C6 | ENSG00000039537 | NCBI 729

Details for: C6

Gene ID: 729

Symbol: C6

Ensembl ID: ENSG00000039537

Description: complement C6

Associated with

Complement cascade
(R-HSA-166658)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Regulation of complement cascade
(R-HSA-977606)
Terminal pathway of complement
(R-HSA-166665)
Complement activation
(GO:0006956)
Complement activation, classical pathway
(GO:0006958)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Innate immune response
(GO:0045087)
In utero embryonic development
(GO:0001701)
Killing of cells of another organism
(GO:0031640)
Membrane attack complex
(GO:0005579)
Plasma membrane
(GO:0005886)
Positive regulation of immune response
(GO:0050778)
Protein binding
(GO:0005515)

Other Information

Proteins

Complement component C6

Genular Protein ID: 1264888191

Symbol: CO6_HUMAN

Name: Complement component C6

UniProtKB Accession Codes:

P13671

Database IDs:

Citations:

PubMed ID: 2808363

Title: Complete primary structure and functional characterization of the sixth component of the human complement system. Identification of the C5b-binding domain in complement C6.

PubMed ID: 2808363

DOI: 10.1016/s0021-9258(19)84676-8

PubMed ID: 2789218

Title: The molecular architecture of human complement component C6.

PubMed ID: 2789218

DOI: 10.1016/s0021-9258(18)71607-4

PubMed ID: 8512929

Title: Structure of the human C6 gene.

PubMed ID: 8512929

DOI: 10.1021/bi00075a012

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2468158

Title: Structural homology of complement protein C6 with other channel-forming proteins of complement.

PubMed ID: 2468158

DOI: 10.1073/pnas.86.8.2799

PubMed ID: 9366265

Title: Elucidation of the disulfide-bonding pattern in the factor I modules of the sixth component (C6) of human complement.

PubMed ID: 9366265

DOI: 10.1016/s0167-4838(97)00072-1

PubMed ID: 10551839

Title: The four terminal components of the complement system are C-mannosylated on multiple tryptophan residues.

PubMed ID: 10551839

DOI: 10.1074/jbc.274.46.32786

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 22267737

Title: Structure of complement C6 suggests a mechanism for initiation and unidirectional, sequential assembly of membrane attack complex (MAC).

PubMed ID: 22267737

DOI: 10.1074/jbc.m111.327809

PubMed ID: 8101442

Title: Polymorphism of human complement component C6: an amino acid substitution (Glu/Ala) within the second thrombospondin repeat differentiates between the two common allotypes C6 A and C6 B.

PubMed ID: 8101442

DOI: 10.1006/bbrc.1993.1841

PubMed ID: 15565285

Title: Meningococccal meningitis and complement component 6 deficiency associated with oculocutaneous albinism.

PubMed ID: 15565285

DOI: 10.1007/s00431-004-1582-y

Sequence Information:

Length: 934
Mass: 104786
Checksum: A88F4BED7CC349D3
Sequence:

MARRSVLYFI LLNALINKGQ ACFCDHYAWT QWTSCSKTCN SGTQSRHRQI VVDKYYQENF 
CEQICSKQET RECNWQRCPI NCLLGDFGPW SDCDPCIEKQ SKVRSVLRPS QFGGQPCTAP 
LVAFQPCIPS KLCKIEEADC KNKFRCDSGR CIARKLECNG ENDCGDNSDE RDCGRTKAVC 
TRKYNPIPSV QLMGNGFHFL AGEPRGEVLD NSFTGGICKT VKSSRTSNPY RVPANLENVG 
FEVQTAEDDL KTDFYKDLTS LGHNENQQGS FSSQGGSSFS VPIFYSSKRS ENINHNSAFK 
QAIQASHKKD SSFIRIHKVM KVLNFTTKAK DLHLSDVFLK ALNHLPLEYN SALYSRIFDD 
FGTHYFTSGS LGGVYDLLYQ FSSEELKNSG LTEEEAKHCV RIETKKRVLF AKKTKVEHRC 
TTNKLSEKHE GSFIQGAEKS ISLIRGGRSE YGAALAWEKG SSGLEEKTFS EWLESVKENP 
AVIDFELAPI VDLVRNIPCA VTKRNNLRKA LQEYAAKFDP CQCAPCPNNG RPTLSGTECL 
CVCQSGTYGE NCEKQSPDYK SNAVDGQWGC WSSWSTCDAT YKRSRTRECN NPAPQRGGKR 
CEGEKRQEED CTFSIMENNG QPCINDDEEM KEVDLPEIEA DSGCPQPVPP ENGFIRNEKQ 
LYLVGEDVEI SCLTGFETVG YQYFRCLPDG TWRQGDVECQ RTECIKPVVQ EVLTITPFQR 
LYRIGESIEL TCPKGFVVAG PSRYTCQGNS WTPPISNSLT CEKDTLTKLK GHCQLGQKQS 
GSECICMSPE EDCSHHSEDL CVFDTDSNDY FTSPACKFLA EKCLNNQQLH FLHIGSCQDG 
RQLEWGLERT RLSSNSTKKE SCGYDTCYDW EKCSASTSKC VCLLPPQCFK GGNQLYCVKM 
GSSTSEKTLN ICEVGTIRCA NRKMEILHPG KCLA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: C6

Associated with

Other Information

Complete primary structure and functional characterization of the sixth component of the human complement system. Identification of the C5b-binding domain in complement C6. PubMed ID: 2808363

The molecular architecture of human complement component C6. PubMed ID: 2789218

Structure of the human C6 gene. PubMed ID: 8512929

The DNA sequence and comparative analysis of human chromosome 5. PubMed ID: 15372022

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Structural homology of complement protein C6 with other channel-forming proteins of complement. PubMed ID: 2468158

Elucidation of the disulfide-bonding pattern in the factor I modules of the sixth component (C6) of human complement. PubMed ID: 9366265

The four terminal components of the complement system are C-mannosylated on multiple tryptophan residues. PubMed ID: 10551839

Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. PubMed ID: 16335952

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Structure of complement C6 suggests a mechanism for initiation and unidirectional, sequential assembly of membrane attack complex (MAC). PubMed ID: 22267737

Polymorphism of human complement component C6: an amino acid substitution (Glu/Ala) within the second thrombospondin repeat differentiates between the two common allotypes C6 A and C6 B. PubMed ID: 8101442

Meningococccal meningitis and complement component 6 deficiency associated with oculocutaneous albinism. PubMed ID: 15565285