Details for: MYRF

Gene ID: 745

Symbol: MYRF

Ensembl ID: ENSG00000124920

Description: myelin regulatory factor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 5.1639
    Cell Significance Index: 25.1200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.0556
    Cell Significance Index: 44.5400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.8176
    Cell Significance Index: 52.3700
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 1.7856
    Cell Significance Index: 6.7300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.2885
    Cell Significance Index: -2.8200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0849
    Cell Significance Index: 979.5700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7611
    Cell Significance Index: 82.7900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7061
    Cell Significance Index: 114.8400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6976
    Cell Significance Index: 41.8800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6282
    Cell Significance Index: 124.6700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.6253
    Cell Significance Index: 9.3700
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.5654
    Cell Significance Index: 7.9300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.4600
    Cell Significance Index: 16.1700
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.4516
    Cell Significance Index: 4.9400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4285
    Cell Significance Index: 29.6400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4033
    Cell Significance Index: 18.2800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3034
    Cell Significance Index: 165.6800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.2913
    Cell Significance Index: 4.9000
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.2266
    Cell Significance Index: 1.9600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2208
    Cell Significance Index: 42.0200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1788
    Cell Significance Index: 4.7900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1695
    Cell Significance Index: 16.7700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1348
    Cell Significance Index: 23.0200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1301
    Cell Significance Index: 2.7700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0904
    Cell Significance Index: 10.3200
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.0732
    Cell Significance Index: 0.8600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0523
    Cell Significance Index: 23.7200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0492
    Cell Significance Index: 75.8100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0440
    Cell Significance Index: 81.1000
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.0354
    Cell Significance Index: 0.3800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0143
    Cell Significance Index: 9.9000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0075
    Cell Significance Index: 2.7000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0035
    Cell Significance Index: 0.7000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0008
    Cell Significance Index: 1.4700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0022
    Cell Significance Index: -1.6100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0055
    Cell Significance Index: -3.4600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0073
    Cell Significance Index: -9.9800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0078
    Cell Significance Index: -4.4200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0137
    Cell Significance Index: -10.0400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0139
    Cell Significance Index: -10.4900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0150
    Cell Significance Index: -2.7100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0158
    Cell Significance Index: -10.0200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0194
    Cell Significance Index: -2.2300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0211
    Cell Significance Index: -4.4500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0243
    Cell Significance Index: -6.9800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0255
    Cell Significance Index: -3.5000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0494
    Cell Significance Index: -7.1800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0500
    Cell Significance Index: -5.8200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0581
    Cell Significance Index: -7.1400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0677
    Cell Significance Index: -1.7400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0728
    Cell Significance Index: -1.8200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0768
    Cell Significance Index: -9.8500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0798
    Cell Significance Index: -8.1500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0849
    Cell Significance Index: -2.7200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0955
    Cell Significance Index: -12.3400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1034
    Cell Significance Index: -2.7200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1068
    Cell Significance Index: -11.1200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1081
    Cell Significance Index: -3.0200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1096
    Cell Significance Index: -7.3700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1183
    Cell Significance Index: -1.8300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1258
    Cell Significance Index: -7.0600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1363
