Details for: C7

Gene ID: 730

Symbol: C7

Ensembl ID: ENSG00000112936

Description: complement C7

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 3.43
    Marker Score: 6,604
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 3.41
    Marker Score: 1,899
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.3
    Marker Score: 2,815
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 3.28
    Marker Score: 1,855
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.86
    Marker Score: 7,476
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.82
    Marker Score: 50,008
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.8
    Marker Score: 2,006
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.59
    Marker Score: 16,875
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 2.17
    Marker Score: 2,334
  • Cell Name: fat cell (CL0000136)
    Fold Change: 2.07
    Marker Score: 1,155
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.05
    Marker Score: 853
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.91
    Marker Score: 2,944
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.8
    Marker Score: 1,134
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.73
    Marker Score: 1,987
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.61
    Marker Score: 342
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.58
    Marker Score: 411
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 169,144
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.38
    Marker Score: 303
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.37
    Marker Score: 340
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.35
    Marker Score: 340
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.35
    Marker Score: 858
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 1.35
    Marker Score: 301
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.26
    Marker Score: 302
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,801
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,025
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,407
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.98
    Marker Score: 1,047
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 499
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 452
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.95
    Marker Score: 1,183
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,412
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.95
    Marker Score: 12,581
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,281
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.91
    Marker Score: 366
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,733
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 319
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.88
    Marker Score: 835
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,280
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.85
    Marker Score: 322
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.8
    Marker Score: 185
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.79
    Marker Score: 4,775
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.79
    Marker Score: 430
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.79
    Marker Score: 714
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.78
    Marker Score: 824
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1,248
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.76
    Marker Score: 187
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.75
    Marker Score: 11,780
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 389
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.75
    Marker Score: 205
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.74
    Marker Score: 568
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.74
    Marker Score: 718
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.74
    Marker Score: 1,080
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.73
    Marker Score: 669
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2,972
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.7
    Marker Score: 271
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.64
    Marker Score: 168
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.62
    Marker Score: 164
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.61
    Marker Score: 1,238
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.58
    Marker Score: 284
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.58
    Marker Score: 387
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 145
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 436
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.54
    Marker Score: 259
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.53
    Marker Score: 194
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.5
    Marker Score: 684
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 0.47
    Marker Score: 195
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.44
    Marker Score: 265
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.44
    Marker Score: 613
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.43
    Marker Score: 389
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.42
    Marker Score: 1,505
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.42
    Marker Score: 14,374
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.42
    Marker Score: 453
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.42
    Marker Score: 418
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.41
    Marker Score: 107
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.41
    Marker Score: 291
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.4
    Marker Score: 5,255
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.4
    Marker Score: 126
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 0.39
    Marker Score: 130
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.39
    Marker Score: 258
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.39
    Marker Score: 110
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.39
    Marker Score: 124
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.38
    Marker Score: 260
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.38
    Marker Score: 131
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.37
    Marker Score: 184
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.36
    Marker Score: 8,144
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.36
    Marker Score: 364
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.36
    Marker Score: 182
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.36
    Marker Score: 422
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.36
    Marker Score: 150
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.36
    Marker Score: 492
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.36
    Marker Score: 2,107
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 0.33
    Marker Score: 82
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.33
    Marker Score: 111
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.33
    Marker Score: 119
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.32
    Marker Score: 551
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.32
    Marker Score: 272
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.31
    Marker Score: 311
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.31
    Marker Score: 1,288
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3
    Marker Score: 194

