Details for: C6

Gene ID: 729

Symbol: C6

Ensembl ID: ENSG00000039537

Description: complement C6

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 9.49
    Marker Score: 30,404
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 7.98
    Marker Score: 11,060
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 6.66
    Marker Score: 19,434
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 5.71
    Marker Score: 16,941
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 5.22
    Marker Score: 69,454
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 4.6
    Marker Score: 4,406
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 3.86
    Marker Score: 32,645
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 3.53
    Marker Score: 10,123
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 2.96
    Marker Score: 1,436
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 2.66
    Marker Score: 5,065
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.23
    Marker Score: 6,361
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 2.04
    Marker Score: 10,975
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 2.04
    Marker Score: 7,239
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.92
    Marker Score: 1,074
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.84
    Marker Score: 11,837
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.77
    Marker Score: 7,646
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1,167
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.5
    Marker Score: 1,561
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168,906
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.35
    Marker Score: 30,203
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.17
    Marker Score: 18,355
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4,810
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.12
    Marker Score: 7,477
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.07
    Marker Score: 2,207
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.04
    Marker Score: 6,295
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.04
    Marker Score: 329
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,818
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,043
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 509
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.98
    Marker Score: 667
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.98
    Marker Score: 669
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 462
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.98
    Marker Score: 379
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.95
    Marker Score: 1,548
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,412
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.94
    Marker Score: 1,916
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 374
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5,270
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,738
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.89
    Marker Score: 235
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.86
    Marker Score: 919
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.83
    Marker Score: 4,991
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.83
    Marker Score: 7,214
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.79
    Marker Score: 475
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 703
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.76
    Marker Score: 349
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.7
    Marker Score: 263
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.68
    Marker Score: 1,604
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.66
    Marker Score: 315
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.66
    Marker Score: 313
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.6
    Marker Score: 1,974
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.59
    Marker Score: 379
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.57
    Marker Score: 214
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 174
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.52
    Marker Score: 215
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.48
    Marker Score: 533
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.42
    Marker Score: 183
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.41
    Marker Score: 107
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.41
    Marker Score: 269
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.41
    Marker Score: 182
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.4
    Marker Score: 125
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.37
    Marker Score: 117
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.37
    Marker Score: 367
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.36
    Marker Score: 561
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.36
    Marker Score: 555
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.36
    Marker Score: 234
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.35
    Marker Score: 569
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.35
    Marker Score: 128
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.34
    Marker Score: 645
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.34
    Marker Score: 98
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.32
    Marker Score: 609
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.3
    Marker Score: 97
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.3
    Marker Score: 132
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 0.29
    Marker Score: 166
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.29
    Marker Score: 171
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.28
    Marker Score: 78
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.28
    Marker Score: 140
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.28
    Marker Score: 345
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.27
    Marker Score: 1,110
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.26
    Marker Score: 158
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 90
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.26
    Marker Score: 151
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.26
    Marker Score: 256
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.25
    Marker Score: 412
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.25
    Marker Score: 241
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.24
    Marker Score: 72
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.24
    Marker Score: 137
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 66
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.23
    Marker Score: 221
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.23
    Marker Score: 105
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.23
    Marker Score: 215
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.23
    Marker Score: 49
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.22
    Marker Score: 106
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.22
    Marker Score: 547
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.22
    Marker Score: 54

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The C6 protein is a membrane-bound glycoprotein that belongs to the C3 family of complement components. It is characterized by its ability to bind to the C3b fragment, facilitating the recruitment of factor Bb, which in turn activates the alternative pathway of the complement cascade. C6 is also known to be involved in the regulation of immune responses, including the positive regulation of the complement cascade and the killing of cells of another organism. One of the notable features of the C6 protein is its expression in various tissues, including the retina, where it is expressed in retinal bipolar neurons, cone cells, and Müller cells. This expression suggests a role for C6 in the development and maintenance of retinal function. In addition, C6 is also expressed in cardiac muscle cells, where it may play a role in the regulation of cardiac function and response to injury. **Pathways and Functions** The C6 protein is involved in several key pathways, including: 1. **Complement Activation**: C6 is a crucial component of the terminal pathway of the complement cascade, leading to the formation of the MAC. The MAC is a complex of proteins that inserts into the membrane of target cells, leading to their lysis and death. 2. **Innate Immune Response**: C6 is involved in the regulation of immune responses, including the positive regulation of the complement cascade and the killing of cells of another organism. 3. **Regulation of Complement Cascade**: C6 binds to the C3b fragment, facilitating the recruitment of factor Bb and activating the alternative pathway of the complement cascade. 4. **Extracellular Exosome**: C6 is also involved in the formation of extracellular exosomes, which are small vesicles that are secreted by cells and play a role in intercellular communication. **Clinical Significance** The dysregulation of the complement system, including the C6 gene, has been implicated in several diseases, including: 1. **Complement-Mediated Nephropathy**: Dysregulation of the complement system has been implicated in the development of complement-mediated nephropathy, a condition characterized by the deposition of complement components in the kidneys. 2. **Neuropathic Pain**: The C6 gene has been implicated in the development of neuropathic pain, a condition characterized by chronic pain in the nervous system. 3. **Retinal Diseases**: The expression of C6 in the retina suggests a role for the C6 protein in the development and maintenance of retinal function. Dysregulation of the C6 gene may contribute to the development of retinal diseases, including age-related macular degeneration. In conclusion, the C6 gene plays a crucial role in the regulation of the complement system and is involved in multiple physiological processes, including the development and maintenance of retinal function. The dysregulation of the C6 gene has been implicated in several diseases, highlighting the importance of this gene in human health and disease.

