Details for: MPPED2

Gene ID: 744

Symbol: MPPED2

Ensembl ID: ENSG00000066382

Description: metallophosphoesterase domain containing 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 305.3774
    Cell Significance Index: -47.5000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 186.2852
    Cell Significance Index: -47.2500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 38.5253
    Cell Significance Index: -47.5000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.1362
    Cell Significance Index: -47.8900
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 7.2482
    Cell Significance Index: 64.3400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 6.5847
    Cell Significance Index: 369.5000
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 6.1965
    Cell Significance Index: 38.2300
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 4.8384
    Cell Significance Index: 67.9600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 3.1825
    Cell Significance Index: 140.7700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.9544
    Cell Significance Index: 111.8800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 2.8813
    Cell Significance Index: 193.7400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 2.4720
    Cell Significance Index: 52.8400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.9774
    Cell Significance Index: 396.6700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.7190
    Cell Significance Index: 46.0600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.5513
    Cell Significance Index: 95.1100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.5339
    Cell Significance Index: 94.2800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.2234
    Cell Significance Index: 29.3400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.0311
    Cell Significance Index: 25.7800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.0180
    Cell Significance Index: 29.0500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.9699
    Cell Significance Index: 670.8000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9362
    Cell Significance Index: 115.1100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8297
    Cell Significance Index: 297.6000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.7320
    Cell Significance Index: 56.1700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5819
    Cell Significance Index: 104.9000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3783
    Cell Significance Index: 75.0700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3740
    Cell Significance Index: 71.1700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3652
    Cell Significance Index: 18.9700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3157
    Cell Significance Index: 40.4700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2497
    Cell Significance Index: 225.4700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1775
    Cell Significance Index: 11.1900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1253
    Cell Significance Index: 3.4100
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 0.0610
    Cell Significance Index: 0.6300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0551
    Cell Significance Index: 5.4500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0544
    Cell Significance Index: 2.5400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0484
    Cell Significance Index: 2.5400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0372
    Cell Significance Index: 20.3200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0105
    Cell Significance Index: -19.7400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0236
    Cell Significance Index: -0.8300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0279
    Cell Significance Index: -51.5200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0307
    Cell Significance Index: -4.9900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0361
    Cell Significance Index: -55.5500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0422
    Cell Significance Index: -30.9600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0432
    Cell Significance Index: -0.7400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0433
    Cell Significance Index: -58.8600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0458
    Cell Significance Index: -29.0800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0663
    Cell Significance Index: -50.2200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0693
    Cell Significance Index: -30.6600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0702
    Cell Significance Index: -52.0200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0876
    Cell Significance Index: -54.7000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0895
    Cell Significance Index: -40.6000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0961
    Cell Significance Index: -54.1700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1289
    Cell Significance Index: -37.0800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1518
    Cell Significance Index: -4.3800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1725
    Cell Significance Index: -7.8200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.2152
    Cell Significance Index: -23.4100
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.2421
    Cell Significance Index: -1.7600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2545
    Cell Significance Index: -26.0000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2683
    Cell Significance Index: -56.5200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2811
    Cell Significance Index: -32.2000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2833
    Cell Significance Index: -41.1800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2857
    Cell Significance Index: -48.7900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2934
    Cell Significance Index: -37.9100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3068
    Cell Significance Index: -9.8300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.3175
    Cell Significance Index: -43.6000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3510
    Cell Significance Index: -40.9100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3814
    Cell Significance Index: -44.9800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.3969
    Cell Significance Index: -6.1400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.4287
    Cell Significance Index: -29.6500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4329
    Cell Significance Index: -45.0800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.4812
    Cell Significance Index: -34.0300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4890
    Cell Significance Index: -9.6700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4979
    Cell Significance Index: -16.3000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5059
    Cell Significance Index: -40.0700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5084
    Cell Significance Index: -26.4800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.5402
    Cell Significance Index: -12.4800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.5433
    Cell Significance Index: -40.4900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.5608
    Cell Significance Index: -8.2800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.5654
    Cell Significance Index: -12.2500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5747
    Cell Significance Index: -18.3100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.6022
    Cell Significance Index: -36.1500
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.6111
    Cell Significance Index: -7.6200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.6248
    Cell Significance Index: -7.4500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.6323
    Cell Significance Index: -17.6700
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.6527
    Cell Significance Index: -6.2100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.6619
    Cell Significance Index: -42.7000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.7504
    Cell Significance Index: -35.2700
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.7511
    Cell Significance Index: -9.4800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.7519
    Cell Significance Index: -13.0000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.8437
    Cell Significance Index: -17.6600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.8615
    Cell Significance Index: -30.1800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.8768
    Cell Significance Index: -18.6100
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.9454
    Cell Significance Index: -13.2200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.9810
    Cell Significance Index: -25.8000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.9922
    Cell Significance Index: -19.9200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -1.0915
    Cell Significance Index: -26.4400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -1.0935
    Cell Significance Index: -15.6600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -1.1075
    Cell Significance Index: -18.2500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -1.1571
    Cell Significance Index: -24.1500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -1.1698
    Cell Significance Index: -29.1800
  • Cell Name: neural cell (CL0002319)
    Fold Change: -1.1876
    Cell Significance Index: -13.8600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MPPED2 is a gene with a metallophosphoesterase domain, which is involved in the hydrolysis of phosphoric diesters. This domain is also associated with binding to metal ions, such as manganese, and small molecules like AMP and GMP. The gene is predominantly expressed in photoreceptor cells, cortical cells of the adrenal gland, and various types of epithelial cells, including those in the prostate and kidneys. These cell types suggest that MPPED2 plays a role in maintaining tissue homeostasis and regulating cellular processes. **Pathways and Functions:** MPPED2's involvement in multiple signaling pathways underscores its importance in cellular processes. The gene is implicated in: 1. **Phosphoric diester hydrolase activity**: MPPED2's metallophosphoesterase domain enables the hydrolysis of phosphoric diesters, which is essential for various cellular processes, including DNA repair and cell signaling. 2. **AMP and GMP binding**: The gene's ability to bind to AMP and GMP suggests a role in regulating cellular energy metabolism and signaling pathways. 3. **Manganese ion binding**: MPPED2's interaction with manganese ions may be involved in redox reactions and oxidative stress regulation. 4. **Protein binding**: The gene's capacity to bind to various proteins implies a role in protein-protein interactions, which are crucial for cellular signaling and regulation. **Clinical Significance:** The clinical significance of MPPED2 is an area that warrants further investigation. While the gene's expression in various tissues and its involvement in multiple signaling pathways suggest a role in maintaining tissue homeostasis, its specific clinical implications remain unclear. However, potential applications of MPPED2 in: 1. **Regulating cellular energy metabolism**: MPPED2's involvement in AMP and GMP binding suggests a potential role in regulating cellular energy metabolism, which could be beneficial in treating metabolic disorders. 2. **Mitigating oxidative stress**: The gene's interaction with manganese ions may be involved in regulating oxidative stress, which could have implications for treating diseases associated with oxidative stress, such as cancer and neurodegenerative disorders. 3. **Maintaining tissue homeostasis**: MPPED2's expression in various epithelial cells and its involvement in phosphoric diester hydrolase activity suggest a role in maintaining tissue homeostasis, which could be beneficial in treating diseases associated with tissue damage, such as cancer and inflammatory disorders. In conclusion, MPPED2 is a gene with a complex interplay of pathways and functions that highlight its significance in the immune system. Further investigation is necessary to fully elucidate the clinical implications of MPPED2 and its potential applications in treating various diseases.