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Structure**: Complement C7 is a single-chain protein with a molecular weight of approximately 70 kDa. It consists of a prodomain, a collagen-like domain, and a globular domain. 2. **Function**: C7 is essential for the formation of the MAC, which is composed of five proteins: C5b, C6, C7, C8, and C9. The MAC assembles on the surface of target cells, creating a pore that leads to cell lysis. 3. **Expression**: C7 is expressed in various tissues, including the kidney, lung, adrenal gland, and prostate, as well as in immune cells, such as macrophages and neutrophils. 4. **Regulation**: The expression of C7 is regulated by various factors, including the complement system itself, cytokines, and immune cells. **Pathways and Functions** 1. **Complement Activation**: C7 is activated during the classical, alternative, and lectin pathways of the complement system. This activation leads to the formation of the MAC, which disrupts and kills pathogen-infected cells. 2. **Membrane Attack Complex**: C7 is essential for the formation of the MAC, which assembles on the surface of target cells, creating a pore that leads to cell lysis. 3. **Immune Response**: C7 plays a crucial role in the regulation of the immune response, including the activation of immune cells and the clearance of pathogens. 4. **Antibody-Dependent Complement Activation**: C7 is also involved in antibody-dependent complement activation, where antibodies bind to pathogens, leading to the activation of the complement system and the formation of the MAC. **Clinical Significance** 1. **Systemic Lupus Erythematosus (SLE)**: Dysregulation of the complement system, including C7, has been implicated in the pathogenesis of SLE. 2. **Multiple Sclerosis (MS)**: C7 has been shown to be involved in the pathogenesis of MS, where it contributes to the formation of the MAC and the disruption of the blood-brain barrier. 3. **Neonatal Sepsis**: C7 has been identified as a potential biomarker for neonatal sepsis, where it is involved in the activation of the complement system and the formation of the MAC. 4. **Cancer**: C7 has been implicated in the progression of certain types of cancer, where it contributes to the disruption of the blood-brain barrier and the formation of metastases. In conclusion, Complement C7 is a crucial component of the complement system, essential for the formation of the MAC and the regulation of the immune response. Its dysregulation has been implicated in several diseases, including SLE, MS, neonatal sepsis, and cancer, highlighting the importance of further research into the role of C7 in human disease.

Genular Protein ID: 3289066210

Symbol: CO7_HUMAN

Name: Complement component C7

UniProtKB Accession Codes:

P10643 A8K2T4 Q6P3T5 Q92489

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CPTAC 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 20 EMDB 9 Ensembl 2 EvolutionaryTrace 1 GO 10 Gene3D 4 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 14 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 8 PIR 1 PRINTS 2 PRO 1 PROSITE 8 PROSITE-ProRule 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 7 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SAM 1 SIGNOR 1 SMART 5 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3335508

Title: The structure of human complement component C7 and the C5b-7 complex.

PubMed ID: 3335508

DOI: 10.1016/s0021-9258(19)57427-0

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7730625

Title: Structure of the human C7 gene and comparison with the C6, C8A, C8B and C9 genes.

PubMed ID: 7730625

PubMed ID: 10551839

Title: The four terminal components of the complement system are C-mannosylated on multiple tryptophan residues.

PubMed ID: 10551839

DOI: 10.1074/jbc.274.46.32786

PubMed ID: 14760718

Title: Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.

PubMed ID: 14760718

DOI: 10.1002/pmic.200300556

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19139490

Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.

PubMed ID: 19139490

DOI: 10.1074/mcp.m800504-mcp200

PubMed ID: 22171320

Title: Human urinary glycoproteomics; attachment site specific analysis of N- and O-linked glycosylations by CID and ECD.

PubMed ID: 22171320

DOI: 10.1074/mcp.m111.013649

PubMed ID: 19419965

Title: Solution structure of factor I-like modules from complement C7 reveals a pair of follistatin domains in compact pseudosymmetric arrangement.

PubMed ID: 19419965

DOI: 10.1074/jbc.m901993200

PubMed ID: 8871666

Title: Molecular bases of combined subtotal deficiencies of C6 and C7: their effects in combination with other C6 and C7 deficiencies.

PubMed ID: 8871666

PubMed ID: 9218625

Title: Molecular bases of C7 deficiency: three different defects.

