Details for: ZNHIT2

Gene ID: 741

Symbol: ZNHIT2

Ensembl ID: ENSG00000174276

Description: zinc finger HIT-type containing 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 54.6465
    Cell Significance Index: -8.5000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 35.4435
    Cell Significance Index: -8.9900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 21.1442
    Cell Significance Index: -8.5900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 20.6514
    Cell Significance Index: -9.7500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 9.0705
    Cell Significance Index: -8.6600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 7.8916
    Cell Significance Index: -9.7300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.0423
    Cell Significance Index: -8.1500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.5747
    Cell Significance Index: -10.1600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.2791
    Cell Significance Index: 225.4600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.1228
    Cell Significance Index: -6.5200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.9918
    Cell Significance Index: 62.5100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9435
    Cell Significance Index: 851.9100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9231
    Cell Significance Index: 55.4200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8592
    Cell Significance Index: 93.4600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7120
    Cell Significance Index: 115.8000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7006
    Cell Significance Index: 19.0700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4489
    Cell Significance Index: 31.0500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4108
    Cell Significance Index: 224.3700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3711
    Cell Significance Index: 19.2800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.3582
    Cell Significance Index: 41.7400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3419
    Cell Significance Index: 15.9400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2825
    Cell Significance Index: 8.1400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.2777
    Cell Significance Index: 6.4200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2624
    Cell Significance Index: 3.5800
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.2573
    Cell Significance Index: 0.5800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2501
    Cell Significance Index: 18.6400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2492
    Cell Significance Index: 47.4200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2487
    Cell Significance Index: 109.9600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2436
    Cell Significance Index: 17.2300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2385
    Cell Significance Index: 10.8100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1711
    Cell Significance Index: 30.8500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.1447
    Cell Significance Index: 1.1600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1406
    Cell Significance Index: 18.1700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1399
    Cell Significance Index: 3.0300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1287
    Cell Significance Index: 6.0500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1094
    Cell Significance Index: 7.0600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1086
    Cell Significance Index: 1.0000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1068
    Cell Significance Index: 5.6100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1043
    Cell Significance Index: 14.3300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0881
    Cell Significance Index: 10.8300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0795
    Cell Significance Index: 9.3700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0740
    Cell Significance Index: 9.4800
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.0735
    Cell Significance Index: 0.5600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0386
    Cell Significance Index: 1.0400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.0286
    Cell Significance Index: 0.2400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0224
    Cell Significance Index: 0.5600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0195
    Cell Significance Index: 3.9200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0081
    Cell Significance Index: 0.4200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0080
    Cell Significance Index: 0.2800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0038
    Cell Significance Index: 0.4400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0024
    Cell Significance Index: 0.0300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0007
    Cell Significance Index: 0.0200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0005
    Cell Significance Index: -0.3500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0005
    Cell Significance Index: -0.0900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0008
    Cell Significance Index: -0.1400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0014
    Cell Significance Index: -1.0900
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0026
    Cell Significance Index: -0.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0035
    Cell Significance Index: -6.6300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0068
    Cell Significance Index: -12.5600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0075
    Cell Significance Index: -2.7000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0080
    Cell Significance Index: -12.3500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0090
    Cell Significance Index: -12.2000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0099
    Cell Significance Index: -1.0100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0106
    Cell Significance Index: -7.8700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0117
    Cell Significance Index: -7.4000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0117
    Cell Significance Index: -6.5800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0175
    Cell Significance Index: -10.9400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0204
    Cell Significance Index: -9.2400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0221
    Cell Significance Index: -0.4700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0226
    Cell Significance Index: -0.7300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0235
    Cell Significance Index: -0.6000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0259
    Cell Significance Index: -7.4500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0272
    Cell Significance Index: -0.4600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0371
    Cell Significance Index: -1.2900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0376
    Cell Significance Index: -1.1100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0503
    Cell Significance Index: -10.5900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0554
    Cell Significance Index: -0.6600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0581
    Cell Significance Index: -8.4400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0637
    Cell Significance Index: -1.7800
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.0672
    Cell Significance Index: -0.6700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0763
    Cell Significance Index: -6.0400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0764
    Cell Significance Index: -2.1900
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.0901
    Cell Significance Index: -1.2500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0960
    Cell Significance Index: -10.0000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0974
    Cell Significance Index: -5.9700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1004
    Cell Significance Index: -2.6400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1100
    Cell Significance Index: -1.2500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1162
    Cell Significance Index: -8.9200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1193
    Cell Significance Index: -3.1900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1194
    Cell Significance Index: -2.5000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1217
    Cell Significance Index: -8.1800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1305
    Cell Significance Index: -2.0700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1435
    Cell Significance Index: -8.0500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1503
    Cell Significance Index: -9.2400
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.1596
    Cell Significance Index: -1.6000
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1717
    Cell Significance Index: -2.4600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1884
    Cell Significance Index: -5.5500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2179
    Cell Significance Index: -3.1200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2211
    Cell Significance Index: -11.1700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2229
    Cell Significance Index: -1.5100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Zinc finger HIT domain:** The ZNHIT2 protein contains a zinc finger HIT domain, a type of DNA-binding domain that is involved in protein-protein interactions and metal ion coordination. 2. **Metal ion binding:** The zinc finger HIT domain of ZNHIT2 allows it to bind to metal ions, which is essential for its function in protein-protein interactions and cellular signaling. 3. **Protein-protein interactions:** ZNHIT2 interacts with various proteins, including other transcription factors and signaling molecules, to regulate cellular processes. 4. **Tissue-specific expression:** ZNHIT2 is significantly expressed in multiple cell types, including ciliated columnar cells of the tracheobronchial tree, cerebral cortex GABAergic interneurons, and intestinal epithelial cells. **Pathways and Functions:** 1. **Metal ion homeostasis:** ZNHIT2 plays a crucial role in maintaining metal ion homeostasis in cells by binding to metal ions and regulating their availability for protein-protein interactions. 2. **Cellular signaling:** ZNHIT2 interacts with various signaling molecules to regulate cellular processes, including proliferation, differentiation, and survival. 3. **Transcriptional regulation:** ZNHIT2 regulates transcriptional activity by interacting with transcription factors and other regulatory proteins. 4. **Cellular differentiation:** ZNHIT2 is involved in the regulation of cellular differentiation, particularly in the development of intestinal epithelial cells. **Clinical Significance:** 1. **Cancer:** Aberrant expression of ZNHIT2 has been associated with various types of cancer, including colorectal cancer, where it may contribute to tumorigenesis and metastasis. 2. **Neurological disorders:** ZNHIT2 has been implicated in neurological disorders, such as schizophrenia and autism, where it may contribute to the regulation of neuronal function and behavior. 3. **Gastrointestinal disorders:** ZNHIT2 is involved in the regulation of intestinal epithelial cell function, and its dysregulation may contribute to gastrointestinal disorders, such as inflammatory bowel disease. 4. **Metabolic disorders:** ZNHIT2 may play a role in metabolic disorders, such as diabetes, where it may contribute to the regulation of glucose metabolism and insulin signaling. In conclusion, the ZNHIT2 gene is a critical regulator of cellular processes, and its dysregulation may contribute to various human diseases. Further research is necessary to fully understand the role of ZNHIT2 in human health and disease.

