Details for: VPS51

Gene ID: 738

Symbol: VPS51

Ensembl ID: ENSG00000149823

Description: VPS51 subunit of GARP complex

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 3.07
    Marker Score: 6482
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.29
    Marker Score: 5217
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.9
    Marker Score: 1339
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.83
    Marker Score: 18563
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.72
    Marker Score: 858
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.68
    Marker Score: 1651
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.63
    Marker Score: 1178
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.58
    Marker Score: 1478
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.52
    Marker Score: 3609.5
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.51
    Marker Score: 6496
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.51
    Marker Score: 3158
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.51
    Marker Score: 910
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.5
    Marker Score: 564
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.48
    Marker Score: 6060
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.48
    Marker Score: 6161
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.48
    Marker Score: 985
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.47
    Marker Score: 5792
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.46
    Marker Score: 469
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.46
    Marker Score: 517
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.46
    Marker Score: 2150
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.45
    Marker Score: 1629
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.45
    Marker Score: 6235
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.43
    Marker Score: 75569
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.43
    Marker Score: 2488
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.43
    Marker Score: 2425
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.42
    Marker Score: 4456
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.39
    Marker Score: 1398
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.39
    Marker Score: 421
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.39
    Marker Score: 6654
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.39
    Marker Score: 2346
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.38
    Marker Score: 1438
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.35
    Marker Score: 323
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.35
    Marker Score: 8613
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.32
    Marker Score: 1183
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.32
    Marker Score: 1398
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.32
    Marker Score: 4154.5
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1.32
    Marker Score: 1421
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.31
    Marker Score: 453
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.31
    Marker Score: 2334
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 1.29
    Marker Score: 1282.5
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.29
    Marker Score: 2567
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.28
    Marker Score: 446
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.28
    Marker Score: 596
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.26
    Marker Score: 1157.5
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.26
    Marker Score: 692
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.25
    Marker Score: 2942
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.24
    Marker Score: 775.5
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.24
    Marker Score: 3368
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.24
    Marker Score: 1031.5
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.23
    Marker Score: 517
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 1.23
    Marker Score: 283
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.23
    Marker Score: 1159
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.23
    Marker Score: 13839
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.23
    Marker Score: 2013
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.22
    Marker Score: 2770
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.22
    Marker Score: 2290
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.21
    Marker Score: 451
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.2
    Marker Score: 878
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.2
    Marker Score: 1198.5
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 1.2
    Marker Score: 833
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.2
    Marker Score: 1436
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.2
    Marker Score: 1300
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.19
    Marker Score: 401
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.19
    Marker Score: 486
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.19
    Marker Score: 11310
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.19
    Marker Score: 697
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.19
    Marker Score: 898
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.19
    Marker Score: 302
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.18
    Marker Score: 3206
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.18
    Marker Score: 1238
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.18
    Marker Score: 1690
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.17
    Marker Score: 1515
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.17
    Marker Score: 371
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.17
    Marker Score: 2073
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.17
    Marker Score: 796
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.17
    Marker Score: 488
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.17
    Marker Score: 1407
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 1.16
    Marker Score: 306
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.16
    Marker Score: 1790
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.16
    Marker Score: 2350
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.16
    Marker Score: 271
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.15
    Marker Score: 9911
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 1.15
    Marker Score: 305
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 1.15
    Marker Score: 1972
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.15
    Marker Score: 901
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.15
    Marker Score: 4671
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.15
    Marker Score: 251
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.14
    Marker Score: 1620
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.14
    Marker Score: 7438
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.14
    Marker Score: 1019
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.14
    Marker Score: 8499
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 1.14
    Marker Score: 397
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 1.14
    Marker Score: 1142
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.13
    Marker Score: 3345
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.13
    Marker Score: 1080
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.13
    Marker Score: 1733
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.12
    Marker Score: 9676
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.12
    Marker Score: 1209
  • Cell Name: adipose microvascular endothelial cell (CL2000072)
    Fold Change: 1.12
    Marker Score: 333
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.12
    Marker Score: 347

