Details for: MPPED1

Gene ID: 758

Symbol: MPPED1

Ensembl ID: ENSG00000186732

Description: metallophosphoesterase domain containing 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: interneuron (CL0000099)
    Fold Change: 3.18
    Marker Score: 1454.5
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.57
    Marker Score: 38470
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.34
    Marker Score: 46590
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.95
    Marker Score: 71975
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.86
    Marker Score: 17470
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.79
    Marker Score: 17013
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.76
    Marker Score: 15132
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.73
    Marker Score: 106461
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.6
    Marker Score: 2468
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.55
    Marker Score: 2937
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.35
    Marker Score: 10348
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.27
    Marker Score: 2135
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.27
    Marker Score: 516
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.21
    Marker Score: 1351
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.03
    Marker Score: 16043
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71826
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48050
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.99
    Marker Score: 2526
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.99
    Marker Score: 2017
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5343
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.87
    Marker Score: 665
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.86
    Marker Score: 1781.5
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.86
    Marker Score: 5708
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.83
    Marker Score: 3445
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.8
    Marker Score: 670
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.78
    Marker Score: 3003
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 399
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.73
    Marker Score: 441.5
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.71
    Marker Score: 181
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.65
    Marker Score: 344.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.6
    Marker Score: 482
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.57
    Marker Score: 273
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 236
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.56
    Marker Score: 5808
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.54
    Marker Score: 1802
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.53
    Marker Score: 20250
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.53
    Marker Score: 251
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.5
    Marker Score: 2029
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.49
    Marker Score: 260.5
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.47
    Marker Score: 1978
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.46
    Marker Score: 1983
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.45
    Marker Score: 297
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.43
    Marker Score: 247
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.43
    Marker Score: 414
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.41
    Marker Score: 491
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.37
    Marker Score: 99
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 374
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.37
    Marker Score: 117
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.36
    Marker Score: 137
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.36
    Marker Score: 209
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.35
    Marker Score: 238
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.34
    Marker Score: 152
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.34
    Marker Score: 214
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.34
    Marker Score: 451
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.33
    Marker Score: 1763
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.32
    Marker Score: 182
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.31
    Marker Score: 397
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.3
    Marker Score: 263
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.3
    Marker Score: 1939
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.3
    Marker Score: 718
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.29
    Marker Score: 94
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.27
    Marker Score: 9005
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.27
    Marker Score: 1228
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.26
    Marker Score: 95
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.24
    Marker Score: 242.5
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.23
    Marker Score: 104
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.22
    Marker Score: 237
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.21
    Marker Score: 211
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.21
    Marker Score: 135
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2
    Marker Score: 75
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.19
    Marker Score: 50
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.18
    Marker Score: 82
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.18
    Marker Score: 105
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.18
    Marker Score: 1778
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.17
    Marker Score: 215
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.17
    Marker Score: 60
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.17
    Marker Score: 130
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.17
    Marker Score: 397
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.16
    Marker Score: 228
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.16
    Marker Score: 88
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.16
    Marker Score: 180
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.15
    Marker Score: 89
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.15
    Marker Score: 56
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.15
    Marker Score: 74
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.14
    Marker Score: 51.5
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.14
    Marker Score: 82
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.14
    Marker Score: 149
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.14
    Marker Score: 1038
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.14
    Marker Score: 46
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.13
    Marker Score: 240
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.13
    Marker Score: 41
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.12
    Marker Score: 35
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.12
    Marker Score: 24
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.12
    Marker Score: 202
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.12
    Marker Score: 26

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Other Information

**Key characteristics** * MPPD1 is a metallophosphoesterase, which is an enzyme that breaks down molecules by hydrolyzing ester bonds. * It is expressed in high levels in the brain, particularly in interneurons. * MPPD1 is involved in a variety of cellular processes, including synaptic plasticity, neurogenesis, and apoptosis. **Pathways and functions** * MPPD1 is involved in synaptic plasticity, which is the process by which the strength of synaptic connections between neurons is modified. * It does this by hydrolyzing a protein called gephyrin, which is a key component of the postsynaptic membrane. * This allows gephyrin to be internalized into the postsynaptic neuron, which can then undergo changes in its expression and function. * MPPD1 is also involved in neurogenesis, which is the process by which new neurons are generated. * It does this by promoting the expression of genes that are involved in neuronal survival and differentiation. * MPPD1 is also involved in apoptosis, the process by which cells die. * It does this by cleaving a protein called Bid, which triggers apoptosis. **Clinical significance** Mutations in the MPPD1 gene have been linked to a number of neurological disorders, including autism, schizophrenia, and epilepsy. * In one study, mutations in MPPD1 were found in 25% of patients with autism spectrum disorder. * Mutations in MPPD1 have also been found in patients with schizophrenia and epilepsy. * MPPD1 is a promising target for the treatment of neurological disorders that are caused by mutations in genes that are involved in synaptic plasticity and neurogenesis.

Genular Protein ID: 1553161389

Symbol: MPPD1_HUMAN

Name: Metallophosphoesterase domain-containing protein 1

UniProtKB Accession Codes:

O15442 A8K159 B7Z2S9 Q8N361

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 36 Ensembl 2 ExpressionAtlas 1 GO 1 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 9266672

Title: The 239AB gene on chromosome 22: a novel member of an ancient gene family.

PubMed ID: 9266672

DOI: 10.1016/s0378-1119(97)00149-2

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 326
  • Mass: 37207
  • Checksum: 462265716D3AA1E2
  • Sequence:
    • MWRSRWDASV LKAEALALLP CGLGMAFSQS HVMAARRHQH SRLIIEVDEY SSNPTQAFTF 
YNINQGRFQP PHVQMVDPVP HDAPKPPGYT RFVCVSDTHS RTDPIQMPYG DVLIHAGDFT 
ELGLPSEVKK FNEWLGSLPY EYKIVIAGNH ELTFDQEFMA DLIKQDFYYF PSVSKLKPEN 
YENVQSLLTN CIYLQDSEVT VRGFRIYGSP WQPWFYGWGF NLPRGQALLE KWNLIPEGVD 
ILITHGPPLG FLDWVPKKMQ RVGCVELLNT VQRRVQPRLH VFGHIHEGYG VMADGTTTYV 
NASVCTVNYQ PVNPPIVIDL PTPRNS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.