PubMed ID: 9218625

PubMed ID: 9856499

Title: Complement C7 deficiency: seven further molecular defects and their associated marker haplotypes.

PubMed ID: 9856499

DOI: 10.1007/s004390050859

PubMed ID: 22028381

Title: Quantitative detection of single amino acid polymorphisms by targeted proteomics.

PubMed ID: 22028381

DOI: 10.1093/jmcb/mjr024

Sequence Information:

  • Length: 843
  • Mass: 93518
  • Checksum: DBD5D7C92DF71FA5
  • Sequence:
    • MKVISLFILV GFIGEFQSFS SASSPVNCQW DFYAPWSECN GCTKTQTRRR SVAVYGQYGG 
QPCVGNAFET QSCEPTRGCP TEEGCGERFR CFSGQCISKS LVCNGDSDCD EDSADEDRCE 
DSERRPSCDI DKPPPNIELT GNGYNELTGQ FRNRVINTKS FGGQCRKVFS GDGKDFYRLS 
GNVLSYTFQV KINNDFNYEF YNSTWSYVKH TSTEHTSSSR KRSFFRSSSS SSRSYTSHTN 
EIHKGKSYQL LVVENTVEVA QFINNNPEFL QLAEPFWKEL SHLPSLYDYS AYRRLIDQYG 
THYLQSGSLG GEYRVLFYVD SEKLKQNDFN SVEEKKCKSS GWHFVVKFSS HGCKELENAL 
KAASGTQNNV LRGEPFIRGG GAGFISGLSY LELDNPAGNK RRYSAWAESV TNLPQVIKQK 
LTPLYELVKE VPCASVKKLY LKWALEEYLD EFDPCHCRPC QNGGLATVEG THCLCHCKPY 
TFGAACEQGV LVGNQAGGVD GGWSCWSSWS PCVQGKKTRS RECNNPPPSG GGRSCVGETT 
ESTQCEDEEL EHLRLLEPHC FPLSLVPTEF CPSPPALKDG FVQDEGTMFP VGKNVVYTCN 
EGYSLIGNPV ARCGEDLRWL VGEMHCQKIA CVLPVLMDGI QSHPQKPFYT VGEKVTVSCS 
GGMSLEGPSA FLCGSSLKWS PEMKNARCVQ KENPLTQAVP KCQRWEKLQN SRCVCKMPYE 
CGPSLDVCAQ DERSKRILPL TVCKMHVLHC QGRNYTLTGR DSCTLPASAE KACGACPLWG 
KCDAESSKCV CREASECEEE GFSICVEVNG KEQTMSECEA GALRCRGQSI SVTSIRPCAA 
ETQ

Genular Protein ID: 784520377

Symbol: Q05CI3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q05CI3 D6R8Y6

Database IDs:

ARBA 11 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 5 Gene3D 2 Genevisible 1 GenomeRNAi 1 InterPro 8 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 6 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 ProteomicsDB 1 RefSeq 1 SAM 2 SMART 2 SUPFAM 2

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 343
  • Mass: 39168
  • Checksum: 466484955D295E72
  • Sequence:
    • MKVISLFILV GFIGEFQSFS SASSPVNCQW DFYAPWSECN GCTKTQTRRR SVAVYGQYGG 
QPCVGNAFET QSCEPTRGCP TEEGCGERFR CFSGQCISKS LVCNGDSDCD EDSADEDRCE 
DSERRPSCDI DKPPPNIELT GNGYNELTGQ FRNRVINTKS FGGQCRKVFS GDGKDFYRLS 
GNVLSYTFQV KINNDFNYEF YNSTWSYVKH TSTEHTSSSR KRSFFRSSSS SSRSYTSHTN 
EIHKGKSYQL LVVENTVEVA QFINNNPEFL QLAEPFWKEL SHLPSLYDYS AYRRLIDQYG 
THYLQSGSLG GEYRVLFYVD SEKLKQNDFN SVEKKKKKKK KKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.