Details for: C8G

Gene ID: 733

Symbol: C8G

Ensembl ID: ENSG00000176919

Description: complement C8 gamma chain

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 7.7148
    Cell Significance Index: -1.2000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 4.6522
    Cell Significance Index: -1.1800
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 1.8692
    Cell Significance Index: 7.0400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.8680
    Cell Significance Index: 14.6000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.8532
    Cell Significance Index: 18.1700
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.7901
    Cell Significance Index: 4.5500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7691
    Cell Significance Index: 76.0800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7673
    Cell Significance Index: 692.7800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.7134
    Cell Significance Index: 7.3900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6766
    Cell Significance Index: 40.6200
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.6013
    Cell Significance Index: 4.5600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5804
    Cell Significance Index: 63.1300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.5182
    Cell Significance Index: 8.8800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4308
    Cell Significance Index: 70.0600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3660
    Cell Significance Index: 25.3100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3017
    Cell Significance Index: 8.0900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2947
    Cell Significance Index: 8.4900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2216
    Cell Significance Index: 42.1700
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.1966
    Cell Significance Index: 1.9400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.1924
    Cell Significance Index: 2.8400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.1656
    Cell Significance Index: 2.7900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1449
    Cell Significance Index: 28.7600
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.1109
    Cell Significance Index: 1.7600
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.1100
    Cell Significance Index: 0.7300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0948
    Cell Significance Index: 2.3700
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0809
    Cell Significance Index: 1.1600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0747
    Cell Significance Index: 1.0900
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.0709
    Cell Significance Index: 0.5500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0628
    Cell Significance Index: 1.3600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0488
    Cell Significance Index: 2.2100
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 0.0474
    Cell Significance Index: 0.1300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.0385
    Cell Significance Index: 0.9400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.0376
    Cell Significance Index: 0.6200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0268
    Cell Significance Index: 1.6900
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0233
    Cell Significance Index: 0.3000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0199
    Cell Significance Index: 0.7000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0193
    Cell Significance Index: 1.4800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0134
    Cell Significance Index: 3.8500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0120
    Cell Significance Index: 0.3200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0108
    Cell Significance Index: 1.2600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0086
    Cell Significance Index: 1.7300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0049
    Cell Significance Index: 0.0700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0014
    Cell Significance Index: 0.6200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0013
    Cell Significance Index: 0.1300
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.0007
    Cell Significance Index: 0.0100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0004
    Cell Significance Index: 0.0200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0001
    Cell Significance Index: -0.0300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0001
    Cell Significance Index: -0.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0004
    Cell Significance Index: -0.6900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0007
    Cell Significance Index: -1.3700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0009
    Cell Significance Index: -0.0300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0009
    Cell Significance Index: -1.3700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0011
    Cell Significance Index: -0.8400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0011
    Cell Significance Index: -1.5200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0014
    Cell Significance Index: -1.0900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0015
    Cell Significance Index: -0.0700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0017
    Cell Significance Index: -0.9600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0017
    Cell Significance Index: -0.0800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0025
    Cell Significance Index: -1.8400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0026
    Cell Significance Index: -1.6200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0026
    Cell Significance Index: -0.1600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0026
    Cell Significance Index: -0.1100
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0031
    Cell Significance Index: -0.0400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0035
    Cell Significance Index: -1.5900
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0039
    Cell Significance Index: -0.0500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0041
    Cell Significance Index: -0.7400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0041
    Cell Significance Index: -0.7000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0061
    Cell Significance Index: -0.7000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0063
    Cell Significance Index: -1.3200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0065
    Cell Significance Index: -0.8900
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0081
    Cell Significance Index: -0.0500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0082
    Cell Significance Index: -1.0600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0088
    Cell Significance Index: -0.1000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0111
    Cell Significance Index: -1.1600
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: -0.0112
    Cell Significance Index: -0.1200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0114
    Cell Significance Index: -1.6500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0121
    Cell Significance Index: -1.4900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0136
    Cell Significance Index: -0.8800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0144
    Cell Significance Index: -1.7000
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0147
    Cell Significance Index: -0.2200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0153
    Cell Significance Index: -1.0300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0158
    Cell Significance Index: -0.8300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0162
    Cell Significance Index: -1.2100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0169
    Cell Significance Index: -0.3500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0176
    Cell Significance Index: -0.2400
  • Cell Name: colonocyte (CL1000347)
    Fold Change: -0.0178
    Cell Significance Index: -0.1100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0185
    Cell Significance Index: -1.1400
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0190
    Cell Significance Index: -0.1800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0196
    Cell Significance Index: -0.2900
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.0200
    Cell Significance Index: -0.1900
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0211
    Cell Significance Index: -0.3200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0213
    Cell Significance Index: -1.0000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0221
    Cell Significance Index: -1.2400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0232
    Cell Significance Index: -1.8400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0246
    Cell Significance Index: -1.2800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0250
    Cell Significance Index: -0.8200
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0250
    Cell Significance Index: -0.3000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0255
    Cell Significance Index: -1.1300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0257
    Cell Significance Index: -0.9000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0257
    Cell Significance Index: -0.8200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Protein structure:** The C8 gamma chain is a 24-kDa protein that is composed of 160 amino acids. 2. **Expression:** The C8 gamma chain is significantly expressed in various cell types, including cardiac endothelial cells, granulocyte monocyte progenitor cells, cardiac muscle myoblasts, and intestinal epithelial cells. 3. **Function:** The C8 gamma chain plays a crucial role in the formation of the MAC, which is responsible for the lysis of pathogens. 4. **Pathway involvement:** The C8 gamma chain is involved in the classical and alternative pathways of the complement cascade, as well as the regulation of the complement cascade. **Pathways and Functions:** 1. **Complement activation:** The C8 gamma chain is involved in the activation of the complement cascade, which is a key component of the innate immune response. 2. **Classical pathway:** The C8 gamma chain is involved in the classical pathway of the complement cascade, which is triggered by the binding of C1q to antibodies. 3. **Alternative pathway:** The C8 gamma chain is also involved in the alternative pathway of the complement cascade, which is triggered by the binding of C3b to microbial surfaces. 4. **Regulation of complement cascade:** The C8 gamma chain is involved in the regulation of the complement cascade, which is essential for preventing excessive activation of the complement system. 5. **Immune response modulation:** The C8 gamma chain is also involved in the modulation of immune responses, including the regulation of the production of pro-inflammatory cytokines. **Clinical Significance:** 1. **Autoimmune diseases:** Dysregulation of the complement cascade, including the C8 gamma chain, has been implicated in various autoimmune diseases, such as systemic lupus erythematosus and rheumatoid arthritis. 2. **Infectious diseases:** The C8 gamma chain is also involved in the clearance of pathogens, and dysregulation of the complement cascade has been implicated in various infectious diseases, including sepsis and meningitis. 3. **Cancer:** The C8 gamma chain has also been implicated in the regulation of immune responses in cancer, and dysregulation of the complement cascade has been associated with poor prognosis in various types of cancer. 4. **Transplantation:** The C8 gamma chain is also involved in the regulation of immune responses in transplantation, and dysregulation of the complement cascade has been associated with rejection of transplanted organs. In conclusion, the complement C8 gamma chain is a critical component of the immune system, and dysregulation of this gene has been implicated in various diseases, including autoimmune diseases, infectious diseases, and cancer. Further studies are needed to fully understand the role of the C8 gamma chain in the immune system and its implications for human health.

