C5AR1 | ENSG00000197405 | NCBI 728

Details for: C5AR1

Gene ID: 728

Symbol: C5AR1

Ensembl ID: ENSG00000197405

Description: complement C5a receptor 1

Associated with

Class a/1 (rhodopsin-like receptors)
(R-HSA-373076)
Complement cascade
(R-HSA-166658)
G alpha (i) signalling events
(R-HSA-418594)
Gpcr downstream signalling
(R-HSA-388396)
Gpcr ligand binding
(R-HSA-500792)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Neutrophil degranulation
(R-HSA-6798695)
Peptide ligand-binding receptors
(R-HSA-375276)
Regulation of complement cascade
(R-HSA-977606)
Signaling by gpcr
(R-HSA-372790)
Activation of phospholipase c activity
(GO:0007202)
Amyloid-beta clearance
(GO:0097242)
Apical part of cell
(GO:0045177)
Astrocyte activation
(GO:0048143)
Basolateral plasma membrane
(GO:0016323)
Cellular defense response
(GO:0006968)
Chemotaxis
(GO:0006935)
Cognition
(GO:0050890)
Complement component c5a receptor activity
(GO:0004878)
Complement component c5a signaling pathway
(GO:0038178)
Complement receptor mediated signaling pathway
(GO:0002430)
Defense response to gram-positive bacterium
(GO:0050830)
G protein-coupled receptor activity
(GO:0004930)
Immune response
(GO:0006955)
Inflammatory response
(GO:0006954)
Microglial cell activation
(GO:0001774)
Mrna transcription by rna polymerase ii
(GO:0042789)
Neutrophil chemotaxis
(GO:0030593)
Phospholipase c-activating g protein-coupled receptor signaling pathway
(GO:0007200)
Plasma membrane
(GO:0005886)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of cytosolic calcium ion concentration
(GO:0007204)
Positive regulation of epithelial cell proliferation
(GO:0050679)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of macrophage chemotaxis
(GO:0010759)
Positive regulation of neutrophil chemotaxis
(GO:0090023)
Positive regulation of vascular endothelial growth factor production
(GO:0010575)
Presynapse organization
(GO:0099172)
Regulation of tau-protein kinase activity
(GO:1902947)
Response to peptidoglycan
(GO:0032494)
Secretory granule membrane
(GO:0030667)
Sensory perception of chemical stimulus
(GO:0007606)
Signal transduction
(GO:0007165)

Other Information

Proteins

C5a anaphylatoxin chemotactic receptor 1

Genular Protein ID: 1667935445

Symbol: C5AR1_HUMAN

Name: C5a anaphylatoxin chemotactic receptor 1

UniProtKB Accession Codes:

P21730

Database IDs:

Citations:

PubMed ID: 2007135

Title: Expression cloning of a receptor for C5a anaphylatoxin on differentiated HL-60 cells.

PubMed ID: 2007135

DOI: 10.1021/bi00226a002

PubMed ID: 1847994

Title: The chemotactic receptor for human C5a anaphylatoxin.

PubMed ID: 1847994

DOI: 10.1038/349614a0

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8383526

Title: Human chemotaxis receptor genes cluster at 19q13.3-13.4. Characterization of the human C5a receptor gene.

PubMed ID: 8383526

DOI: 10.1021/bi00056a007

PubMed ID: 8182049

Title: The amino terminus of the human C5a receptor is required for high affinity C5a binding and for receptor activation by C5a but not C5a analogs.

PubMed ID: 8182049

DOI: 10.1016/s0021-9258(17)36643-7

PubMed ID: 7622471

Title: Mutation of glutamate 199 of the human C5a receptor defines a binding site for ligand distinct from the receptor N terminus.

PubMed ID: 7622471

DOI: 10.1074/jbc.270.28.16625

PubMed ID: 7642584

Title: Identification of the major phosphorylation sites in human C5a anaphylatoxin receptor in vivo.

PubMed ID: 7642584

DOI: 10.1074/jbc.270.32.19166

PubMed ID: 9553099

Title: Residues 21-30 within the extracellular N-terminal region of the C5a receptor represent a binding domain for the C5a anaphylatoxin.

PubMed ID: 9553099

DOI: 10.1074/jbc.273.17.10411

PubMed ID: 10636859

Title: Human complement 5a (C5a) anaphylatoxin receptor (CD88) phosphorylation sites and their specific role in receptor phosphorylation and attenuation of G protein-mediated responses. Desensitization of C5a receptor controls superoxide production but not receptor sequestration in HL-60 cells.

PubMed ID: 10636859

DOI: 10.1074/jbc.275.3.1656

PubMed ID: 11342590

Title: Sulfated tyrosines contribute to the formation of the c5a docking site of the human c5a anaphylatoxin receptor.

