Details for: C8B

Gene ID: 732

Symbol: C8B

Ensembl ID: ENSG00000021852

Description: complement C8 beta chain

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.44
    Marker Score: 2457
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2
    Marker Score: 1997
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.74
    Marker Score: 9355
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1173
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.6
    Marker Score: 6918.5
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.56
    Marker Score: 10003
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.27
    Marker Score: 1351
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 858
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.21
    Marker Score: 3966
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.2
    Marker Score: 1336.5
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.18
    Marker Score: 490
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4817
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.12
    Marker Score: 7459
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1
    Marker Score: 506
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.06
    Marker Score: 2186
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.05
    Marker Score: 6366
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71827
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48052
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 512
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 465
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5355
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 376
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.92
    Marker Score: 626
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 328
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1266
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 399
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 465
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.69
    Marker Score: 739
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.65
    Marker Score: 343.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.6
    Marker Score: 482
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.59
    Marker Score: 244
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.57
    Marker Score: 1073
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.56
    Marker Score: 176
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.54
    Marker Score: 205
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.5
    Marker Score: 552
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.47
    Marker Score: 176
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 279
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.47
    Marker Score: 950
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.37
    Marker Score: 368
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.36
    Marker Score: 584
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.36
    Marker Score: 5639
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.33
    Marker Score: 103
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.33
    Marker Score: 196
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.31
    Marker Score: 99.5
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.31
    Marker Score: 7980
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.3
    Marker Score: 396
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.29
    Marker Score: 297
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.28
    Marker Score: 651
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.27
    Marker Score: 74
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.24
    Marker Score: 287
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.23
    Marker Score: 131
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.23
    Marker Score: 258
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.22
    Marker Score: 104
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.2
    Marker Score: 73.5
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.18
    Marker Score: 328
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.18
    Marker Score: 85
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.17
    Marker Score: 114
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.16
    Marker Score: 94
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.15
    Marker Score: 133
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.15
    Marker Score: 65
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.15
    Marker Score: 113
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.13
    Marker Score: 394
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.13
    Marker Score: 434
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.11
    Marker Score: 107
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.11
    Marker Score: 50
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.1
    Marker Score: 150.5
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.09
    Marker Score: 30
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.09
    Marker Score: 51
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.09
    Marker Score: 27
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.08
    Marker Score: 22
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.08
    Marker Score: 31
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.08
    Marker Score: 21
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.08
    Marker Score: 18
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.08
    Marker Score: 145
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.08
    Marker Score: 49
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.08
    Marker Score: 58
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.07
    Marker Score: 21
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.07
    Marker Score: 21
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.07
    Marker Score: 21
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.07
    Marker Score: 66
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.07
    Marker Score: 94
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: chorionic trophoblast cell (CL0011101)
    Fold Change: 0.06
    Marker Score: 23
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.06
    Marker Score: 37
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.06
    Marker Score: 23
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.06
    Marker Score: 23
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.06
    Marker Score: 48
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.06
    Marker Score: 105
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.05
    Marker Score: 94
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.05
    Marker Score: 53
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.05
    Marker Score: 314

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Other Information

**Key characteristics:** * The C8B gene is located on chromosome 1 and is approximately 2.5kb in length. * It encodes a protein of 183 amino acids. * The C8B protein is a glycoprotein that is found in complex with other proteins to form the membrane attack complex (MAC). * The C8B protein is a key regulator of the classical pathway of complement activation. **Pathways and functions:** * The C8B protein is involved in the classical pathway of complement activation. * The classical pathway is a non-inflammatory pathway of complement that is activated by the binding of antibodies to antigens on the surface of a target cell. * The C8B protein is one of the first proteins to be activated by the classical pathway, and it is responsible for triggering the subsequent activation of the pathway. * The C8B protein also plays a role in the alternative pathway of complement activation. **Clinical significance:** * Mutations in the C8B gene have been linked to several human diseases, including systemic lupus erythematosus, rheumatoid arthritis, and sepsis. * The C8B protein is a potential target for therapeutic intervention in these diseases. * Inhibition of the C8B protein has been shown to be effective in preventing the development of these diseases. **Additional notes:** * The C8B gene is also expressed in some invertebrates, including mice and rats. * The C8B protein is a highly conserved protein, with a similar sequence found in organisms from different species.

Genular Protein ID: 2702548213

Symbol: CO8B_HUMAN

Name: Complement component C8 beta chain

UniProtKB Accession Codes:

P07358 A1L4K7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EMBL 6 EMDB 9 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 8 PIR 1 PRINTS 1 PRO 1 PROSITE 6 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 2 SAM 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2820472

Title: Complementary DNA and derived amino acid sequence of the beta subunit of human complement protein C8: identification of a close structural and ancestral relationship to the alpha subunit and C9.

PubMed ID: 2820472

DOI: 10.1021/bi00386a047

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3651397

Title: Complementary DNA cloning of complement C8 beta and its sequence homology to C9.

PubMed ID: 3651397

DOI: 10.1021/bi00386a045

PubMed ID: 7440581

Title: The eighth component of human complement. Purification and physicochemical characterization of its unusual subunit structure.

PubMed ID: 7440581

DOI: 10.1016/s0021-9258(19)70233-6

PubMed ID: 10551839

Title: The four terminal components of the complement system are C-mannosylated on multiple tryptophan residues.

PubMed ID: 10551839

DOI: 10.1074/jbc.274.46.32786

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 21454577

Title: Structure of human C8 protein provides mechanistic insight into membrane pore formation by complement.

