Details for: LDLRAD4

Gene ID: 753

Symbol: LDLRAD4

Ensembl ID: ENSG00000168675

Description: low density lipoprotein receptor class A domain containing 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 494.2614
    Cell Significance Index: -76.8800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 297.6226
    Cell Significance Index: -75.4900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 163.1568
    Cell Significance Index: -77.0300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 154.8527
    Cell Significance Index: -62.9100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 143.8124
    Cell Significance Index: -73.9800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 114.8099
    Cell Significance Index: -77.0400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 65.9287
    Cell Significance Index: -62.9500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 63.0355
    Cell Significance Index: -77.7200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 27.6434
    Cell Significance Index: -60.5000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 24.6463
    Cell Significance Index: -75.7000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 21.2618
    Cell Significance Index: -56.9600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 19.8705
    Cell Significance Index: -78.4100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 7.1677
    Cell Significance Index: 402.2200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 6.4380
    Cell Significance Index: 284.7700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 6.2280
    Cell Significance Index: 235.8400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 5.3539
    Cell Significance Index: 91.7500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 3.8225
    Cell Significance Index: 293.3400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 3.4853
    Cell Significance Index: 74.5000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 3.0668
    Cell Significance Index: 615.1900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.6455
    Cell Significance Index: 525.0000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.3544
    Cell Significance Index: 60.5200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.2886
    Cell Significance Index: 147.6500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.0632
    Cell Significance Index: 740.0500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.9556
    Cell Significance Index: 193.4500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.9536
    Cell Significance Index: 131.3600
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.8413
    Cell Significance Index: 11.3600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.8182
    Cell Significance Index: 26.1500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.6326
    Cell Significance Index: 1129.2000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.4586
    Cell Significance Index: 36.4600
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.2783
    Cell Significance Index: 13.2400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.1796
    Cell Significance Index: 212.6400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1005
    Cell Significance Index: 993.7000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.9562
    Cell Significance Index: 58.7700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.7714
    Cell Significance Index: 13.0000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.6926
    Cell Significance Index: 16.6100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6049
    Cell Significance Index: 98.3800
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.5988
    Cell Significance Index: 7.5400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.5665
    Cell Significance Index: 359.7800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.5071
    Cell Significance Index: 689.5300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.4958
    Cell Significance Index: 225.0100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.3667
    Cell Significance Index: 564.5000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2380
    Cell Significance Index: 448.1200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.2012
    Cell Significance Index: 371.1400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1704
    Cell Significance Index: 4.9100
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.0543
    Cell Significance Index: 0.7600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0108
    Cell Significance Index: -2.0500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0229
    Cell Significance Index: -1.3800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0273
    Cell Significance Index: -0.9600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0542
    Cell Significance Index: -1.1800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0580
    Cell Significance Index: -8.4300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0736
    Cell Significance Index: -5.0900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0783
    Cell Significance Index: -3.5500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0916
    Cell Significance Index: -67.1300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1024
    Cell Significance Index: -75.8800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.1129
    Cell Significance Index: -85.4400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.1147
    Cell Significance Index: -62.6200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1216
    Cell Significance Index: -3.4700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1379
    Cell Significance Index: -86.1300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1393
    Cell Significance Index: -78.5700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.1514
    Cell Significance Index: -66.9500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2410
    Cell Significance Index: -69.3300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2809
    Cell Significance Index: -34.5400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2860
    Cell Significance Index: -39.2800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3065
    Cell Significance Index: -4.5300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3148
    Cell Significance Index: -37.1300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3336
    Cell Significance Index: -6.5100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3553
    Cell Significance Index: -36.2900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3582
    Cell Significance Index: -46.2800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.4023
    Cell Significance Index: -84.7400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.4540
    Cell Significance Index: -77.5200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4603
    Cell Significance Index: -10.0800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.4844
    Cell Significance Index: -7.1500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4905
    Cell Significance Index: -23.0600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4991
    Cell Significance Index: -12.7500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5016
    Cell Significance Index: -52.2300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.5410
    Cell Significance Index: -69.3500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.6426
    Cell Significance Index: -47.8900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.6854
    Cell Significance Index: -79.8700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.6933
    Cell Significance Index: -79.4300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.7647
    Cell Significance Index: -16.2300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.8425
    Cell Significance Index: -6.8700
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.8473
    Cell Significance Index: -12.8900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.8920
    Cell Significance Index: -70.6500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.9176
    Cell Significance Index: -56.2600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.9389
    Cell Significance Index: -59.1800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.9785
    Cell Significance Index: -31.3400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.9839
    Cell Significance Index: -51.2500
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -1.0336
    Cell Significance Index: -13.0500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.0736
    Cell Significance Index: -56.3700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -1.0923
    Cell Significance Index: -21.9300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -1.1029
    Cell Significance Index: -15.8000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -1.1463
    Cell Significance Index: -59.5500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -1.1768
    Cell Significance Index: -23.2700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.2112
    Cell Significance Index: -39.6600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.3489
    Cell Significance Index: -42.9600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -1.3630
    Cell Significance Index: -14.8500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.3953
    Cell Significance Index: -29.7200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -1.4240
    Cell Significance Index: -61.9200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.4647
    Cell Significance Index: -17.4600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -1.5157
    Cell Significance Index: -70.6700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** LDLRAD4 is a member of the low-density lipoprotein receptor class A domain-containing family of proteins. It possesses a conserved domain structure, which includes a low-density lipoprotein receptor class A (LDLR-A) domain. The protein is characterized by its ability to interact with various signaling pathways, including those involved in negative regulation of cell migration, epithelial-to-mesenchymal transition, and Smad protein signal transduction. LDLRAD4 is also involved in the regulation of transforming growth factor beta (TGF-β) receptor signaling pathway and R-smad binding. **Pathways and Functions:** LDLRAD4 is involved in several key signaling pathways, including: 1. **Negative regulation of cell migration**: LDLRAD4 interacts with signaling molecules to inhibit cell migration, thereby preventing the formation of invasive cancer cells. 2. **Negative regulation of epithelial-to-mesenchymal transition (EMT)**: LDLRAD4 suppresses EMT, a process involved in the development of cancer and other diseases. 3. **Negative regulation of Smad protein signal transduction**: LDLRAD4 modulates the activity of Smad proteins, which are key signaling molecules involved in TGF-β signaling. 4. **Regulation of TGF-β receptor signaling pathway**: LDLRAD4 interacts with the TGF-β receptor to inhibit its signaling activity. 5. **R-smad binding**: LDLRAD4 binds to R-smad proteins, which are essential for the activation of TGF-β signaling. **Clinical Significance:** The dysregulation of LDLRAD4 has been implicated in various diseases, including: 1. **Cancer**: Alterations in LDLRAD4 expression have been observed in various types of cancer, including breast, lung, and colon cancer. 2. **Neurodegenerative diseases**: LDLRAD4 has been shown to play a role in the pathogenesis of neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. 3. **Cardiovascular disease**: LDLRAD4 has been implicated in the regulation of lipid metabolism and cardiovascular disease. 4. **Inflammatory disorders**: LDLRAD4 has been shown to regulate inflammatory responses in various tissues, including the central nervous system. In conclusion, LDLRAD4 is a critical gene that regulates various cellular processes, including cell migration, EMT, and TGF-β signaling. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the function and significance of LDLRAD4.

