Details for: OSGIN2

Gene ID: 734

Symbol: OSGIN2

Ensembl ID: ENSG00000164823

Description: oxidative stress induced growth inhibitor family member 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 98.9423
    Cell Significance Index: -15.3900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 59.3353
    Cell Significance Index: -15.0500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 33.1810
    Cell Significance Index: -13.4800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 14.4123
    Cell Significance Index: -13.7600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 12.7823
    Cell Significance Index: -15.7600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.5546
    Cell Significance Index: -14.8800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 5.0126
    Cell Significance Index: 80.4200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.0623
    Cell Significance Index: -16.0300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.0111
    Cell Significance Index: -12.3200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0893
    Cell Significance Index: 107.7600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.0579
    Cell Significance Index: 22.5300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8799
    Cell Significance Index: 794.4600
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.7095
    Cell Significance Index: 6.0300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.6378
    Cell Significance Index: 74.3300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6141
    Cell Significance Index: 66.8000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5882
    Cell Significance Index: 35.3100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5675
    Cell Significance Index: 29.4800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5664
    Cell Significance Index: 92.1200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.5467
    Cell Significance Index: 11.6900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.5123
    Cell Significance Index: 6.9900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4678
    Cell Significance Index: 93.8500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.4057
    Cell Significance Index: 11.6300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3699
    Cell Significance Index: 19.2700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3049
    Cell Significance Index: 21.0900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2566
    Cell Significance Index: 46.2500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2439
    Cell Significance Index: 48.4100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2410
    Cell Significance Index: 131.6000
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.2059
    Cell Significance Index: 2.8900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2050
    Cell Significance Index: 14.5000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2009
    Cell Significance Index: 1.8500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1795
    Cell Significance Index: 276.3500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1643
    Cell Significance Index: 7.6600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.1578
    Cell Significance Index: 3.0800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1428
    Cell Significance Index: 63.1300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1426
    Cell Significance Index: 17.5300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1289
    Cell Significance Index: 46.2200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1267
    Cell Significance Index: 87.6100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1090
    Cell Significance Index: 201.0200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0923
    Cell Significance Index: 17.5600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0626
    Cell Significance Index: 8.5900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0548
    Cell Significance Index: 1.5800
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.0529
    Cell Significance Index: 0.7400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0457
    Cell Significance Index: 7.8100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0408
    Cell Significance Index: 1.8500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0301
    Cell Significance Index: 56.6600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0296
    Cell Significance Index: 1.6600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0097
    Cell Significance Index: 0.3400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0085
    Cell Significance Index: 11.5100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0006
    Cell Significance Index: -0.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0019
    Cell Significance Index: -1.4000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0038
    Cell Significance Index: -2.7500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0042
    Cell Significance Index: -2.6700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0052
    Cell Significance Index: -0.3400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0056
    Cell Significance Index: -0.1400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0061
    Cell Significance Index: -3.8200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0074
    Cell Significance Index: -0.0600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0078
    Cell Significance Index: -0.6000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0102
    Cell Significance Index: -0.7600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0113
    Cell Significance Index: -8.5300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0114
    Cell Significance Index: -0.5800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0131
    Cell Significance Index: -7.3800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0164
    Cell Significance Index: -7.4300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0189
    Cell Significance Index: -2.2300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0311
    Cell Significance Index: -2.0900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0315
    Cell Significance Index: -4.5800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0325
    Cell Significance Index: -4.1700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0330
    Cell Significance Index: -3.3700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0348
    Cell Significance Index: -7.3400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0379
    Cell Significance Index: -4.3400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0411
    Cell Significance Index: -2.5300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0417
    Cell Significance Index: -12.0100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0431
    Cell Significance Index: -1.9100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0519
    Cell Significance Index: -3.2700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0584
    Cell Significance Index: -7.5500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0694
    Cell Significance Index: -1.9800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0771
    Cell Significance Index: -2.9200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0794
    Cell Significance Index: -2.1200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0833
    Cell Significance Index: -2.1900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0926
    Cell Significance Index: -2.5200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0955
    Cell Significance Index: -2.0700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1040
    Cell Significance Index: -3.3300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1105
    Cell Significance Index: -2.4200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1219
    Cell Significance Index: -13.9200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1252
    Cell Significance Index: -13.0400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1302
    Cell Significance Index: -3.4900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1340
    Cell Significance Index: -2.7800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1413
    Cell Significance Index: -3.9500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1418
    Cell Significance Index: -2.6200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1510
    Cell Significance Index: -11.9600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1522
    Cell Significance Index: -2.1800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1832
    Cell Significance Index: -3.1400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1929
    Cell Significance Index: -5.1600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2016
    Cell Significance Index: -10.5900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2067
    Cell Significance Index: -12.6700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2272
    Cell Significance Index: -5.8400
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.2517
    Cell Significance Index: -3.1700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2577
    Cell Significance Index: -5.4700
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2730
    Cell Significance Index: -4.7200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2809
    Cell Significance Index: -9.7600
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.2974
    Cell Significance Index: -3.1600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Oxidative Stress Response:** OSGIN2 is induced in response to oxidative stress, a condition characterized by an imbalance between the production of reactive oxygen species (ROS) and the body's ability to detoxify these harmful compounds. 2. **Negative Regulation of Cell Growth:** OSGIN2 acts as a negative regulator of cell growth, inhibiting the proliferation of cells in response to oxidative stress. 3. **Cellular Localization:** OSGIN2 is expressed in various cell types, including lens epithelial cells, mural cells, and intestinal epithelial cells. 4. **Signal Transduction:** OSGIN2 is involved in signal transduction pathways, including the meiotic cell cycle and growth factor activity. **Pathways and Functions:** 1. **Negative Regulation of Cell Growth:** OSGIN2 inhibits cell growth and proliferation by interacting with signaling pathways that regulate cell cycle progression. 2. **Oxidative Stress Response:** OSGIN2 is induced in response to oxidative stress, which triggers a signaling cascade that leads to the expression of OSGIN2. 3. **Meiotic Cell Cycle:** OSGIN2 is involved in the regulation of the meiotic cell cycle, a critical process in the development of gametes. 4. **Signal Transduction:** OSGIN2 interacts with signaling pathways, including growth factor activity, to regulate cell growth and proliferation. **Clinical Significance:** 1. **Cancer:** OSGIN2 may play a role in cancer development, as its expression is often downregulated in cancerous tissues. 2. **Neurological Disorders:** OSGIN2 may be involved in the pathogenesis of neurological disorders, such as Alzheimer's disease, where oxidative stress is a key contributor. 3. **Regenerative Medicine:** OSGIN2 may have potential applications in regenerative medicine, as its expression can be induced in response to oxidative stress, promoting tissue repair and regeneration. 4. **Oxidative Stress-Related Diseases:** OSGIN2 may be involved in the pathogenesis of oxidative stress-related diseases, such as atherosclerosis and diabetes, where oxidative stress is a key contributor. In conclusion, OSGIN2 is a gene that plays a critical role in regulating oxidative stress and cell growth. Its expression is significantly induced in response to oxidative stress, and it acts as a negative regulator of cell growth. Further research is needed to fully understand the mechanisms of OSGIN2 and its potential applications in regenerative medicine and the treatment of oxidative stress-related diseases.