Genular Protein ID: 1264888191

Symbol: CO6_HUMAN

Name: Complement component C6

UniProtKB Accession Codes:

P13671

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 CarbonylDB 1 ChiTaRS 1 ComplexPortal 2 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EMDB 8 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 11 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 14 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 16 PDBsum 11 PIR 1 PRINTS 1 PRO 1 PROSITE 8 PROSITE-ProRule 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMART 5 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2808363

Title: Complete primary structure and functional characterization of the sixth component of the human complement system. Identification of the C5b-binding domain in complement C6.

PubMed ID: 2808363

DOI: 10.1016/s0021-9258(19)84676-8

PubMed ID: 2789218

Title: The molecular architecture of human complement component C6.

PubMed ID: 2789218

DOI: 10.1016/s0021-9258(18)71607-4

PubMed ID: 8512929

Title: Structure of the human C6 gene.

PubMed ID: 8512929

DOI: 10.1021/bi00075a012

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2468158

Title: Structural homology of complement protein C6 with other channel-forming proteins of complement.

PubMed ID: 2468158

DOI: 10.1073/pnas.86.8.2799

PubMed ID: 9366265

Title: Elucidation of the disulfide-bonding pattern in the factor I modules of the sixth component (C6) of human complement.

PubMed ID: 9366265

DOI: 10.1016/s0167-4838(97)00072-1

PubMed ID: 10551839

Title: The four terminal components of the complement system are C-mannosylated on multiple tryptophan residues.

PubMed ID: 10551839

DOI: 10.1074/jbc.274.46.32786

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 22267737

Title: Structure of complement C6 suggests a mechanism for initiation and unidirectional, sequential assembly of membrane attack complex (MAC).

PubMed ID: 22267737

DOI: 10.1074/jbc.m111.327809

PubMed ID: 8101442

Title: Polymorphism of human complement component C6: an amino acid substitution (Glu/Ala) within the second thrombospondin repeat differentiates between the two common allotypes C6 A and C6 B.

PubMed ID: 8101442

DOI: 10.1006/bbrc.1993.1841

PubMed ID: 15565285

Title: Meningococccal meningitis and complement component 6 deficiency associated with oculocutaneous albinism.

PubMed ID: 15565285

DOI: 10.1007/s00431-004-1582-y

Sequence Information:

  • Length: 934
  • Mass: 104786
  • Checksum: A88F4BED7CC349D3
  • Sequence:
    • MARRSVLYFI LLNALINKGQ ACFCDHYAWT QWTSCSKTCN SGTQSRHRQI VVDKYYQENF 
CEQICSKQET RECNWQRCPI NCLLGDFGPW SDCDPCIEKQ SKVRSVLRPS QFGGQPCTAP 
LVAFQPCIPS KLCKIEEADC KNKFRCDSGR CIARKLECNG ENDCGDNSDE RDCGRTKAVC 
TRKYNPIPSV QLMGNGFHFL AGEPRGEVLD NSFTGGICKT VKSSRTSNPY RVPANLENVG 
FEVQTAEDDL KTDFYKDLTS LGHNENQQGS FSSQGGSSFS VPIFYSSKRS ENINHNSAFK 
QAIQASHKKD SSFIRIHKVM KVLNFTTKAK DLHLSDVFLK ALNHLPLEYN SALYSRIFDD 
FGTHYFTSGS LGGVYDLLYQ FSSEELKNSG LTEEEAKHCV RIETKKRVLF AKKTKVEHRC 
TTNKLSEKHE GSFIQGAEKS ISLIRGGRSE YGAALAWEKG SSGLEEKTFS EWLESVKENP 
AVIDFELAPI VDLVRNIPCA VTKRNNLRKA LQEYAAKFDP CQCAPCPNNG RPTLSGTECL 
CVCQSGTYGE NCEKQSPDYK SNAVDGQWGC WSSWSTCDAT YKRSRTRECN NPAPQRGGKR 
CEGEKRQEED CTFSIMENNG QPCINDDEEM KEVDLPEIEA DSGCPQPVPP ENGFIRNEKQ 
LYLVGEDVEI SCLTGFETVG YQYFRCLPDG TWRQGDVECQ RTECIKPVVQ EVLTITPFQR 
LYRIGESIEL TCPKGFVVAG PSRYTCQGNS WTPPISNSLT CEKDTLTKLK GHCQLGQKQS 
GSECICMSPE EDCSHHSEDL CVFDTDSNDY FTSPACKFLA EKCLNNQQLH FLHIGSCQDG 
RQLEWGLERT RLSSNSTKKE SCGYDTCYDW EKCSASTSKC VCLLPPQCFK GGNQLYCVKM 
GSSTSEKTLN ICEVGTIRCA NRKMEILHPG KCLA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.