Details for: FMNL1

Gene ID: 752

Symbol: FMNL1

Ensembl ID: ENSG00000184922

Description: formin like 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.62
    Marker Score: 146495
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 2.44
    Marker Score: 1473
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 2.32
    Marker Score: 2281
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 2.16
    Marker Score: 766
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.12
    Marker Score: 1784
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.06
    Marker Score: 888
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.05
    Marker Score: 1920
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.01
    Marker Score: 5001
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.97
    Marker Score: 19936.5
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.9
    Marker Score: 3704
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1.85
    Marker Score: 2000
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.84
    Marker Score: 5150
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 1.81
    Marker Score: 596
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 1.74
    Marker Score: 5070.5
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.71
    Marker Score: 4712.5
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.63
    Marker Score: 1969.5
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 1.62
    Marker Score: 1757.5
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.6
    Marker Score: 3856
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.56
    Marker Score: 1788
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.55
    Marker Score: 1127
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.49
    Marker Score: 14791
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.48
    Marker Score: 1303
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.48
    Marker Score: 2182
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.47
    Marker Score: 17083
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167596.5
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.45
    Marker Score: 988
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.43
    Marker Score: 442
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.42
    Marker Score: 692
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 1.41
    Marker Score: 491
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.4
    Marker Score: 3626
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 1.37
    Marker Score: 801
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.36
    Marker Score: 681.5
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.34
    Marker Score: 408
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.31
    Marker Score: 4120
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.29
    Marker Score: 3140.5
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 1.28
    Marker Score: 932
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.26
    Marker Score: 1188
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.24
    Marker Score: 713
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.21
    Marker Score: 822
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 1.21
    Marker Score: 623
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.21
    Marker Score: 728
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 1.2
    Marker Score: 391
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.18
    Marker Score: 30292.5
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.15
    Marker Score: 791
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.14
    Marker Score: 392.5
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.13
    Marker Score: 4727
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.13
    Marker Score: 820.5
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.12
    Marker Score: 361
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 1.1
    Marker Score: 459
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.1
    Marker Score: 833
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.1
    Marker Score: 17158
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.09
    Marker Score: 1113
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.09
    Marker Score: 1950
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.09
    Marker Score: 2211.5
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.09
    Marker Score: 1094
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 1.08
    Marker Score: 1198
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 1.07
    Marker Score: 235
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.07
    Marker Score: 907
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.07
    Marker Score: 4437
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 1.06
    Marker Score: 655
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.06
    Marker Score: 2001.5
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.06
    Marker Score: 6414.5
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 1.05
    Marker Score: 239
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 1.05
    Marker Score: 237
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.04
    Marker Score: 849
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 1.03
    Marker Score: 571
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.02
    Marker Score: 1413
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 1.02
    Marker Score: 746
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.01
    Marker Score: 4145
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.01
    Marker Score: 53423
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71701
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47924
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30394
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.98
    Marker Score: 4200
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.96
    Marker Score: 253
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.96
    Marker Score: 430
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.96
    Marker Score: 411
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.95
    Marker Score: 329
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.95
    Marker Score: 1628
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.95
    Marker Score: 1230
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2402
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 485
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 442
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.93
    Marker Score: 834
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.93
    Marker Score: 234
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.91
    Marker Score: 395
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.91
    Marker Score: 454
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 0.91
    Marker Score: 241
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2714
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.9
    Marker Score: 361
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.9
    Marker Score: 5750
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.89
    Marker Score: 5105
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.89
    Marker Score: 1547
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.88
    Marker Score: 605
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.88
    Marker Score: 958
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 315
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 0.87
    Marker Score: 220
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0.87
    Marker Score: 1817
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.87
    Marker Score: 1576
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5246

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Other Information

**Key characteristics:** * FMNL1 is a protein of the Actin cytoskeleton family. * It is a secreted protein that is expressed in a variety of cell types. * It is a key regulator of the actin filament cytoskeleton, and its expression is often associated with cell migration, differentiation, and signaling. * It is a major regulator of the Rho GTPase cycle. * It is also involved in the regulation of the Cdc42 gtpase cycle and the cell cycle. **Pathways and functions:** * FMNL1 is involved in the regulation of cell shape. It is a key regulator of the actin filament cytoskeleton, and its expression is often associated with cell migration, differentiation, and signaling. * It is also involved in the regulation of the cell cycle. * It is involved in the activation of the Rho GTPase cycle. * It is also involved in the regulation of the Cdc42 gtpase cycle. **Clinical significance:** * Mutations in the FMNL1 gene have been linked to a number of human diseases, including cancer and autoimmune disorders. * These diseases are often characterized by abnormal cell migration and differentiation. * Therefore, FMNL1 is a promising target for the treatment of cancer and autoimmune disorders. **Additional information:** * The FMNL1 gene is located on chromosome 12q21.1. * It is a large protein that is composed of 1141 amino acids. * It is a well-characterized protein that has been extensively studied in both humans and mice.

