VPS51 | ENSG00000149823 | NCBI 738

Details for: VPS51

Gene ID: 738

Symbol: VPS51

Ensembl ID: ENSG00000149823

Description: VPS51 subunit of GARP complex

Associated with

Intra-golgi and retrograde golgi-to-er traffic
(R-HSA-6811442)
Membrane trafficking
(R-HSA-199991)
Retrograde transport at the trans-golgi-network
(R-HSA-6811440)
Vesicle-mediated transport
(R-HSA-5653656)
Autophagy
(GO:0006914)
Brain morphogenesis
(GO:0048854)
Cytosol
(GO:0005829)
Earp complex
(GO:1990745)
Endocytic recycling
(GO:0032456)
Garp complex
(GO:0000938)
Golgi apparatus
(GO:0005794)
Golgi organization
(GO:0007030)
Golgi vesicle transport
(GO:0048193)
Intracellular membrane-bounded organelle
(GO:0043231)
Lysosomal transport
(GO:0007041)
Membrane
(GO:0016020)
Molecular_function
(GO:0003674)
Nucleolus
(GO:0005730)
Protein binding
(GO:0005515)
Protein targeting
(GO:0006605)
Protein transport
(GO:0015031)
Recycling endosome
(GO:0055037)
Retrograde transport, endosome to golgi
(GO:0042147)
Trans-golgi network membrane
(GO:0032588)
Vesicle-mediated cholesterol transport
(GO:0090119)

Other Information

Proteins

Vacuolar protein sorting-associated protein 51 homolog

Genular Protein ID: 4034449102

Symbol: VPS51_HUMAN

Name: Vacuolar protein sorting-associated protein 51 homolog

UniProtKB Accession Codes:

Q9UID3 Q6PJV5 Q7L8A6 Q8WZ35 Q96DF4 Q96GR3

Database IDs:

Citations:

PubMed ID: 9615229

Title: Identification and molecular characterization of TM7SF2 in the FAUNA gene cluster on human chromosome 11q13.

PubMed ID: 9615229

DOI: 10.1006/geno.1998.5296

PubMed ID: 15498874

Title: Large-scale cDNA transfection screening for genes related to cancer development and progression.

PubMed ID: 15498874

DOI: 10.1073/pnas.0404089101

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20685960

Title: Ang2/fat-free is a conserved subunit of the Golgi-associated retrograde protein complex.

PubMed ID: 20685960

DOI: 10.1091/mbc.e10-05-0392

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25799061

Title: EARP is a multisubunit tethering complex involved in endocytic recycling.

PubMed ID: 25799061

DOI: 10.1038/ncb3129

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27440922

Title: TSSC1 is novel component of the endosomal retrieval machinery.

PubMed ID: 27440922

DOI: 10.1091/mbc.e16-04-0209

PubMed ID: 31721635

Title: EIPR1 controls dense-core vesicle cargo retention and EARP complex localization in insulin-secreting cells.

PubMed ID: 31721635

DOI: 10.1091/mbc.e18-07-0469

PubMed ID: 30624672

Title: A neurodevelopmental disorder caused by mutations in the VPS51 subunit of the GARP and EARP complexes.

PubMed ID: 30624672

DOI: 10.1093/hmg/ddy423

PubMed ID: 31207318

Title: VPS51 biallelic variants cause microcephaly with brain malformations: A confirmatory report.

PubMed ID: 31207318

DOI: 10.1016/j.ejmg.2019.103704

Sequence Information:

Length: 782
Mass: 86042
Checksum: 0E858672E4C656DD
Sequence:

MAAAAAAGPS PGSGPGDSPE GPEGEAPERR RKAHGMLKLY YGLSEGEAAG RPAGPDPLDP 
TDLNGAHFDP EVYLDKLRRE CPLAQLMDSE TDMVRQIRAL DSDMQTLVYE NYNKFISATD 
TIRKMKNDFR KMEDEMDRLA TNMAVITDFS ARISATLQDR HERITKLAGV HALLRKLQFL 
FELPSRLTKC VELGAYGQAV RYQGRAQAVL QQYQHLPSFR AIQDDCQVIT ARLAQQLRQR 
FREGGSGAPE QAECVELLLA LGEPAEELCE EFLAHARGRL EKELRNLEAE LGPSPPAPDV 
LEFTDHGGSG FVGGLCQVAA AYQELFAAQG PAGAEKLAAF ARQLGSRYFA LVERRLAQEQ 
GGGDNSLLVR ALDRFHRRLR APGALLAAAG LADAATEIVE RVARERLGHH LQGLRAAFLG 
CLTDVRQALA APRVAGKEGP GLAELLANVA SSILSHIKAS LAAVHLFTAK EVSFSNKPYF 
RGEFCSQGVR EGLIVGFVHS MCQTAQSFCD SPGEKGGATP PALLLLLSRL CLDYETATIS 
YILTLTDEQF LVQDQFPVTP VSTLCAEARE TARRLLTHYV KVQGLVISQM LRKSVETRDW 
LSTLEPRNVR AVMKRVVEDT TAIDVQVGLL YEEGVRKAQS SDSSKRTFSV YSSSRQQGRY 
APSYTPSAPM DTNLLSNIQK LFSERIDVFS PVEFNKVSVL TGIIKISLKT LLECVRLRTF 
GRFGLQQVQV DCHFLQLYLW RFVADEELVH LLLDEVVASA ALRCPDPVPM EPSVVEVICE 
RG

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: VPS51

Associated with

Other Information

Identification and molecular characterization of TM7SF2 in the FAUNA gene cluster on human chromosome 11q13. PubMed ID: 9615229

Large-scale cDNA transfection screening for genes related to cancer development and progression. PubMed ID: 15498874

Human chromosome 11 DNA sequence and analysis including novel gene identification. PubMed ID: 16554811

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Ang2/fat-free is a conserved subunit of the Golgi-associated retrograde protein complex. PubMed ID: 20685960

Initial characterization of the human central proteome. PubMed ID: 21269460

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

EARP is a multisubunit tethering complex involved in endocytic recycling. PubMed ID: 25799061

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

TSSC1 is novel component of the endosomal retrieval machinery. PubMed ID: 27440922

EIPR1 controls dense-core vesicle cargo retention and EARP complex localization in insulin-secreting cells. PubMed ID: 31721635

A neurodevelopmental disorder caused by mutations in the VPS51 subunit of the GARP and EARP complexes. PubMed ID: 30624672

VPS51 biallelic variants cause microcephaly with brain malformations: A confirmatory report. PubMed ID: 31207318