PubMed ID: 11342590

DOI: 10.1084/jem.193.9.1059

PubMed ID: 12464600

Title: Phosphorylation of key serine residues is required for internalization of the complement 5a (C5a) anaphylatoxin receptor via a beta-arrestin, dynamin, and clathrin-dependent pathway.

PubMed ID: 12464600

DOI: 10.1074/jbc.m210120200

PubMed ID: 12835319

Title: C5a receptor oligomerization. I. Disulfide trapping reveals oligomers and potential contact surfaces in a G protein-coupled receptor.

PubMed ID: 12835319

DOI: 10.1074/jbc.m305606200

PubMed ID: 15153520

Title: Chemotaxis inhibitory protein of Staphylococcus aureus binds specifically to the C5a and formylated peptide receptor.

PubMed ID: 15153520

DOI: 10.4049/jimmunol.172.11.6994

PubMed ID: 15542591

Title: Residues 10-18 within the C5a receptor N terminus compose a binding domain for chemotaxis inhibitory protein of Staphylococcus aureus.

PubMed ID: 15542591

DOI: 10.1074/jbc.m412230200

PubMed ID: 21706042

Title: Tyrosine sulfation in N-terminal domain of human C5a receptor is necessary for binding of chemotaxis inhibitory protein of Staphylococcus aureus.

PubMed ID: 21706042

DOI: 10.1038/aps.2011.53

PubMed ID: 29300009

Title: Structure of the complement C5a receptor bound to the extra-helical antagonist NDT9513727.

PubMed ID: 29300009

DOI: 10.1038/nature25025

Sequence Information:

Length: 350
Mass: 39336
Checksum: 9334BB39A2C96D3D
Sequence:

MDSFNYTTPD YGHYDDKDTL DLNTPVDKTS NTLRVPDILA LVIFAVVFLV GVLGNALVVW 
VTAFEAKRTI NAIWFLNLAV ADFLSCLALP ILFTSIVQHH HWPFGGAACS ILPSLILLNM 
YASILLLATI SADRFLLVFK PIWCQNFRGA GLAWIACAVA WGLALLLTIP SFLYRVVREE 
YFPPKVLCGV DYSHDKRRER AVAIVRLVLG FLWPLLTLTI CYTFILLRTW SRRATRSTKT 
LKVVVAVVAS FFIFWLPYQV TGIMMSFLEP SSPTFLLLKK LDSLCVSFAY INCCINPIIY 
VVAGQGFQGR LRKSLPSLLR NVLTEESVVR ESKSFTRSTV DTMAQKTQAV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: C5AR1

Associated with

Other Information

Expression cloning of a receptor for C5a anaphylatoxin on differentiated HL-60 cells. PubMed ID: 2007135

The chemotactic receptor for human C5a anaphylatoxin. PubMed ID: 1847994

The DNA sequence and biology of human chromosome 19. PubMed ID: 15057824

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Human chemotaxis receptor genes cluster at 19q13.3-13.4. Characterization of the human C5a receptor gene. PubMed ID: 8383526

The amino terminus of the human C5a receptor is required for high affinity C5a binding and for receptor activation by C5a but not C5a analogs. PubMed ID: 8182049

Mutation of glutamate 199 of the human C5a receptor defines a binding site for ligand distinct from the receptor N terminus. PubMed ID: 7622471

Identification of the major phosphorylation sites in human C5a anaphylatoxin receptor in vivo. PubMed ID: 7642584

Residues 21-30 within the extracellular N-terminal region of the C5a receptor represent a binding domain for the C5a anaphylatoxin. PubMed ID: 9553099

Sulfated tyrosines contribute to the formation of the c5a docking site of the human c5a anaphylatoxin receptor. PubMed ID: 11342590

Phosphorylation of key serine residues is required for internalization of the complement 5a (C5a) anaphylatoxin receptor via a beta-arrestin, dynamin, and clathrin-dependent pathway. PubMed ID: 12464600

C5a receptor oligomerization. I. Disulfide trapping reveals oligomers and potential contact surfaces in a G protein-coupled receptor. PubMed ID: 12835319

Chemotaxis inhibitory protein of Staphylococcus aureus binds specifically to the C5a and formylated peptide receptor. PubMed ID: 15153520

Residues 10-18 within the C5a receptor N terminus compose a binding domain for chemotaxis inhibitory protein of Staphylococcus aureus. PubMed ID: 15542591

Tyrosine sulfation in N-terminal domain of human C5a receptor is necessary for binding of chemotaxis inhibitory protein of Staphylococcus aureus. PubMed ID: 21706042

Structure of the complement C5a receptor bound to the extra-helical antagonist NDT9513727. PubMed ID: 29300009