Details for: C7

Gene ID: 730

Symbol: C7

Ensembl ID: ENSG00000112936

Description: complement C7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 39.7531
    Cell Significance Index: -16.1500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 37.2361
    Cell Significance Index: -17.5800
  • Cell Name: theca cell (CL0000503)
    Fold Change: 19.5863
    Cell Significance Index: 115.0700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 16.8841
    Cell Significance Index: -16.1200
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 13.4780
    Cell Significance Index: 83.3900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 10.5574
    Cell Significance Index: 135.2100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 6.2346
    Cell Significance Index: 89.5300
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 5.9533
    Cell Significance Index: 29.7000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 5.3795
    Cell Significance Index: 144.1500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 4.8384
    Cell Significance Index: 296.6400
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 3.5003
    Cell Significance Index: 39.1200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 3.4603
    Cell Significance Index: 73.9700
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 2.9779
    Cell Significance Index: 10.3600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 2.8001
    Cell Significance Index: 54.6500
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 2.2434
    Cell Significance Index: 13.2500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1659
    Cell Significance Index: 115.3400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 1.0605
    Cell Significance Index: 53.6000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8439
    Cell Significance Index: 761.9800
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 0.7535
    Cell Significance Index: 3.3400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6677
    Cell Significance Index: 72.6300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6240
    Cell Significance Index: 37.4600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6058
    Cell Significance Index: 98.5200
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.5638
    Cell Significance Index: 7.1000
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.4440
    Cell Significance Index: 3.5100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3946
    Cell Significance Index: 50.5900
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.3780
    Cell Significance Index: 1.8000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3428
    Cell Significance Index: 23.7100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2972
    Cell Significance Index: 22.8100
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.2909
    Cell Significance Index: 2.7700
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.2794
    Cell Significance Index: 3.0500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2712
    Cell Significance Index: 51.6200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2532
    Cell Significance Index: 45.6500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.2060
    Cell Significance Index: 4.9900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1524
    Cell Significance Index: 4.3700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.1486
    Cell Significance Index: 2.2400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1050
    Cell Significance Index: 5.4700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0785
    Cell Significance Index: 15.5800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0609
    Cell Significance Index: 8.3700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0448
    Cell Significance Index: 28.0000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0125
    Cell Significance Index: 0.3600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0097
    Cell Significance Index: 0.1500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.0042
    Cell Significance Index: 0.0600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0011
    Cell Significance Index: -0.0400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0058
    Cell Significance Index: -4.2800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0059
    Cell Significance Index: -11.1200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0090
    Cell Significance Index: -0.1500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0092
    Cell Significance Index: -0.2000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0105
    Cell Significance Index: -19.4300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0144
    Cell Significance Index: -22.1700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0162
    Cell Significance Index: -9.1200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0174
    Cell Significance Index: -23.6100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0193
    Cell Significance Index: -14.6200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0225
    Cell Significance Index: -1.0200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0234
    Cell Significance Index: -14.8800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0242
    Cell Significance Index: -4.1300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0244
    Cell Significance Index: -17.9000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0349
    Cell Significance Index: -19.0700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0357
    Cell Significance Index: -16.2200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0430
    Cell Significance Index: -9.0600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0446
    Cell Significance Index: -16.0000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0485
    Cell Significance Index: -0.8000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0516
    Cell Significance Index: -1.0800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0560
    Cell Significance Index: -0.4700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0603