Genular Protein ID: 322412053

Symbol: LRAD4_HUMAN

Name: Low-density lipoprotein receptor class A domain-containing protein 4

UniProtKB Accession Codes:

O15165 B3KNT9 E9PAY9 K7EN38 O15166 O15167 O15168 Q5U646 Q6NXP3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 14 Ensembl 8 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 7 RNAct 1 RefSeq 17 SMART 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9479497

Title: Multiple transcriptional variants and RNA editing in C18orf1, a novel gene with LDLRA and transmembrane domains on 18p11.2.

PubMed ID: 9479497

DOI: 10.1006/geno.1997.5118

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19461657

Title: Analysis of a t(18;21)(p11.1;p11.1) translocation in a family with schizophrenia.

PubMed ID: 19461657

DOI: 10.1038/jhg.2009.47

PubMed ID: 24627487

Title: C18 ORF1, a novel negative regulator of transforming growth factor-beta signaling.

PubMed ID: 24627487

DOI: 10.1074/jbc.m114.558981

Sequence Information:

  • Length: 306
  • Mass: 33900
  • Checksum: F48EF66E329201BD
  • Sequence:
    • MPEAGFQATN AFTECKFTCT SGKCLYLGSL VCNQQNDCGD NSDEENCLLV TEHPPPGIFN 
SELEFAQIII IVVVVTVMVV VIVCLLNHYK VSTRSFINRP NQSRRREDGL PQEGCLWPSD 
SAAPRLGASE IMHAPRSRDR FTAPSFIQRD RFSRFQPTYP YVQHEIDLPP TISLSDGEEP 
PPYQGPCTLQ LRDPEQQMEL NRESVRAPPN RTIFDSDLID IAMYSGGPCP PSSNSGISAS 
TCSSNGRMEG PPPTYSEVMG HHPGASFLHH QRSNAHRGSR LQFQQNNAES TIVPIKGKDR 
KPGNLV

Genular Protein ID: 3137062394

Symbol: A8K6A9_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K6A9

Database IDs:

ARBA 9 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 InterPro 1 NCBI Taxonomy 1 PANTHER 2 PeptideAtlas 1 RefSeq 1 SAM 1

Sequence Information:

  • Length: 229
  • Mass: 25629
  • Checksum: D124C6E2402A031E
  • Sequence:
    • MVVVIVCLLN HYKVSTRSFI NRPNQSRRRE DGLPQEGCLW PSDSAAPRLG ASEIMHAPRS 
RDRFTAPSFI QRDRFSRFQP TYPYVQHEID LPPTISLSDG EEPPPYQGPC TLQLRDPEQQ 
MELNRESVRA PPNRTIFDSD LIDIAMYSGG PCPPSSNSGI SASTCSSNGR MEGPPPTYSE 
VMGHHPGASF LHHQRSNAHR GRRLQFQQNN AESTIVPIKG KDRKPGNLV

Genular Protein ID: 2377798016

Symbol: A0A7I2V575_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A7I2V575

Database IDs:

ARBA 9 Bgee 1 CTD 1 DisGeNET 1 EMBL 4 Ensembl 4 GO 4 GeneTree 1 HGNC 1 InterPro 1 NCBI Taxonomy 1 PANTHER 2 PeptideAtlas 1 Proteomes 2 ProteomicsDB 1 RefSeq 3 SAM 2

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

Sequence Information:

  • Length: 259
  • Mass: 28764
  • Checksum: A53C0A337FE0737C
  • Sequence:
    • MPEAGFQATN AFTAELEFAQ IIIIVVVVTV MVVVIVCLLN HYKVSTRSFI NRPNQSRRRE 
DGLPQEGCLW PSDSAAPRLG ASEIMHAPRS RDRFTAPSFI QRDRFSRFQP TYPYVQHEID 
LPPTISLSDG EEPPPYQGPC TLQLRDPEQQ MELNRESVRA PPNRTIFDSD LIDIAMYSGG 
PCPPSSNSGI SASTCSSNGR MEGPPPTYSE VMGHHPGASF LHHQRSNAHR GSRLQFQQNN 
AESTIVPIKG KDRKPGNLV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.