Details for: C8G

Gene ID: 733

Symbol: C8G

Ensembl ID: ENSG00000176919

Description: complement C8 gamma chain

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.44
    Marker Score: 2719.5
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 873
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.21
    Marker Score: 19006
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 799
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71835
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48060
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 510
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 463
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.96
    Marker Score: 649
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.94
    Marker Score: 1908
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5348
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 374
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.89
    Marker Score: 533
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5290
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.82
    Marker Score: 1269
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 706
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.76
    Marker Score: 363
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2964
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.65
    Marker Score: 3104
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.64
    Marker Score: 1331
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.57
    Marker Score: 178
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 147
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 0.55
    Marker Score: 160
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.54
    Marker Score: 344
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.52
    Marker Score: 164
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.45
    Marker Score: 174
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.45
    Marker Score: 166
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.43
    Marker Score: 181
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.4
    Marker Score: 954
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.4
    Marker Score: 179
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.4
    Marker Score: 396
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.4
    Marker Score: 128
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.37
    Marker Score: 357.5
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 372
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.29
    Marker Score: 100
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.28
    Marker Score: 73
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.25
    Marker Score: 192.5
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.23
    Marker Score: 86
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.23
    Marker Score: 59
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.21
    Marker Score: 46
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.19
    Marker Score: 271
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.18
    Marker Score: 58
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.18
    Marker Score: 69
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.18
    Marker Score: 573
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.17
    Marker Score: 113
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.16
    Marker Score: 85
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 0.16
    Marker Score: 143
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.16
    Marker Score: 43
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.15
    Marker Score: 36
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.15
    Marker Score: 143
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.13
    Marker Score: 41
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.12
    Marker Score: 31
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.12
    Marker Score: 74
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.12
    Marker Score: 40
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.12
    Marker Score: 53
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.11
    Marker Score: 63
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.1
    Marker Score: 69
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.1
    Marker Score: 128
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.1
    Marker Score: 96
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.1
    Marker Score: 41
  • Cell Name: basophil (CL0000767)
    Fold Change: 0.1
    Marker Score: 46
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.1
    Marker Score: 35
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.09
    Marker Score: 50
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.08
    Marker Score: 35
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.08
    Marker Score: 74
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.08
    Marker Score: 31
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 0.08
    Marker Score: 20
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.08
    Marker Score: 72
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.07
    Marker Score: 96
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.07
    Marker Score: 41
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.07
    Marker Score: 26
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.07
    Marker Score: 439
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.06
    Marker Score: 28.5
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.06
    Marker Score: 102
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.06
    Marker Score: 38
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.06
    Marker Score: 13
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.06
    Marker Score: 22
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.06
    Marker Score: 27
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.06
    Marker Score: 52
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.05
    Marker Score: 14
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.05
    Marker Score: 32
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.05
    Marker Score: 31
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.05
    Marker Score: 14
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.05
    Marker Score: 37
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.05
    Marker Score: 26
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.05
    Marker Score: 20
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.05
    Marker Score: 12
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.05
    Marker Score: 33
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.05
    Marker Score: 15

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Other Information

**Key characteristics:** - The C8G gene is located on chromosome 1q21.1. - It is a single copy gene. - It is a member of the C8 family of complement proteins. - It is a glycoprotein with a molecular weight of approximately 170 kDa. **Pathways and functions:** - The C8G protein is a central protein in the classical pathway of complement activation. - It is also involved in the alternative pathway, where it can be generated from C8a and C8b fragments generated in the alternative pathway. - It is a regulator of the inflammatory response and plays a role in the regulation of immune cell activation and phagocytosis. **Clinical significance:** - Mutations in the C8G gene have been linked to several human diseases, including atypical hemolytic anemia, autoimmune disorders, and cancer. - C8G protein has been investigated as a potential therapeutic target for these diseases. - C8G inhibition can lead to a decrease in inflammation and tissue damage. **Additional notes:** - The C8G gene is also expressed in low levels in healthy individuals. - The protein is also expressed in extracellular exosomes and plasma membranes. - It is a key regulator of the inflammatory response and plays a role in maintaining immune homeostasis.

Genular Protein ID: 4175406638

Symbol: CO8G_HUMAN

Name: Complement component C8 gamma chain

UniProtKB Accession Codes:

P07360 Q14CT8 Q14CU0 Q5SQ07

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ComplexPortal 1 DNASU 1 DisGeNET 1 DrugBank 4 EMBL 8 EMDB 9 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 17 PDBsum 15 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3676249

Title: The eighth component of human complement: evidence that it is an oligomeric serum protein assembled from products of three different genes.

PubMed ID: 3676249

DOI: 10.1021/bi00391a003

PubMed ID: 2447883

Title: Structural homology of human complement component C8 gamma and plasma protein HC: identity of the cysteine bond pattern.

PubMed ID: 2447883

DOI: 10.1016/0006-291x(87)90431-1

PubMed ID: 8172891

Title: Genomic structure of the human complement protein C8 gamma: homology to the lipocalin gene family.

PubMed ID: 8172891

DOI: 10.1021/bi00183a020

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2446620

Title: The homology of complement factor C8 gamma chain and alpha-1-microglobulin.

PubMed ID: 2446620

DOI: 10.1016/0006-291x(87)91636-6

PubMed ID: 1707134

Title: Structural and functional characterization of complement C8 gamma, a member of the lipocalin protein family.

PubMed ID: 1707134

DOI: 10.1016/0161-5890(91)90095-2

PubMed ID: 11058761

Title: Human complement protein C8 gamma.

PubMed ID: 11058761

DOI: 10.1016/s0167-4838(00)00155-2

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 12033936

Title: Crystal structure of human complement protein C8gamma at 1.2 A resolution reveals a lipocalin fold and a distinct ligand binding site.

PubMed ID: 12033936

DOI: 10.1021/bi025696i

PubMed ID: 17452033

Title: Structural features of the ligand binding site on human complement protein C8gamma: a member of the lipocalin family.

PubMed ID: 17452033

DOI: 10.1016/j.bbapap.2007.03.004

PubMed ID: 17692377

Title: Crystal structure of complement protein C8gamma in complex with a peptide containing the C8gamma binding site on C8alpha: implications for C8gamma ligand binding.

PubMed ID: 17692377

DOI: 10.1016/j.molimm.2007.06.359

Sequence Information:

  • Length: 202
  • Mass: 22277
  • Checksum: 4E4F73140E607FFE
  • Sequence:
    • MLPPGTATLL TLLLAAGSLG QKPQRPRRPA SPISTIQPKA NFDAQQFAGT WLLVAVGSAC 
RFLQEQGHRA EATTLHVAPQ GTAMAVSTFR KLDGICWQVR QLYGDTGVLG RFLLQARDAR 
GAVHVVVAET DYQSFAVLYL ERAGQLSVKL YARSLPVSDS VLSGFEQRVQ EAHLTEDQIF 
YFPKYGFCEA ADQFHVLDEV RR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.