Details for: FMNL1

Gene ID: 752

Symbol: FMNL1

Ensembl ID: ENSG00000184922

Description: formin like 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 110.0645
    Cell Significance Index: -17.1200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 51.6668
    Cell Significance Index: -20.9900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 46.5220
    Cell Significance Index: -11.8000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 44.3053
    Cell Significance Index: -22.7900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 30.5877
    Cell Significance Index: -20.5300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.9664
    Cell Significance Index: -17.2200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.5135
    Cell Significance Index: -14.7700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.8250
    Cell Significance Index: -10.5600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.7583
    Cell Significance Index: -14.6200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.4680
    Cell Significance Index: 82.5800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.4551
    Cell Significance Index: -17.5800
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 3.5500
    Cell Significance Index: 9.5100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.5248
    Cell Significance Index: 162.8900
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.9678
    Cell Significance Index: 8.8000
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 1.2692
    Cell Significance Index: 8.4200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.9218
    Cell Significance Index: 19.9700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7748
    Cell Significance Index: 20.7300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.6304
    Cell Significance Index: 18.5200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.6277
    Cell Significance Index: 10.0700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.4883
    Cell Significance Index: 12.8400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4722
    Cell Significance Index: 89.8600
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 0.4238
    Cell Significance Index: 7.2800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3700
    Cell Significance Index: 255.9400
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.3610
    Cell Significance Index: 2.1800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3259
    Cell Significance Index: 65.3700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3090
    Cell Significance Index: 30.5700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2497
    Cell Significance Index: 29.4500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2385
    Cell Significance Index: 215.3100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1417
    Cell Significance Index: 23.0500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1280
    Cell Significance Index: 45.9100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0938
    Cell Significance Index: 6.3100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0455
    Cell Significance Index: 4.9500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0295
    Cell Significance Index: 13.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0046
    Cell Significance Index: -8.6900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0064
    Cell Significance Index: -11.7200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0074
    Cell Significance Index: -11.3300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0116
    Cell Significance Index: -0.3300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0131
    Cell Significance Index: -0.4600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0135
    Cell Significance Index: -0.3900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0135
    Cell Significance Index: -18.3000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0163
    Cell Significance Index: -8.9200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0213
    Cell Significance Index: -16.0900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0256
    Cell Significance Index: -19.0000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0279
    Cell Significance Index: -17.7300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0309
    Cell Significance Index: -22.6600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0338
    Cell Significance Index: -19.0700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0347
    Cell Significance Index: -21.6600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0376
    Cell Significance Index: -0.9400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0458
    Cell Significance Index: -20.8000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0482
    Cell Significance Index: -4.9200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0511
    Cell Significance Index: -14.7000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0511
    Cell Significance Index: -7.0200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0622
    Cell Significance Index: -2.8200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0651
    Cell Significance Index: -4.5000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0714
    Cell Significance Index: -12.8800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0726
    Cell Significance Index: -3.2100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0728
    Cell Significance Index: -14.4500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0948
    Cell Significance Index: -5.6900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0982
    Cell Significance Index: -20.6800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1036
    Cell Significance Index: -13.2800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1046
    Cell Significance Index: -3.9600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1116
    Cell Significance Index: -2.8500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1125
    Cell Significance Index: -19.2100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1156
    Cell Significance Index: -6.0700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1170
    Cell Significance Index: -8.9800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1199
    Cell Significance Index: -7.3500
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1305
    Cell Significance Index: -2.2500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1310
    Cell Significance Index: -15.2700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1317
    Cell Significance Index: -17.0200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1323
    Cell Significance Index: -16.2700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1358
    Cell Significance Index: -19.7500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1371
    Cell Significance Index: -6.4500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1449
    Cell Significance Index: -6.3000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1465
    Cell Significance Index: -16.7800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1571
    Cell Significance Index: -16.3600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1615
    Cell Significance Index: -9.9300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1890
    Cell Significance Index: -3.9200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2070
    Cell Significance Index: -14.6400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2127
    Cell Significance Index: -4.5300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2209
    Cell Significance Index: -10.3000
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.2256
    Cell Significance Index: -1.4400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2318
    Cell Significance Index: -3.3200
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.2332
    Cell Significance Index: -3.4100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2582
    Cell Significance Index: -5.0400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2679
    Cell Significance Index: -19.9700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2957
    Cell Significance Index: -15.3600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3075
    Cell Significance Index: -5.2700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3127
    Cell Significance Index: -9.9600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3183
    Cell Significance Index: -20.0600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3208
    Cell Significance Index: -18.0000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3213
    Cell Significance Index: -10.2900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3238
    Cell Significance Index: -10.6000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3523
    Cell Significance Index: -12.3400
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.3570
    Cell Significance Index: -3.5800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3627
    Cell Significance Index: -18.8900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3788
    Cell Significance Index: -8.0400
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.3896
    Cell Significance Index: -4.9400
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.3988
    Cell Significance Index: -6.7700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4226
    Cell Significance Index: -21.3600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.4296
    Cell Significance Index: -8.4000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** FMNL1 is a protein-coding gene located on human chromosome 1p36.33. It is highly expressed in various immune cells, including classical monocytes, memory B cells, and T cells. The FMNL1 protein is a member of the formin family, which is characterized by its ability to polymerize actin filaments. The FMNL1 protein contains a unique N-terminal domain that is involved in the interaction with other proteins, such as Rho GTPases and GTPase-activating proteins. **Pathways and Functions:** FMNL1 is involved in several key pathways that regulate immune cell function and migration: 1. **Actin filament organization:** FMNL1 is responsible for the formation and organization of actin filaments, which are essential for cell migration, phagocytosis, and signaling. 2. **Rho GTPase cycle:** FMNL1 interacts with Rho GTPases, which are key regulators of the actin cytoskeleton. The FMNL1-Rho GTPase interaction is crucial for the regulation of actin filament dynamics. 3. **Cytoskeleton regulation:** FMNL1 is involved in the regulation of cytoskeleton dynamics, including the formation and disassembly of actin filaments. 4. **Signaling pathways:** FMNL1 is involved in various signaling pathways, including the Rho GTPase-activated formin pathway, which regulates the activity of formins, such as FMNL1. **Clinical Significance:** Dysregulation of FMNL1 has been implicated in various immune system disorders, including: 1. **Autoimmune diseases:** FMNL1 has been shown to play a role in the regulation of immune cell function and migration, and its dysregulation has been implicated in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 2. **Cancer:** FMNL1 has been shown to be overexpressed in various cancers, including leukemia and lymphoma. The dysregulation of FMNL1 has been implicated in the development and progression of these cancers. 3. **Immunodeficiency disorders:** FMNL1 has been shown to play a role in the regulation of immune cell function and migration, and its dysregulation has been implicated in immunodeficiency disorders, such as chronic granulomatous disease. In conclusion, FMNL1 is a critical component of the actin cytoskeleton machinery, playing a pivotal role in the regulation of immune cell function and migration. Its dysregulation has been implicated in various immune system disorders, including autoimmune diseases, cancer, and immunodeficiency disorders. Further research is needed to fully understand the role of FMNL1 in the immune system and to explore its potential as a therapeutic target for the treatment of these disorders.

