Details for: TMEM50B

Gene ID: 757

Symbol: TMEM50B

Ensembl ID: ENSG00000142188

Description: transmembrane protein 50B

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 2.65
    Marker Score: 35219
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.46
    Marker Score: 6210
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 2.14
    Marker Score: 1910
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.88
    Marker Score: 2709
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.87
    Marker Score: 2334
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.81
    Marker Score: 2996
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.78
    Marker Score: 3913
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.75
    Marker Score: 1610
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.75
    Marker Score: 1044
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.62
    Marker Score: 2383
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.61
    Marker Score: 1264
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.58
    Marker Score: 4238
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.57
    Marker Score: 6497
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.56
    Marker Score: 2201
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.55
    Marker Score: 57291
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.55
    Marker Score: 903
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.53
    Marker Score: 22916
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.52
    Marker Score: 2207
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.51
    Marker Score: 1739
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.5
    Marker Score: 5788
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.46
    Marker Score: 55446
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.46
    Marker Score: 12647
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.41
    Marker Score: 1428
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 1.39
    Marker Score: 845
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.38
    Marker Score: 1172
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.37
    Marker Score: 402
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.37
    Marker Score: 2776
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.34
    Marker Score: 398
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.33
    Marker Score: 10197
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.32
    Marker Score: 1658.5
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.31
    Marker Score: 1389
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.31
    Marker Score: 26013
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.31
    Marker Score: 492
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.3
    Marker Score: 11193
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.3
    Marker Score: 1804
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.29
    Marker Score: 5393
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.28
    Marker Score: 12176
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.28
    Marker Score: 2095.5
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.28
    Marker Score: 1344
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.28
    Marker Score: 743
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.28
    Marker Score: 2894
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.27
    Marker Score: 842.5
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 1.27
    Marker Score: 707
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.26
    Marker Score: 368
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.26
    Marker Score: 610
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.24
    Marker Score: 1911
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.24
    Marker Score: 26405
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.23
    Marker Score: 973
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.23
    Marker Score: 585
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.22
    Marker Score: 2315
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.21
    Marker Score: 5237
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 1.21
    Marker Score: 552
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.2
    Marker Score: 659
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.18
    Marker Score: 3001
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.18
    Marker Score: 11084
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.18
    Marker Score: 2874
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.17
    Marker Score: 339
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.16
    Marker Score: 71475
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.16
    Marker Score: 433
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 1.16
    Marker Score: 777
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.16
    Marker Score: 10000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.15
    Marker Score: 3273
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.14
    Marker Score: 39326
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.13
    Marker Score: 4191
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.13
    Marker Score: 1814
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.13
    Marker Score: 7353
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.13
    Marker Score: 1169
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 1.12
    Marker Score: 389
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.12
    Marker Score: 267
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.12
    Marker Score: 952
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.11
    Marker Score: 352
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.11
    Marker Score: 4261
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.1
    Marker Score: 2592
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.1
    Marker Score: 353.5
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.09
    Marker Score: 8123
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.09
    Marker Score: 817
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.09
    Marker Score: 839
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.09
    Marker Score: 935
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.08
    Marker Score: 343
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.08
    Marker Score: 253
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.08
    Marker Score: 1027
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.07
    Marker Score: 36557
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.07
    Marker Score: 3803
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.07
    Marker Score: 446
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.06
    Marker Score: 5591
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.06
    Marker Score: 5075
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.06
    Marker Score: 261
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.06
    Marker Score: 1135
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.06
    Marker Score: 6731
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.05
    Marker Score: 426
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.05
    Marker Score: 741
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.05
    Marker Score: 698
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.04
    Marker Score: 364
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.04
    Marker Score: 424
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.04
    Marker Score: 1256
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.04
    Marker Score: 1380
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 1.04
    Marker Score: 273
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.04
    Marker Score: 978
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.03
    Marker Score: 1085
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.02
    Marker Score: 695

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

## Summary TMEM50B is a transmembrane protein that plays a crucial role in the cardiovascular system, particularly in the heart and blood vessels. It is involved in the regulation of cardiac contractility, blood pressure, and vascular tone. ## Key characteristics * TMEM50B is a type I transmembrane protein, which are characterized by the presence of a cytoplasmic domain and a transmembrane domain. * It is highly expressed in cardiac muscle cells, kidney cells, and endothelial cells. * It is also expressed in extravillous trophoblasts, oogonial cells, and ciliary muscle cells. ## Pathways and functions * TMEM50B is involved in the regulation of cardiac contractility through its interaction with the sarcoplasmic reticulum (SR). * It acts as a calcium release channel, modulating the release of calcium ions from the SR into the cytosol. * In the resting state, TMEM50B is predominantly located in the SR, where it prevents the release of calcium ions. * Upon stimulation, TMEM50B undergoes a conformational change that exposes the calcium release channel, leading to the release of calcium ions and subsequent cardiac contraction. * TMEM50B also plays a role in blood pressure regulation. It is expressed in blood vessels and is involved in the regulation of vascular tone. * It interacts with the angiotensin II receptor type 1 (AAAR1), which is a key regulator of blood pressure. * TMEM50B modulates the activity of the angiotensin II receptor, thereby affecting blood pressure. ## Clinical significance Mutations in TMEM50B have been linked to various cardiovascular diseases, including cardiomyopathy, hypertension, and heart failure. * Mutations in TMEM50B can disrupt the calcium signaling pathway, leading to abnormal cardiac contractility and hypertension. * Targeting TMEM50B has emerged as a potential therapeutic strategy for these cardiovascular diseases.

Genular Protein ID: 3521827145

Symbol: TM50B_HUMAN

Name: Transmembrane protein 50B

UniProtKB Accession Codes:

P56557 B2R4L4 D3DSF1 O60537 Q5PY47

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 4 ExpressionAtlas 1 GO 5 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10077530

Title: Comparative genomic analysis of the interferon/interleukin-10 receptor gene cluster.

PubMed ID: 10077530

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

Sequence Information:

  • Length: 158
  • Mass: 17936
  • Checksum: 515ABB6AAA817DEB
  • Sequence:
    • MAGFLDNFRW PECECIDWSE RRNAVASVVA GILFFTGWWI MIDAAVVYPK PEQLNHAFHT 
CGVFSTLAFF MINAVSNAQV RGDSYESGCL GRTGARVWLF IGFMLMFGSL IASMWILFGA 
YVTQNTDVYP GLAVFFQNAL IFFSTLIYKF GRTEELWT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.