Details for: CA2
Associated with
Other Information
Genular Protein ID: 724538490
Symbol: CAH2_HUMAN
Name: Carbonic anhydrase 2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3108857
Title: Nucleotide sequence of human liver carbonic anhydrase II cDNA.
PubMed ID: 3108857
PubMed ID: 3121496
Title: Cloning, expression, and sequence homologies of cDNA for human carbonic anhydrase II.
PubMed ID: 3121496
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 4207120
Title: Human carbonic anhydrases. XII. The complete primary structure of the C isozyme.
PubMed ID: 4207120
PubMed ID: 823150
Title: Primary structure of human carbonic anhydrase C.
PubMed ID: 823150
PubMed ID: 3000449
Title: Comparison of the 5' regions of human and mouse carbonic anhydrase II genes and identification of possible regulatory elements.
PubMed ID: 3000449
PubMed ID: 14567693
Title: Direct extracellular interaction between carbonic anhydrase IV and the human NBC1 sodium/bicarbonate co-transporter.
PubMed ID: 14567693
DOI: 10.1021/bi0353124
PubMed ID: 14736710
Title: Regulation of the human NBC3 Na+/HCO3- cotransporter by carbonic anhydrase II and PKA.
PubMed ID: 14736710
PubMed ID: 15218065
Title: Molecular mechanism of kNBC1-carbonic anhydrase II interaction in proximal tubule cells.
PubMed ID: 15218065
PubMed ID: 15990874
Title: Metabolon disruption: a mechanism that regulates bicarbonate transport.
PubMed ID: 15990874
PubMed ID: 17314045
Title: Phosph(on)ate as a zinc-binding group in metalloenzyme inhibitors: X-ray crystal structure of the antiviral drug foscarnet complexed to human carbonic anhydrase I.
PubMed ID: 17314045
PubMed ID: 18618712
Title: Crystal structure of human carbonic anhydrase XIII and its complex with the inhibitor acetazolamide.
PubMed ID: 18618712
DOI: 10.1002/prot.22144
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 4621826
Title: Crystal structure of human carbonic anhydrase C.
PubMed ID: 4621826
PubMed ID: 3151019
Title: Refined structure of human carbonic anhydrase II at 2.0-A resolution.
PubMed ID: 3151019
PubMed ID: 3151020
Title: Crystallographic studies of inhibitor binding sites in human carbonic anhydrase II: a pentacoordinated binding of the SCN-ion to the zinc at high pH.
PubMed ID: 3151020
PubMed ID: 1909891
Title: Conformational mobility of His-64 in the Thr-200TO: human carbonic anhydrase II.
PubMed ID: 1909891
DOI: 10.1021/bi00102a005
PubMed ID: 1932029
Title: Engineering the hydrophobic pocket of carbonic anhydrase II.
PubMed ID: 1932029
DOI: 10.1021/bi00110a008
PubMed ID: 1910042
Title: Altering the mouth of a hydrophobic pocket. Structure and kinetics of human carbonic anhydrase II mutants at residue Val-121.
PubMed ID: 1910042
PubMed ID: 1336460
Title: Crystallographic studies of the binding of protonated and unprotonated inhibitors to carbonic anhydrase using hydrogen sulphide and nitrate anions.
PubMed ID: 1336460
PubMed ID: 1433293
Title: Structure of native and apo carbonic anhydrase II and structure of some of its anion-ligand complexes.
PubMed ID: 1433293
PubMed ID: 1474587
Title: Structure of cobalt carbonic anhydrase complexed with bicarbonate.
PubMed ID: 1474587
PubMed ID: 8431430
Title: Engineering the zinc binding site of human carbonic anhydrase II: structure of the His-94-->Cys apoenzyme in a new crystalline form.
PubMed ID: 8431430
DOI: 10.1021/bi00057a015
PubMed ID: 8485129
Title: Structural consequences of hydrophilic amino acid substitutions in the hydrophobic pocket of human carbonic anhydrase II.