Genular Protein ID: 4175406638

Symbol: CO8G_HUMAN

Name: Complement component C8 gamma chain

UniProtKB Accession Codes:

P07360 Q14CT8 Q14CU0 Q5SQ07

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ComplexPortal 1 DNASU 1 DisGeNET 1 DrugBank 4 EMBL 8 EMDB 9 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 15 PDBsum 15 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3676249

Title: The eighth component of human complement: evidence that it is an oligomeric serum protein assembled from products of three different genes.

PubMed ID: 3676249

DOI: 10.1021/bi00391a003

PubMed ID: 2447883

Title: Structural homology of human complement component C8 gamma and plasma protein HC: identity of the cysteine bond pattern.

PubMed ID: 2447883

DOI: 10.1016/0006-291x(87)90431-1

PubMed ID: 8172891

Title: Genomic structure of the human complement protein C8 gamma: homology to the lipocalin gene family.

PubMed ID: 8172891

DOI: 10.1021/bi00183a020

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2446620

Title: The homology of complement factor C8 gamma chain and alpha-1-microglobulin.

PubMed ID: 2446620

DOI: 10.1016/0006-291x(87)91636-6

PubMed ID: 1707134

Title: Structural and functional characterization of complement C8 gamma, a member of the lipocalin protein family.

PubMed ID: 1707134

DOI: 10.1016/0161-5890(91)90095-2

PubMed ID: 11058761

Title: Human complement protein C8 gamma.

PubMed ID: 11058761

DOI: 10.1016/s0167-4838(00)00155-2

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 12033936

Title: Crystal structure of human complement protein C8gamma at 1.2 A resolution reveals a lipocalin fold and a distinct ligand binding site.

PubMed ID: 12033936

DOI: 10.1021/bi025696i

PubMed ID: 17452033

Title: Structural features of the ligand binding site on human complement protein C8gamma: a member of the lipocalin family.

PubMed ID: 17452033

DOI: 10.1016/j.bbapap.2007.03.004

PubMed ID: 17692377

Title: Crystal structure of complement protein C8gamma in complex with a peptide containing the C8gamma binding site on C8alpha: implications for C8gamma ligand binding.

PubMed ID: 17692377

DOI: 10.1016/j.molimm.2007.06.359

Sequence Information:

  • Length: 202
  • Mass: 22277
  • Checksum: 4E4F73140E607FFE
  • Sequence:
    • MLPPGTATLL TLLLAAGSLG QKPQRPRRPA SPISTIQPKA NFDAQQFAGT WLLVAVGSAC 
RFLQEQGHRA EATTLHVAPQ GTAMAVSTFR KLDGICWQVR QLYGDTGVLG RFLLQARDAR 
GAVHVVVAET DYQSFAVLYL ERAGQLSVKL YARSLPVSDS VLSGFEQRVQ EAHLTEDQIF 
YFPKYGFCEA ADQFHVLDEV RR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.