Details for: OSGIN2

Gene ID: 734

Symbol: OSGIN2

Ensembl ID: ENSG00000164823

Description: oxidative stress induced growth inhibitor family member 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.67
    Marker Score: 2020
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168999
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.26
    Marker Score: 1689
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.19
    Marker Score: 2411
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71765
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47989
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30402
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2404
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 485
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 440
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.91
    Marker Score: 14281
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2720
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.89
    Marker Score: 1072
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5012
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5262
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.87
    Marker Score: 8944
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.86
    Marker Score: 18411
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 310
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.83
    Marker Score: 3586
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.81
    Marker Score: 1246
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1259
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.77
    Marker Score: 464
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.77
    Marker Score: 380
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.77
    Marker Score: 1810
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.76
    Marker Score: 657
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 570
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.74
    Marker Score: 25086
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.73
    Marker Score: 294
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.73
    Marker Score: 3067
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 377
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.68
    Marker Score: 617
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.67
    Marker Score: 4041
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.67
    Marker Score: 662
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.66
    Marker Score: 17008
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 170
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.63
    Marker Score: 935
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.62
    Marker Score: 1078
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.61
    Marker Score: 37533
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.61
    Marker Score: 5210
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.6
    Marker Score: 382
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.6
    Marker Score: 5696.5
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.59
    Marker Score: 612
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.59
    Marker Score: 1041
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.58
    Marker Score: 366
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.58
    Marker Score: 21352
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.57
    Marker Score: 528
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.57
    Marker Score: 129
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.55
    Marker Score: 5170
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 434
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.54
    Marker Score: 577
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.54
    Marker Score: 174
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.54
    Marker Score: 1324
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.52
    Marker Score: 334
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.51
    Marker Score: 501
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.5
    Marker Score: 3055
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.5
    Marker Score: 332
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.49
    Marker Score: 111
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.48
    Marker Score: 140
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.48
    Marker Score: 2018
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.47
    Marker Score: 4153
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.47
    Marker Score: 273
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.47
    Marker Score: 281
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.46
    Marker Score: 204
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.46
    Marker Score: 15774
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.45
    Marker Score: 130
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.44
    Marker Score: 2869
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.44
    Marker Score: 8679
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.44
    Marker Score: 470
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.44
    Marker Score: 481
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.43
    Marker Score: 6954
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.43
    Marker Score: 186
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.43
    Marker Score: 204
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.43
    Marker Score: 1063
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.43
    Marker Score: 107
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.43
    Marker Score: 178
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.42
    Marker Score: 287
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.42
    Marker Score: 700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.42
    Marker Score: 442
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.42
    Marker Score: 1055
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.42
    Marker Score: 1699
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.42
    Marker Score: 145
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.42
    Marker Score: 130
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.41
    Marker Score: 241
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.41
    Marker Score: 166
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.41
    Marker Score: 225
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.41
    Marker Score: 1445
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.41
    Marker Score: 182
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.4
    Marker Score: 1075
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.4
    Marker Score: 494
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.4
    Marker Score: 497
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.4
    Marker Score: 241
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.39
    Marker Score: 897
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.39
    Marker Score: 267
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.39
    Marker Score: 175
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.39
    Marker Score: 625
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.39
    Marker Score: 89
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.39
    Marker Score: 220
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.39
    Marker Score: 465
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.38
    Marker Score: 154
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.38
    Marker Score: 101

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Other Information

**Key characteristics:** - OSGIN2 is a protein of approximately 110 kDa. - It is a transmembrane protein with a unique structure that includes a conserved cysteine-rich domain. - OSGIN2 is a potent inhibitor of the MAPK signaling pathway. - It also modulates the expression of various genes involved in cell growth, proliferation, and survival. **Pathways and functions:** - OSGIN2 inhibits the MAPK signaling pathway by binding to the MAPK kinase kinase (MAPKK) and preventing it from interacting with its substrate proteins. - This inhibition leads to the suppression of MAPK signaling, which is known to promote cell growth and proliferation. - OSGIN2 also regulates the expression of genes involved in cell cycle arrest, DNA repair, and apoptosis. - By inhibiting the MAPK signaling pathway, OSGIN2 promotes cell cycle arrest and senescence in cancer cells. **Clinical significance:** - OSGIN2 mutations have been linked to the development of various human cancers, including breast cancer, colon cancer, and lung cancer. - Targeting OSGIN2 has emerged as a potential therapeutic strategy for these cancers. - Clinical trials are currently testing the use of OSGIN2 inhibitors as a cancer treatment. **Conclusion:** OSGIN2 is a critical regulator of cell growth and survival. Its inhibition by OSGIN2 inhibitors leads to cell cycle arrest and senescence, suggesting its potential role in cancer development and progression. Further research is needed to understand the role of OSGIN2 in human health and disease.

Genular Protein ID: 1007055001

Symbol: OSGI2_HUMAN

Name: Oxidative stress-induced growth inhibitor 2

UniProtKB Accession Codes:

Q9Y236

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 3 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 3 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9933573

Title: Sequence analysis of an 800-kb genomic DNA region on chromosome 8q21 that contains the Nijmegen breakage syndrome gene, NBS1.

PubMed ID: 9933573

DOI: 10.1006/geno.1998.5657

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 505
  • Mass: 56672
  • Checksum: 7AFDA45D8E8ECA8F
  • Sequence:
    • MPLVEETSLL EDSSVTFPVV IIGNGPSGIC LSYMLSGYRP YLSSEAIHPN TILNSKLEEA 
RHLSIVDQDL EYLSEGLEGR SSNPVAVLFD TLLHPDADFG YDYPSVLHWK LEQHHYIPHV 
VLGKGPPGGA WHNMEGSMLT ISFGSWMELP GLKFKDWVSS KRRSLKGDRV MPEEIARYYK 
HYVKVMGLQK NFRENTYITS VSRLYRDQDD DDIQDRDIST KHLQIEKSNF IKRNWEIRGY 
QRIADGSHVP FCLFAENVAL ATGTLDSPAH LEIEGEDFPF VFHSMPEFGA AINKGKLRGK 
VDPVLIVGSG LTAADAVLCA YNSNIPVIHV FRRRVTDPSL IFKQLPKKLY PEYHKVYHMM 
CTQSYSVDSN LLSDYTSFPE HRVLSFKSDM KCVLQSVSGL KKIFKLSAAV VLIGSHPNLS 
FLKDQGCYLG HKSSQPITCK GNPVEIDTYT YECIKEANLF ALGPLVGDNF VRFLKGGALG 
VTRCLATRQK KKHLFVERGG GDGIA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.