Details for: C8A

Gene ID: 731

Symbol: C8A

Ensembl ID: ENSG00000157131

Description: complement C8 alpha chain

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.14
    Marker Score: 2,151
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 2.04
    Marker Score: 10,993
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.88
    Marker Score: 6,143
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.82
    Marker Score: 3,772
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.79
    Marker Score: 11,532
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.76
    Marker Score: 7,605
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.62
    Marker Score: 1,174
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.54
    Marker Score: 1,534
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 858
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.1
    Marker Score: 582
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.09
    Marker Score: 1,221
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.06
    Marker Score: 439
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.02
    Marker Score: 697
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,832
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,055
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1
    Marker Score: 513
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.99
    Marker Score: 466
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.98
    Marker Score: 452
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.97
    Marker Score: 569
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,412
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 377
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,352
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.92
    Marker Score: 330
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,743
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.9
    Marker Score: 967
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,296
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.84
    Marker Score: 489
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 712
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,266
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.77
    Marker Score: 1,465
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 467
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.73
    Marker Score: 3,058
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.72
    Marker Score: 1,686
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.7
    Marker Score: 715
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.67
    Marker Score: 10,445
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.67
    Marker Score: 1,356
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.56
    Marker Score: 176
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.52
    Marker Score: 187
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.49
    Marker Score: 3,288
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 281
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.47
    Marker Score: 177
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.44
    Marker Score: 231
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.4
    Marker Score: 243
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.4
    Marker Score: 404
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.39
    Marker Score: 125
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.38
    Marker Score: 117
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.33
    Marker Score: 125
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.32
    Marker Score: 153
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.31
    Marker Score: 236
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.25
    Marker Score: 68
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.24
    Marker Score: 369
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.24
    Marker Score: 77
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.21
    Marker Score: 98
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.21
    Marker Score: 88
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.2
    Marker Score: 52
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.2
    Marker Score: 88
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.18
    Marker Score: 102
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.18
    Marker Score: 56
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.15
    Marker Score: 94
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.14
    Marker Score: 92
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.12
    Marker Score: 176
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.12
    Marker Score: 69
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.12
    Marker Score: 73
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.11
    Marker Score: 49
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.11
    Marker Score: 39
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.1
    Marker Score: 45
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.1
    Marker Score: 88
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.09
    Marker Score: 264
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.08
    Marker Score: 78
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.08
    Marker Score: 60
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.08
    Marker Score: 76
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.08
    Marker Score: 52
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.08
    Marker Score: 86
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.07
    Marker Score: 61
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.07
    Marker Score: 148
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.07
    Marker Score: 96
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.07
    Marker Score: 20
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.07
    Marker Score: 117
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.07
    Marker Score: 17
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.07
    Marker Score: 78
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.07
    Marker Score: 70
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.06
    Marker Score: 103
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.06
    Marker Score: 1,536
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.06
    Marker Score: 192
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.05
    Marker Score: 12
  • Cell Name: GIP cell (CL0002278)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: type D enteroendocrine cell (CL0000502)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.05
    Marker Score: 19
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.05
    Marker Score: 20

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** C8A is a protein that belongs to the complement system, a group of proteins that work together to defend against infections. It is a key component of the terminal pathway of the complement cascade, which is activated in response to the presence of pathogens. C8A is characterized by its ability to form a stable complex with the C9 protein, which is necessary for the formation of the MAC. This complex is then inserted into the pathogen's membrane, creating pores that lead to cell lysis and death. **Pathways and Functions:** The complement C8 alpha chain is involved in several key pathways, including: 1. **Complement Activation:** C8A is activated by the binding of C3b to the C4b2a complex, which is the central component of the complement cascade. This binding triggers a series of reactions that lead to the activation of C8A. 2. **Alternative Pathway:** C8A is also involved in the alternative pathway of complement activation, which is activated in response to the presence of pathogens that are not recognized by the classical pathway. 3. **Classical Pathway:** C8A is also involved in the classical pathway of complement activation, which is activated in response to the presence of pathogens that are recognized by the immune system. 4. **Membrane Attack Complex Formation:** C8A is essential for the formation of the MAC, which is the terminal product of the complement cascade. The MAC is a complex of proteins that inserts into the pathogen's membrane, creating pores that lead to cell lysis and death. **Clinical Significance:** Dysregulation of the complement system, including the C8A gene, has been implicated in several diseases, including: 1. **Systemic Lupus Erythematosus (SLE):** C8A has been shown to be involved in the pathogenesis of SLE, a chronic autoimmune disease characterized by the production of autoantibodies. 2. **Complement Deficiency:** Deficiencies in the C8A gene can lead to impaired complement function, making individuals more susceptible to infections. 3. **Neurodegenerative Diseases:** Dysregulation of the complement system, including the C8A gene, has been implicated in several neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. In conclusion, the complement C8 alpha chain is a critical component of the innate immune system, playing a key role in the activation of the complement cascade and the formation of the membrane attack complex. Dysregulation of the C8A gene has been implicated in several diseases, highlighting the importance of this gene in maintaining immune homeostasis.

