Details for: C6

Gene ID: 729

Symbol: C6

Ensembl ID: ENSG00000039537

Description: complement C6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 5.3654
    Cell Significance Index: 90.3800
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 4.1606
    Cell Significance Index: 15.6700
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 2.6422
    Cell Significance Index: 6.9700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.5725
    Cell Significance Index: 30.6900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.3313
    Cell Significance Index: 102.1600
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.9262
    Cell Significance Index: 13.3000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.8503
    Cell Significance Index: 12.5500
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.8491
    Cell Significance Index: 4.8900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7185
    Cell Significance Index: 142.5800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5793
    Cell Significance Index: 12.5500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.5576
    Cell Significance Index: 16.4300
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.4592
    Cell Significance Index: 4.5300
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.4439
    Cell Significance Index: 5.5900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.3978
    Cell Significance Index: 9.6400
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.3228
    Cell Significance Index: 4.7100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2478
    Cell Significance Index: 47.1600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1258
    Cell Significance Index: 7.5500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0856
    Cell Significance Index: 1.4400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0837
    Cell Significance Index: 30.0100
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.0807
    Cell Significance Index: 0.7900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0592
    Cell Significance Index: 36.9700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0536
    Cell Significance Index: 5.8300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0502
    Cell Significance Index: 45.3400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0343
    Cell Significance Index: 18.7400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0325
    Cell Significance Index: 0.7500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0310
    Cell Significance Index: 5.0400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0307
    Cell Significance Index: 3.0400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0295
    Cell Significance Index: 0.3100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0287
    Cell Significance Index: 5.7500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0220
    Cell Significance Index: 0.5500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0181
    Cell Significance Index: 1.2500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0151
    Cell Significance Index: 9.5600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0144
    Cell Significance Index: 2.4600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0135
    Cell Significance Index: 25.4700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0125
    Cell Significance Index: 0.4400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0085
    Cell Significance Index: 1.2400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0071
    Cell Significance Index: 0.1100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0059
    Cell Significance Index: 0.1700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0034
    Cell Significance Index: 4.6200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0014
    Cell Significance Index: 2.2100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0005
    Cell Significance Index: -0.8800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0007
    Cell Significance Index: -0.0100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0018
    Cell Significance Index: -1.3700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0059
    Cell Significance Index: -0.6700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0062
    Cell Significance Index: -3.4700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0072
    Cell Significance Index: -0.8300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0102
    Cell Significance Index: -2.1400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0120
    Cell Significance Index: -9.0800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0133
    Cell Significance Index: -9.7700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0140
    Cell Significance Index: -1.8000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0153
    Cell Significance Index: -0.9400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0185
    Cell Significance Index: -8.3900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0215
    Cell Significance Index: -2.9500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0239
    Cell Significance Index: -6.8800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0269
    Cell Significance Index: -1.2200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0313
    Cell Significance Index: -0.6500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0357
    Cell Significance Index: -3.6500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0392
    Cell Significance Index: -0.5900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0439
    Cell Significance Index: -7.9200
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.0439
    Cell Significance Index: -0.4400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0556
    Cell Significance Index: -1.7800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0614
    Cell Significance Index: -0.8800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0665
    Cell Significance Index: -7.7600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0705
    Cell Significance Index: -8.6700
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0819
    Cell Significance Index: -1.0500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0843
