Details for: C8A
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 2.14
Marker Score: 2,151 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 2.04
Marker Score: 10,993 - Cell Name: hepatoblast (CL0005026)
Fold Change: 1.88
Marker Score: 6,143 - Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 1.82
Marker Score: 3,772 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 1.79
Marker Score: 11,532 - Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 1.76
Marker Score: 7,605 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.62
Marker Score: 1,174 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.54
Marker Score: 1,534 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.27
Marker Score: 858 - Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 1.1
Marker Score: 582 - Cell Name: plasma cell (CL0000786)
Fold Change: 1.09
Marker Score: 1,221 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.06
Marker Score: 439 - Cell Name: hepatocyte (CL0000182)
Fold Change: 1.02
Marker Score: 697 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,832 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48,055 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1
Marker Score: 513 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.99
Marker Score: 466 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.98
Marker Score: 452 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,408 - Cell Name: pericyte (CL0000669)
Fold Change: 0.97
Marker Score: 569 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,412 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.94
Marker Score: 377 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5,352 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.92
Marker Score: 330 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2,743 - Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 0.9
Marker Score: 967 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,296 - Cell Name: mast cell (CL0000097)
Fold Change: 0.84
Marker Score: 489 - Cell Name: brush cell (CL0002204)
Fold Change: 0.78
Marker Score: 712 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1,266 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.77
Marker Score: 1,465 - Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.77
Marker Score: 400 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.73
Marker Score: 467 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.73
Marker Score: 3,058 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.72
Marker Score: 1,686 - Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.7
Marker Score: 715 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.67
Marker Score: 10,445 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.67
Marker Score: 1,356 - Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 444 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.56
Marker Score: 176 - Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.52
Marker Score: 187 - Cell Name: goblet cell (CL0000160)
Fold Change: 0.49
Marker Score: 3,288 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.47
Marker Score: 281 - Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 0.47
Marker Score: 177 - Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.44
Marker Score: 231 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.4
Marker Score: 243 - Cell Name: Kupffer cell (CL0000091)
Fold Change: 0.4
Marker Score: 404 - Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.39
Marker Score: 125 - Cell Name: inflammatory macrophage (CL0000863)
Fold Change: 0.38
Marker Score: 117 - Cell Name: cholangiocyte (CL1000488)
Fold Change: 0.33
Marker Score: 125 - Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.32
Marker Score: 153 - Cell Name: renal principal cell (CL0005009)
Fold Change: 0.31
Marker Score: 236 - Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
Fold Change: 0.25
Marker Score: 68 - Cell Name: enterocyte of colon (CL1000347)
Fold Change: 0.24
Marker Score: 369 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.24
Marker Score: 77 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.23
Marker Score: 65 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.22
Marker Score: 75 - Cell Name: mature NK T cell (CL0000814)
Fold Change: 0.21
Marker Score: 98 - Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.21
Marker Score: 88 - Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.2
Marker Score: 52 - Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.2
Marker Score: 88 - Cell Name: erythrocyte (CL0000232)
Fold Change: 0.18
Marker Score: 102 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.18
Marker Score: 56 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.17
Marker Score: 43 - Cell Name: erythroblast (CL0000765)
Fold Change: 0.15
Marker Score: 94 - Cell Name: smooth muscle cell (CL0000192)
Fold Change: 0.14
Marker Score: 92 - Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 0.12
Marker Score: 176 - Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.12
Marker Score: 69 - Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: 0.12