PubMed ID: 8485129
DOI: 10.1021/bi00068a005
PubMed ID: 8399159
Title: Structure of an engineered His3Cys zinc binding site in human carbonic anhydrase II.
PubMed ID: 8399159
DOI: 10.1021/bi00089a005
PubMed ID: 8218160
Title: Structure and energetics of a non-proline cis-peptidyl linkage in a proline-202-->alanine carbonic anhydrase II variant.
PubMed ID: 8218160
DOI: 10.1021/bi00092a003
PubMed ID: 8482389
Title: The structure of human carbonic anhydrase II in complex with bromide and azide.
PubMed ID: 8482389
PubMed ID: 8262987
Title: Structural and functional importance of a conserved hydrogen bond network in human carbonic anhydrase II.
PubMed ID: 8262987
PubMed ID: 8331673
Title: Crystal structure of the complex between human carbonic anhydrase II and the aromatic inhibitor 1,2,4-triazole.
PubMed ID: 8331673
PubMed ID: 8451242
Title: Crystallographic analysis of Thr-200-->His human carbonic anhydrase II and its complex with the substrate, HCO3-.
PubMed ID: 8451242
PubMed ID: 7901850
Title: Structural analysis of the zinc hydroxide-Thr-199-Glu-106 hydrogen-bond network in human carbonic anhydrase II.
PubMed ID: 7901850
PubMed ID: 15299481
Title: X-ray analysis of metal-substituted human carbonic anhydrase II derivatives.
PubMed ID: 15299481
PubMed ID: 15299482
Title: Wild-type and E106Q mutant carbonic anhydrase complexed with acetate.
PubMed ID: 15299482
PubMed ID: 7803386
Title: Structural consequences of redesigning a protein-zinc binding site.
PubMed ID: 7803386
DOI: 10.1021/bi00255a004
PubMed ID: 8070585
Title: The structure of a complex between carbonic anhydrase II and a new inhibitor, trifluoromethane sulphonamide.
PubMed ID: 8070585
PubMed ID: 8142888
Title: Positions of His-64 and a bound water in human carbonic anhydrase II upon binding three structurally related inhibitors.
PubMed ID: 8142888
PubMed ID: 7696263
Title: Structural basis of inhibitor affinity to variants of human carbonic anhydrase II.
PubMed ID: 7696263
DOI: 10.1021/bi00012a016
PubMed ID: 7608893
Title: Secondary interactions significantly removed from the sulfonamide binding pocket of carbonic anhydrase II influence inhibitor binding constants.
PubMed ID: 7608893
DOI: 10.1021/jm00013a004
PubMed ID: 7761440
Title: Structure-assisted redesign of a protein-zinc-binding site with femtomolar affinity.
PubMed ID: 7761440
PubMed ID: 8639494
Title: Reversal of the hydrogen bond to zinc ligand histidine-119 dramatically diminishes catalysis and enhances metal equilibration kinetics in carbonic anhydrase II.
PubMed ID: 8639494
DOI: 10.1021/bi9526692
PubMed ID: 8987974
Title: X-ray crystallographic studies of alanine-65 variants of carbonic anhydrase II reveal the structural basis of compromised proton transfer in catalysis.
PubMed ID: 8987974
DOI: 10.1021/bi9617872
PubMed ID: 8557623
Title: Unexpected binding mode of the sulfonamide fluorophore 5-dimethylamino-1-naphthalene sulfonamide to human carbonic anhydrase II. Implications for the development of a zinc biosensor.
PubMed ID: 8557623
PubMed ID: 9265618
Title: Carbonic anhydrase activators: X-ray crystallographic and spectroscopic investigations for the interaction of isozymes I and II with histamine.
PubMed ID: 9265618
DOI: 10.1021/bi970760v
PubMed ID: 9398308
Title: Histidine --> carboxamide ligand substitutions in the zinc binding site of carbonic anhydrase II alter metal coordination geometry but retain catalytic activity.