Genular Protein ID: 3426203482

Symbol: CO8A_HUMAN

Name: Complement component C8 alpha chain

UniProtKB Accession Codes:

P07357 A2RUI4 A2RUI5 Q13668 Q9H130

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 15 EMDB 10 Ensembl 1 EvolutionaryTrace 1 GO 15 Gene3D 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 17 PDBsum 11 PIR 1 PRINTS 2 PRO 1 PROSITE 6 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SAM 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2820471

Title: Complementary DNA and derived amino acid sequence of the alpha subunit of human complement protein C8: evidence for the existence of a separate alpha subunit messenger RNA.

PubMed ID: 2820471

DOI: 10.1021/bi00386a046

PubMed ID: 7759071

Title: Genomic organization of human complement protein C8 alpha and further examination of its linkage to C8 beta.

PubMed ID: 7759071

DOI: 10.1007/bf00223862

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7440581

Title: The eighth component of human complement. Purification and physicochemical characterization of its unusual subunit structure.

PubMed ID: 7440581

DOI: 10.1016/s0021-9258(19)70233-6

PubMed ID: 10551839

Title: The four terminal components of the complement system are C-mannosylated on multiple tryptophan residues.

PubMed ID: 10551839

DOI: 10.1074/jbc.274.46.32786

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 17872444

Title: Structure of C8alpha-MACPF reveals mechanism of membrane attack in complement immune defense.

PubMed ID: 17872444

DOI: 10.1126/science.1147103

PubMed ID: 18440555

Title: Crystal structure of the MACPF domain of human complement protein C8 alpha in complex with the C8 gamma subunit.

PubMed ID: 18440555

DOI: 10.1016/j.jmb.2008.03.061

PubMed ID: 17692377

Title: Crystal structure of complement protein C8gamma in complex with a peptide containing the C8gamma binding site on C8alpha: implications for C8gamma ligand binding.

PubMed ID: 17692377

DOI: 10.1016/j.molimm.2007.06.359

PubMed ID: 7649542

Title: The eighth component of human complement: molecular basis of C8A (C81) polymorphism.

PubMed ID: 7649542

DOI: 10.1007/bf00210407

Sequence Information:

  • Length: 584
  • Mass: 65163
  • Checksum: 9F61DDA51D2F3BBA
  • Sequence:
    • MFAVVFFILS LMTCQPGVTA QEKVNQRVRR AATPAAVTCQ LSNWSEWTDC FPCQDKKYRH 
RSLLQPNKFG GTICSGDIWD QASCSSSTTC VRQAQCGQDF QCKETGRCLK RHLVCNGDQD 
CLDGSDEDDC EDVRAIDEDC SQYEPIPGSQ KAALGYNILT QEDAQSVYDA SYYGGQCETV 
YNGEWRELRY DSTCERLYYG DDEKYFRKPY NFLKYHFEAL ADTGISSEFY DNANDLLSKV 
KKDKSDSFGV TIGIGPAGSP LLVGVGVSHS QDTSFLNELN KYNEKKFIFT RIFTKVQTAH 
FKMRKDDIML DEGMLQSLME LPDQYNYGMY AKFINDYGTH YITSGSMGGI YEYILVIDKA 
KMESLGITSR DITTCFGGSL GIQYEDKINV GGGLSGDHCK KFGGGKTERA RKAMAVEDII 
SRVRGGSSGW SGGLAQNRST ITYRSWGRSL KYNPVVIDFE MQPIHEVLRH TSLGPLEAKR 
QNLRRALDQY LMEFNACRCG PCFNNGVPIL EGTSCRCQCR LGSLGAACEQ TQTEGAKADG 
SWSCWSSWSV CRAGIQERRR ECDNPAPQNG GASCPGRKVQ TQAC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.