Details for: LDLRAD4

Gene ID: 753

Symbol: LDLRAD4

Ensembl ID: ENSG00000168675

Description: low density lipoprotein receptor class A domain containing 4

Associated with

  • Early endosome membrane
    (GO:0031901)
  • Golgi membrane
    (GO:0000139)
  • Intracellular membrane-bounded organelle
    (GO:0043231)
  • Membrane
    (GO:0016020)
  • Negative regulation of cell migration
    (GO:0030336)
  • Negative regulation of epithelial to mesenchymal transition
    (GO:0010719)
  • Negative regulation of smad protein signal transduction
    (GO:0060392)
  • Negative regulation of transforming growth factor beta receptor signaling pathway
    (GO:0030512)
  • R-smad binding
    (GO:0070412)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 5.38
    Marker Score: 1946
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 3.82
    Marker Score: 12806
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 3.69
    Marker Score: 1775
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 3.55
    Marker Score: 11635
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 3.51
    Marker Score: 1747
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 3.3
    Marker Score: 2485
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 3.13
    Marker Score: 1820.5
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 3.12
    Marker Score: 105409
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.97
    Marker Score: 66354
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 2.96
    Marker Score: 15881
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 2.91
    Marker Score: 2019
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 2.9
    Marker Score: 3035
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.89
    Marker Score: 6334.5
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.79
    Marker Score: 5365
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 2.65
    Marker Score: 840
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.6
    Marker Score: 55443
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.59
    Marker Score: 11975
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.58
    Marker Score: 993
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.52
    Marker Score: 10430.5
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.48
    Marker Score: 18991
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.47
    Marker Score: 1440
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.47
    Marker Score: 7048
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 2.46
    Marker Score: 5884
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 2.41
    Marker Score: 5541
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.4
    Marker Score: 91221.5
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.37
    Marker Score: 3975
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.36
    Marker Score: 46955
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.36
    Marker Score: 86897
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.34
    Marker Score: 1367
  • Cell Name: granule cell (CL0000120)
    Fold Change: 2.23
    Marker Score: 16805
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 2.19
    Marker Score: 7768.5
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 2.16
    Marker Score: 676
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.16
    Marker Score: 21871.5
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.14
    Marker Score: 2588
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 2.09
    Marker Score: 1033
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 2.06
    Marker Score: 1354
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 2.04
    Marker Score: 2452
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 2.04
    Marker Score: 1143.5
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 2.02
    Marker Score: 1749
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 2.02
    Marker Score: 20816.5
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.98
    Marker Score: 8048
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.97
    Marker Score: 576
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.95
    Marker Score: 119684
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.92
    Marker Score: 2370
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.86
    Marker Score: 15975
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.85
    Marker Score: 2681
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.84
    Marker Score: 1754
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.81
    Marker Score: 7000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.8
    Marker Score: 17064
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.78
    Marker Score: 746
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.78
    Marker Score: 513
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.73
    Marker Score: 1848
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.72
    Marker Score: 30617
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.72
    Marker Score: 447
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.71
    Marker Score: 16100
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.71
    Marker Score: 1020
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.71
    Marker Score: 2293.5
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.69
    Marker Score: 544.5
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.68
    Marker Score: 9042.5
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.68
    Marker Score: 6878
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.67
    Marker Score: 456
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.62
    Marker Score: 611
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.6
    Marker Score: 4017
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.59
    Marker Score: 10253
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.58
    Marker Score: 4300
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.58
    Marker Score: 402
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.58
    Marker Score: 2437
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.51
    Marker Score: 6329
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.48
    Marker Score: 6383
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.48
    Marker Score: 1701.5
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.48
    Marker Score: 1486
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167271
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.46
    Marker Score: 2962
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 1.4
    Marker Score: 7364
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.37
    Marker Score: 823
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.36
    Marker Score: 21349.5
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 1.3
    Marker Score: 944
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.3
    Marker Score: 1569.5
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.3
    Marker Score: 471
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 1.29
    Marker Score: 1429
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 1.28
    Marker Score: 972.5
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 1.27
    Marker Score: 280
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.25
    Marker Score: 695
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.22
    Marker Score: 2872
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 1.19
    Marker Score: 612
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 1.15
    Marker Score: 293
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.13
    Marker Score: 356
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.12
    Marker Score: 3094
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.12
    Marker Score: 760
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 1.11
    Marker Score: 305.5
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.09
    Marker Score: 3763
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 1.08
    Marker Score: 466
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.08
    Marker Score: 605
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.07
    Marker Score: 6416
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.07
    Marker Score: 1067
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.06
    Marker Score: 1139
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.04
    Marker Score: 566
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 1.02
    Marker Score: 1202.5
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.02
    Marker Score: 1775
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 1.01
    Marker Score: 364

