Details for: DAGLA

Gene ID: 747

Symbol: DAGLA

Ensembl ID: ENSG00000134780

Description: diacylglycerol lipase alpha

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 37.3753
    Cell Significance Index: -9.4800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.5743
    Cell Significance Index: -9.5800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.3521
    Cell Significance Index: 19.6300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0162
    Cell Significance Index: 100.5200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7391
    Cell Significance Index: 667.3400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7333
    Cell Significance Index: 147.1000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5741
    Cell Significance Index: 26.0200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5654
    Cell Significance Index: 61.5000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5286
    Cell Significance Index: 85.9700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.4809
    Cell Significance Index: 10.5300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.4192
    Cell Significance Index: 60.9300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.3318
    Cell Significance Index: 22.3100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.3252
    Cell Significance Index: 9.2800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3002
    Cell Significance Index: 59.5700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2990
    Cell Significance Index: 107.2600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2585
    Cell Significance Index: 17.8800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2145
    Cell Significance Index: 40.8200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.1748
    Cell Significance Index: 2.8800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1708
    Cell Significance Index: 3.7000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1670
    Cell Significance Index: 115.5100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1252
    Cell Significance Index: 4.7400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1236
    Cell Significance Index: 3.0900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.1232
    Cell Significance Index: 5.4500
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.0817
    Cell Significance Index: 1.0900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0712
    Cell Significance Index: 2.0500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0581
    Cell Significance Index: 0.8700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0450
    Cell Significance Index: 2.1000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0216
    Cell Significance Index: 0.4600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0136
    Cell Significance Index: 0.3800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0117
    Cell Significance Index: 0.7200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0112
    Cell Significance Index: 21.1100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0085
    Cell Significance Index: 15.7000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0070
    Cell Significance Index: 0.2500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0014
    Cell Significance Index: 0.1900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0024
    Cell Significance Index: -3.6200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0043
    Cell Significance Index: -0.7300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0066
    Cell Significance Index: -4.9200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0069
    Cell Significance Index: -9.4100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0081
    Cell Significance Index: -4.4300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0088
    Cell Significance Index: -5.5900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0101
    Cell Significance Index: -7.4300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0117
    Cell Significance Index: -1.3600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0135
    Cell Significance Index: -10.2500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0144
    Cell Significance Index: -8.1100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0161
    Cell Significance Index: -7.2900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0171
    Cell Significance Index: -10.6700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0180
    Cell Significance Index: -2.3100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0202
    Cell Significance Index: -3.6500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0241
    Cell Significance Index: -0.3500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0268
    Cell Significance Index: -2.0600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0269
    Cell Significance Index: -7.7500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0316
    Cell Significance Index: -3.6200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0464
    Cell Significance Index: -9.7800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0495
    Cell Significance Index: -6.0900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0516
    Cell Significance Index: -1.0700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0611
    Cell Significance Index: -3.4300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0621
    Cell Significance Index: -8.0200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0634
    Cell Significance Index: -2.0300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0656
    Cell Significance Index: -6.7000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0706
    Cell Significance Index: -4.3300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0724
    Cell Significance Index: -1.2400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0749
    Cell Significance Index: -4.7200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0778
    Cell Significance Index: -0.9700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0900
    Cell Significance Index: -9.3700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0919
    Cell Significance Index: -10.8400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0955
    Cell Significance Index: -5.0200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0975
    Cell Significance Index: -2.0700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0993
    Cell Significance Index: -1.3600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1006
    Cell Significance Index: -3.2100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1049
    Cell Significance Index: -7.8200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1147
    Cell Significance Index: -2.7500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1154
    Cell Significance Index: -9.1400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1157
    Cell Significance Index: -2.5000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1231
    Cell Significance Index: -4.0300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1272
    Cell Significance Index: -5.9800
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1315
    Cell Significance Index: -1.6600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1439
    Cell Significance Index: -7.4800
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.1487
    Cell Significance Index: -2.0800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1530
    Cell Significance Index: -9.8700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1544
    Cell Significance Index: -3.8500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1588
    Cell Significance Index: -1.9700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1692
    Cell Significance Index: -4.2200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1727
    Cell Significance Index: -6.0500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1741
    Cell Significance Index: -3.0100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1763
    Cell Significance Index: -3.5400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1811
    Cell Significance Index: -3.5800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1873
    Cell Significance Index: -3.1600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1908
    Cell Significance Index: -1.9800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1982
    Cell Significance Index: -2.9300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2027
    Cell Significance Index: -5.2100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2037
    Cell Significance Index: -3.9800
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.2078
    Cell Significance Index: -1.7200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2084
    Cell Significance Index: -2.2700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2138
    Cell Significance Index: -5.8200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2179
    Cell Significance Index: -9.4700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2221
    Cell Significance Index: -4.6400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.2339
    Cell Significance Index: -3.3300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2348
    Cell Significance Index: -8.6200
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.2447
    Cell Significance Index: -2.7000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2515
    Cell Significance Index: -7.2100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzyme activity:** DAGLA is a lipase enzyme responsible for the hydrolysis of diacylglycerol (DAG) into fatty acids and glycerol. 2. **Tissue distribution:** DAGLA is highly expressed in various tissues, including the brain, heart, and immune cells, such as immature innate lymphoid cells and early T lineage precursors. 3. **Signaling pathways:** DAGLA is involved in multiple signaling pathways, including G-protein coupled receptor (GPCR) signaling, G alpha (q) signaling events, and arachidonic acid metabolic processes. **Pathways and Functions:** 1. **Arachidonic acid metabolism:** DAGLA plays a critical role in the production of arachidonic acid, a key player in the synthesis of eicosanoids, which regulate various physiological and pathological processes. 2. **Neurotransmission:** DAGLA is involved in the regulation of neurotransmission, particularly in the context of GPCR signaling and retrograde trans-synaptic signaling by endocannabinoids. 3. **Immune regulation:** DAGLA is expressed in immune cells, where it modulates immune responses and regulates the production of cytokines and chemokines. 4. **Lipid metabolism:** DAGLA is involved in the regulation of lipid metabolism, particularly in the context of diacylglycerol catabolism and monoacylglycerol biosynthesis. **Clinical Significance:** 1. **Neurological disorders:** Alterations in DAGLA expression and activity have been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. 2. **Immune-mediated diseases:** DAGLA has been implicated in the pathogenesis of immune-mediated diseases, such as rheumatoid arthritis and lupus. 3. **Cancer:** DAGLA has been shown to be overexpressed in certain types of cancer, including breast cancer and lung cancer. 4. **Pharmacological applications:** DAGLA inhibitors have been explored as potential therapeutic agents for the treatment of various diseases, including neurological disorders and cancer. In conclusion, DAGLA is a multifunctional enzyme with significant implications in lipid metabolism, neurotransmission, and immune regulation. Further research is necessary to fully elucidate the role of DAGLA in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 1496816460

