Details for: C9

Gene ID: 735

Symbol: C9

Ensembl ID: ENSG00000113600

Description: complement C9

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 20.6751
    Cell Significance Index: 54.5400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 9.3523
    Cell Significance Index: 157.5400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.2798
    Cell Significance Index: 18.8900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.9012
    Cell Significance Index: 21.8300
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.6607
    Cell Significance Index: 3.8100
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.3133
    Cell Significance Index: 1.1800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1528
    Cell Significance Index: 4.1000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1405
    Cell Significance Index: 27.8900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.1312
    Cell Significance Index: 2.5600
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.1074
    Cell Significance Index: 1.0600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0981
    Cell Significance Index: 0.8000
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.0925
    Cell Significance Index: 0.7300
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.0842
    Cell Significance Index: 0.8000
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0647
    Cell Significance Index: 0.9200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0508
    Cell Significance Index: 1.4200
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 0.0485
    Cell Significance Index: 0.1300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0404
    Cell Significance Index: 0.5100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0249
    Cell Significance Index: 7.1700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0122
    Cell Significance Index: 8.4300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0102
    Cell Significance Index: 0.5200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0039
    Cell Significance Index: 0.4000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0021
    Cell Significance Index: -3.9600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0027
    Cell Significance Index: -0.0700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0044
    Cell Significance Index: -6.8300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0045
    Cell Significance Index: -8.2600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0088
    Cell Significance Index: -6.5100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0102
    Cell Significance Index: -7.4600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0103
    Cell Significance Index: -1.3300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0112
    Cell Significance Index: -7.1100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0114
    Cell Significance Index: -6.4400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0116
    Cell Significance Index: -15.8200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0161
    Cell Significance Index: -2.9000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0164
    Cell Significance Index: -5.8800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0211
    Cell Significance Index: -9.5800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0217
    Cell Significance Index: -4.3500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0268
    Cell Significance Index: -4.5800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0272
    Cell Significance Index: -0.3900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0366
    Cell Significance Index: -5.3200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0384
    Cell Significance Index: -5.2800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0414
    Cell Significance Index: -2.1500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0423
    Cell Significance Index: -4.8500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0460
    Cell Significance Index: -5.6600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0461
    Cell Significance Index: -2.1500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0513
    Cell Significance Index: -1.3700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0522
    Cell Significance Index: -6.7400
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0534
    Cell Significance Index: -0.7400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0569
    Cell Significance Index: -1.1900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0638
    Cell Significance Index: -7.4300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0678
    Cell Significance Index: -7.0600
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0694
    Cell Significance Index: -0.7200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0698
    Cell Significance Index: -1.9000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0709
    Cell Significance Index: -1.7700
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0782
    Cell Significance Index: -1.1400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0828
    Cell Significance Index: -0.7600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0882
    Cell Significance Index: -5.9300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0907
    Cell Significance Index: -6.7600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0975
    Cell Significance Index: -7.7300
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.1016
    Cell Significance Index: -1.5200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1058
    Cell Significance Index: -6.5000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1071
    Cell Significance Index: -8.2200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1089
    Cell Significance Index: -5.1200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1209
    Cell Significance Index: -7.4100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1209
    Cell Significance Index: -1.9400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1215
