Details for: VPS51
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 295.0910
Cell Significance Index: -45.9000 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 156.9526
Cell Significance Index: -39.8100 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 111.3482
Cell Significance Index: -52.5700 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 107.7150
Cell Significance Index: -43.7600 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 99.5169
Cell Significance Index: -51.1900 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 78.3283
Cell Significance Index: -52.5600 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 46.1171
Cell Significance Index: -44.0300 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 40.0582
Cell Significance Index: -49.3900 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 17.3693
Cell Significance Index: -46.5300 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 13.0916
Cell Significance Index: -51.6600 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 10.4104
Cell Significance Index: -31.9800 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 8.8870
Cell Significance Index: -19.4500 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 3.0219
Cell Significance Index: 491.4800 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.7585
Cell Significance Index: 1587.7900 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.6688
Cell Significance Index: 107.6700 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.5683
Cell Significance Index: 73.1200 - Cell Name: lactocyte (CL0002325)
Fold Change: 1.4047
Cell Significance Index: 181.4800 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.3970
Cell Significance Index: 19.0600 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.3478
Cell Significance Index: 61.0900 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 1.2150
Cell Significance Index: 32.5000 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.1495
Cell Significance Index: 157.8600 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: 1.1132
Cell Significance Index: 16.6800 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.9520
Cell Significance Index: 171.6100 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.8743
Cell Significance Index: 95.1000 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.8295
Cell Significance Index: 102.0000 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.8165
Cell Significance Index: 23.5300 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.8090
Cell Significance Index: 162.2900 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.7923
Cell Significance Index: 157.2300 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.7702
Cell Significance Index: 36.2000 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.7686
Cell Significance Index: 531.6200 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.7226
Cell Significance Index: 319.5000 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.6730
Cell Significance Index: 47.6000 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.5844
Cell Significance Index: 319.1400 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.5663
Cell Significance Index: 66.7800 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.5356
Cell Significance Index: 27.9000 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.5213
Cell Significance Index: 27.0800 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.4646
Cell Significance Index: 13.6500 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.4491
Cell Significance Index: 161.0700 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.3888
Cell Significance Index: 28.9800 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.3654
Cell Significance Index: 9.9500 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.3645
Cell Significance Index: 7.6300 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.3345
Cell Significance Index: 42.8800 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.2968
Cell Significance Index: 50.6800 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.2877
Cell Significance Index: 8.0400 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.2704
Cell Significance Index: 17.0400 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2454
Cell Significance Index: 46.7000 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 0.2202
Cell Significance Index: 1.8500 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.2064
Cell Significance Index: 15.8400 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.1931
Cell Significance Index: 6.7100 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1216
Cell Significance Index: 12.0300 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0986
Cell Significance Index: 3.4700 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.0724
Cell Significance Index: 3.8000 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0407
Cell Significance Index: 76.6500 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0201
Cell Significance Index: 37.1200 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0188
Cell Significance Index: 28.9700 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.0157
Cell Significance Index: 0.4200 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0030
Cell Significance Index: -1.9100 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0131
Cell Significance Index: -9.5900 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0167
Cell Significance Index: -12.6600 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0227
Cell Significance Index: -30.8800 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0340
Cell Significance Index: -2.0900 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0417
Cell Significance Index: -18.9100 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0620
Cell Significance Index: -45.9300 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0696
Cell Significance Index: -7.1100 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0741
Cell Significance Index: -1.2400 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0838
Cell Significance Index: -47.2700 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0909
Cell Significance Index: -56.7700 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.1119
Cell Significance Index: -1.0300 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1402
Cell Significance Index: -16.3400 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1496
Cell Significance Index: -43.0400 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.1552
Cell Significance Index: -1.8500 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1879
Cell Significance Index: -27.3200 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.2311
Cell Significance Index: -3.9600 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.2513
Cell Significance Index: -14.1000 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.2622
Cell Significance Index: -17.6300 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2635
Cell Significance Index: -30.1900 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.2704
Cell Significance Index: -7.1100 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2781
Cell Significance Index: -58.5900 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.3359
Cell Significance Index: -8.5800 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.3532
Cell Significance Index: -3.8400 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.4168
Cell Significance Index: -9.0300 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.4458
Cell Significance Index: -46.4200 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.4534
Cell Significance Index: -12.1500 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.4553
Cell Significance Index: -20.1400 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.4597
Cell Significance Index: -36.4100 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.4768
Cell Significance Index: -8.4300 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.5577
Cell Significance Index: -21.1200 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.5582
Cell Significance Index: -16.0000 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.6062
Cell Significance Index: -12.9100 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.6131
Cell Significance Index: -15.7600 - Cell Name: kidney cell (CL1000497)
Fold Change: -0.6751
Cell Significance Index: -5.3900 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.7156
Cell Significance Index: -43.8700 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.8283
Cell Significance Index: -8.5800 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.8406
Cell Significance Index: -9.5500 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.8591
Cell Significance Index: -27.5200 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.8809
Cell Significance Index: -18.8300 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.8960
Cell Significance Index: -26.3900 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -1.0469
Cell Significance Index: -26.1700 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -1.0606
Cell Significance Index: -33.7800 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -1.1021
Cell Significance Index: -31.4500
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 4034449102
Symbol: VPS51_HUMAN
Name: Vacuolar protein sorting-associated protein 51 homolog
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9615229
Title: Identification and molecular characterization of TM7SF2 in the FAUNA gene cluster on human chromosome 11q13.
