Details for: C5AR1

Gene ID: 728

Symbol: C5AR1

Ensembl ID: ENSG00000197405

Description: complement C5a receptor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 112.4432
    Cell Significance Index: -17.4900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 70.7292
    Cell Significance Index: -17.9400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 46.1530
    Cell Significance Index: -18.7500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 40.4075
    Cell Significance Index: -20.7900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 19.8169
    Cell Significance Index: -18.9200
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 14.3596
    Cell Significance Index: 37.8800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 14.1611
    Cell Significance Index: -17.4600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.5107
    Cell Significance Index: 83.3700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.4275
    Cell Significance Index: -9.6900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 3.8820
    Cell Significance Index: 60.0600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.8242
    Cell Significance Index: 48.8000
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.3840
    Cell Significance Index: 17.1200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9749
    Cell Significance Index: 185.5200
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 0.5963
    Cell Significance Index: 10.2500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5941
    Cell Significance Index: 58.7700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5736
    Cell Significance Index: 517.9500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3023
    Cell Significance Index: 60.0000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3023
    Cell Significance Index: 23.2000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2950
    Cell Significance Index: 47.9900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.1889
    Cell Significance Index: 1.5400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1782
    Cell Significance Index: 19.3800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.0914
    Cell Significance Index: 1.5400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0773
    Cell Significance Index: 5.3400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0767
    Cell Significance Index: 11.1500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0569
    Cell Significance Index: 35.5500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0437
    Cell Significance Index: 23.8900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0422
    Cell Significance Index: 8.4700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0343
    Cell Significance Index: 12.2900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0180
    Cell Significance Index: 0.4500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0148
    Cell Significance Index: 1.5100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0001
    Cell Significance Index: -0.2300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0017
    Cell Significance Index: -3.1300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0030
    Cell Significance Index: -4.5500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0051
    Cell Significance Index: -3.5000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0053
    Cell Significance Index: -7.1400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0065
    Cell Significance Index: -0.2300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0082
    Cell Significance Index: -6.0400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0110
    Cell Significance Index: -6.9600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0120
    Cell Significance Index: -1.4700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0132
    Cell Significance Index: -0.3800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0152
    Cell Significance Index: -8.5500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0198
    Cell Significance Index: -5.6900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0203
    Cell Significance Index: -15.3800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0238
    Cell Significance Index: -4.3000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0241
    Cell Significance Index: -17.6700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0344
    Cell Significance Index: -15.2000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0396
    Cell Significance Index: -8.3500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0428
    Cell Significance Index: -19.4200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0429
    Cell Significance Index: -0.9300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0567
    Cell Significance Index: -3.4100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0638
    Cell Significance Index: -7.4400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0640
    Cell Significance Index: -10.9300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0684
    Cell Significance Index: -3.1000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1073
    Cell Significance Index: -14.7400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1137
    Cell Significance Index: -14.5700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1429
    Cell Significance Index: -16.3100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1486
    Cell Significance Index: -19.2000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1505
    Cell Significance Index: -7.6100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1566
    Cell Significance Index: -2.3600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1592
    Cell Significance Index: -2.3500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1660
    Cell Significance Index: -19.5800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1672