    Cell Significance Index: -6.3300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1247
    Cell Significance Index: -2.1500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1288
    Cell Significance Index: -1.4000
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.1322
    Cell Significance Index: -1.8800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1354
    Cell Significance Index: -5.9900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1416
    Cell Significance Index: -3.1000
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.1433
    Cell Significance Index: -1.3900
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.1455
    Cell Significance Index: -1.4300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1487
    Cell Significance Index: -6.1000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1504
    Cell Significance Index: -8.4400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1516
    Cell Significance Index: -6.8700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1540
    Cell Significance Index: -5.8300
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1656
    Cell Significance Index: -2.8300
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.1665
    Cell Significance Index: -1.4400
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: -0.1682
    Cell Significance Index: -0.5900
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.1682
    Cell Significance Index: -1.7400
  • Cell Name: brush cell (CL0002204)
    Fold Change: -0.1691
    Cell Significance Index: -1.5500
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: -0.1750
    Cell Significance Index: -1.3900
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.1768
    Cell Significance Index: -1.9300
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.1797
    Cell Significance Index: -2.3000
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.1812
    Cell Significance Index: -1.1100
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.1820
    Cell Significance Index: -1.5500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1840
    Cell Significance Index: -9.6600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1885
    Cell Significance Index: -3.1700
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.1946
    Cell Significance Index: -1.9600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1948
    Cell Significance Index: -5.5600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1984
    Cell Significance Index: -6.9500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1988
    Cell Significance Index: -5.7000
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.2087
    Cell Significance Index: -2.1600
  • Cell Name: group 3 innate lymphoid cell, human (CL0001078)
    Fold Change: -0.2092
    Cell Significance Index: -1.9600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2108
    Cell Significance Index: -5.3700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2111
    Cell Significance Index: -6.9100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2153
    Cell Significance Index: -5.3700
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.2160
    Cell Significance Index: -2.5000
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.2195
    Cell Significance Index: -2.8200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2201
    Cell Significance Index: -2.5000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2222
    Cell Significance Index: -7.7200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** C9 has several key characteristics that make it an essential component of the complement cascade. These include: * **Structure**: C9 is a pentamer, composed of five identical subunits, which are linked together by disulfide bonds. * **Function**: C9 is a membrane attack complex component, which forms a pore in the membrane of target cells, leading to cell lysis and death. * **Expression**: C9 is expressed in various tissues, including the liver, kidney, and immune cells such as T cells and endothelial cells. * **Regulation**: C9 is regulated by several mechanisms, including negative feedback loops and interactions with other complement components. **Pathways and Functions** The complement cascade is a complex series of reactions that involve multiple proteins and pathways. C9 plays a critical role in the terminal pathway of the complement cascade, which is responsible for the formation of the membrane attack complex. The key pathways and functions of C9 include: * **Complement activation**: C9 is activated during the complement cascade, leading to the formation of the membrane attack complex. * **Membrane attack complex formation**: C9 forms a pore in the membrane of target cells, leading to cell lysis and death. * **Positive regulation of immune response**: C9 plays a role in regulating the immune response, including the activation of immune cells such as T cells. * **Cell killing**: C9 is involved in the killing of cells, including pathogens and foreign substances. **Clinical Significance** C9 plays a critical role in protecting against infections and diseases. Dysregulation of C9 has been implicated in several diseases, including: * **Complement-mediated glomerulonephritis**: C9 is involved in the pathogenesis of this disease, which is characterized by inflammation and damage to the kidneys. * **Neurological disorders**: C9 has been implicated in the pathogenesis of neurological disorders, including multiple sclerosis and Alzheimer's disease. * **Infectious diseases**: C9 plays a critical role in protecting against infections, including bacterial and viral diseases. In conclusion, complement component C9 is a critical regulator of the membrane attack complex and immune response. Its dysregulation has been implicated in several diseases, highlighting the importance of C9 in protecting against infections and diseases. Further research is needed to fully understand the mechanisms of C9 and its role in the immune response.