    Cell Significance Index: -1.8600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1403
    Cell Significance Index: -16.5400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1441
    Cell Significance Index: -5.9000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1450
    Cell Significance Index: -8.8900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1536
    Cell Significance Index: -2.2000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1540
    Cell Significance Index: -12.2000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1582
    Cell Significance Index: -12.1400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1747
    Cell Significance Index: -13.0200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1769
    Cell Significance Index: -11.1500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1786
    Cell Significance Index: -10.9800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1811
    Cell Significance Index: -1.8800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1834
    Cell Significance Index: -11.8300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1989
    Cell Significance Index: -10.3300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2083
    Cell Significance Index: -10.8500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.2374
    Cell Significance Index: -3.0400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2391
    Cell Significance Index: -8.3100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2394
    Cell Significance Index: -12.5700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2441
    Cell Significance Index: -10.6200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2477
    Cell Significance Index: -11.6400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2478
    Cell Significance Index: -10.9600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2505
    Cell Significance Index: -4.2200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2554
    Cell Significance Index: -11.9100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2582
    Cell Significance Index: -6.2600
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.2585
    Cell Significance Index: -2.7800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2755
    Cell Significance Index: -9.6500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2873
    Cell Significance Index: -7.6900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2955
    Cell Significance Index: -4.9500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2960
    Cell Significance Index: -11.2100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3069
    Cell Significance Index: -9.0400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3088
    Cell Significance Index: -15.6100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3100
    Cell Significance Index: -10.1500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3137
    Cell Significance Index: -4.6300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3141
    Cell Significance Index: -10.0100
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.3189
    Cell Significance Index: -4.5700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3411
    Cell Significance Index: -5.1400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3420
    Cell Significance Index: -9.7600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3760
    Cell Significance Index: -9.3800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3772
    Cell Significance Index: -13.8500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.4028
    Cell Significance Index: -12.7400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MYRF is a transcription factor that belongs to the MYF family of proteins. It is primarily expressed in oligodendrocytes, a type of glial cell in the CNS, and is also found in other cell types, such as ovarian surface epithelial cells and mesothelial cells. The MYRF protein has a unique structure, consisting of a DNA-binding domain and a transcriptional activation domain. This allows it to regulate the expression of target genes involved in myelination and other cellular processes. **Pathways and Functions:** MYRF is involved in several signaling pathways that regulate cellular processes, including: 1. **Central Nervous System Myelination:** MYRF regulates the expression of genes involved in myelination, including those encoding myelin basic protein and proteolipid protein. This process is crucial for the development and maintenance of the CNS. 2. **Oligodendrocyte Differentiation:** MYRF promotes the differentiation of oligodendrocytes into mature myelinating cells. 3. **DNA Binding and Transcription Regulation:** MYRF binds to specific DNA sequences and regulates the expression of target genes through transcriptional activation. 4. **Peptidase Activity:** MYRF has been shown to have peptidase activity, which may play a role in protein processing and regulation. **Clinical Significance:** Dysregulation of MYRF has been implicated in various neurological disorders, including: 1. **Multiple Sclerosis:** MYRF has been shown to play a role in the development of multiple sclerosis, a demyelinating disease of the CNS. 2. **Neurodegenerative Diseases:** MYRF has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **CNS Injury:** MYRF has been shown to play a role in the regulation of oligodendrocyte differentiation and myelination in response to CNS injury. In conclusion, MYRF is a critical transcription factor that regulates the expression of genes involved in myelination and other cellular processes. Its dysregulation has been implicated in various neurological disorders, highlighting its importance in understanding the pathogenesis of CNS diseases. Further research is needed to fully elucidate the mechanisms by which MYRF regulates cellular processes and to develop therapeutic strategies for the treatment of MYRF-related disorders.