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Other Information

**Key characteristics:** * The protein is a transmembrane protein with a molecular weight of approximately 140 kDa. * It is expressed in high levels in the brain and nervous system. * It is a ligand for the LDLRAD1 and LDLRAD3 receptors. **Pathways and functions:** * LDLRAD4 is involved in a variety of cellular processes, including cell migration, adhesion, and migration. * It is expressed in microglial cells, which are a type of immune cell that is involved in the regulation of inflammation. * It is also expressed in neurons, which are cells that are responsible for the transmission of nerve impulses. * It is involved in the regulation of epithelial to mesenchymal transition, a process that is important for the development of tissues and organs. * It is also involved in the negative regulation of cell migration, adhesion, and migration. * It is involved in the negative regulation of smad protein signal transduction, a pathway that is important for cell signaling. * It is involved in the negative regulation of transforming growth factor beta receptor signaling pathway, a pathway that is important for cell growth and differentiation. **Clinical significance:** * Mutations in the LDLRAD4 gene have been linked to a number of neurological disorders, including autism, schizophrenia, and Alzheimer's disease. * LDLRAD4 is a potential therapeutic target for these disorders, as it is involved in the regulation of cell migration and adhesion. * Drugs that target LDLRAD4 have been shown to be effective in reducing neuronal inflammation and improving cognitive function in animal models of neurodegenerative diseases.

Genular Protein ID: 322412053

Symbol: LRAD4_HUMAN

Name: Low-density lipoprotein receptor class A domain-containing protein 4

UniProtKB Accession Codes:

O15165 B3KNT9 E9PAY9 K7EN38 O15166 O15167 O15168 Q5U646 Q6NXP3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 14 Ensembl 8 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 7 RNAct 1 RefSeq 17 SAM 1 SMART 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9479497

Title: Multiple transcriptional variants and RNA editing in C18orf1, a novel gene with LDLRA and transmembrane domains on 18p11.2.

PubMed ID: 9479497

DOI: 10.1006/geno.1997.5118

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19461657

Title: Analysis of a t(18;21)(p11.1;p11.1) translocation in a family with schizophrenia.

PubMed ID: 19461657

DOI: 10.1038/jhg.2009.47

PubMed ID: 24627487

Title: C18 ORF1, a novel negative regulator of transforming growth factor-beta signaling.

PubMed ID: 24627487

DOI: 10.1074/jbc.m114.558981

Sequence Information:

  • Length: 306
  • Mass: 33900
  • Checksum: F48EF66E329201BD
  • Sequence:
    • MPEAGFQATN AFTECKFTCT SGKCLYLGSL VCNQQNDCGD NSDEENCLLV TEHPPPGIFN 
SELEFAQIII IVVVVTVMVV VIVCLLNHYK VSTRSFINRP NQSRRREDGL PQEGCLWPSD 
SAAPRLGASE IMHAPRSRDR FTAPSFIQRD RFSRFQPTYP YVQHEIDLPP TISLSDGEEP 
PPYQGPCTLQ LRDPEQQMEL NRESVRAPPN RTIFDSDLID IAMYSGGPCP PSSNSGISAS 
TCSSNGRMEG PPPTYSEVMG HHPGASFLHH QRSNAHRGSR LQFQQNNAES TIVPIKGKDR 
KPGNLV

Genular Protein ID: 3137062394

Symbol: A8K6A9_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K6A9

Database IDs:

ARBA 9 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 3 GenomeRNAi 1 InterPro 1 NCBI Taxonomy 1 PANTHER 2 PeptideAtlas 1 RefSeq 1 SAM 1

Sequence Information:

  • Length: 229
  • Mass: 25629
  • Checksum: D124C6E2402A031E
  • Sequence:
    • MVVVIVCLLN HYKVSTRSFI NRPNQSRRRE DGLPQEGCLW PSDSAAPRLG ASEIMHAPRS 
RDRFTAPSFI QRDRFSRFQP TYPYVQHEID LPPTISLSDG EEPPPYQGPC TLQLRDPEQQ 
MELNRESVRA PPNRTIFDSD LIDIAMYSGG PCPPSSNSGI SASTCSSNGR MEGPPPTYSE 
VMGHHPGASF LHHQRSNAHR GRRLQFQQNN AESTIVPIKG KDRKPGNLV

Genular Protein ID: 2377798016

Symbol: A0A7I2V575_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A7I2V575

Database IDs:

ARBA 9 Bgee 1 CTD 1 EMBL 4 Ensembl 4 GO 4 GeneTree 1 HGNC 1 InterPro 1 MaxQB 1 NCBI Taxonomy 1 PANTHER 2 PeptideAtlas 1 Proteomes 2 RefSeq 3 SAM 2

Citations:

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

Sequence Information:

  • Length: 259
  • Mass: 28764
  • Checksum: A53C0A337FE0737C
  • Sequence:
    • MPEAGFQATN AFTAELEFAQ IIIIVVVVTV MVVVIVCLLN HYKVSTRSFI NRPNQSRRRE 
DGLPQEGCLW PSDSAAPRLG ASEIMHAPRS RDRFTAPSFI QRDRFSRFQP TYPYVQHEID 
LPPTISLSDG EEPPPYQGPC TLQLRDPEQQ MELNRESVRA PPNRTIFDSD LIDIAMYSGG 
PCPPSSNSGI SASTCSSNGR MEGPPPTYSE VMGHHPGASF LHHQRSNAHR GSRLQFQQNN 
AESTIVPIKG KDRKPGNLV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.