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Other Information

**Key characteristics:** * VPS51 is a transmembrane protein with a molecular weight of approximately 150 kDa. * It is a member of the VPS51 family of proteins, which are involved in the sorting of proteins in the ER. * VPS51 is expressed in a variety of cell types, including pancreatic acinar cells, acinar cells of the salivary gland, early pro-B cells, DN3 thymocytes, IgG-negative class switched memory B cells, CD34-positive hematopoietic stem cells, effector CD4-positive T cells, and stem cells. **Pathways and functions:** * VPS51 is involved in the following pathways: * ER-to-Golgi transport pathway * Autophagy * Brain morphogenesis * Endocytic recycling * Golgi organization * Golgi vesicle transport * Intra-golgi and retrograde Golgi-to-er traffic * Lysosomal transport * Membrane trafficking * Molecular_function * Protein binding * Protein targeting * Protein transport * Retrograde transport * Endosome to golgi * Retrograde transport at the trans-golgi-network * Vesicle-mediated cholesterol transport * Vesicle-mediated transport **Clinical significance:** VPS51 is a potential therapeutic target for a variety of diseases, including cancer and neurodegenerative disorders. Mutations in VPS51 have been linked to several human diseases, including cancer, neurodegenerative disorders, and diabetes. Studies have shown that VPS51 inhibitors can suppress tumor growth in vitro and in vivo, suggesting that VPS51 is a potential therapeutic target for cancer.

Genular Protein ID: 4034449102

Symbol: VPS51_HUMAN

Name: Vacuolar protein sorting-associated protein 51 homolog

UniProtKB Accession Codes:

Q9UID3 Q6PJV5 Q7L8A6 Q8WZ35 Q96DF4 Q96GR3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 18 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9615229

Title: Identification and molecular characterization of TM7SF2 in the FAUNA gene cluster on human chromosome 11q13.

PubMed ID: 9615229

DOI: 10.1006/geno.1998.5296

PubMed ID: 15498874

Title: Large-scale cDNA transfection screening for genes related to cancer development and progression.

PubMed ID: 15498874

DOI: 10.1073/pnas.0404089101

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20685960

Title: Ang2/fat-free is a conserved subunit of the Golgi-associated retrograde protein complex.

PubMed ID: 20685960

DOI: 10.1091/mbc.e10-05-0392

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25799061

Title: EARP is a multisubunit tethering complex involved in endocytic recycling.

PubMed ID: 25799061

DOI: 10.1038/ncb3129

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27440922

Title: TSSC1 is novel component of the endosomal retrieval machinery.

PubMed ID: 27440922

DOI: 10.1091/mbc.e16-04-0209

PubMed ID: 31721635

Title: EIPR1 controls dense-core vesicle cargo retention and EARP complex localization in insulin-secreting cells.

PubMed ID: 31721635

DOI: 10.1091/mbc.e18-07-0469

PubMed ID: 30624672

Title: A neurodevelopmental disorder caused by mutations in the VPS51 subunit of the GARP and EARP complexes.

PubMed ID: 30624672

DOI: 10.1093/hmg/ddy423

PubMed ID: 31207318

Title: VPS51 biallelic variants cause microcephaly with brain malformations: A confirmatory report.

PubMed ID: 31207318

DOI: 10.1016/j.ejmg.2019.103704

Sequence Information:

  • Length: 782
  • Mass: 86042
  • Checksum: 0E858672E4C656DD
  • Sequence:
    • MAAAAAAGPS PGSGPGDSPE GPEGEAPERR RKAHGMLKLY YGLSEGEAAG RPAGPDPLDP 
TDLNGAHFDP EVYLDKLRRE CPLAQLMDSE TDMVRQIRAL DSDMQTLVYE NYNKFISATD 
TIRKMKNDFR KMEDEMDRLA TNMAVITDFS ARISATLQDR HERITKLAGV HALLRKLQFL 
FELPSRLTKC VELGAYGQAV RYQGRAQAVL QQYQHLPSFR AIQDDCQVIT ARLAQQLRQR 
FREGGSGAPE QAECVELLLA LGEPAEELCE EFLAHARGRL EKELRNLEAE LGPSPPAPDV 
LEFTDHGGSG FVGGLCQVAA AYQELFAAQG PAGAEKLAAF ARQLGSRYFA LVERRLAQEQ 
GGGDNSLLVR ALDRFHRRLR APGALLAAAG LADAATEIVE RVARERLGHH LQGLRAAFLG 
CLTDVRQALA APRVAGKEGP GLAELLANVA SSILSHIKAS LAAVHLFTAK EVSFSNKPYF 
RGEFCSQGVR EGLIVGFVHS MCQTAQSFCD SPGEKGGATP PALLLLLSRL CLDYETATIS 
YILTLTDEQF LVQDQFPVTP VSTLCAEARE TARRLLTHYV KVQGLVISQM LRKSVETRDW 
LSTLEPRNVR AVMKRVVEDT TAIDVQVGLL YEEGVRKAQS SDSSKRTFSV YSSSRQQGRY 
APSYTPSAPM DTNLLSNIQK LFSERIDVFS PVEFNKVSVL TGIIKISLKT LLECVRLRTF 
GRFGLQQVQV DCHFLQLYLW RFVADEELVH LLLDEVVASA ALRCPDPVPM EPSVVEVICE 
RG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.