C9 | ENSG00000113600 | NCBI 735

Details for: C9

Gene ID: 735

Symbol: C9

Ensembl ID: ENSG00000113600

Description: complement C9

Associated with

Complement cascade
(R-HSA-166658)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Regulation of complement cascade
(R-HSA-977606)
Terminal pathway of complement
(R-HSA-166665)
Blood microparticle
(GO:0072562)
Cell killing
(GO:0001906)
Complement activation
(GO:0006956)
Complement activation, alternative pathway
(GO:0006957)
Complement activation, classical pathway
(GO:0006958)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Killing of cells of another organism
(GO:0031640)
Membrane attack complex
(GO:0005579)
Other organism cell membrane
(GO:0044218)
Plasma membrane
(GO:0005886)
Positive regulation of immune response
(GO:0050778)
Protein binding
(GO:0005515)
Protein homooligomerization
(GO:0051260)

Other Information

Proteins

Complement component C9

Genular Protein ID: 2177454364

Symbol: CO9_HUMAN

Name: Complement component C9

UniProtKB Accession Codes:

P02748

Database IDs:

Citations:

PubMed ID: 4018030

Title: The sequence and topology of human complement component C9.

PubMed ID: 4018030

DOI: 10.1002/j.1460-2075.1985.tb03639.x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 6095282

Title: Nucleotide sequence of cDNA and derived amino acid sequence of human complement component C9.

PubMed ID: 6095282

DOI: 10.1073/pnas.81.23.7298

PubMed ID: 3219351

Title: Relationships between the gene and protein structure in human complement component C9.

PubMed ID: 3219351

DOI: 10.1021/bi00417a050

PubMed ID: 9634479

Title: Heterogeneity in the genetic basis of human complement C9 deficiency.

PubMed ID: 9634479

DOI: 10.1007/s002510050415

PubMed ID: 4055801

Title: The architecture of complement component C9 and poly(C9).

PubMed ID: 4055801

DOI: 10.1016/s0021-9258(17)38643-x

PubMed ID: 8603752

Title: Identification of disulfide bonds in the ninth component (C9) of human complement.

PubMed ID: 8603752

DOI: 10.1016/0014-5793(95)01541-8

PubMed ID: 9212048

Title: The administration of complement component C9 enhances the survival of neonatal rats with Escherichia coli sepsis.

PubMed ID: 9212048

DOI: 10.1203/00006450-199707000-00021

PubMed ID: 10551839

Title: The four terminal components of the complement system are C-mannosylated on multiple tryptophan residues.

PubMed ID: 10551839

DOI: 10.1074/jbc.274.46.32786

PubMed ID: 14760718

Title: Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.

PubMed ID: 14760718

DOI: 10.1002/pmic.200300556

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 16263699

Title: Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach.

PubMed ID: 16263699

DOI: 10.1074/mcp.m500324-mcp200

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19139490

Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.

PubMed ID: 19139490

DOI: 10.1074/mcp.m800504-mcp200

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 2395434

Title: Localization and molecular modelling of the membrane-inserted domain of the ninth component of human complement and perforin.

PubMed ID: 2395434

DOI: 10.1016/0161-5890(90)90001-g

PubMed ID: 22832194

Title: Assembly and regulation of the membrane attack complex based on structures of C5b6 and sC5b9.

PubMed ID: 22832194

DOI: 10.1016/j.celrep.2012.02.003

PubMed ID: 26841934

Title: Structure of the poly-C9 component of the complement membrane attack complex.

PubMed ID: 26841934

DOI: 10.1038/ncomms10588

PubMed ID: 30111885

Title: The first transmembrane region of complement component-9 acts as a brake on its self-assembly.

PubMed ID: 30111885

DOI: 10.1038/s41467-018-05717-0

PubMed ID: 24036952

Title: Rare variants in CFI, C3 and C9 are associated with high risk of advanced age-related macular degeneration.

PubMed ID: 24036952

DOI: 10.1038/ng.2741

Sequence Information:

Length: 559
Mass: 63173
Checksum: 7403F6AD77B3ECE1
Sequence:

MSACRSFAVA ICILEISILT AQYTTSYDPE LTESSGSASH IDCRMSPWSE WSQCDPCLRQ 
MFRSRSIEVF GQFNGKRCTD AVGDRRQCVP TEPCEDAEDD CGNDFQCSTG RCIKMRLRCN 
GDNDCGDFSD EDDCESEPRP PCRDRVVEES ELARTAGYGI NILGMDPLST PFDNEFYNGL 
CNRDRDGNTL TYYRRPWNVA SLIYETKGEK NFRTEHYEEQ IEAFKSIIQE KTSNFNAAIS 
LKFTPTETNK AEQCCEETAS SISLHGKGSF RFSYSKNETY QLFLSYSSKK EKMFLHVKGE 
IHLGRFVMRN RDVVLTTTFV DDIKALPTTY EKGEYFAFLE TYGTHYSSSG SLGGLYELIY 
VLDKASMKRK GVELKDIKRC LGYHLDVSLA FSEISVGAEF NKDDCVKRGE GRAVNITSEN 
LIDDVVSLIR GGTRKYAFEL KEKLLRGTVI DVTDFVNWAS SINDAPVLIS QKLSPIYNLV 
PVKMKNAHLK KQNLERAIED YINEFSVRKC HTCQNGGTVI LMDGKCLCAC PFKFEGIACE 
ISKQKISEGL PALEFPNEK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: C9

Associated with

Other Information

The sequence and topology of human complement component C9. PubMed ID: 4018030

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Nucleotide sequence of cDNA and derived amino acid sequence of human complement component C9. PubMed ID: 6095282

Relationships between the gene and protein structure in human complement component C9. PubMed ID: 3219351

Heterogeneity in the genetic basis of human complement C9 deficiency. PubMed ID: 9634479

The architecture of complement component C9 and poly(C9). PubMed ID: 4055801

Identification of disulfide bonds in the ninth component (C9) of human complement. PubMed ID: 8603752

The administration of complement component C9 enhances the survival of neonatal rats with Escherichia coli sepsis. PubMed ID: 9212048

The four terminal components of the complement system are C-mannosylated on multiple tryptophan residues. PubMed ID: 10551839

Screening for N-glycosylated proteins by liquid chromatography mass spectrometry. PubMed ID: 14760718

Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. PubMed ID: 16335952

Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach. PubMed ID: 16263699

Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. PubMed ID: 19159218

A strategy for precise and large scale identification of core fucosylated glycoproteins. PubMed ID: 19139490

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Localization and molecular modelling of the membrane-inserted domain of the ninth component of human complement and perforin. PubMed ID: 2395434

Assembly and regulation of the membrane attack complex based on structures of C5b6 and sC5b9. PubMed ID: 22832194

Structure of the poly-C9 component of the complement membrane attack complex. PubMed ID: 26841934

The first transmembrane region of complement component-9 acts as a brake on its self-assembly. PubMed ID: 30111885

Rare variants in CFI, C3 and C9 are associated with high risk of advanced age-related macular degeneration. PubMed ID: 24036952