    Cell Significance Index: -17.3600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0637
    Cell Significance Index: -2.0400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0664
    Cell Significance Index: -7.7400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0747
    Cell Significance Index: -1.5500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0823
    Cell Significance Index: -16.5000
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: -0.0833
    Cell Significance Index: -0.7100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0849
    Cell Significance Index: -10.4400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0925
    Cell Significance Index: -9.4500
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0960
    Cell Significance Index: -1.5400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1044
    Cell Significance Index: -15.1700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1045
    Cell Significance Index: -2.2300
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.1076
    Cell Significance Index: -1.2500
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.1224
    Cell Significance Index: -1.1800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1259
    Cell Significance Index: -14.3700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1435
    Cell Significance Index: -18.5400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1582
    Cell Significance Index: -18.1200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1690
    Cell Significance Index: -1.9200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1781
    Cell Significance Index: -18.5400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2008
    Cell Significance Index: -5.0200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2275
    Cell Significance Index: -18.0200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2304
    Cell Significance Index: -6.4400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2369
    Cell Significance Index: -6.2300
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.2389
    Cell Significance Index: -2.8400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2411
    Cell Significance Index: -17.9700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2560
    Cell Significance Index: -6.5800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2756
    Cell Significance Index: -18.5300
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.2927
    Cell Significance Index: -3.6200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3166
    Cell Significance Index: -19.4600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3277
    Cell Significance Index: -18.3900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3449
    Cell Significance Index: -16.2100
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.3635
    Cell Significance Index: -3.7500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3657
    Cell Significance Index: -19.2000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3714
    Cell Significance Index: -9.9400
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.3750
    Cell Significance Index: -5.2600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3856
    Cell Significance Index: -17.9800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3874
    Cell Significance Index: -5.7200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3942
    Cell Significance Index: -20.4800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Structure**: Complement C7 is a single-chain protein with a molecular weight of approximately 70 kDa. It consists of a prodomain, a collagen-like domain, and a globular domain. 2. **Function**: C7 is essential for the formation of the MAC, which is composed of five proteins: C5b, C6, C7, C8, and C9. The MAC assembles on the surface of target cells, creating a pore that leads to cell lysis. 3. **Expression**: C7 is expressed in various tissues, including the kidney, lung, adrenal gland, and prostate, as well as in immune cells, such as macrophages and neutrophils. 4. **Regulation**: The expression of C7 is regulated by various factors, including the complement system itself, cytokines, and immune cells. **Pathways and Functions** 1. **Complement Activation**: C7 is activated during the classical, alternative, and lectin pathways of the complement system. This activation leads to the formation of the MAC, which disrupts and kills pathogen-infected cells. 2. **Membrane Attack Complex**: C7 is essential for the formation of the MAC, which assembles on the surface of target cells, creating a pore that leads to cell lysis. 3. **Immune Response**: C7 plays a crucial role in the regulation of the immune response, including the activation of immune cells and the clearance of pathogens. 4. **Antibody-Dependent Complement Activation**: C7 is also involved in antibody-dependent complement activation, where antibodies bind to pathogens, leading to the activation of the complement system and the formation of the MAC. **Clinical Significance** 1. **Systemic Lupus Erythematosus (SLE)**: Dysregulation of the complement system, including C7, has been implicated in the pathogenesis of SLE. 2. **Multiple Sclerosis (MS)**: C7 has been shown to be involved in the pathogenesis of MS, where it contributes to the formation of the MAC and the disruption of the blood-brain barrier. 3. **Neonatal Sepsis**: C7 has been identified as a potential biomarker for neonatal sepsis, where it is involved in the activation of the complement system and the formation of the MAC. 4. **Cancer**: C7 has been implicated in the progression of certain types of cancer, where it contributes to the disruption of the blood-brain barrier and the formation of metastases. In conclusion, Complement C7 is a crucial component of the complement system, essential for the formation of the MAC and the regulation of the immune response. Its dysregulation has been implicated in several diseases, including SLE, MS, neonatal sepsis, and cancer, highlighting the importance of further research into the role of C7 in human disease.

