN DDLKPAKRET VLTFIDPEGS 
EVDMVEEIDH IGIISFPDFK IPSNPRYGMW TIKAKYKEDF STTGTAYFEV KEYVLPHFSV 
SIEPEYNFIG YKNFKNFEIT IKARYFYNKV VTEADVYITF GIREDLKDDQ KEMMQTAMQN 
TMLINGIAQV TFDSETAVKE LSYYSLEDLN NKYLYIAVTV IESTGGFSEE AEIPGIKYVL 
SPYKLNLVAT PLFLKPGIPY PIKVQVKDSL DQLVGGVPVT LNAQTIDVNQ ETSDLDPSKS 
VTRVDDGVAS FVLNLPSGVT VLEFNVKTDA PDLPEENQAR EGYRAIAYSS LSQSYLYIDW 
TDNHKALLVG EHLNIIVTPK SPYIDKITHY NYLILSKGKI IHFGTREKFS DASYQSINIP 
VTQNMVPSSR LLVYYIVTGE QTAELVSDSV WLNIEEKCGN QLQVHLSPDA DAYSPGQTVS 
LNMATGMDSW VALAAVDSAV YGVQRGAKKP LERVFQFLEK SDLGCGAGGG LNNANVFHLA 
GLTFLTNANA DDSQENDEPC KEILRPRRTL QKKIEEIAAK YKHSVVKKCC YDGACVNNDE 
TCEQRAARIS LGPRCIKAFT ECCVVASQLR ANISHKDMQL GRLHMKTLLP VSKPEIRSYF 
PESWLWEVHL VPRRKQLQFA LPDSLTTWEI QGVGISNTGI CVADTVKAKV FKDVFLEMNI 
PYSVVRGEQI QLKGTVYNYR TSGMQFCVKM SAVEGICTSE SPVIDHQGTK SSKCVRQKVE 
GSSSHLVTFT VLPLEIGLHN INFSLETWFG KEILVKTLRV VPEGVKRESY SGVTLDPRGI 
YGTISRRKEF PYRIPLDLVP KTEIKRILSV KGLLVGEILS AVLSQEGINI LTHLPKGSAE 
AELMSVVPVF YVFLPGNRKS LEHFSF

Genular Protein ID: 3667407407

Symbol: A0A8Q3SID6_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A8Q3SID6

Database IDs:

ARBA 10 CDD 3 CTD 1 EMBL 1 Ensembl 2 GO 5 Gene3D 10 GeneTree 1 HGNC 1 InterPro 18 NCBI Taxonomy 1 PANTHER 2 PRINTS 1 PROSITE 3 Pfam 11 Proteomes 2 RefSeq 1 SMART 5 SMR 1 SUPFAM 4

Citations:

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

Sequence Information:

  • Length: 1682
  • Mass: 188619
  • Checksum: 9A59940315D0DD38
  • Sequence:
    • MPGSLGREAS GRAGPTGCGA FAFGLRCRYV ISAPKIFRVG ASENIVIQVY GYTEAFDATI 
SIKSYPDKKF SYSSGHVHLS SENKFQNSAI LTIQPKQLPG GQNPVSYVYL EVVSKHFSKS 
KRMPITYDNG FLFIHTDKPV YTPDQSVKVR VYSLNDDLKP AKRETVLTFI DPEGSEVDMV 
EEIDHIGIIS FPDFKIPSNP RYGMWTIKAK YKEDFSTTGT AYFEVKEYVL PHFSVSIEPE 
YNFIGYKNFK NFEITIKARY FYNKVVTEAD VYITFGIRED LKDDQKEMMQ TAMQNTMLIN 
GIAQVTFDSE TAVKELSYYS LEDLNNKYLY IAVTVIESTG GFSEEAEIPG IKYVLSPYKL 
NLVATPLFLK PGIPYPIKVQ VKDSLDQLVG GVPVTLNAQT IDVNQETSDL DPSKSVTRVD 
DGVASFVLNL PSGVTVLEFN VKTDAPDLPE ENQAREGYRA IAYSSLSQSY LYIDWTDNHK 
ALLVGEHLNI IVTPKSPYID KITHYNYLIL SKGKIIHFGT REKFSDASYQ SINIPVTQNM 
VPSSRLLVYY IVTGEQTAEL VSDSVWLNIE EKCGNQLQVH LSPDADAYSP GQTVSLNMAT 
GMDSWVALAA VDSAVYGVQR GAKKPLERVF QFLEKSDLGC GAGGGLNNAN VFHLAGLTFL 
TNANADDSQE NDEPCKEILR PRRTLQKKIE EIAAKYKHSV VKKCCYDGAC VNNDETCEQR 
AARISLGPRC IKAFTECCVV ASQLRANISH KDMQLGRLHM KTLLPVSKPE IRSYFPESWL 
WEVHLVPRRK QLQFALPDSL TTWEIQGVGI SNTGICVADT VKAKVFKDVF LEMNIPYSVV 
RGEQIQLKGT VYNYRTSGMQ FCVKMSAVEG ICTSESPVID HQGTKSSKCV RQKVEGSSSH 
LVTFTVLPLE IGLHNINFSL ETWFGKEILV KTLRVVPEGV KRESYSGVTL DPRGIYGTIS 
RRKEFPYRIP LDLVPKTEIK RILSVKGLLV GEILSAVLSQ EGINILTHLP KGSAEAELMS 
VVPVFYVFHY LETGNHWNIF HSDPLIEKQK LKKKLKEGML SIMSYRNADY SYSVWKGGSA 
STWLTAFALR VLGQVNKYVE QNQNSICNSL LWLVENYQLD NGSFKENSQY QPIKLQGTLP 
VEARENSLYL TAFTVIGIRK AFDICPLVKI DTALIKADNF LLENTLPAQS TFTLAISAYA 
LSLGDKTHPQ FRSIVSALKR EALVKGNPPI YRFWKDNLQH KDSSVPNTGT ARMVETTAYA 
LLTSLNLKDI NYVNPVIKWL SEEQRYGGGF YSTQDTINAI EGLTEYSLLV KQLRLSMDID 
VSYKHKGALH NYKMTDKNFL GRPVEVLLND DLIVSTGFGS GLATVHVTTV VHKTSTSEEV 
CSFYLKIDTQ DIEASHYRGY GNSDYKRIVA CASYKPSREE SSSGSSHAVM DISLPTGISA 
NEEDLKALVE GVDQLFTDYQ IKDGHVILQL NSIPSSDFLC VRFRIFELFE VGFLSPATFT 
VYEYHRPDKQ CTMFYSTSNI KIQKVCEGAA CKCVEADCGQ MQEELDLTIS AETRKQTACK 
PEIAYAYKVS ITSITVENVF VKYKATLLDI YKTGEAVAEK DSEITFIKKV TCTNAELVKG 
RQYLIMGKEA LQIKYNFSFR YIYPLDSLTW IEYWPRDTTC SSCQAFLANL DEFAEDIFLN 
GC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.