Genular Protein ID: 2822222650

Symbol: ZNHI2_HUMAN

Name: Zinc finger HIT domain-containing protein 2

UniProtKB Accession Codes:

Q9UHR6 Q3SY14 Q8IUV0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 8 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 1 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10602999

Title: Molecular characterization of human and murine c11orf5, a new member of the FAUNA gene cluster.

PubMed ID: 10602999

DOI: 10.1007/s003350010016

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28561026

Title: R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein.

PubMed ID: 28561026

DOI: 10.1038/ncomms15615

PubMed ID: 17656577

Title: Solution structure of the zinc finger HIT domain in protein FON.

PubMed ID: 17656577

DOI: 10.1110/ps.062635107

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 403
  • Mass: 42884
  • Checksum: 2384BF806CC40E71
  • Sequence:
    • MEPAGPCGFC PAGEVQPARY TCPRCNAPYC SLRCYRTHGT CAENFYRDQV LGELRGCSAP 
PSRLASALRR LRQQRETEDE PGEAGLSSGP APGGLSGLWE RLAPGEKAAF ERLLSRGEAG 
RLLPPWRPWW WNRGAGPQLL EELDNAPGSD AAELELAPAR TPPDSVKDAS AAEPAAAERV 
LGDVPGACTP VVPTRIPAIV SLSRGPVSPL VRFQLPNVLF AYAHTLALYH GGDDALLSDF 
CATLLGVSGA LGAQQVFASA EEALQAAAHV LEAGEHPPGP LGTRGAMHEV ARILLGEGPT 
NQKGYTLAAL GDLAQTLGRA RKQAVAREER DHLYRARKKC QFLLAWTNEN EAALTPLALD 
CARAHQAHAV VAEEVAALTG ELERLWGGPV PPAPRTLIEE LPS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.