    Cell Significance Index: -17.4100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1741
    Cell Significance Index: -4.8700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1835
    Cell Significance Index: -21.0200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1874
    Cell Significance Index: -11.4900
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1959
    Cell Significance Index: -3.8300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1974
    Cell Significance Index: -13.2700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1989
    Cell Significance Index: -9.3500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2127
    Cell Significance Index: -4.5300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2371
    Cell Significance Index: -16.7700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2468
    Cell Significance Index: -19.5500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2484
    Cell Significance Index: -10.8000
  • Cell Name: CD14-positive, CD16-low monocyte (CL0001055)
    Fold Change: -0.2526
    Cell Significance Index: -2.4300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2585
    Cell Significance Index: -13.4300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2600
    Cell Significance Index: -19.3800
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.2739
    Cell Significance Index: -3.6400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2883
    Cell Significance Index: -17.7200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2935
    Cell Significance Index: -18.5000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2937
    Cell Significance Index: -16.4800
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.2954
    Cell Significance Index: -2.7500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2983
    Cell Significance Index: -15.5400
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.3054
    Cell Significance Index: -2.6700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3193
    Cell Significance Index: -20.6000
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.3223
    Cell Significance Index: -2.8400
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.3384
    Cell Significance Index: -4.9500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3466
    Cell Significance Index: -15.3300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.3608
    Cell Significance Index: -8.7400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3668
    Cell Significance Index: -15.0300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3719
    Cell Significance Index: -11.9100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3839
    Cell Significance Index: -10.9600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3882
    Cell Significance Index: -13.6000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3950
    Cell Significance Index: -20.7400
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.3987
    Cell Significance Index: -4.0700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4003
    Cell Significance Index: -15.1600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4008
    Cell Significance Index: -18.6900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.4284
    Cell Significance Index: -6.2200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4381
    Cell Significance Index: -11.2600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4382
    Cell Significance Index: -11.7000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4389
    Cell Significance Index: -14.3700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4392
    Cell Significance Index: -5.2400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** C5AR1 is a member of the class A/1 rhodopsin-like receptor family, which is characterized by the presence of seven transmembrane alpha-helices. The receptor is expressed on various immune cells, including macrophages, monocytes, and dendritic cells, as well as on epithelial cells and endothelial cells. C5AR1 is a high-affinity receptor for C5a, with a binding constant of approximately 10^-9 M. The receptor is also capable of binding to other anaphylatoxins, such as C3a and C4a. **Pathways and Functions** C5AR1 is involved in various signaling pathways, including: 1. **Phospholipase C-activating G protein-coupled receptor signaling pathway**: Activation of C5AR1 triggers the activation of phospholipase C (PLC), which leads to the production of inositol trisphosphate (IP3) and diacylglycerol (DAG). 2. **G alpha (i) signaling events**: C5AR1 activation also triggers the activation of Gi proteins, which inhibit adenylate cyclase and lead to a decrease in cAMP levels. 3. **G protein-coupled receptor activity**: C5AR1 is a GPCR that interacts with G proteins to initiate signaling cascades. 4. **Immune response**: C5AR1 plays a key role in the regulation of immune responses, including chemotaxis, degranulation, and the production of pro-inflammatory cytokines. 5. **Inflammatory response**: C5AR1 is involved in the regulation of inflammatory responses, including the production of pro-inflammatory cytokines and chemokines. **Clinical Significance** C5AR1 has been implicated in various diseases, including: 1. **Inflammatory disorders**: C5AR1 has been implicated in the pathogenesis of inflammatory disorders, such as rheumatoid arthritis, lupus, and multiple sclerosis. 2. **Allergic diseases**: C5AR1 has been implicated in the pathogenesis of allergic diseases, such as asthma and atopic dermatitis. 3. **Cancer**: C5AR1 has been implicated in the regulation of tumor progression and metastasis. 4. **Neurological disorders**: C5AR1 has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In summary, C5AR1 is a key regulator of the immune response, particularly in the context of inflammation and tissue injury. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of C5AR1 signaling and its role in human disease.

