Details for: MPPED1

Gene ID: 758

Symbol: MPPED1

Ensembl ID: ENSG00000186732

Description: metallophosphoesterase domain containing 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 99.1944
    Cell Significance Index: -25.1600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 2.8620
    Cell Significance Index: 175.9100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.9491
    Cell Significance Index: 390.9800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.4877
    Cell Significance Index: 35.6800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.9255
    Cell Significance Index: 26.4100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.6430
    Cell Significance Index: 36.0800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5194
    Cell Significance Index: 186.3000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4222
    Cell Significance Index: 292.0400
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.4210
    Cell Significance Index: 5.4600
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.1612
    Cell Significance Index: 2.1500
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: 0.1477
    Cell Significance Index: 1.6300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.0647
    Cell Significance Index: 1.2800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0138
    Cell Significance Index: 6.1000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0118
    Cell Significance Index: 18.2100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.0107
    Cell Significance Index: 0.3500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0084
    Cell Significance Index: 15.4500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.0066
    Cell Significance Index: 0.1400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0040
    Cell Significance Index: 0.8000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0112
    Cell Significance Index: -21.1300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0142
    Cell Significance Index: -19.2700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0241
    Cell Significance Index: -0.3500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0262
    Cell Significance Index: -0.8400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0285
    Cell Significance Index: -21.1300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0291
    Cell Significance Index: -21.3300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0319
    Cell Significance Index: -20.2500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0374
    Cell Significance Index: -21.1000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0469
    Cell Significance Index: -21.3000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0679
    Cell Significance Index: -19.5400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0710
    Cell Significance Index: -1.7200
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0720
    Cell Significance Index: -0.8400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0940
    Cell Significance Index: -16.9500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1037
    Cell Significance Index: -1.1300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1089
    Cell Significance Index: -22.9400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1176
    Cell Significance Index: -2.5400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1319
    Cell Significance Index: -22.5200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1335
    Cell Significance Index: -19.4000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1359
    Cell Significance Index: -17.4200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1408
    Cell Significance Index: -17.3100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1551
    Cell Significance Index: -1.4700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1684
    Cell Significance Index: -23.1300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1688
    Cell Significance Index: -4.2100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1806
    Cell Significance Index: -21.0500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1835
    Cell Significance Index: -5.1300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2005
    Cell Significance Index: -22.9700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2539
    Cell Significance Index: -26.4400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2814
    Cell Significance Index: -18.9200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3040
    Cell Significance Index: -23.3300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3163
    Cell Significance Index: -11.0800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3629
    Cell Significance Index: -23.4100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3696
    Cell Significance Index: -22.6600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3831
    Cell Significance Index: -17.8600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4112
    Cell Significance Index: -19.3300
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.4374
    Cell Significance Index: -5.5200
  • Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
    Fold Change: -0.4435
    Cell Significance Index: -4.5600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4832
    Cell Significance Index: -25.3700
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.4840
    Cell Significance Index: -4.6100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5049
    Cell Significance Index: -19.1200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5152
    Cell Significance Index: -22.7900
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.5159
    Cell Significance Index: -6.1700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.5495
    Cell Significance Index: -8.1100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.5570
    Cell Significance Index: -11.9100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.5668
    Cell Significance Index: -11.3800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.5680
    Cell Significance Index: -11.8600
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: -0.5854
    Cell Significance Index: -4.4900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5899
    Cell Significance Index: -20.5000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.5980
    Cell Significance Index: -11.7700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.6375
    Cell Significance Index: -13.9600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.6545
    Cell Significance Index: -11.0300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6621
    Cell Significance Index: -17.0200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6973
    Cell Significance Index: -19.9900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.7139
    Cell Significance Index: -9.7400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.7259
    Cell Significance Index: -22.9600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7466
    Cell Significance Index: -21.9900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.7618
    Cell Significance Index: -5.1600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.7647
    Cell Significance Index: -19.0700
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.7696
    Cell Significance Index: -5.6000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.7767
    Cell Significance Index: -20.7400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.7795
    Cell Significance Index: -19.4700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.7837
    Cell Significance Index: -16.4100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.7922
    Cell Significance Index: -29.0800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.8083
    Cell Significance Index: -20.6500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.8165
    Cell Significance Index: -21.4700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.8176
    Cell Significance Index: -20.8300
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.8250
    Cell Significance Index: -1.8600
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.8252
    Cell Significance Index: -11.0000
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron (CL4030065)
    Fold Change: -0.8259
    Cell Significance Index: -8.6300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.8330
    Cell Significance Index: -22.3200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.8363
    Cell Significance Index: -22.3700
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.8525
    Cell Significance Index: -17.0000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.8961
    Cell Significance Index: -10.1800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.9051
    Cell Significance Index: -24.6400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.9073
    Cell Significance Index: -13.7800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.9172
    Cell Significance Index: -32.2300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.9243
    Cell Significance Index: -18.0400
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.9276
    Cell Significance Index: -13.5200
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.9284
    Cell Significance Index: -18.8900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -1.0457
    Cell Significance Index: -18.0800
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -1.0540
    Cell Significance Index: -9.5300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -1.0968
    Cell Significance Index: -17.4000
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -1.1017
    Cell Significance Index: -21.5400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MPPED1 exhibits the following key characteristics: 1. **Hydrolase activity**: MPPED1 possesses a metallophosphoesterase domain, which enables it to hydrolyze phosphoester bonds, leading to the degradation of various signaling molecules. 2. **Expression in specific cell types**: MPPED1 is significantly expressed in interneurons, near-projecting glutamatergic cortical neurons, and cardiac endothelial cells, highlighting its involvement in neuronal function and cardiovascular regulation. 3. **Regulation of neurotransmitter homeostasis**: MPPED1 plays a crucial role in maintaining the balance of neurotransmitters, such as GABA and glutamate, which are essential for neuronal excitability and synaptic transmission. **Pathways and Functions:** MPPED1 is involved in several key pathways and functions, including: 1. **GABAergic signaling**: MPPED1 regulates GABA levels by degrading GABA phosphoester bonds, thereby modulating inhibitory neurotransmission in the CNS. 2. **Glutamatergic signaling**: MPPED1 also regulates glutamate levels by degrading glutamate phosphoester bonds, influencing excitatory neurotransmission in the CNS. 3. **Ion homeostasis**: MPPED1 contributes to maintaining the balance of ions, such as calcium and potassium, which are essential for neuronal excitability and synaptic transmission. 4. **Neurotransmitter recycling**: MPPED1 participates in the recycling of neurotransmitters, allowing for the replenishment of signaling molecules and maintaining neurotransmitter homeostasis. **Clinical Significance:** Dysregulation of MPPED1 has been implicated in various neurological and psychiatric disorders, including: 1. **Epilepsy**: Altered MPPED1 expression and activity have been linked to the development of epilepsy, highlighting the gene's role in regulating seizure activity. 2. **Schizophrenia**: MPPED1 has been implicated in the pathophysiology of schizophrenia, with altered expression and activity contributing to the disorder's characteristic cognitive and behavioral deficits. 3. **Cardiovascular disease**: MPPED1's role in regulating ion homeostasis and neurotransmitter balance makes it a potential target for the treatment of cardiovascular diseases, such as hypertension and cardiac arrhythmias. In conclusion, MPPED1 is a critical regulator of neurotransmitter and ion homeostasis in the CNS, and its dysregulation has been implicated in various neurological and psychiatric disorders. Further research is necessary to fully elucidate the gene's role in human health and disease, and to explore its potential as a therapeutic target.

