Details for: TMEM50B

Gene ID: 757

Symbol: TMEM50B

Ensembl ID: ENSG00000142188

Description: transmembrane protein 50B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 250.5381
    Cell Significance Index: -38.9700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 166.7499
    Cell Significance Index: -42.3000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 108.2176
    Cell Significance Index: -44.5800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 104.6550
    Cell Significance Index: -49.4100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 87.2109
    Cell Significance Index: -44.8600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 74.0363
    Cell Significance Index: -49.6800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.4917
    Cell Significance Index: -41.5000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.4304
    Cell Significance Index: -45.1100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 10.8987
    Cell Significance Index: -33.4800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.5038
    Cell Significance Index: -20.8000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 5.5945
    Cell Significance Index: 89.7600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.6764
    Cell Significance Index: 72.8500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.3197
    Cell Significance Index: 441.4400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.3822
    Cell Significance Index: 150.3400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.2931
    Cell Significance Index: 81.5000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.2199
    Cell Significance Index: 219.9200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.1427
    Cell Significance Index: 15.5900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0885
    Cell Significance Index: 56.5500
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.0310
    Cell Significance Index: 23.8200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.0184
    Cell Significance Index: 365.2800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9568
    Cell Significance Index: 191.9400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8924
    Cell Significance Index: 109.7300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.8109
    Cell Significance Index: 7.4700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7946
    Cell Significance Index: 109.1200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.7844
    Cell Significance Index: 9.3500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.7647
    Cell Significance Index: 35.6600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.7426
    Cell Significance Index: 38.9900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6679
    Cell Significance Index: 46.1900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6583
    Cell Significance Index: 359.5200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.6566
    Cell Significance Index: 84.1800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.4459
    Cell Significance Index: 33.2300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4240
    Cell Significance Index: 32.5400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3769
    Cell Significance Index: 260.7100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3364
    Cell Significance Index: 66.7600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3253
    Cell Significance Index: 143.8100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1130
    Cell Significance Index: 212.7000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0928
    Cell Significance Index: 15.8400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0833
    Cell Significance Index: 8.2400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0730
    Cell Significance Index: 33.1100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0690
    Cell Significance Index: 43.8100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0192
    Cell Significance Index: 35.3500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0177
    Cell Significance Index: 27.2800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0037
    Cell Significance Index: 2.7300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0019
    Cell Significance Index: 1.4500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0006
    Cell Significance Index: -0.0300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0115
    Cell Significance Index: -0.8100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0209
    Cell Significance Index: -0.5500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0216
    Cell Significance Index: -29.3500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0223
    Cell Significance Index: -16.5000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0293
    Cell Significance Index: -18.3000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0465
    Cell Significance Index: -26.2500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0645
    Cell Significance Index: -1.0800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0665
    Cell Significance Index: -6.7900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0705
    Cell Significance Index: -9.1100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0984
    Cell Significance Index: -4.4600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1040
    Cell Significance Index: -4.6000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1070
    Cell Significance Index: -22.5300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1164
    Cell Significance Index: -13.7300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1203
    Cell Significance Index: -17.4800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1394
    Cell Significance Index: -9.0000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1451
    Cell Significance Index: -5.1000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1645
    Cell Significance Index: -47.3200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1796
    Cell Significance Index: -10.0800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1946
    Cell Significance Index: -22.2900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1981
    Cell Significance Index: -4.2200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2086
    Cell Significance Index: -5.9800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2100
    Cell Significance Index: -24.4700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2110