Marker Score: 73 - Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 0.11
Marker Score: 49 - Cell Name: podocyte (CL0000653)
Fold Change: 0.11
Marker Score: 39 - Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.1
Marker Score: 45 - Cell Name: endothelial cell (CL0000115)
Fold Change: 0.1
Marker Score: 88 - Cell Name: Unknown (CL0000003)
Fold Change: 0.09
Marker Score: 264 - Cell Name: B cell (CL0000236)
Fold Change: 0.08
Marker Score: 78 - Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 0.08
Marker Score: 60 - Cell Name: fibroblast (CL0000057)
Fold Change: 0.08
Marker Score: 76 - Cell Name: precursor B cell (CL0000817)
Fold Change: 0.08
Marker Score: 52 - Cell Name: macrophage (CL0000235)
Fold Change: 0.08
Marker Score: 86 - Cell Name: M cell of gut (CL0000682)
Fold Change: 0.07
Marker Score: 19 - Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 0.07
Marker Score: 61 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.07
Marker Score: 148 - Cell Name: type L enteroendocrine cell (CL0002279)
Fold Change: 0.07
Marker Score: 19 - Cell Name: double negative thymocyte (CL0002489)
Fold Change: 0.07
Marker Score: 96 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.07
Marker Score: 20 - Cell Name: T cell (CL0000084)
Fold Change: 0.07
Marker Score: 117 - Cell Name: mucus secreting cell (CL0000319)
Fold Change: 0.07
Marker Score: 17 - Cell Name: stromal cell (CL0000499)
Fold Change: 0.07
Marker Score: 78 - Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.07
Marker Score: 70 - Cell Name: myeloid cell (CL0000763)
Fold Change: 0.06
Marker Score: 103 - Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.06
Marker Score: 14 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.06
Marker Score: 15 - Cell Name: type I enteroendocrine cell (CL0002277)
Fold Change: 0.06
Marker Score: 15 - Cell Name: alveolar macrophage (CL0000583)
Fold Change: 0.06
Marker Score: 1,536 - Cell Name: ciliated cell (CL0000064)
Fold Change: 0.06
Marker Score: 192 - Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
Fold Change: 0.05
Marker Score: 12 - Cell Name: GIP cell (CL0002278)
Fold Change: 0.05
Marker Score: 17 - Cell Name: type D enteroendocrine cell (CL0000502)
Fold Change: 0.05
Marker Score: 16 - Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: 0.05
Marker Score: 19 - Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 0.05
Marker Score: 20
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3426203482
Symbol: CO8A_HUMAN
Name: Complement component C8 alpha chain
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2820471
Title: Complementary DNA and derived amino acid sequence of the alpha subunit of human complement protein C8: evidence for the existence of a separate alpha subunit messenger RNA.
PubMed ID: 2820471
DOI: 10.1021/bi00386a046
PubMed ID: 7759071
Title: Genomic organization of human complement protein C8 alpha and further examination of its linkage to C8 beta.
PubMed ID: 7759071
DOI: 10.1007/bf00223862
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 7440581
Title: The eighth component of human complement. Purification and physicochemical characterization of its unusual subunit structure.
PubMed ID: 7440581
PubMed ID: 10551839
Title: The four terminal components of the complement system are C-mannosylated on multiple tryptophan residues.
PubMed ID: 10551839
PubMed ID: 16335952
Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.
PubMed ID: 16335952
DOI: 10.1021/pr0502065
PubMed ID: 19159218
Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
PubMed ID: 19159218
DOI: 10.1021/pr8008012
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 17872444
Title: Structure of C8alpha-MACPF reveals mechanism of membrane attack in complement immune defense.
PubMed ID: 17872444
PubMed ID: 18440555
Title: Crystal structure of the MACPF domain of human complement protein C8 alpha in complex with the C8 gamma subunit.
PubMed ID: 18440555
PubMed ID: 17692377
Title: Crystal structure of complement protein C8gamma in complex with a peptide containing the C8gamma binding site on C8alpha: implications for C8gamma ligand binding.
PubMed ID: 17692377
PubMed ID: 7649542
Title: The eighth component of human complement: molecular basis of C8A (C81) polymorphism.
PubMed ID: 7649542
DOI: 10.1007/bf00210407
Sequence Information:
- Length: 584
- Mass: 65163
- Checksum: 9F61DDA51D2F3BBA
- Sequence:
MFAVVFFILS LMTCQPGVTA QEKVNQRVRR AATPAAVTCQ LSNWSEWTDC FPCQDKKYRH RSLLQPNKFG GTICSGDIWD QASCSSSTTC VRQAQCGQDF QCKETGRCLK RHLVCNGDQD CLDGSDEDDC EDVRAIDEDC SQYEPIPGSQ KAALGYNILT QEDAQSVYDA SYYGGQCETV YNGEWRELRY DSTCERLYYG DDEKYFRKPY NFLKYHFEAL ADTGISSEFY DNANDLLSKV KKDKSDSFGV TIGIGPAGSP LLVGVGVSHS QDTSFLNELN KYNEKKFIFT RIFTKVQTAH FKMRKDDIML DEGMLQSLME LPDQYNYGMY AKFINDYGTH YITSGSMGGI YEYILVIDKA KMESLGITSR DITTCFGGSL GIQYEDKINV GGGLSGDHCK KFGGGKTERA RKAMAVEDII SRVRGGSSGW SGGLAQNRST ITYRSWGRSL KYNPVVIDFE MQPIHEVLRH TSLGPLEAKR QNLRRALDQY LMEFNACRCG PCFNNGVPIL EGTSCRCQCR LGSLGAACEQ TQTEGAKADG SWSCWSSWSV CRAGIQERRR ECDNPAPQNG GASCPGRKVQ TQAC
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.