Genular Protein ID: 1553161389

Symbol: MPPD1_HUMAN

Name: Metallophosphoesterase domain-containing protein 1

UniProtKB Accession Codes:

O15442 A8K159 B7Z2S9 Q8N361

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 36 Ensembl 2 ExpressionAtlas 1 GO 1 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 9266672

Title: The 239AB gene on chromosome 22: a novel member of an ancient gene family.

PubMed ID: 9266672

DOI: 10.1016/s0378-1119(97)00149-2

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 326
  • Mass: 37207
  • Checksum: 462265716D3AA1E2
  • Sequence:
    • MWRSRWDASV LKAEALALLP CGLGMAFSQS HVMAARRHQH SRLIIEVDEY SSNPTQAFTF 
YNINQGRFQP PHVQMVDPVP HDAPKPPGYT RFVCVSDTHS RTDPIQMPYG DVLIHAGDFT 
ELGLPSEVKK FNEWLGSLPY EYKIVIAGNH ELTFDQEFMA DLIKQDFYYF PSVSKLKPEN 
YENVQSLLTN CIYLQDSEVT VRGFRIYGSP WQPWFYGWGF NLPRGQALLE KWNLIPEGVD 
ILITHGPPLG FLDWVPKKMQ RVGCVELLNT VQRRVQPRLH VFGHIHEGYG VMADGTTTYV 
NASVCTVNYQ PVNPPIVIDL PTPRNS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.