PubMed ID: 9398308
DOI: 10.1021/bi971296x
PubMed ID: 9541386
Title: Structures of murine carbonic anhydrase IV and human carbonic anhydrase II complexed with brinzolamide: molecular basis of isozyme-drug discrimination.
PubMed ID: 9541386
PubMed ID: 9865942
Title: Structural analysis of inhibitor binding to human carbonic anhydrase II.
PubMed ID: 9865942
PubMed ID: 10550681
Title: Carbonic anhydrase catalyzes cyanamide hydration to urea: is it mimicking the physiological reaction?
PubMed ID: 10550681
PubMed ID: 11015219
Title: Mechanism of cyanamide hydration catalyzed by carbonic anhydrase II suggested by cryogenic X-ray diffraction.
PubMed ID: 11015219
DOI: 10.1021/bi000937c
PubMed ID: 11076507
Title: Structural influence of hydrophobic core residues on metal binding and specificity in carbonic anhydrase II.
PubMed ID: 11076507
DOI: 10.1021/bi001649j
PubMed ID: 11327835
Title: Structural and kinetic analysis of the chemical rescue of the proton transfer function of carbonic anhydrase II.
PubMed ID: 11327835
DOI: 10.1021/bi002295z
PubMed ID: 11572683
Title: Fluoroaromatic-fluoroaromatic interactions between inhibitors bound in the crystal lattice of human carbonic anhydrase II.
PubMed ID: 11572683
DOI: 10.1021/ja011034p
PubMed ID: 11802772
Title: Crystal structure of human carbonic anhydrase II complexed with an anti-convulsant sugar sulphamate.
PubMed ID: 11802772
PubMed ID: 12056894
Title: Organization of an efficient carbonic anhydrase: implications for the mechanism based on structure-function studies of a T199P/C206S mutant.
PubMed ID: 12056894
DOI: 10.1021/bi020053o
PubMed ID: 12171926
Title: Kinetic analysis of multiple proton shuttles in the active site of human carbonic anhydrase.
PubMed ID: 12171926
PubMed ID: 11831900
Title: Structural aspects of isozyme selectivity in the binding of inhibitors to carbonic anhydrases II and IV.
PubMed ID: 11831900
DOI: 10.1021/jm010163d
PubMed ID: 12166932
Title: Successful virtual screening for novel inhibitors of human carbonic anhydrase: strategy and experimental confirmation.
PubMed ID: 12166932
DOI: 10.1021/jm011112j
PubMed ID: 11818565
Title: Combinatorial computational method gives new picomolar ligands for a known enzyme.
PubMed ID: 11818565
PubMed ID: 12499545
Title: The refined atomic structure of carbonic anhydrase II at 1.05 A resolution: implications of chemical rescue of proton transfer.
PubMed ID: 12499545
PubMed ID: 14736236
Title: Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: new pharmacological opportunities due to related binding site recognition.
PubMed ID: 14736236
DOI: 10.1021/jm030912m
PubMed ID: 15453828
Title: Crystal structure of human carbonic anhydrase II at 1.95 A resolution in complex with 667-coumate, a novel anti-cancer agent.
PubMed ID: 15453828
DOI: 10.1042/bj20041037
PubMed ID: 15667203
Title: Structural and kinetic characterization of active-site histidine as a proton shuttle in catalysis by human carbonic anhydrase II.
PubMed ID: 15667203
DOI: 10.1021/bi0480279
PubMed ID: 15865431
Title: First crystal structures of human carbonic anhydrase II in complex with dual aromatase-steroid sulfatase inhibitors.
PubMed ID: 15865431
DOI: 10.1021/bi047692e
PubMed ID: 16214338
Title: Carbonic anhydrase activators: X-ray crystal structure of the adduct of human isozyme II with L-histidine as a platform for the design of stronger activators.