Genular Protein ID: 1667935445

Symbol: C5AR1_HUMAN

Name: C5a anaphylatoxin chemotactic receptor 1

UniProtKB Accession Codes:

P21730

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EMBL 9 EMDB 11 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 32 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 15 PDBsum 15 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 4 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2007135

Title: Expression cloning of a receptor for C5a anaphylatoxin on differentiated HL-60 cells.

PubMed ID: 2007135

DOI: 10.1021/bi00226a002

PubMed ID: 1847994

Title: The chemotactic receptor for human C5a anaphylatoxin.

PubMed ID: 1847994

DOI: 10.1038/349614a0

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8383526

Title: Human chemotaxis receptor genes cluster at 19q13.3-13.4. Characterization of the human C5a receptor gene.

PubMed ID: 8383526

DOI: 10.1021/bi00056a007

PubMed ID: 8182049

Title: The amino terminus of the human C5a receptor is required for high affinity C5a binding and for receptor activation by C5a but not C5a analogs.

PubMed ID: 8182049

DOI: 10.1016/s0021-9258(17)36643-7

PubMed ID: 7622471

Title: Mutation of glutamate 199 of the human C5a receptor defines a binding site for ligand distinct from the receptor N terminus.

PubMed ID: 7622471

DOI: 10.1074/jbc.270.28.16625

PubMed ID: 7642584

Title: Identification of the major phosphorylation sites in human C5a anaphylatoxin receptor in vivo.

PubMed ID: 7642584

DOI: 10.1074/jbc.270.32.19166

PubMed ID: 9553099

Title: Residues 21-30 within the extracellular N-terminal region of the C5a receptor represent a binding domain for the C5a anaphylatoxin.

PubMed ID: 9553099

DOI: 10.1074/jbc.273.17.10411

PubMed ID: 10636859

Title: Human complement 5a (C5a) anaphylatoxin receptor (CD88) phosphorylation sites and their specific role in receptor phosphorylation and attenuation of G protein-mediated responses. Desensitization of C5a receptor controls superoxide production but not receptor sequestration in HL-60 cells.

PubMed ID: 10636859

DOI: 10.1074/jbc.275.3.1656

PubMed ID: 11342590

Title: Sulfated tyrosines contribute to the formation of the c5a docking site of the human c5a anaphylatoxin receptor.

PubMed ID: 11342590

DOI: 10.1084/jem.193.9.1059

PubMed ID: 12464600

Title: Phosphorylation of key serine residues is required for internalization of the complement 5a (C5a) anaphylatoxin receptor via a beta-arrestin, dynamin, and clathrin-dependent pathway.

PubMed ID: 12464600

DOI: 10.1074/jbc.m210120200

PubMed ID: 12835319

Title: C5a receptor oligomerization. I. Disulfide trapping reveals oligomers and potential contact surfaces in a G protein-coupled receptor.

PubMed ID: 12835319

DOI: 10.1074/jbc.m305606200

PubMed ID: 15153520

Title: Chemotaxis inhibitory protein of Staphylococcus aureus binds specifically to the C5a and formylated peptide receptor.

PubMed ID: 15153520

DOI: 10.4049/jimmunol.172.11.6994

PubMed ID: 15542591

Title: Residues 10-18 within the C5a receptor N terminus compose a binding domain for chemotaxis inhibitory protein of Staphylococcus aureus.

PubMed ID: 15542591

DOI: 10.1074/jbc.m412230200

PubMed ID: 21706042

Title: Tyrosine sulfation in N-terminal domain of human C5a receptor is necessary for binding of chemotaxis inhibitory protein of Staphylococcus aureus.

PubMed ID: 21706042

DOI: 10.1038/aps.2011.53

PubMed ID: 29300009

Title: Structure of the complement C5a receptor bound to the extra-helical antagonist NDT9513727.

PubMed ID: 29300009

DOI: 10.1038/nature25025

Sequence Information:

  • Length: 350
  • Mass: 39336
  • Checksum: 9334BB39A2C96D3D
  • Sequence:
    • MDSFNYTTPD YGHYDDKDTL DLNTPVDKTS NTLRVPDILA LVIFAVVFLV GVLGNALVVW 
VTAFEAKRTI NAIWFLNLAV ADFLSCLALP ILFTSIVQHH HWPFGGAACS ILPSLILLNM 
YASILLLATI SADRFLLVFK PIWCQNFRGA GLAWIACAVA WGLALLLTIP SFLYRVVREE 
YFPPKVLCGV DYSHDKRRER AVAIVRLVLG FLWPLLTLTI CYTFILLRTW SRRATRSTKT 
LKVVVAVVAS FFIFWLPYQV TGIMMSFLEP SSPTFLLLKK LDSLCVSFAY INCCINPIIY 
VVAGQGFQGR LRKSLPSLLR NVLTEESVVR ESKSFTRSTV DTMAQKTQAV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.