Details for: MRPL49

Gene ID: 740

Symbol: MRPL49

Ensembl ID: ENSG00000149792

Description: mitochondrial ribosomal protein L49

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 107.9429
    Cell Significance Index: -16.7900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 71.7543
    Cell Significance Index: -18.2000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 42.4254
    Cell Significance Index: -20.0300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 42.1408
    Cell Significance Index: -17.1200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 16.3672
    Cell Significance Index: -20.1800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.2863
    Cell Significance Index: -20.8600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.1962
    Cell Significance Index: -13.9200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.9455
    Cell Significance Index: -15.1900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.5911
    Cell Significance Index: 42.6400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.4511
    Cell Significance Index: 1310.2700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.3791
    Cell Significance Index: 160.7200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0174
    Cell Significance Index: 165.4700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.0032
    Cell Significance Index: 34.8600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.9851
    Cell Significance Index: 13.4400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.6126
    Cell Significance Index: 16.6800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6070
    Cell Significance Index: 41.9800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.5788
    Cell Significance Index: 5.3300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4730
    Cell Significance Index: 24.5700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.4690
    Cell Significance Index: 3.7500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.4567
    Cell Significance Index: 9.5600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.4528
    Cell Significance Index: 33.7500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3897
    Cell Significance Index: 70.2500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3235
    Cell Significance Index: 39.7800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3161
    Cell Significance Index: 19.9200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3144
    Cell Significance Index: 43.1800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3122
    Cell Significance Index: 20.1400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3061
    Cell Significance Index: 36.1000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2956
    Cell Significance Index: 13.9000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2893
    Cell Significance Index: 158.0000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2869
    Cell Significance Index: 126.8300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2693
    Cell Significance Index: 7.7600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2576
    Cell Significance Index: 5.5800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2276
    Cell Significance Index: 16.1000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2205
    Cell Significance Index: 10.2800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2002
    Cell Significance Index: 38.0900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1958
    Cell Significance Index: 25.1000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1824
    Cell Significance Index: 18.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1772
    Cell Significance Index: 35.5400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1769
    Cell Significance Index: 2.0100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1762
    Cell Significance Index: 9.2500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1753
    Cell Significance Index: 4.6100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1678
    Cell Significance Index: 4.4800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1592
    Cell Significance Index: 5.1000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1461
    Cell Significance Index: 6.6200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.1348
    Cell Significance Index: 1.4700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1269
    Cell Significance Index: 25.1900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1184
    Cell Significance Index: 15.2900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.0690
    Cell Significance Index: 0.5800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0665
    Cell Significance Index: 11.3500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0418
    Cell Significance Index: 14.9800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0144
    Cell Significance Index: 0.3600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0144
    Cell Significance Index: 10.8700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0117
    Cell Significance Index: 0.2500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0034
    Cell Significance Index: 0.1200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0018
    Cell Significance Index: -1.3600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0018
    Cell Significance Index: -3.3300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0020
    Cell Significance Index: -1.4900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0051
    Cell Significance Index: -3.1700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0075
    Cell Significance Index: -0.2200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0117
    Cell Significance Index: -21.5900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0151
    Cell Significance Index: -23.2400
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0166
    Cell Significance Index: -0.1100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0171
    Cell Significance Index: -23.2400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0175
    Cell Significance Index: -9.8900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0179
    Cell Significance Index: -11.3900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0257
    Cell Significance Index: -17.7900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0259
    Cell Significance Index: -2.6500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0388
    Cell Significance Index: -17.6000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0442
    Cell Significance Index: -9.3200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0498
    Cell Significance Index: -5.7100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0552
    Cell Significance Index: -15.8800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1048
    Cell Significance Index: -15.2300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1053
    Cell Significance Index: -2.6900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1501
    Cell Significance Index: -11.8900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1532
    Cell Significance Index: -17.4900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1754
    Cell Significance Index: -2.9400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1941
    Cell Significance Index: -5.5700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1952
    Cell Significance Index: -20.3300
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1978
    Cell Significance Index: -2.8100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2183
    Cell Significance Index: -13.4200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2210
    Cell Significance Index: -14.8600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.2289
    Cell Significance Index: -4.0500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2344
    Cell Significance Index: -17.9900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2374
    Cell Significance Index: -14.5600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.2397
    Cell Significance Index: -3.0700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2517
    Cell Significance Index: -3.0000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2697
    Cell Significance Index: -14.0500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2726
    Cell Significance Index: -8.0300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3188
    Cell Significance Index: -17.8900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3409
    Cell Significance Index: -9.1200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3563
    Cell Significance Index: -18.0100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3701
    Cell Significance Index: -8.5500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3776
    Cell Significance Index: -16.7000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3917
    Cell Significance Index: -16.0500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.4010
    Cell Significance Index: -3.2700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4163
    Cell Significance Index: -4.3100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4293
    Cell Significance Index: -16.2600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4326
    Cell Significance Index: -15.8800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4767
    Cell Significance Index: -16.7000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5060
    Cell Significance Index: -16.5700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MRPL49 is a mitochondrial ribosomal protein that belongs to the 39S ribosomal protein family. It is a large protein with a molecular weight of approximately 49 kDa and is highly expressed in cells that require high energy demands. MRPL49 is a structural component of the mitochondrial large ribosomal subunit and plays a critical role in the translation of mitochondrial mRNAs into proteins. It is also involved in the regulation of mitochondrial translation, interacting with other ribosomal proteins and mitochondrial factors to ensure the proper assembly and function of the ribosome. **Pathways and Functions:** MRPL49 is involved in various pathways and functions, including: 1. **Mitochondrial translation:** MRPL49 plays a critical role in the translation of mitochondrial mRNAs into proteins essential for the proper functioning of the mitochondria. 2. **Mitochondrial inner membrane:** MRPL49 is a structural component of the mitochondrial inner membrane and is involved in the regulation of mitochondrial inner membrane dynamics. 3. **Mitochondrial large ribosomal subunit:** MRPL49 is a member of the large ribosomal subunit and plays a critical role in the assembly and function of the ribosome. 4. **Protein binding:** MRPL49 interacts with other ribosomal proteins and mitochondrial factors to regulate mitochondrial translation. 5. **Structural constituent of ribosome:** MRPL49 is a structural component of the mitochondrial ribosome and plays a critical role in the assembly and function of the ribosome. **Clinical Significance:** Recent studies have highlighted the significance of MRPL49 in various diseases, including: 1. **Neurodegenerative disorders:** Mutations in the MRPL49 gene have been associated with neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. 2. **Metabolic disorders:** MRPL49 has been implicated in metabolic disorders, such as diabetes and obesity. 3. **Cancer:** MRPL49 has been shown to be overexpressed in various types of cancer, including breast cancer and lung cancer. 4. **Mitochondrial disorders:** Mutations in the MRPL49 gene have been associated with mitochondrial disorders, such as mitochondrial myopathies and encephalopathies. In conclusion, MRPL49 is a critical component of the mitochondrial ribosome, playing a vital role in the translation of mitochondrial mRNAs into proteins essential for the proper functioning of the mitochondria. Its dysregulation has been implicated in various diseases, highlighting the importance of this gene in human health and disease. Further research is needed to fully understand the mechanisms by which MRPL49 regulates mitochondrial function and to develop therapeutic strategies to target this gene in the treatment of disease.