    Cell Significance Index: -8.7800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0968
    Cell Significance Index: -5.9500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1061
    Cell Significance Index: -2.2600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1135
    Cell Significance Index: -7.6300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1195
    Cell Significance Index: -6.0400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1295
    Cell Significance Index: -3.3300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1330
    Cell Significance Index: -2.2800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1343
    Cell Significance Index: -10.0100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1523
    Cell Significance Index: -5.5900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1538
    Cell Significance Index: -8.6300
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.1557
    Cell Significance Index: -1.4300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1643
    Cell Significance Index: -3.4400
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.1676
    Cell Significance Index: -2.2600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1728
    Cell Significance Index: -9.0000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1730
    Cell Significance Index: -7.6500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1744
    Cell Significance Index: -9.0600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1912
    Cell Significance Index: -8.9900
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1926
    Cell Significance Index: -2.4300
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.2023
    Cell Significance Index: -2.1300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2052
    Cell Significance Index: -7.7700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2063
    Cell Significance Index: -9.6200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2070
    Cell Significance Index: -7.2500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2080
    Cell Significance Index: -6.8100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2112
    Cell Significance Index: -3.3500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2116
    Cell Significance Index: -6.7400
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.2141
    Cell Significance Index: -2.8000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2191
    Cell Significance Index: -4.6500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2482
    Cell Significance Index: -7.8500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2592
    Cell Significance Index: -3.0900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2597
    Cell Significance Index: -6.9600
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.2603
    Cell Significance Index: -3.6100
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.2651
    Cell Significance Index: -3.2000
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.2668
    Cell Significance Index: -2.7900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.2682
    Cell Significance Index: -4.4200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2755
    Cell Significance Index: -7.5000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The C6 protein is a membrane-bound glycoprotein that belongs to the C3 family of complement components. It is characterized by its ability to bind to the C3b fragment, facilitating the recruitment of factor Bb, which in turn activates the alternative pathway of the complement cascade. C6 is also known to be involved in the regulation of immune responses, including the positive regulation of the complement cascade and the killing of cells of another organism. One of the notable features of the C6 protein is its expression in various tissues, including the retina, where it is expressed in retinal bipolar neurons, cone cells, and Müller cells. This expression suggests a role for C6 in the development and maintenance of retinal function. In addition, C6 is also expressed in cardiac muscle cells, where it may play a role in the regulation of cardiac function and response to injury. **Pathways and Functions** The C6 protein is involved in several key pathways, including: 1. **Complement Activation**: C6 is a crucial component of the terminal pathway of the complement cascade, leading to the formation of the MAC. The MAC is a complex of proteins that inserts into the membrane of target cells, leading to their lysis and death. 2. **Innate Immune Response**: C6 is involved in the regulation of immune responses, including the positive regulation of the complement cascade and the killing of cells of another organism. 3. **Regulation of Complement Cascade**: C6 binds to the C3b fragment, facilitating the recruitment of factor Bb and activating the alternative pathway of the complement cascade. 4. **Extracellular Exosome**: C6 is also involved in the formation of extracellular exosomes, which are small vesicles that are secreted by cells and play a role in intercellular communication. **Clinical Significance** The dysregulation of the complement system, including the C6 gene, has been implicated in several diseases, including: 1. **Complement-Mediated Nephropathy**: Dysregulation of the complement system has been implicated in the development of complement-mediated nephropathy, a condition characterized by the deposition of complement components in the kidneys. 2. **Neuropathic Pain**: The C6 gene has been implicated in the development of neuropathic pain, a condition characterized by chronic pain in the nervous system. 3. **Retinal Diseases**: The expression of C6 in the retina suggests a role for the C6 protein in the development and maintenance of retinal function. Dysregulation of the C6 gene may contribute to the development of retinal diseases, including age-related macular degeneration. In conclusion, the C6 gene plays a crucial role in the regulation of the complement system and is involved in multiple physiological processes, including the development and maintenance of retinal function. The dysregulation of the C6 gene has been implicated in several diseases, highlighting the importance of this gene in human health and disease.