PubMed ID: 16214338
PubMed ID: 16134940
Title: Carbonic anhydrase inhibitors: stacking with Phe131 determines active site binding region of inhibitors as exemplified by the X-ray crystal structure of a membrane-impermeant antitumor sulfonamide complexed with isozyme II.
PubMed ID: 16134940
DOI: 10.1021/jm050333c
PubMed ID: 16106378
Title: Proton transfer in a Thr200His mutant of human carbonic anhydrase II.
PubMed ID: 16106378
DOI: 10.1002/prot.20615
PubMed ID: 16511248
Title: Production and X-ray crystallographic analysis of fully deuterated human carbonic anhydrase II.
PubMed ID: 16511248
PubMed ID: 16820676
Title: X-ray crystallographic studies reveal that the incorporation of spacer groups in carbonic anhydrase inhibitors causes alternate binding modes.
PubMed ID: 16820676
PubMed ID: 16290146
Title: Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II 'selective' inhibitor celecoxib.
PubMed ID: 16290146
PubMed ID: 16759856
Title: N-hydroxyurea -- a versatile zinc binding function in the design of metalloenzyme inhibitors.
PubMed ID: 16759856
PubMed ID: 17000110
Title: Carbonic anhydrase inhibitors: X-ray crystallographic studies for the binding of 5-amino-1,3,4-thiadiazole-2-sulfonamide and 5-(4-amino-3-chloro-5-fluorophenylsulfonamido)-1,3,4-thiadiazole-2-sulfonamide to human isoform II.
PubMed ID: 17000110
PubMed ID: 16807956
Title: Carbonic anhydrase activators. Activation of isozymes I, II, IV, VA, VII, and XIV with l- and d-histidine and crystallographic analysis of their adducts with isoform II: engineering proton-transfer processes within the active site of an enzyme.
PubMed ID: 16807956
PubMed ID: 16506782
Title: Ultrahigh resolution crystal structures of human carbonic anhydrases I and II complexed with 'two-prong' inhibitors reveal the molecular basis of high affinity.
PubMed ID: 16506782
DOI: 10.1021/ja057257n
PubMed ID: 16787097
Title: Carbonic anhydrase inhibitors: X-ray and molecular modeling study for the interaction of a fluorescent antitumor sulfonamide with isozyme II and IX.
PubMed ID: 16787097
DOI: 10.1021/ja061574s
PubMed ID: 16686544
Title: Carbonic anhydrase activators. Activation of isoforms I, II, IV, VA, VII, and XIV with L- and D-phenylalanine and crystallographic analysis of their adducts with isozyme II: stereospecific recognition within the active site of an enzyme and its consequences for the drug design.
PubMed ID: 16686544
DOI: 10.1021/jm0603320
PubMed ID: 16942027
Title: Carbonic anhydrase inhibitors: Hypoxia-activatable sulfonamides incorporating disulfide bonds that target the tumor-associated isoform IX.
PubMed ID: 16942027
DOI: 10.1021/jm060531j
PubMed ID: 17125255
Title: Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue.
PubMed ID: 17125255
DOI: 10.1021/jm060807n
PubMed ID: 17181151
Title: 2-substituted estradiol bis-sulfamates, multitargeted antitumor agents: synthesis, in vitro SAR, protein crystallography, and in vivo activity.
PubMed ID: 17181151
DOI: 10.1021/jm060705x
PubMed ID: 17705204
Title: Saccharin inhibits carbonic anhydrases: possible explanation for its unpleasant metallic aftertaste.
PubMed ID: 17705204
PubMed ID: 17319692
Title: Atomic crystal and molecular dynamics simulation structures of human carbonic anhydrase II: insights into the proton transfer mechanism.
PubMed ID: 17319692
DOI: 10.1021/bi062066y
PubMed ID: 17330962
Title: Speeding up proton transfer in a fast enzyme: kinetic and crystallographic studies on the effect of hydrophobic amino acid substitutions in the active site of human carbonic anhydrase II.