Genular Protein ID: 3289066210

Symbol: CO7_HUMAN

Name: Complement component C7

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 3335508

Title: The structure of human complement component C7 and the C5b-7 complex.

PubMed ID: 3335508

DOI: 10.1016/s0021-9258(19)57427-0

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7730625

Title: Structure of the human C7 gene and comparison with the C6, C8A, C8B and C9 genes.

PubMed ID: 7730625

PubMed ID: 10551839

Title: The four terminal components of the complement system are C-mannosylated on multiple tryptophan residues.

PubMed ID: 10551839

DOI: 10.1074/jbc.274.46.32786

PubMed ID: 14760718

Title: Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.

PubMed ID: 14760718

DOI: 10.1002/pmic.200300556

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19139490

Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.

PubMed ID: 19139490

DOI: 10.1074/mcp.m800504-mcp200

PubMed ID: 22171320

Title: Human urinary glycoproteomics; attachment site specific analysis of N- and O-linked glycosylations by CID and ECD.

PubMed ID: 22171320

DOI: 10.1074/mcp.m111.013649

PubMed ID: 19419965

Title: Solution structure of factor I-like modules from complement C7 reveals a pair of follistatin domains in compact pseudosymmetric arrangement.

PubMed ID: 19419965

DOI: 10.1074/jbc.m901993200

PubMed ID: 8871666

Title: Molecular bases of combined subtotal deficiencies of C6 and C7: their effects in combination with other C6 and C7 deficiencies.

PubMed ID: 8871666

PubMed ID: 9218625

Title: Molecular bases of C7 deficiency: three different defects.

PubMed ID: 9218625

PubMed ID: 9856499

Title: Complement C7 deficiency: seven further molecular defects and their associated marker haplotypes.

PubMed ID: 9856499

DOI: 10.1007/s004390050859

PubMed ID: 22028381

Title: Quantitative detection of single amino acid polymorphisms by targeted proteomics.

PubMed ID: 22028381

DOI: 10.1093/jmcb/mjr024

Sequence Information:

  • Length: 843
  • Mass: 93518
  • Checksum: DBD5D7C92DF71FA5
  • Sequence:
  • MKVISLFILV GFIGEFQSFS SASSPVNCQW DFYAPWSECN GCTKTQTRRR SVAVYGQYGG 
    QPCVGNAFET QSCEPTRGCP TEEGCGERFR CFSGQCISKS LVCNGDSDCD EDSADEDRCE 
    DSERRPSCDI DKPPPNIELT GNGYNELTGQ FRNRVINTKS FGGQCRKVFS GDGKDFYRLS 
    GNVLSYTFQV KINNDFNYEF YNSTWSYVKH TSTEHTSSSR KRSFFRSSSS SSRSYTSHTN 
    EIHKGKSYQL LVVENTVEVA QFINNNPEFL QLAEPFWKEL SHLPSLYDYS AYRRLIDQYG 
    THYLQSGSLG GEYRVLFYVD SEKLKQNDFN SVEEKKCKSS GWHFVVKFSS HGCKELENAL 
    KAASGTQNNV LRGEPFIRGG GAGFISGLSY LELDNPAGNK RRYSAWAESV TNLPQVIKQK 
    LTPLYELVKE VPCASVKKLY LKWALEEYLD EFDPCHCRPC QNGGLATVEG THCLCHCKPY 
    TFGAACEQGV LVGNQAGGVD GGWSCWSSWS PCVQGKKTRS RECNNPPPSG GGRSCVGETT 
    ESTQCEDEEL EHLRLLEPHC FPLSLVPTEF CPSPPALKDG FVQDEGTMFP VGKNVVYTCN 
    EGYSLIGNPV ARCGEDLRWL VGEMHCQKIA CVLPVLMDGI QSHPQKPFYT VGEKVTVSCS 
    GGMSLEGPSA FLCGSSLKWS PEMKNARCVQ KENPLTQAVP KCQRWEKLQN SRCVCKMPYE 
    CGPSLDVCAQ DERSKRILPL TVCKMHVLHC QGRNYTLTGR DSCTLPASAE KACGACPLWG 
    KCDAESSKCV CREASECEEE GFSICVEVNG KEQTMSECEA GALRCRGQSI SVTSIRPCAA 
    ETQ

Genular Protein ID: 784520377

Symbol: Q05CI3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 343
  • Mass: 39168
  • Checksum: 466484955D295E72
  • Sequence:
  • MKVISLFILV GFIGEFQSFS SASSPVNCQW DFYAPWSECN GCTKTQTRRR SVAVYGQYGG 
    QPCVGNAFET QSCEPTRGCP TEEGCGERFR CFSGQCISKS LVCNGDSDCD EDSADEDRCE 
    DSERRPSCDI DKPPPNIELT GNGYNELTGQ FRNRVINTKS FGGQCRKVFS GDGKDFYRLS 
    GNVLSYTFQV KINNDFNYEF YNSTWSYVKH TSTEHTSSSR KRSFFRSSSS SSRSYTSHTN 
    EIHKGKSYQL LVVENTVEVA QFINNNPEFL QLAEPFWKEL SHLPSLYDYS AYRRLIDQYG 
    THYLQSGSLG GEYRVLFYVD SEKLKQNDFN SVEKKKKKKK KKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.