Genular Protein ID: 1264888191

Symbol: CO6_HUMAN

Name: Complement component C6

UniProtKB Accession Codes:

P13671

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 CarbonylDB 1 ChiTaRS 1 ComplexPortal 2 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 EMDB 8 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 14 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 11 PIR 1 PRINTS 1 PRO 1 PROSITE 8 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMART 5 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2808363

Title: Complete primary structure and functional characterization of the sixth component of the human complement system. Identification of the C5b-binding domain in complement C6.

PubMed ID: 2808363

DOI: 10.1016/s0021-9258(19)84676-8

PubMed ID: 2789218

Title: The molecular architecture of human complement component C6.

PubMed ID: 2789218

DOI: 10.1016/s0021-9258(18)71607-4

PubMed ID: 8512929

Title: Structure of the human C6 gene.

PubMed ID: 8512929

DOI: 10.1021/bi00075a012

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2468158

Title: Structural homology of complement protein C6 with other channel-forming proteins of complement.

PubMed ID: 2468158

DOI: 10.1073/pnas.86.8.2799

PubMed ID: 9366265

Title: Elucidation of the disulfide-bonding pattern in the factor I modules of the sixth component (C6) of human complement.

PubMed ID: 9366265

DOI: 10.1016/s0167-4838(97)00072-1

PubMed ID: 10551839

Title: The four terminal components of the complement system are C-mannosylated on multiple tryptophan residues.

PubMed ID: 10551839

DOI: 10.1074/jbc.274.46.32786

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 22267737

Title: Structure of complement C6 suggests a mechanism for initiation and unidirectional, sequential assembly of membrane attack complex (MAC).

PubMed ID: 22267737

DOI: 10.1074/jbc.m111.327809

PubMed ID: 8101442

Title: Polymorphism of human complement component C6: an amino acid substitution (Glu/Ala) within the second thrombospondin repeat differentiates between the two common allotypes C6 A and C6 B.

PubMed ID: 8101442

DOI: 10.1006/bbrc.1993.1841

PubMed ID: 15565285

Title: Meningococccal meningitis and complement component 6 deficiency associated with oculocutaneous albinism.

PubMed ID: 15565285

DOI: 10.1007/s00431-004-1582-y

Sequence Information:

  • Length: 934
  • Mass: 104786
  • Checksum: A88F4BED7CC349D3
  • Sequence:
    • MARRSVLYFI LLNALINKGQ ACFCDHYAWT QWTSCSKTCN SGTQSRHRQI VVDKYYQENF 
CEQICSKQET RECNWQRCPI NCLLGDFGPW SDCDPCIEKQ SKVRSVLRPS QFGGQPCTAP 
LVAFQPCIPS KLCKIEEADC KNKFRCDSGR CIARKLECNG ENDCGDNSDE RDCGRTKAVC 
TRKYNPIPSV QLMGNGFHFL AGEPRGEVLD NSFTGGICKT VKSSRTSNPY RVPANLENVG 
FEVQTAEDDL KTDFYKDLTS LGHNENQQGS FSSQGGSSFS VPIFYSSKRS ENINHNSAFK 
QAIQASHKKD SSFIRIHKVM KVLNFTTKAK DLHLSDVFLK ALNHLPLEYN SALYSRIFDD 
FGTHYFTSGS LGGVYDLLYQ FSSEELKNSG LTEEEAKHCV RIETKKRVLF AKKTKVEHRC 
TTNKLSEKHE GSFIQGAEKS ISLIRGGRSE YGAALAWEKG SSGLEEKTFS EWLESVKENP 
AVIDFELAPI VDLVRNIPCA VTKRNNLRKA LQEYAAKFDP CQCAPCPNNG RPTLSGTECL 
CVCQSGTYGE NCEKQSPDYK SNAVDGQWGC WSSWSTCDAT YKRSRTRECN NPAPQRGGKR 
CEGEKRQEED CTFSIMENNG QPCINDDEEM KEVDLPEIEA DSGCPQPVPP ENGFIRNEKQ 
LYLVGEDVEI SCLTGFETVG YQYFRCLPDG TWRQGDVECQ RTECIKPVVQ EVLTITPFQR 
LYRIGESIEL TCPKGFVVAG PSRYTCQGNS WTPPISNSLT CEKDTLTKLK GHCQLGQKQS 
GSECICMSPE EDCSHHSEDL CVFDTDSNDY FTSPACKFLA EKCLNNQQLH FLHIGSCQDG 
RQLEWGLERT RLSSNSTKKE SCGYDTCYDW EKCSASTSKC VCLLPPQCFK GGNQLYCVKM 
GSSTSEKTLN ICEVGTIRCA NRKMEILHPG KCLA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.