C8A | ENSG00000157131 | NCBI 731

Details for: C8A

Gene ID: 731

Symbol: C8A

Ensembl ID: ENSG00000157131

Description: complement C8 alpha chain

Associated with

Complement cascade
(R-HSA-166658)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Regulation of complement cascade
(R-HSA-977606)
Terminal pathway of complement
(R-HSA-166665)
Blood microparticle
(GO:0072562)
Complement activation
(GO:0006956)
Complement activation, alternative pathway
(GO:0006957)
Complement activation, classical pathway
(GO:0006958)
Complement binding
(GO:0001848)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Immune response
(GO:0006955)
Killing of cells of another organism
(GO:0031640)
Membrane
(GO:0016020)
Membrane attack complex
(GO:0005579)
Plasma membrane
(GO:0005886)
Positive regulation of immune response
(GO:0050778)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)

Other Information

Proteins

Complement component C8 alpha chain

Genular Protein ID: 3426203482

Symbol: CO8A_HUMAN

Name: Complement component C8 alpha chain

UniProtKB Accession Codes:

P07357 A2RUI4 A2RUI5 Q13668 Q9H130

Database IDs:

Citations:

PubMed ID: 2820471

Title: Complementary DNA and derived amino acid sequence of the alpha subunit of human complement protein C8: evidence for the existence of a separate alpha subunit messenger RNA.

PubMed ID: 2820471

DOI: 10.1021/bi00386a046

PubMed ID: 7759071

Title: Genomic organization of human complement protein C8 alpha and further examination of its linkage to C8 beta.

PubMed ID: 7759071

DOI: 10.1007/bf00223862

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7440581

Title: The eighth component of human complement. Purification and physicochemical characterization of its unusual subunit structure.

PubMed ID: 7440581

DOI: 10.1016/s0021-9258(19)70233-6

PubMed ID: 10551839

Title: The four terminal components of the complement system are C-mannosylated on multiple tryptophan residues.

PubMed ID: 10551839

DOI: 10.1074/jbc.274.46.32786

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 17872444

Title: Structure of C8alpha-MACPF reveals mechanism of membrane attack in complement immune defense.

PubMed ID: 17872444

DOI: 10.1126/science.1147103

PubMed ID: 18440555

Title: Crystal structure of the MACPF domain of human complement protein C8 alpha in complex with the C8 gamma subunit.

PubMed ID: 18440555

DOI: 10.1016/j.jmb.2008.03.061

PubMed ID: 17692377

Title: Crystal structure of complement protein C8gamma in complex with a peptide containing the C8gamma binding site on C8alpha: implications for C8gamma ligand binding.

PubMed ID: 17692377

DOI: 10.1016/j.molimm.2007.06.359

PubMed ID: 7649542

Title: The eighth component of human complement: molecular basis of C8A (C81) polymorphism.

PubMed ID: 7649542

DOI: 10.1007/bf00210407

Sequence Information:

Length: 584
Mass: 65163
Checksum: 9F61DDA51D2F3BBA
Sequence:

MFAVVFFILS LMTCQPGVTA QEKVNQRVRR AATPAAVTCQ LSNWSEWTDC FPCQDKKYRH 
RSLLQPNKFG GTICSGDIWD QASCSSSTTC VRQAQCGQDF QCKETGRCLK RHLVCNGDQD 
CLDGSDEDDC EDVRAIDEDC SQYEPIPGSQ KAALGYNILT QEDAQSVYDA SYYGGQCETV 
YNGEWRELRY DSTCERLYYG DDEKYFRKPY NFLKYHFEAL ADTGISSEFY DNANDLLSKV 
KKDKSDSFGV TIGIGPAGSP LLVGVGVSHS QDTSFLNELN KYNEKKFIFT RIFTKVQTAH 
FKMRKDDIML DEGMLQSLME LPDQYNYGMY AKFINDYGTH YITSGSMGGI YEYILVIDKA 
KMESLGITSR DITTCFGGSL GIQYEDKINV GGGLSGDHCK KFGGGKTERA RKAMAVEDII 
SRVRGGSSGW SGGLAQNRST ITYRSWGRSL KYNPVVIDFE MQPIHEVLRH TSLGPLEAKR 
QNLRRALDQY LMEFNACRCG PCFNNGVPIL EGTSCRCQCR LGSLGAACEQ TQTEGAKADG 
SWSCWSSWSV CRAGIQERRR ECDNPAPQNG GASCPGRKVQ TQAC

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: C8A

Associated with

Other Information

Complementary DNA and derived amino acid sequence of the alpha subunit of human complement protein C8: evidence for the existence of a separate alpha subunit messenger RNA. PubMed ID: 2820471

Genomic organization of human complement protein C8 alpha and further examination of its linkage to C8 beta. PubMed ID: 7759071

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The eighth component of human complement. Purification and physicochemical characterization of its unusual subunit structure. PubMed ID: 7440581

The four terminal components of the complement system are C-mannosylated on multiple tryptophan residues. PubMed ID: 10551839

Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. PubMed ID: 16335952

Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. PubMed ID: 19159218

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Structure of C8alpha-MACPF reveals mechanism of membrane attack in complement immune defense. PubMed ID: 17872444

Crystal structure of the MACPF domain of human complement protein C8 alpha in complex with the C8 gamma subunit. PubMed ID: 18440555

Crystal structure of complement protein C8gamma in complex with a peptide containing the C8gamma binding site on C8alpha: implications for C8gamma ligand binding. PubMed ID: 17692377

The eighth component of human complement: molecular basis of C8A (C81) polymorphism. PubMed ID: 7649542