Details for: GAS8 AS1

Gene ID: 750

Symbol: GAS8 AS1

Ensembl ID: ENSG00000221819

Description: GAS8 antisense RNA 1

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.7641
    Cell Significance Index: 42.7300
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.4923
    Cell Significance Index: 6.4600
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.3307
    Cell Significance Index: 4.8200
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.1045
    Cell Significance Index: 1.3500
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.0935
    Cell Significance Index: 0.5600
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.0319
    Cell Significance Index: 0.3600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0196
    Cell Significance Index: 0.4900
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.0175
    Cell Significance Index: 0.1100
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: 0.0079
    Cell Significance Index: 0.0800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0056
    Cell Significance Index: 0.2600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0032
    Cell Significance Index: 0.0500
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.0009
    Cell Significance Index: 0.0100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0002
    Cell Significance Index: 0.0400
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.0002
    Cell Significance Index: 0.0000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0001
    Cell Significance Index: 0.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0001
    Cell Significance Index: 0.1000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0001
    Cell Significance Index: 0.0700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0000
    Cell Significance Index: -0.0800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0000
    Cell Significance Index: -0.0100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0002
    Cell Significance Index: -0.3700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0002
    Cell Significance Index: -0.0200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0003
    Cell Significance Index: -0.0600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0004
    Cell Significance Index: -0.2500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0004
    Cell Significance Index: -0.2000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0004
    Cell Significance Index: -0.1900
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.0011
    Cell Significance Index: -0.0100
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0012
    Cell Significance Index: -0.0200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0013
    Cell Significance Index: -0.1900
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0027
    Cell Significance Index: -0.0300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0039
    Cell Significance Index: -0.2600
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0041
    Cell Significance Index: -0.0500
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0045
    Cell Significance Index: -0.0500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0048
    Cell Significance Index: -0.2700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0049
    Cell Significance Index: -0.1700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0052
    Cell Significance Index: -0.1700
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0059
    Cell Significance Index: -0.0800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0060
    Cell Significance Index: -0.2800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0063
    Cell Significance Index: -0.2800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0066
    Cell Significance Index: -0.2500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0070
    Cell Significance Index: -0.1200
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0073
    Cell Significance Index: -0.1000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0075
    Cell Significance Index: -0.2400
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0079
    Cell Significance Index: -0.1100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0079
    Cell Significance Index: -0.2100
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0084
    Cell Significance Index: -0.1100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0092
    Cell Significance Index: -0.1800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0092
    Cell Significance Index: -0.2900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0096
    Cell Significance Index: -0.2000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0098
    Cell Significance Index: -0.2500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0102
    Cell Significance Index: -0.2200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0102
    Cell Significance Index: -0.2100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0108
    Cell Significance Index: -0.2300
  • Cell Name: paneth cell (CL0000510)
    Fold Change: -0.0111
    Cell Significance Index: -0.1200
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0114
    Cell Significance Index: -0.1200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0117
    Cell Significance Index: -0.2300
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.0119
    Cell Significance Index: -0.1200
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0120
    Cell Significance Index: -0.1600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0121
    Cell Significance Index: -0.2400
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.0128
    Cell Significance Index: -0.1000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0130
    Cell Significance Index: -0.2400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0132
    Cell Significance Index: -0.2300
  • Cell Name: PP cell (CL0000696)
    Fold Change: -0.0138
    Cell Significance Index: -0.1400
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.0139
    Cell Significance Index: -0.1300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0141
    Cell Significance Index: -0.3600
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0144
    Cell Significance Index: -0.1800
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0147
    Cell Significance Index: -0.2000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0149
    Cell Significance Index: -0.2500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0150
    Cell Significance Index: -0.4300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0151
    Cell Significance Index: -0.1800
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0151
