Details for: PTTG1IP

Gene ID: 754

Symbol: PTTG1IP

Ensembl ID: ENSG00000183255

Description: PTTG1 interacting protein

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 2.69
    Marker Score: 3900
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.56
    Marker Score: 3525
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2.56
    Marker Score: 6512
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.49
    Marker Score: 21857
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.38
    Marker Score: 82388
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.29
    Marker Score: 1369.5
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.26
    Marker Score: 6058.5
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2.26
    Marker Score: 2727
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.24
    Marker Score: 7043
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.24
    Marker Score: 4473
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 2.23
    Marker Score: 1920
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 2.2
    Marker Score: 1474
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.16
    Marker Score: 3176
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.14
    Marker Score: 3791.5
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.12
    Marker Score: 3085.5
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.09
    Marker Score: 4367
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 2.09
    Marker Score: 2514
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 2.09
    Marker Score: 1421
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.07
    Marker Score: 8154
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.06
    Marker Score: 8883
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.04
    Marker Score: 4300.5
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 2.04
    Marker Score: 577
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.99
    Marker Score: 5014
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.98
    Marker Score: 2133
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.98
    Marker Score: 924
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.98
    Marker Score: 4503.5
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.98
    Marker Score: 12608
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.98
    Marker Score: 2110
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.93
    Marker Score: 1730
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.92
    Marker Score: 1948
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.92
    Marker Score: 19282
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.91
    Marker Score: 9360
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.89
    Marker Score: 1994
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.89
    Marker Score: 1779
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.88
    Marker Score: 9043
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.88
    Marker Score: 21215
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.87
    Marker Score: 1251
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.86
    Marker Score: 9794
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.85
    Marker Score: 3143
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.84
    Marker Score: 16023
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.82
    Marker Score: 2124
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.82
    Marker Score: 525
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.81
    Marker Score: 4934
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.81
    Marker Score: 3304
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.8
    Marker Score: 6186
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.8
    Marker Score: 1623
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.8
    Marker Score: 38322
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.78
    Marker Score: 1888
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.77
    Marker Score: 13167
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.74
    Marker Score: 1847
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.73
    Marker Score: 979
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.73
    Marker Score: 96675
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.71
    Marker Score: 1349
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.71
    Marker Score: 540.5
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 1.7
    Marker Score: 395
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.69
    Marker Score: 965
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.69
    Marker Score: 57440.5
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.68
    Marker Score: 830
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.68
    Marker Score: 796
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.68
    Marker Score: 863
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.67
    Marker Score: 2773
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.66
    Marker Score: 10809
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.65
    Marker Score: 1754.5
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.65
    Marker Score: 2544
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.65
    Marker Score: 2619
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.63
    Marker Score: 346
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.63
    Marker Score: 374
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.62
    Marker Score: 41532
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.62
    Marker Score: 2289
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.62
    Marker Score: 3803
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.61
    Marker Score: 887
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.6
    Marker Score: 460
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.59
    Marker Score: 4167
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 1.59
    Marker Score: 973
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.58
    Marker Score: 1812
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.58
    Marker Score: 3001.5
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.58
    Marker Score: 1636
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.57
    Marker Score: 378
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.57
    Marker Score: 9292
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.56
    Marker Score: 367
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.56
    Marker Score: 10173
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.56
    Marker Score: 630
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.55
    Marker Score: 5521
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.55
    Marker Score: 1661
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 1.55
    Marker Score: 642
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.54
    Marker Score: 1982.5
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.53
    Marker Score: 492
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.52
    Marker Score: 1711
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.52
    Marker Score: 887
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.52
    Marker Score: 17701
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.52
    Marker Score: 719
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.52
    Marker Score: 1522
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 1.51
    Marker Score: 812.5
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.51
    Marker Score: 5600.5
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.51
    Marker Score: 632
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.5
    Marker Score: 1414
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.5
    Marker Score: 3409
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.5
    Marker Score: 790
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.5
    Marker Score: 1615
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.49
    Marker Score: 1750

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Other Information

**Key characteristics:** * The protein is a protein-interacting protein (PPI) that physically interacts with the p53 class mediator. * It is expressed in a variety of cell types, including endothelial cells, leukocytes, and cancer cells. * It is involved in the regulation of DNA damage response, cell cycle control, and apoptosis. * It is a key regulator of the p53 class mediator, a key regulator of cell cycle arrest and apoptosis. **Pathways and functions:** * PTTG1IP is involved in the regulation of DNA damage response by interacting with the p53 class mediator. * It helps to regulate the binding of the p53 class mediator to DNA damage response proteins. * It also helps to regulate the phosphorylation of p53, which is a key step in the activation of the p53 class mediator. * PTTG1IP is also involved in the regulation of cell cycle control and apoptosis. * It helps to regulate the expression of genes that are involved in cell cycle arrest and apoptosis. **Clinical significance:** * Mutations in the PTTG1IP gene have been linked to a number of human cancers, including lung cancer, breast cancer, and colon cancer. * Inhibition of PTTG1IP has been shown to inhibit cancer cell growth and metastasis. * Therefore, PTTG1IP is a potential target for cancer therapy. **Additional information:** * The PTTG1IP gene is located on chromosome 17q21.1. * It is a member of the PTTG family of PPI proteins. * It is expressed in high levels in normal cells, but its expression is often increased in cancer cells. * It is a well-characterized target for cancer therapy.

Genular Protein ID: 2077971388

Symbol: PTTG_HUMAN

Name: Pituitary tumor-transforming gene 1 protein-interacting protein

UniProtKB Accession Codes:

P53801 B2RDP7 D3DSL9 Q9NS09

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 10 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 SAM 1 SMART 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9570958

Title: Cloning of a novel human putative type Ia integral membrane protein mapping to 21q22.3.

PubMed ID: 9570958

DOI: 10.1006/geno.1998.5217

PubMed ID: 10781616

Title: A novel binding factor facilitates nuclear translocation and transcriptional activation function of the pituitary tumor-transforming gene product.

PubMed ID: 10781616

DOI: 10.1074/jbc.m910105199

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15190888

Title: Identification of novel genes of the bone-specific transcription factor Runx2.

PubMed ID: 15190888

DOI: 10.1359/jbmr.2004.19.6.959

Sequence Information:

  • Length: 180
  • Mass: 20324
  • Checksum: F1E66014D49EC1DE
  • Sequence:
    • MAPGVARGPT PYWRLRLGGA ALLLLLIPVA AAQEPPGAAC SQNTNKTCEE CLKNVSCLWC 
NTNKACLDYP VTSVLPPASL CKLSSARWGV CWVNFEALII TMSVVGGTLL LGIAICCCCC 
CRRKRSRKPD RSEEKAMRER EERRIRQEER RAEMKTRHDE IRKKYGLFKE ENPYARFENN

Genular Protein ID: 3657135982

Symbol: B4DPZ0_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DPZ0

Database IDs:

Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 Ensembl 2 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

Sequence Information:

  • Length: 142
  • Mass: 14893
  • Checksum: 641913C193A0E8C8
  • Sequence:
    • MAPGVARGPT PYWRLRLGGA ALLLLLIPVA AAQEPPGAAC SQNTNKTCEE CLKNVSACLK 
KKTRMLDLKT TKALQHISPD ASCEVHAPQP SPAGRPRGHC GLLTLASEPA SLPGQAAGEL 
PLKDSPLVLQ TGDLLFPVHL CF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.