Genular Protein ID: 1026472126

Symbol: FMNL1_HUMAN

Name: Formin-like protein 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9799091

Title: The NIK protein kinase and C17orf1 genes: chromosomal mapping, gene structures and mutational screening in frontotemporal dementia and parkinsonism linked to chromosome 17.

PubMed ID: 9799091

DOI: 10.1007/s004390050827

PubMed ID: 19815554

Title: Formin-like 1 (FMNL1) is regulated by N-terminal myristoylation and induces polarized membrane blebbing.

PubMed ID: 19815554

DOI: 10.1074/jbc.m109.060699

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 19367720

Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.

PubMed ID: 19367720

DOI: 10.1021/pr800500r

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21834987

Title: Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration.

PubMed ID: 21834987

DOI: 10.1186/1741-7007-9-54

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21148482

Title: Bi-modal regulation of a formin by srGAP2.

PubMed ID: 21148482

DOI: 10.1074/jbc.m110.190397

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25255805

Title: Global profiling of co- and post-translationally N-myristoylated proteomes in human cells.

PubMed ID: 25255805

DOI: 10.1038/ncomms5919

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 1100
  • Mass: 121854
  • Checksum: 91F9CE2B3B526FFC
  • Sequence:
  • MGNAAGSAEQ PAGPAAPPPK QPAPPKQPMP AAGELEERFN RALNCMNLPP DKVQLLSQYD 
    NEKKWELICD QERFQVKNPP AAYIQKLKSY VDTGGVSRKV AADWMSNLGF KRRVQESTQV 
    LRELETSLRT NHIGWVQEFL NEENRGLDVL LEYLAFAQCS VTYDMESTDN GASNSEKNKP 
    LEQSVEDLSK GPPSSVPKSR HLTIKLTPAH SRKALRNSRI VSQKDDVHVC IMCLRAIMNY 
    QSGFSLVMNH PACVNEIALS LNNKNPRTKA LVLELLAAVC LVRGGHDIIL AAFDNFKEVC 
    GEQHRFEKLM EYFRNEDSNI DFMVACMQFI NIVVHSVENM NFRVFLQYEF THLGLDLYLE 
    RLRLTESDKL QVQIQAYLDN IFDVGALLED TETKNAVLEH MEELQEQVAL LTERLRDAEN 
    ESMAKIAELE KQLSQARKEL ETLRERFSES TAMGPSRRPP EPEKAPPAAP TRPSALELKV 
    EELEEKGLIR ILRGPGDAVS IEILPVAVAT PSGGDAPTPG VPTGSPSPDL APAAEPAPGA 
    APPPPPPLPG LPSPQEAPPS APPQAPPLPG SPEPPPAPPL PGDLPPPPPP PPPPPGTDGP 
    VPPPPPPPPP PPGGPPDALG RRDSELGPGV KAKKPIQTKF RMPLLNWVAL KPSQITGTVF 
    TELNDEKVLQ ELDMSDFEEQ FKTKSQGPSL DLSALKSKAA QKAPSKATLI EANRAKNLAI 
    TLRKGNLGAE RICQAIEAYD LQALGLDFLE LLMRFLPTEY ERSLITRFER EQRPMEELSE 
    EDRFMLCFSR IPRLPERMTT LTFLGNFPDT AQLLMPQLNA IIAASMSIKS SDKLRQILEI 
    VLAFGNYMNS SKRGAAYGFR LQSLDALLEM KSTDRKQTLL HYLVKVIAEK YPQLTGFHSD 
    LHFLDKAGSV SLDSVLADVR SLQRGLELTQ REFVRQDDCM VLKEFLRANS PTMDKLLADS 
    KTAQEAFESV VEYFGENPKT TSPGLFFSLF SRFIKAYKKA EQEVEQWKKE AAAQEAGADT 
    PGKGEPPAPK SPPKARRPQM DLISELKRRQ QKEPLIYESD RDGAIEDIIT VIKTVPFTAR 
    TGKRTSRLLC EASLGEEMPL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.