Genular Protein ID: 1026472126

Symbol: FMNL1_HUMAN

Name: Formin-like protein 1

UniProtKB Accession Codes:

O95466 D2DGW2 Q6DKG5 Q6IBP3 Q86UH1 Q8N671 Q8TDH1 Q96H10

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 10 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 14 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 3 RefSeq 3 SAM 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 2 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9799091

Title: The NIK protein kinase and C17orf1 genes: chromosomal mapping, gene structures and mutational screening in frontotemporal dementia and parkinsonism linked to chromosome 17.

PubMed ID: 9799091

DOI: 10.1007/s004390050827

PubMed ID: 19815554

Title: Formin-like 1 (FMNL1) is regulated by N-terminal myristoylation and induces polarized membrane blebbing.

PubMed ID: 19815554

DOI: 10.1074/jbc.m109.060699

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 19367720

Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.

PubMed ID: 19367720

DOI: 10.1021/pr800500r

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21834987

Title: Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration.

PubMed ID: 21834987

DOI: 10.1186/1741-7007-9-54

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21148482

Title: Bi-modal regulation of a formin by srGAP2.

PubMed ID: 21148482

DOI: 10.1074/jbc.m110.190397

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25255805

Title: Global profiling of co- and post-translationally N-myristoylated proteomes in human cells.

PubMed ID: 25255805

DOI: 10.1038/ncomms5919

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 1100
  • Mass: 121854
  • Checksum: 91F9CE2B3B526FFC
  • Sequence:
    • MGNAAGSAEQ PAGPAAPPPK QPAPPKQPMP AAGELEERFN RALNCMNLPP DKVQLLSQYD 
NEKKWELICD QERFQVKNPP AAYIQKLKSY VDTGGVSRKV AADWMSNLGF KRRVQESTQV 
LRELETSLRT NHIGWVQEFL NEENRGLDVL LEYLAFAQCS VTYDMESTDN GASNSEKNKP 
LEQSVEDLSK GPPSSVPKSR HLTIKLTPAH SRKALRNSRI VSQKDDVHVC IMCLRAIMNY 
QSGFSLVMNH PACVNEIALS LNNKNPRTKA LVLELLAAVC LVRGGHDIIL AAFDNFKEVC 
GEQHRFEKLM EYFRNEDSNI DFMVACMQFI NIVVHSVENM NFRVFLQYEF THLGLDLYLE 
RLRLTESDKL QVQIQAYLDN IFDVGALLED TETKNAVLEH MEELQEQVAL LTERLRDAEN 
ESMAKIAELE KQLSQARKEL ETLRERFSES TAMGPSRRPP EPEKAPPAAP TRPSALELKV 
EELEEKGLIR ILRGPGDAVS IEILPVAVAT PSGGDAPTPG VPTGSPSPDL APAAEPAPGA 
APPPPPPLPG LPSPQEAPPS APPQAPPLPG SPEPPPAPPL PGDLPPPPPP PPPPPGTDGP 
VPPPPPPPPP PPGGPPDALG RRDSELGPGV KAKKPIQTKF RMPLLNWVAL KPSQITGTVF 
TELNDEKVLQ ELDMSDFEEQ FKTKSQGPSL DLSALKSKAA QKAPSKATLI EANRAKNLAI 
TLRKGNLGAE RICQAIEAYD LQALGLDFLE LLMRFLPTEY ERSLITRFER EQRPMEELSE 
EDRFMLCFSR IPRLPERMTT LTFLGNFPDT AQLLMPQLNA IIAASMSIKS SDKLRQILEI 
VLAFGNYMNS SKRGAAYGFR LQSLDALLEM KSTDRKQTLL HYLVKVIAEK YPQLTGFHSD 
LHFLDKAGSV SLDSVLADVR SLQRGLELTQ REFVRQDDCM VLKEFLRANS PTMDKLLADS 
KTAQEAFESV VEYFGENPKT TSPGLFFSLF SRFIKAYKKA EQEVEQWKKE AAAQEAGADT 
PGKGEPPAPK SPPKARRPQM DLISELKRRQ QKEPLIYESD RDGAIEDIIT VIKTVPFTAR 
TGKRTSRLLC EASLGEEMPL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.