Genular Protein ID: 1007055001

Symbol: OSGI2_HUMAN

Name: Oxidative stress-induced growth inhibitor 2

UniProtKB Accession Codes:

Q9Y236

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 3 ExpressionAtlas 1 GO 3 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 3 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9933573

Title: Sequence analysis of an 800-kb genomic DNA region on chromosome 8q21 that contains the Nijmegen breakage syndrome gene, NBS1.

PubMed ID: 9933573

DOI: 10.1006/geno.1998.5657

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 505
  • Mass: 56672
  • Checksum: 7AFDA45D8E8ECA8F
  • Sequence:
    • MPLVEETSLL EDSSVTFPVV IIGNGPSGIC LSYMLSGYRP YLSSEAIHPN TILNSKLEEA 
RHLSIVDQDL EYLSEGLEGR SSNPVAVLFD TLLHPDADFG YDYPSVLHWK LEQHHYIPHV 
VLGKGPPGGA WHNMEGSMLT ISFGSWMELP GLKFKDWVSS KRRSLKGDRV MPEEIARYYK 
HYVKVMGLQK NFRENTYITS VSRLYRDQDD DDIQDRDIST KHLQIEKSNF IKRNWEIRGY 
QRIADGSHVP FCLFAENVAL ATGTLDSPAH LEIEGEDFPF VFHSMPEFGA AINKGKLRGK 
VDPVLIVGSG LTAADAVLCA YNSNIPVIHV FRRRVTDPSL IFKQLPKKLY PEYHKVYHMM 
CTQSYSVDSN LLSDYTSFPE HRVLSFKSDM KCVLQSVSGL KKIFKLSAAV VLIGSHPNLS 
FLKDQGCYLG HKSSQPITCK GNPVEIDTYT YECIKEANLF ALGPLVGDNF VRFLKGGALG 
VTRCLATRQK KKHLFVERGG GDGIA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.