Genular Protein ID: 2860642080

Symbol: RM49_HUMAN

Name: 39S ribosomal protein L49, mitochondrial

UniProtKB Accession Codes:

Q13405 B2R4G6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DNASU 1 DisGeNET 1 EMBL 5 EMDB 57 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 60 PDBsum 60 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8786148

Title: Isolation, cDNA, and genomic structure of a conserved gene (NOF) at chromosome 11q13 next to FAU and oriented in the opposite transcriptional orientation.

PubMed ID: 8786148

DOI: 10.1006/geno.1996.0310

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11551941

Title: The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present.

PubMed ID: 11551941

DOI: 10.1074/jbc.m106510200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 25278503

Title: Structure of the large ribosomal subunit from human mitochondria.

PubMed ID: 25278503

DOI: 10.1126/science.1258026

PubMed ID: 25838379

Title: Ribosome. The structure of the human mitochondrial ribosome.

PubMed ID: 25838379

DOI: 10.1126/science.aaa1193

PubMed ID: 28892042

Title: Structures of the human mitochondrial ribosome in native states of assembly.

PubMed ID: 28892042

DOI: 10.1038/nsmb.3464

PubMed ID: 35177605

Title: A late-stage assembly checkpoint of the human mitochondrial ribosome large subunit.

PubMed ID: 35177605

DOI: 10.1038/s41467-022-28503-5

Sequence Information:

  • Length: 166
  • Mass: 19198
  • Checksum: 66AB18FDE25D92B4
  • Sequence:
    • MAATMFRATL RGWRTGVQRG CGLRLLSQTQ GPPDYPRFVE SVDEYQFVER LLPATRIPDP 
PKHEHYPTPS GWQPPRDPPP NLPYFVRRSR MHNIPVYKDI THGNRQMTVI RKVEGDIWAL 
QKDVEDFLSP LLGKTPVTQV NEVTGTLRIK GYFDQELKAW LLEKGF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.