Genular Protein ID: 2177454364

Symbol: CO9_HUMAN

Name: Complement component C9

UniProtKB Accession Codes:

P02748

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 3 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 ELM 1 EMBL 14 EMDB 12 Ensembl 1 GO 14 Gene3D 3 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 9 PIR 1 PRINTS 1 PRO 1 PROSITE 7 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 4018030

Title: The sequence and topology of human complement component C9.

PubMed ID: 4018030

DOI: 10.1002/j.1460-2075.1985.tb03639.x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 6095282

Title: Nucleotide sequence of cDNA and derived amino acid sequence of human complement component C9.

PubMed ID: 6095282

DOI: 10.1073/pnas.81.23.7298

PubMed ID: 3219351

Title: Relationships between the gene and protein structure in human complement component C9.

PubMed ID: 3219351

DOI: 10.1021/bi00417a050

PubMed ID: 9634479

Title: Heterogeneity in the genetic basis of human complement C9 deficiency.

PubMed ID: 9634479

DOI: 10.1007/s002510050415

PubMed ID: 4055801

Title: The architecture of complement component C9 and poly(C9).

PubMed ID: 4055801

DOI: 10.1016/s0021-9258(17)38643-x

PubMed ID: 8603752

Title: Identification of disulfide bonds in the ninth component (C9) of human complement.

PubMed ID: 8603752

DOI: 10.1016/0014-5793(95)01541-8

PubMed ID: 9212048

Title: The administration of complement component C9 enhances the survival of neonatal rats with Escherichia coli sepsis.

PubMed ID: 9212048

DOI: 10.1203/00006450-199707000-00020

PubMed ID: 10551839

Title: The four terminal components of the complement system are C-mannosylated on multiple tryptophan residues.

PubMed ID: 10551839

DOI: 10.1074/jbc.274.46.32786

PubMed ID: 14760718

Title: Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.

PubMed ID: 14760718

DOI: 10.1002/pmic.200300556

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 16263699

Title: Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach.

PubMed ID: 16263699

DOI: 10.1074/mcp.m500324-mcp200

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19139490

Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.

PubMed ID: 19139490

DOI: 10.1074/mcp.m800504-mcp200

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 2395434

Title: Localization and molecular modelling of the membrane-inserted domain of the ninth component of human complement and perforin.

PubMed ID: 2395434

DOI: 10.1016/0161-5890(90)90001-g

PubMed ID: 22832194

Title: Assembly and regulation of the membrane attack complex based on structures of C5b6 and sC5b9.

PubMed ID: 22832194

DOI: 10.1016/j.celrep.2012.02.003

PubMed ID: 26841934

Title: Structure of the poly-C9 component of the complement membrane attack complex.

PubMed ID: 26841934

DOI: 10.1038/ncomms10588

PubMed ID: 30111885

Title: The first transmembrane region of complement component-9 acts as a brake on its self-assembly.

PubMed ID: 30111885

DOI: 10.1038/s41467-018-05717-0

PubMed ID: 24036952

Title: Rare variants in CFI, C3 and C9 are associated with high risk of advanced age-related macular degeneration.

PubMed ID: 24036952

DOI: 10.1038/ng.2741

Sequence Information:

  • Length: 559
  • Mass: 63173
  • Checksum: 7403F6AD77B3ECE1
  • Sequence:
    • MSACRSFAVA ICILEISILT AQYTTSYDPE LTESSGSASH IDCRMSPWSE WSQCDPCLRQ 
MFRSRSIEVF GQFNGKRCTD AVGDRRQCVP TEPCEDAEDD CGNDFQCSTG RCIKMRLRCN 
GDNDCGDFSD EDDCESEPRP PCRDRVVEES ELARTAGYGI NILGMDPLST PFDNEFYNGL 
CNRDRDGNTL TYYRRPWNVA SLIYETKGEK NFRTEHYEEQ IEAFKSIIQE KTSNFNAAIS 
LKFTPTETNK AEQCCEETAS SISLHGKGSF RFSYSKNETY QLFLSYSSKK EKMFLHVKGE 
IHLGRFVMRN RDVVLTTTFV DDIKALPTTY EKGEYFAFLE TYGTHYSSSG SLGGLYELIY 
VLDKASMKRK GVELKDIKRC LGYHLDVSLA FSEISVGAEF NKDDCVKRGE GRAVNITSEN 
LIDDVVSLIR GGTRKYAFEL KEKLLRGTVI DVTDFVNWAS SINDAPVLIS QKLSPIYNLV 
PVKMKNAHLK KQNLERAIED YINEFSVRKC HTCQNGGTVI LMDGKCLCAC PFKFEGIACE 
ISKQKISEGL PALEFPNEK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.