PubMed ID: 9615229
PubMed ID: 15498874
Title: Large-scale cDNA transfection screening for genes related to cancer development and progression.
PubMed ID: 15498874
PubMed ID: 16554811
Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.
PubMed ID: 16554811
DOI: 10.1038/nature04632
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 20685960
Title: Ang2/fat-free is a conserved subunit of the Golgi-associated retrograde protein complex.
PubMed ID: 20685960
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22223895
Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
PubMed ID: 22223895
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 25799061
Title: EARP is a multisubunit tethering complex involved in endocytic recycling.
PubMed ID: 25799061
DOI: 10.1038/ncb3129
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 27440922
Title: TSSC1 is novel component of the endosomal retrieval machinery.
PubMed ID: 27440922
PubMed ID: 31721635
Title: EIPR1 controls dense-core vesicle cargo retention and EARP complex localization in insulin-secreting cells.
PubMed ID: 31721635
PubMed ID: 30624672
Title: A neurodevelopmental disorder caused by mutations in the VPS51 subunit of the GARP and EARP complexes.
PubMed ID: 30624672
DOI: 10.1093/hmg/ddy423
PubMed ID: 31207318
Title: VPS51 biallelic variants cause microcephaly with brain malformations: A confirmatory report.
PubMed ID: 31207318
Sequence Information:
- Length: 782
- Mass: 86042
- Checksum: 0E858672E4C656DD
- Sequence:
MAAAAAAGPS PGSGPGDSPE GPEGEAPERR RKAHGMLKLY YGLSEGEAAG RPAGPDPLDP TDLNGAHFDP EVYLDKLRRE CPLAQLMDSE TDMVRQIRAL DSDMQTLVYE NYNKFISATD TIRKMKNDFR KMEDEMDRLA TNMAVITDFS ARISATLQDR HERITKLAGV HALLRKLQFL FELPSRLTKC VELGAYGQAV RYQGRAQAVL QQYQHLPSFR AIQDDCQVIT ARLAQQLRQR FREGGSGAPE QAECVELLLA LGEPAEELCE EFLAHARGRL EKELRNLEAE LGPSPPAPDV LEFTDHGGSG FVGGLCQVAA AYQELFAAQG PAGAEKLAAF ARQLGSRYFA LVERRLAQEQ GGGDNSLLVR ALDRFHRRLR APGALLAAAG LADAATEIVE RVARERLGHH LQGLRAAFLG CLTDVRQALA APRVAGKEGP GLAELLANVA SSILSHIKAS LAAVHLFTAK EVSFSNKPYF RGEFCSQGVR EGLIVGFVHS MCQTAQSFCD SPGEKGGATP PALLLLLSRL CLDYETATIS YILTLTDEQF LVQDQFPVTP VSTLCAEARE TARRLLTHYV KVQGLVISQM LRKSVETRDW LSTLEPRNVR AVMKRVVEDT TAIDVQVGLL YEEGVRKAQS SDSSKRTFSV YSSSRQQGRY APSYTPSAPM DTNLLSNIQK LFSERIDVFS PVEFNKVSVL TGIIKISLKT LLECVRLRTF GRFGLQQVQV DCHFLQLYLW RFVADEELVH LLLDEVVASA ALRCPDPVPM EPSVVEVICE RG
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.