Genular Protein ID: 548831933

Symbol: MPPD2_HUMAN

Name: Metallophosphoesterase MPPED2

UniProtKB Accession Codes:

Q15777 D3DQZ5 E9PB10 Q59GE6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 12 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 6 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 7527372

Title: A WAGR region gene between PAX-6 and FSHB expressed in fetal brain.

PubMed ID: 7527372

DOI: 10.1007/bf00206960

PubMed ID: 8666403

Title: cDNA sequence, genomic organization, and evolutionary conservation of a novel gene from the WAGR region.

PubMed ID: 8666403

DOI: 10.1006/geno.1995.9973

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 294
  • Mass: 33360
  • Checksum: 43B2BC0DA1BFD1F0
  • Sequence:
    • MAHGIPSQGK VTITVDEYSS NPTQAFTHYN INQSRFQPPH VHMVDPIPYD TPKPAGHTRF 
VCISDTHSRT DGIQMPYGDI LLHTGDFTEL GLPSEVKKFN DWLGNLPYEY KIVIAGNHEL 
TFDKEFMADL VKQDYYRFPS VSKLKPEDFD NVQSLLTNSI YLQDSEVTVK GFRIYGAPWT 
PWFNGWGFNL PRGQSLLDKW NLIPEGIDIL MTHGPPLGFR DWVPKELQRV GCVELLNTVQ 
RRVRPKLHVF GGIHEGYGIM TDGYTTYINA STCTVSFQPT NPPIIFDLPN PQGS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.