Details for: C8A

Gene ID: 731

Symbol: C8A

Ensembl ID: ENSG00000157131

Description: complement C8 alpha chain

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: plasmablast (CL0000980)
    Fold Change: 3.0046
    Cell Significance Index: 27.8900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 2.7293
    Cell Significance Index: 45.9800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.5494
    Cell Significance Index: 37.5300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.3071
    Cell Significance Index: 259.3900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1006
    Cell Significance Index: 35.2500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.6974
    Cell Significance Index: 11.7300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.6355
    Cell Significance Index: 9.3800
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.6160
    Cell Significance Index: 2.3200
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.5616
    Cell Significance Index: 8.1900
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.4154
    Cell Significance Index: 4.1100
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 0.4132
    Cell Significance Index: 1.0900
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.3360
    Cell Significance Index: 1.9400
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.3269
    Cell Significance Index: 2.7900
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.3074
    Cell Significance Index: 5.2600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1761
    Cell Significance Index: 10.5700
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.1444
    Cell Significance Index: 1.4300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1376
    Cell Significance Index: 22.3900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1075
    Cell Significance Index: 2.2300
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.1070
    Cell Significance Index: 0.8500
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 0.1064
    Cell Significance Index: 0.2900
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.1062
    Cell Significance Index: 0.8600
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.1041
    Cell Significance Index: 0.9900
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.1028
    Cell Significance Index: 0.7900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0836
    Cell Significance Index: 2.4100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0611
    Cell Significance Index: 6.0400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.0390
    Cell Significance Index: 1.1500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0373
    Cell Significance Index: 1.0000
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0324
    Cell Significance Index: 0.4100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0245
    Cell Significance Index: 2.6700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0200
    Cell Significance Index: 0.5000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.0176
    Cell Significance Index: 0.2900
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.0155
    Cell Significance Index: 0.1600
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.0111
    Cell Significance Index: 0.1400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0106
    Cell Significance Index: 0.7400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0065
    Cell Significance Index: 1.2300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0049
    Cell Significance Index: 0.0700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0027
    Cell Significance Index: 0.3200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0018
    Cell Significance Index: 0.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0011
    Cell Significance Index: 0.2200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0009
    Cell Significance Index: 0.3200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0001
    Cell Significance Index: -0.0200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0001
    Cell Significance Index: -0.1000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0002
    Cell Significance Index: -0.3600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0002
    Cell Significance Index: -0.3800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0003
    Cell Significance Index: -0.4600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0004
    Cell Significance Index: -0.2700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0006
    Cell Significance Index: -0.3200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0009
    Cell Significance Index: -0.6800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0010
    Cell Significance Index: -0.5300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0013
    Cell Significance Index: -0.2200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0020
    Cell Significance Index: -1.2800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0021
    Cell Significance Index: -0.9500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0021
    Cell Significance Index: -0.4400
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0029
    Cell Significance Index: -0.0400
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0031
    Cell Significance Index: -0.0400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0031
    Cell Significance Index: -0.1500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0040
    Cell Significance Index: -0.7300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0046
    Cell Significance Index: -0.0700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0057
    Cell Significance Index: -0.2600
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0062
    Cell Significance Index: -0.0900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0066
    Cell Significance Index: -0.7600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0068
    Cell Significance Index: -0.0700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0069
    Cell Significance Index: -0.7200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0074
    Cell Significance Index: -1.0800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0075
    Cell Significance Index: -0.4600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0077
    Cell Significance Index: -0.5200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0083
    Cell Significance Index: -0.1800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0088
    Cell Significance Index: -0.1200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0089
    Cell Significance Index: -0.4600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0104
    Cell Significance Index: -1.2800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0113
    Cell Significance Index: -0.5700
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0128
    Cell Significance Index: -0.1700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0137
    Cell Significance Index: -0.8400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0138
    Cell Significance Index: -0.3500
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0140
    Cell Significance Index: -0.2100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0142
    Cell Significance Index: -0.5000
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0150
    Cell Significance Index: -0.1500
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.0158
    Cell Significance Index: -0.1500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0161
    Cell Significance Index: -0.7100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0162
    Cell Significance Index: -0.6600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0164
    Cell Significance Index: -0.3200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0164
    Cell Significance Index: -0.9200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0166
    Cell Significance Index: -0.5800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0168
    Cell Significance Index: -0.5300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0168
    Cell Significance Index: -0.4700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0176
    Cell Significance Index: -0.5600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0177
    Cell Significance Index: -1.4000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0177
    Cell Significance Index: -0.5800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0184
    Cell Significance Index: -0.7000
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: -0.0185
    Cell Significance Index: -0.2300
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: -0.0206
    Cell Significance Index: -0.2300
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0207
    Cell Significance Index: -0.2100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0216
    Cell Significance Index: -1.0200
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0221
    Cell Significance Index: -0.2500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0228
    Cell Significance Index: -0.6500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0235
    Cell Significance Index: -0.5900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0239
    Cell Significance Index: -0.6100
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0243
    Cell Significance Index: -0.2900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0254
    Cell Significance Index: -0.6200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0266
    Cell Significance Index: -0.5300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** C8A is a protein that belongs to the complement system, a group of proteins that work together to defend against infections. It is a key component of the terminal pathway of the complement cascade, which is activated in response to the presence of pathogens. C8A is characterized by its ability to form a stable complex with the C9 protein, which is necessary for the formation of the MAC. This complex is then inserted into the pathogen's membrane, creating pores that lead to cell lysis and death. **Pathways and Functions:** The complement C8 alpha chain is involved in several key pathways, including: 1. **Complement Activation:** C8A is activated by the binding of C3b to the C4b2a complex, which is the central component of the complement cascade. This binding triggers a series of reactions that lead to the activation of C8A. 2. **Alternative Pathway:** C8A is also involved in the alternative pathway of complement activation, which is activated in response to the presence of pathogens that are not recognized by the classical pathway. 3. **Classical Pathway:** C8A is also involved in the classical pathway of complement activation, which is activated in response to the presence of pathogens that are recognized by the immune system. 4. **Membrane Attack Complex Formation:** C8A is essential for the formation of the MAC, which is the terminal product of the complement cascade. The MAC is a complex of proteins that inserts into the pathogen's membrane, creating pores that lead to cell lysis and death. **Clinical Significance:** Dysregulation of the complement system, including the C8A gene, has been implicated in several diseases, including: 1. **Systemic Lupus Erythematosus (SLE):** C8A has been shown to be involved in the pathogenesis of SLE, a chronic autoimmune disease characterized by the production of autoantibodies. 2. **Complement Deficiency:** Deficiencies in the C8A gene can lead to impaired complement function, making individuals more susceptible to infections. 3. **Neurodegenerative Diseases:** Dysregulation of the complement system, including the C8A gene, has been implicated in several neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. In conclusion, the complement C8 alpha chain is a critical component of the innate immune system, playing a key role in the activation of the complement cascade and the formation of the membrane attack complex. Dysregulation of the C8A gene has been implicated in several diseases, highlighting the importance of this gene in maintaining immune homeostasis.