PubMed ID: 21454577

DOI: 10.1074/jbc.m111.219766

PubMed ID: 8131848

Title: Human complement component C8. Molecular basis of the beta-chain polymorphism.

PubMed ID: 8131848

DOI: 10.1016/0014-5793(94)80140-1

Sequence Information:

  • Length: 591
  • Mass: 66948
  • Checksum: 1DBC54FF833AF6BF
  • Sequence:
    • MKNSRTWAWR APVELFLLCA ALGCLSLPGS RGERPHSFGS NAVNKSFAKS RQMRSVDVTL 
MPIDCELSSW SSWTTCDPCQ KKRYRYAYLL QPSQFHGEPC NFSDKEVEDC VTNRPCGSQV 
RCEGFVCAQT GRCVNRRLLC NGDNDCGDQS DEANCRRIYK KCQHEMDQYW GIGSLASGIN 
LFTNSFEGPV LDHRYYAGGC SPHYILNTRF RKPYNVESYT PQTQGKYEFI LKEYESYSDF 
ERNVTEKMAS KSGFSFGFKI PGIFELGISS QSDRGKHYIR RTKRFSHTKS VFLHARSDLE 
VAHYKLKPRS LMLHYEFLQR VKRLPLEYSY GEYRDLFRDF GTHYITEAVL GGIYEYTLVM 
NKEAMERGDY TLNNVHACAK NDFKIGGAIE EVYVSLGVSV GKCRGILNEI KDRNKRDTMV 
EDLVVLVRGG ASEHITTLAY QELPTADLMQ EWGDAVQYNP AIIKVKVEPL YELVTATDFA 
YSSTVRQNMK QALEEFQKEV SSCHCAPCQG NGVPVLKGSR CDCICPVGSQ GLACEVSYRK 
NTPIDGKWNC WSNWSSCSGR RKTRQRQCNN PPPQNGGSPC SGPASETLDC S

Genular Protein ID: 1614822922

Symbol: B7Z550_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z550

Database IDs:

ARBA 16 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 4 GO 5 Gene3D 2 GenomeRNAi 1 InterPro 9 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 6 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 3 RefSeq 1 SAM 1 SMART 2 SUPFAM 2

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 529
  • Mass: 60140
  • Checksum: 684E69408EB2A118
  • Sequence:
    • MDTCMTLAFT LSGRFFMLLS QYRYAYLLQP SQFHGEPCNF SDKEVEDCVT NRPCRSQVRC 
EGFVCAQTGR CVNRRLLCNG DNDCGDQSDE ANCRRIYKKC QHEMDQYWGI GSLASGINLF 
TNSFEGPVLD HRYYAGGCSP HYILNTRFRK PYNVESYTPQ TQGKYEFILK EYESYSDFER 
NVTEKMASKS GFSFGFKIPG IFELGISSQS DRGKHYIRRT KRFSHTKSVF LHARSDLEVA 
HYKLKPRSLM LHYEFLQRVK RLPLEYSYGE YRDLFRDFGT HYITEAVLGG IYEYTLVMNK 
EAMERGDYTL NNVHACAKND FKIGGAIEEV YVSLGVSVGK CRGILNEIKD RNKRDTMVED 
LVVLVRGGAS EHITTLAYQE LPTADLMQEW GDAVQYNPAI IKVKVEPLYE LVTATDFAYS 
STVRQNMKQA LEEFQKEVSS CHCAPCQGNG VPVLKGSRCD CICPVGSQGL ACEVSYRKNT 
PIDGKWNCWS NWSSCSGRRK TRQRQCNNPP PQNGGSPCSG PASETLDCS

Genular Protein ID: 1381035942

Symbol: B7Z555_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z555

Database IDs:

ARBA 16 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 5 Gene3D 2 GenomeRNAi 1 InterPro 9 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 6 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 4 RefSeq 1 SAM 1 SMART 3 SUPFAM 2

Sequence Information:

  • Length: 539
  • Mass: 61330
  • Checksum: 5AFF682D2C9E59E5
  • Sequence:
    • MRSVDVTLMP IDCELSSWSS WTTCDPCQKK RYRYAYLLQP SQFHGEPCNF SDKEVEDCVT 
NRPCRSQVRC EGFVCAQTGR CVNRRLLCNG DNDCGDQSDE ANCRRIYKKC QHEMDQYWGI 
GSLASGINLF TNSFEGPVLD HRYYAGGCSP HYILNTRFRK PYNVESYTPQ TQGKYEFILK 
EYESYSDFER NVTEKMASKS GFSFGFKIPG IFELGISSQS DRGKHYIRRT KRFSHTKSVF 
LHARSDLEVA HYKLKPRSLM LHYEFLQRVK RLPLEYSYGE YRDLFRDFGT HYITEAVLGG 
IYEYTLVMNK EAMERGDYTL NNVHACAKND FKIGGAIEEV YVSLGVSVGK CRGILNEIKD 
RNKRDTMVED LVVLVRGGAS EHITTLAYQE LPTADLMQEW GDAVQYNPAI IKVKVEPLYE 
LVTATDFAYS STVRQNMKQA LEEFQKEVSS CHCAPCQGNG VPVLKGSRCD CICPVGSQGL 
ACEVSYRKNT PIDGKWNCWS NWSSCSGRRK TRQRQCNNPP PQNGGSPCSG PASETLDCS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.