    Cell Significance Index: -14.1900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2197
    Cell Significance Index: -7.6400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2230
    Cell Significance Index: -8.4500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2430
    Cell Significance Index: -6.7900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2442
    Cell Significance Index: -6.5200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2900
    Cell Significance Index: -5.6600
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.2935
    Cell Significance Index: -3.6400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3128
    Cell Significance Index: -35.7100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3324
    Cell Significance Index: -34.6100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3478
    Cell Significance Index: -21.3800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3558
    Cell Significance Index: -10.4500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3915
    Cell Significance Index: -6.7100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4131
    Cell Significance Index: -13.2300
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.4433
    Cell Significance Index: -2.8900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4996
    Cell Significance Index: -39.5700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5231
    Cell Significance Index: -13.0800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.5709
    Cell Significance Index: -11.9500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.6065
    Cell Significance Index: -13.1400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6314
    Cell Significance Index: -38.7100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.6355
    Cell Significance Index: -13.5900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.6550
    Cell Significance Index: -9.6700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.6617
    Cell Significance Index: -33.4400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.7652
    Cell Significance Index: -6.2400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.7702
    Cell Significance Index: -21.9800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.8260
    Cell Significance Index: -24.3300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.8547
    Cell Significance Index: -18.1400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.9675
    Cell Significance Index: -30.8200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.9723
    Cell Significance Index: -24.8400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.9842
    Cell Significance Index: -19.7600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.9918
    Cell Significance Index: -32.4700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -1.0013
    Cell Significance Index: -16.5000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.0093
    Cell Significance Index: -37.0500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.0510
    Cell Significance Index: -36.8200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TMEM50B is a transmembrane protein, consisting of four transmembrane domains and a cytoplasmic tail. Its expression is significantly elevated in various cell types, including cardiac muscle cells, kidney collecting duct principal cells, extravillous trophoblasts, oogonial cells, cardiac neurons, kidney collecting duct intercalated cells, ciliary muscle cells, choroid plexus epithelial cells, cerebral cortex endothelial cells, and bladder urothelial cells. This widespread expression suggests that TMEM50B plays a crucial role in maintaining cellular homeostasis and regulating various physiological processes. **Pathways and Functions:** TMEM50B is involved in multiple cellular pathways, including: 1. **Endoplasmic Reticulum (ER) and Golgi Membrane Trafficking**: TMEM50B is implicated in the regulation of ER and Golgi membrane trafficking, which is essential for protein folding, sorting, and transport. 2. **Late Endosome to Vacuole Transport via Multivesicular Body Sorting Pathway**: TMEM50B is also involved in the regulation of late endosome to vacuole transport, which is crucial for the degradation and recycling of cellular waste. 3. **Protein Binding**: TMEM50B interacts with various proteins, including receptors, transporters, and signaling molecules, which suggests its involvement in protein-protein interactions and signaling cascades. **Clinical Significance:** TMEM50B has been implicated in various diseases and disorders, including: 1. **Cardiovascular Disease**: Elevated TMEM50B expression has been observed in cardiac muscle cells, suggesting its potential role in the development of cardiovascular disease. 2. **Kidney Disease**: TMEM50B expression is significantly elevated in kidney collecting duct principal cells, which may contribute to the pathogenesis of kidney disease. 3. **Neurological Disorders**: TMEM50B has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease, where it may play a role in protein misfolding and aggregation. In conclusion, TMEM50B is a transmembrane protein with broad implications in human health. Its unique characteristics and functions suggest its involvement in various cellular pathways, including ER and Golgi membrane trafficking, late endosome to vacuole transport, and protein binding. Further research is necessary to elucidate the exact mechanisms by which TMEM50B contributes to disease development and progression. As an expert immunologist, I am excited to explore the potential therapeutic applications of TMEM50B in the treatment of various diseases and disorders.

Genular Protein ID: 3521827145

Symbol: TM50B_HUMAN

Name: Transmembrane protein 50B

UniProtKB Accession Codes:

P56557 B2R4L4 D3DSF1 O60537 Q5PY47

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 4 ExpressionAtlas 1 GO 5 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10077530

Title: Comparative genomic analysis of the interferon/interleukin-10 receptor gene cluster.

PubMed ID: 10077530

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

Sequence Information:

  • Length: 158
  • Mass: 17936
  • Checksum: 515ABB6AAA817DEB
  • Sequence:
    • MAGFLDNFRW PECECIDWSE RRNAVASVVA GILFFTGWWI MIDAAVVYPK PEQLNHAFHT 
CGVFSTLAFF MINAVSNAQV RGDSYESGCL GRTGARVWLF IGFMLMFGSL IASMWILFGA 
YVTQNTDVYP GLAVFFQNAL IFFSTLIYKF GRTEELWT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.