Symbol: DGLA_HUMAN

Name: Diacylglycerol lipase-alpha

UniProtKB Accession Codes:

Q9Y4D2 A0A024R517 A7E233 Q6WQJ0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 36 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EC 1 EMBL 8 ESTHER 1 Ensembl 1 ExpressionAtlas 1 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 5 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 14 SABIO-RK 1 SIGNOR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9734811

Title: Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

PubMed ID: 9734811

DOI: 10.1093/dnares/5.3.169

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14610053

Title: Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain.

PubMed ID: 14610053

DOI: 10.1083/jcb.200305129

PubMed ID: 16051747

Title: Stimulation of endocannabinoid formation in brain slice cultures through activation of group I metabotropic glutamate receptors.

PubMed ID: 16051747

DOI: 10.1124/mol.105.013961

PubMed ID: 23502535

Title: CaMKII regulates diacylglycerol lipase-alpha and striatal endocannabinoid signaling.

PubMed ID: 23502535

DOI: 10.1038/nn.3353

PubMed ID: 27595600

Title: Regulated endosomal trafficking of Diacylglycerol lipase alpha (DAGLalpha) generates distinct cellular pools; implications for endocannabinoid signaling.

PubMed ID: 27595600

DOI: 10.1016/j.mcn.2016.08.011

PubMed ID: 26668358

Title: Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition.

PubMed ID: 26668358

DOI: 10.1073/pnas.1522364112

PubMed ID: 18801880

Title: A duplication at chromosome 11q12.2-11q12.3 is associated with spinocerebellar ataxia type 20.

PubMed ID: 18801880

DOI: 10.1093/hmg/ddn283

PubMed ID: 35737950

Title: Endocannabinoid dysfunction in neurological disease: neuro-ocular DAGLA-related syndrome.

PubMed ID: 35737950

DOI: 10.1093/brain/awac223

Sequence Information:

  • Length: 1042
  • Mass: 114952
  • Checksum: A6E675984E89CB2F
  • Sequence:
    • MPGIVVFRRR WSVGSDDLVL PAIFLFLLHT TWFVILSVVL FGLVYNPHEA CSLNLVDHGR 
GYLGILLSCM IAEMAIIWLS MRGGILYTEP RDSMQYVLYV RLAILVIEFI YAIVGIVWLT 
QYYTSCNDLT AKNVTLGMVV CNWVVILSVC ITVLCVFDPT GRTFVKLRAT KRRQRNLRTY 
NLRHRLEEGQ ATSWSRRLKV FLCCTRTKDS QSDAYSEIAY LFAEFFRDLD IVPSDIIAGL 
VLLRQRQRAK RNAVLDEANN DILAFLSGMP VTRNTKYLDL KNSQEMLRYK EVCYYMLFAL 
AAYGWPMYLM RKPACGLCQL ARSCSCCLCP ARPRFAPGVT IEEDNCCGCN AIAIRRHFLD 
ENMTAVDIVY TSCHDAVYET PFYVAVDHDK KKVVISIRGT LSPKDALTDL TGDAERLPVE 
GHHGTWLGHK GMVLSAEYIK KKLEQEMVLS QAFGRDLGRG TKHYGLIVVG HSLGAGTAAI 
LSFLLRPQYP TLKCFAYSPP GGLLSEDAME YSKEFVTAVV LGKDLVPRIG LSQLEGFRRQ 
LLDVLQRSTK PKWRIIVGAT KCIPKSELPE EVEVTTLAST RLWTHPSDLT IALSASTPLY 
PPGRIIHVVH NHPAEQCCCC EQEEPTYFAI WGDNKAFNEV IISPAMLHEH LPYVVMEGLN 
KVLENYNKGK TALLSAAKVM VSPTEVDLTP ELIFQQQPLP TGPPMPTGLA LELPTADHRN 
SSVRSKSQSE MSLEGFSEGR LLSPVVAAAA RQDPVELLLL STQERLAAEL QARRAPLATM 
ESLSDTESLY SFDSRRSSGF RSIRGSPSLH AVLERDEGHL FYIDPAIPEE NPSLSSRTEL 
LAADSLSKHS QDTQPLEAAL GSGGVTPERP PSAAANDEEE EVGGGGGGPA SRGELALHNG 
RLGDSPSPQV LEFAEFIDSL FNLDSKSSSF QDLYCMVVPE SPTSDYAEGP KSPSQQEILL 
RAQFEPNLVP KPPRLFAGSA DPSSGISLSP SFPLSSSGEL MDLTPTGLSS QECLAADKIR 
TSTPTGHGAS PAKQDELVIS AR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.