Genular Protein ID: 3426203482

Symbol: CO8A_HUMAN

Name: Complement component C8 alpha chain

UniProtKB Accession Codes:

P07357 A2RUI4 A2RUI5 Q13668 Q9H130

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 15 EMDB 9 Ensembl 1 EvolutionaryTrace 1 GO 15 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 11 PIR 1 PRINTS 2 PRO 1 PROSITE 6 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2820471

Title: Complementary DNA and derived amino acid sequence of the alpha subunit of human complement protein C8: evidence for the existence of a separate alpha subunit messenger RNA.

PubMed ID: 2820471

DOI: 10.1021/bi00386a046

PubMed ID: 7759071

Title: Genomic organization of human complement protein C8 alpha and further examination of its linkage to C8 beta.

PubMed ID: 7759071

DOI: 10.1007/bf00223862

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7440581

Title: The eighth component of human complement. Purification and physicochemical characterization of its unusual subunit structure.

PubMed ID: 7440581

DOI: 10.1016/s0021-9258(19)70233-6

PubMed ID: 10551839

Title: The four terminal components of the complement system are C-mannosylated on multiple tryptophan residues.

PubMed ID: 10551839

DOI: 10.1074/jbc.274.46.32786

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 17872444

Title: Structure of C8alpha-MACPF reveals mechanism of membrane attack in complement immune defense.

PubMed ID: 17872444

DOI: 10.1126/science.1147103

PubMed ID: 18440555

Title: Crystal structure of the MACPF domain of human complement protein C8 alpha in complex with the C8 gamma subunit.

PubMed ID: 18440555

DOI: 10.1016/j.jmb.2008.03.061

PubMed ID: 17692377

Title: Crystal structure of complement protein C8gamma in complex with a peptide containing the C8gamma binding site on C8alpha: implications for C8gamma ligand binding.

PubMed ID: 17692377

DOI: 10.1016/j.molimm.2007.06.359

PubMed ID: 7649542

Title: The eighth component of human complement: molecular basis of C8A (C81) polymorphism.

PubMed ID: 7649542

DOI: 10.1007/bf00210407

Sequence Information:

  • Length: 584
  • Mass: 65163
  • Checksum: 9F61DDA51D2F3BBA
  • Sequence:
    • MFAVVFFILS LMTCQPGVTA QEKVNQRVRR AATPAAVTCQ LSNWSEWTDC FPCQDKKYRH 
RSLLQPNKFG GTICSGDIWD QASCSSSTTC VRQAQCGQDF QCKETGRCLK RHLVCNGDQD 
CLDGSDEDDC EDVRAIDEDC SQYEPIPGSQ KAALGYNILT QEDAQSVYDA SYYGGQCETV 
YNGEWRELRY DSTCERLYYG DDEKYFRKPY NFLKYHFEAL ADTGISSEFY DNANDLLSKV 
KKDKSDSFGV TIGIGPAGSP LLVGVGVSHS QDTSFLNELN KYNEKKFIFT RIFTKVQTAH 
FKMRKDDIML DEGMLQSLME LPDQYNYGMY AKFINDYGTH YITSGSMGGI YEYILVIDKA 
KMESLGITSR DITTCFGGSL GIQYEDKINV GGGLSGDHCK KFGGGKTERA RKAMAVEDII 
SRVRGGSSGW SGGLAQNRST ITYRSWGRSL KYNPVVIDFE MQPIHEVLRH TSLGPLEAKR 
QNLRRALDQY LMEFNACRCG PCFNNGVPIL EGTSCRCQCR LGSLGAACEQ TQTEGAKADG 
SWSCWSSWSV CRAGIQERRR ECDNPAPQNG GASCPGRKVQ TQAC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.