PubMed ID: 17330962
DOI: 10.1021/bi602620k
PubMed ID: 17127057
Title: Carbonic anhydrase activators: L-Adrenaline plugs the active site entrance of isozyme II, activating better isoforms I, IV, VA, VII, and XIV.
PubMed ID: 17127057
PubMed ID: 17251017
Title: Carbonic anhydrase inhibitors: binding of an antiglaucoma glycosyl-sulfanilamide derivative to human isoform II and its consequences for the drug design of enzyme inhibitors incorporating sugar moieties.
PubMed ID: 17251017
PubMed ID: 17346964
Title: Carbonic anhydrase inhibitors: the X-ray crystal structure of the adduct of N-hydroxysulfamide with isozyme II explains why this new zinc binding function is effective in the design of potent inhibitors.
PubMed ID: 17346964
PubMed ID: 17540563
Title: Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides -- solution and crystallographic studies.
PubMed ID: 17540563
PubMed ID: 17588751
Title: Carbonic anhydrase inhibitors. Interaction of the antiepileptic drug sulthiame with twelve mammalian isoforms: kinetic and X-ray crystallographic studies.
PubMed ID: 17588751
PubMed ID: 17071654
Title: Location of binding sites in small molecule rescue of human carbonic anhydrase II.
PubMed ID: 17071654
PubMed ID: 17407288
Title: Structural analysis of charge discrimination in the binding of inhibitors to human carbonic anhydrases I and II.
PubMed ID: 17407288
DOI: 10.1021/ja068359w
PubMed ID: 18266323
Title: Inhibition of carbonic anhydrase II by thioxolone: a mechanistic and structural study.
PubMed ID: 18266323
DOI: 10.1021/bi702385k
PubMed ID: 18942852
Title: Role of hydrophilic residues in proton transfer during catalysis by human carbonic anhydrase II.
PubMed ID: 18942852
DOI: 10.1021/bi801473w
PubMed ID: 18024029
Title: Carbonic anhydrase inhibitors. Interaction of 2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies.
PubMed ID: 18024029
PubMed ID: 18162396
Title: Carbonic anhydrase inhibitors. Interaction of 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies.
PubMed ID: 18162396
PubMed ID: 18374572
Title: Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.
PubMed ID: 18374572
PubMed ID: 18359629
Title: Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors.
PubMed ID: 18359629
PubMed ID: 18640037
Title: Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-ray crystallographic studies.
PubMed ID: 18640037
PubMed ID: 18161740
Title: Carbonic anhydrase inhibitors: binding of indanesulfonamides to the human isoform II.
PubMed ID: 18161740
PubMed ID: 18461940
Title: Structure of a (129)Xe-cryptophane biosensor complexed with human carbonic anhydrase II.
PubMed ID: 18461940
DOI: 10.1021/ja802214x
PubMed ID: 18768466
Title: Entrapment of carbon dioxide in the active site of carbonic anhydrase II.
PubMed ID: 18768466
PubMed ID: 18260615
Title: Structure-activity relationships of C-17 cyano-substituted estratrienes as anticancer agents.
PubMed ID: 18260615
DOI: 10.1021/jm701319c
Sequence Information:
- Length: 260
- Mass: 29246
- Checksum: 2EC2BB7548F10558
- Sequence:
MSHHWGYGKH NGPEHWHKDF PIAKGERQSP VDIDTHTAKY DPSLKPLSVS YDQATSLRIL NNGHAFNVEF DDSQDKAVLK GGPLDGTYRL IQFHFHWGSL DGQGSEHTVD KKKYAAELHL VHWNTKYGDF GKAVQQPDGL AVLGIFLKVG SAKPGLQKVV DVLDSIKTKG KSADFTNFDP RGLLPESLDY WTYPGSLTTP PLLECVTWIV LKEPISVSSE QVLKFRKLNF NGEGEPEELM VDNWRPAQPL KNRQIKASFK
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.