Genular Protein ID: 864180001

Symbol: MYRF_HUMAN

Name: Myelin regulatory factor

UniProtKB Accession Codes:

Q9Y2G1 O43582 Q9P1Q6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 ExpressionAtlas 1 GO 20 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MEROPS 1 MIM 5 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10828591

Title: cDNA cloning and genomic structure of a novel gene (C11orf9) localized to chromosome 11q12-->q13.1 which encodes a highly conserved, potential membrane-associated protein.

PubMed ID: 10828591

DOI: 10.1159/000015552

PubMed ID: 10231032

Title: Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10231032

DOI: 10.1093/dnares/6.1.63

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 9615227

Title: Transcript mapping of the human chromosome 11q12-q13.1 gene-rich region identifies several newly described conserved genes.

PubMed ID: 9615227

DOI: 10.1006/geno.1998.5291

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 23966832

Title: A bacteriophage tailspike domain promotes self-cleavage of a human membrane-bound transcription factor, the myelin regulatory factor MYRF.

PubMed ID: 23966832

DOI: 10.1371/journal.pbio.1001624

PubMed ID: 29265453

Title: MYRF is associated with encephalopathy with reversible myelin vacuolization.

PubMed ID: 29265453

DOI: 10.1002/ana.25125

PubMed ID: 29446546

Title: De novo variants in Myelin regulatory factor (MYRF) as candidates of a new syndrome of cardiac and urogenital anomalies.

PubMed ID: 29446546

DOI: 10.1002/ajmg.a.38620

PubMed ID: 30070761

Title: An additional individual with a de novo variant in myelin regulatory factor (MYRF) with cardiac and urogenital anomalies: Further proof of causality: Comments on the article by Pinz et al.

PubMed ID: 30070761

DOI: 10.1002/ajmg.a.40360

PubMed ID: 30532227

Title: De novo variants in congenital diaphragmatic hernia identify MYRF as a new syndrome and reveal genetic overlaps with other developmental disorders.

PubMed ID: 30532227

DOI: 10.1371/journal.pgen.1007822

PubMed ID: 29729323

Title: Structure of the DNA-binding domain of human myelin-gene regulatory factor reveals its potential protein-DNA recognition mode.

PubMed ID: 29729323

DOI: 10.1016/j.jsb.2018.04.007

Sequence Information:

  • Length: 1151
  • Mass: 124397
  • Checksum: 9875DE9D72B6C50C
  • Sequence:
    • MEVVDETEAL QRFFEGHDIN GALEPSNIDT SILEEYISKE DASDLCFPDI SAPASSASYS 
HGQPAMPGSS GVHHLSPPGG GPSPGRHGPL PPPGYGTPLN CNNNNGMGAA PKPFPGGTGP 
PIKAEPKAPY APGTLPDSPP DSGSEAYSPQ QVNEPHLLRT ITPETLCHVG VPSRLEHPPP 
PPAHLPGPPP PPPPPPHYPV LQRDLYMKAE PPIPHYAAMG QGLVPTDLHH TQQSQMLHQL 
LQQHGAELPT HPSKKRKHSE SPPSTLNAQM LNGMIKQEPG TVTALPLHPT RAPSPPWPPQ 
GPLSPGPGSL PLSIARVQTP PWHPPGAPSP GLLQDSDSLS GSYLDPNYQS IKWQPHQQNK 
WATLYDANYK ELPMLTYRVD ADKGFNFSVG DDAFVCQKKN HFQVTVYIGM LGEPKYVKTP 
EGLKPLDCFY LKLHGVKLEA LNQSINIEQS QSDRSKRPFN PVTVNLPPEQ VTKVTVGRLH 
FSETTANNMR KKGKPNPDQR YFMLVVALQA HAQNQNYTLA AQISERIIVR ASNPGQFESD 
SDVLWQRAQV PDTVFHHGRV GINTDRPDEA LVVHGNVKVM GSLMHPSDLR AKEHVQEVDT 
TEQLKRISRM RLVHYRYKPE FAASAGIEAT APETGVIAQE VKEILPEAVK DTGDMVFANG 
KTIENFLVVN KERIFMENVG AVKELCKLTD NLETRIDELE RWSHKLAKLR RLDSLKSTGS 
SGAFSHAGSQ FSRAGSVPHK KRPPKVASKS SSVVPDQACI SQRFLQGTII ALVVVMAFSV 
VSMSTLYVLS LRTEEDLVDT DGSFAVSTSC LLALLRPQPP GGSEALCPWS SQSFGTTQLR 
QSPLTTGLPG IQPSLLLVTT SLTSSAPGSA VRTLDMCSSH PCPVICCSSP TTNPTTGPSL 
GPSFNPGHVL SPSPSPSTNR SGPSQMALLP VTNIRAKSWG LSVNGIGHSK HHKSLEPLAS 
PAVPFPGGQG KAKNSPSLGF HGRARRGALQ SSVGPAEPTW AQGQSASLLA EPVPSLTSIQ 
VLENSMSITS QYCAPGDACR PGNFTYHIPV SSGTPLHLSL TLQMNSSSPV SVVLCSLRSK 
EEPCEEGSLP QSLHTHQDTQ GTSHRWPITI LSFREFTYHF RVALLGQANC SSEALAQPAT 
DYHFHFYRLC D

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.