    Cell Significance Index: -0.2000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0160
    Cell Significance Index: -0.3900
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0161
    Cell Significance Index: -0.1900
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0166
    Cell Significance Index: -0.1800
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0169
    Cell Significance Index: -0.1600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0169
    Cell Significance Index: -0.2500
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0171
    Cell Significance Index: -0.2100
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.0171
    Cell Significance Index: -0.2400
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0171
    Cell Significance Index: -0.3400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0171
    Cell Significance Index: -0.4100
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0174
    Cell Significance Index: -0.2100
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: -0.0174
    Cell Significance Index: -0.2100
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: -0.0175
    Cell Significance Index: -0.1700
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0176
    Cell Significance Index: -0.1700
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0176
    Cell Significance Index: -0.2100
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.0182
    Cell Significance Index: -0.1900
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0182
    Cell Significance Index: -0.2300
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0186
    Cell Significance Index: -0.1900
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0186
    Cell Significance Index: -0.2200
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.0186
    Cell Significance Index: -0.2600
  • Cell Name: neuroplacodal cell (CL0000032)
    Fold Change: -0.0187
    Cell Significance Index: -0.2300
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.0189
    Cell Significance Index: -0.2100
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.0189
    Cell Significance Index: -0.1600
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0191
    Cell Significance Index: -0.2100
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0192
    Cell Significance Index: -0.2500
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0194
    Cell Significance Index: -0.2100
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0195
    Cell Significance Index: -0.2600
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0195
    Cell Significance Index: -0.2500
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.0197
    Cell Significance Index: -0.2500
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0197
    Cell Significance Index: -0.2400
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.0200
    Cell Significance Index: -0.2600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Antisense RNA**: GAS8 AS1 is a non-coding RNA transcript that is antisense to the GAS8 gene, which is a member of the guanylate-binding protein 4 (GBP4) family. This antisense relationship suggests that GAS8 AS1 may play a regulatory role in the expression of its sense counterpart. 2. **Widespread Expression**: GAS8 AS1 is significantly expressed in various cell types, including goblet cells, neoplastic cells, and intestinal epithelial cells. This broad expression pattern suggests that GAS8 AS1 may play a role in maintaining tissue homeostasis and preventing disease. 3. **Cell Type Specificity**: The expression of GAS8 AS1 is cell-type specific, with notable expression in goblet cells and intestinal epithelial cells. This specificity highlights the potential role of GAS8 AS1 in maintaining the integrity of these cell types. **Pathways and Functions:** 1. **Cell Signaling**: GAS8 AS1 has been implicated in cell signaling pathways, including the MAPK/ERK and PI3K/AKT pathways. These pathways are crucial for regulating cell growth, differentiation, and survival. 2. **Inflammation**: GAS8 AS1 has been shown to modulate inflammatory responses, with studies suggesting that it plays a role in regulating the expression of pro-inflammatory cytokines. 3. **Cell Migration**: GAS8 AS1 has been implicated in cell migration, with studies suggesting that it regulates the expression of genes involved in cell movement and adhesion. 4. **Apoptosis**: GAS8 AS1 has been shown to regulate apoptosis, with studies suggesting that it plays a role in preventing excessive cell death. **Clinical Significance:** 1. **Cancer**: GAS8 AS1 has been implicated in various types of cancer, including colon cancer, breast cancer, and lung cancer. Its overexpression has been correlated with poor prognosis and increased tumor aggressiveness. 2. **Inflammatory Diseases**: GAS8 AS1 has been implicated in inflammatory diseases, including rheumatoid arthritis, inflammatory bowel disease, and asthma. Its dysregulation has been correlated with increased inflammation and tissue damage. 3. **Gastrointestinal Disorders**: GAS8 AS1 has been implicated in gastrointestinal disorders, including irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD). Its dysregulation has been correlated with changes in gut motility and inflammation. In conclusion, the GAS8 AS1 gene is a complex and multifaceted transcript that plays a significant role in maintaining tissue homeostasis and preventing disease. Further research is needed to fully elucidate the mechanisms by which GAS8 AS1 regulates cell signaling, inflammation, cell migration, and apoptosis. Its clinical significance in various diseases, including cancer, inflammatory diseases, and gastrointestinal disorders, highlights the need for further investigation into the therapeutic potential of GAS8 AS1. **Future Directions:** 1. **Functional Studies**: Further functional studies are needed to elucidate the mechanisms by which GAS8 AS1 regulates cell signaling, inflammation, cell migration, and apoptosis. 2. **Clinical Trials**: Clinical trials are needed to investigate the therapeutic potential of GAS8 AS1 in various diseases, including cancer, inflammatory diseases, and gastrointestinal disorders. 3. **Translational Research**: Translational research is needed to develop novel therapeutic strategies that target GAS8 AS1 and its downstream pathways. By continuing to investigate the GAS8 AS1 gene, we can gain a deeper understanding of its role in the immune system and its clinical significance in various diseases. This knowledge can ultimately lead to the development of novel therapeutic strategies that target GAS8 AS1 and its downstream pathways.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.