Details for: CA3

Gene ID: 761

Symbol: CA3

Ensembl ID: ENSG00000164879

Description: carbonic anhydrase 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 44.1171
    Cell Significance Index: -11.1900
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 8.6217
    Cell Significance Index: 53.3400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 7.7618
    Cell Significance Index: -9.5700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 5.6249
    Cell Significance Index: 137.2500
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 3.3009
    Cell Significance Index: 53.2600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.8586
    Cell Significance Index: -11.2800
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.4071
    Cell Significance Index: 14.6900
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.3695
    Cell Significance Index: 19.6300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 1.1921
    Cell Significance Index: 41.8900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.1145
    Cell Significance Index: 399.7500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8516
    Cell Significance Index: 169.0000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6796
    Cell Significance Index: 129.3300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.5895
    Cell Significance Index: 85.6900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3999
    Cell Significance Index: 39.5600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3845
    Cell Significance Index: 347.2200
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.3723
    Cell Significance Index: 5.0200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3497
    Cell Significance Index: 9.3700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3107
    Cell Significance Index: 23.8400
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.2358
    Cell Significance Index: 2.1400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2236
    Cell Significance Index: 5.5900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2046
    Cell Significance Index: 33.2700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1865
    Cell Significance Index: 24.0900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1745
    Cell Significance Index: 18.9800
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.1612
    Cell Significance Index: 2.0900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1610
    Cell Significance Index: 4.6400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1269
    Cell Significance Index: 2.7500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1038
    Cell Significance Index: 6.2300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0773
    Cell Significance Index: 4.3400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0670
    Cell Significance Index: 4.6300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0641
    Cell Significance Index: 12.8500
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.0615
    Cell Significance Index: 0.9200
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.0480
    Cell Significance Index: 0.7300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0464
    Cell Significance Index: 29.4700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0449
    Cell Significance Index: 84.4600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0401
    Cell Significance Index: 1.8900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0313
    Cell Significance Index: 1.4200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0149
    Cell Significance Index: 0.0900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0080
    Cell Significance Index: 14.8200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0073
    Cell Significance Index: 11.2000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0020
    Cell Significance Index: 2.7100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0037
    Cell Significance Index: -1.0700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0058
    Cell Significance Index: -0.0600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0064
    Cell Significance Index: -0.1800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0083
    Cell Significance Index: -0.5100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0109
    Cell Significance Index: -8.1000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0124
    Cell Significance Index: -9.3700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0131
    Cell Significance Index: -9.6100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0132
    Cell Significance Index: -2.3800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0138
    Cell Significance Index: -7.5100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0166
    Cell Significance Index: -7.3500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0170
    Cell Significance Index: -9.5900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0173
    Cell Significance Index: -7.8600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0173
    Cell Significance Index: -10.7900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0264
    Cell Significance Index: -0.3600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0286
    Cell Significance Index: -1.3400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0369
    Cell Significance Index: -4.3000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0375
    Cell Significance Index: -4.6100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0491
    Cell Significance Index: -10.3500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0509
    Cell Significance Index: -3.1200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0521
    Cell Significance Index: -8.9000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0555
    Cell Significance Index: -5.6700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0613
    Cell Significance Index: -7.8600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0622
    Cell Significance Index: -7.1300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0671
    Cell Significance Index: -1.4500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0710
    Cell Significance Index: -9.7500
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: -0.0839
    Cell Significance Index: -0.8400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0849
    Cell Significance Index: -2.0400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0879
    Cell Significance Index: -10.3700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0899
    Cell Significance Index: -1.5400
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0901
    Cell Significance Index: -1.1800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0941
    Cell Significance Index: -2.2800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0987
    Cell Significance Index: -10.2800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1080
    Cell Significance Index: -8.0500
  • Cell Name: secondary lymphoid organ macrophage (CL0000867)
    Fold Change: -0.1131
    Cell Significance Index: -0.8300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1220
    Cell Significance Index: -8.2000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1234
    Cell Significance Index: -8.7300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1256
    Cell Significance Index: -9.9500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1295
    Cell Significance Index: -3.3300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1352
    Cell Significance Index: -8.5200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1382
    Cell Significance Index: -3.0300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1446
    Cell Significance Index: -2.1400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1479
    Cell Significance Index: -6.5400
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.1520
    Cell Significance Index: -1.4500
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.1583
    Cell Significance Index: -1.2100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1596
    Cell Significance Index: -3.4000
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.1655
    Cell Significance Index: -2.3300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1703
    Cell Significance Index: -8.8700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1809
    Cell Significance Index: -3.5300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1843
    Cell Significance Index: -6.9800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1868
    Cell Significance Index: -5.3300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1871
    Cell Significance Index: -9.7200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1996
    Cell Significance Index: -10.0900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2002
    Cell Significance Index: -10.5100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2150
    Cell Significance Index: -3.2400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2173
    Cell Significance Index: -6.9600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2354
    Cell Significance Index: -3.9400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2460
    Cell Significance Index: -8.5500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2531
    Cell Significance Index: -8.0600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2553
    Cell Significance Index: -8.3600
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.2593
    Cell Significance Index: -2.8300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CA3 is a zinc-dependent enzyme, with a molecular weight of approximately 29 kDa. The enzyme's catalytic site is characterized by a unique arrangement of amino acids, which enables it to facilitate the reversible hydration of CO2. This process involves the binding of CO2 to the enzyme, followed by the conformational change that facilitates the release of bicarbonate (HCO3-) and the regeneration of the zinc ion. The enzyme's activity is significantly influenced by the presence of nickel ions, which are essential cofactors for its catalytic function. **Pathways and Functions:** CA3 is involved in several key biological pathways, including: 1. **Carbonate Dehydratase Activity:** CA3 catalyzes the reversible hydration of CO2, a process that is essential for maintaining the acid-base balance within cells. 2. **One-Carbon Metabolic Process:** CA3 participates in the one-carbon metabolic pathway, which is critical for the synthesis of nucleic acids, amino acids, and other biomolecules. 3. **Metabolism:** CA3 is involved in the regulation of metabolic processes, including glycolysis, gluconeogenesis, and fatty acid oxidation. 4. **Protein Binding:** CA3 interacts with various proteins, including those involved in cellular signaling, transcription, and translation. **Clinical Significance:** The dysregulation of CA3 expression has been implicated in various diseases, including: 1. **Respiratory Disorders:** Altered CA3 expression has been linked to respiratory diseases, such as chronic obstructive pulmonary disease (COPD) and asthma. 2. **Neurological Disorders:** CA3 dysfunction has been implicated in neurological disorders, including epilepsy, Alzheimer's disease, and Parkinson's disease. 3. **Cardiovascular Diseases:** Altered CA3 expression has been linked to cardiovascular diseases, including hypertension and atherosclerosis. 4. **Cancer:** CA3 has been identified as a potential biomarker for cancer diagnosis and prognosis, particularly in the context of lung and colon cancer. In conclusion, CA3 is a multifaceted enzyme that plays a critical role in maintaining the acid-base balance within cells, regulating metabolic processes, and interacting with various proteins. The dysregulation of CA3 expression has significant implications for various diseases, highlighting the need for further research into the molecular mechanisms underlying its function and the development of therapeutic strategies to modulate its activity.

Genular Protein ID: 3184628330

Symbol: CAH3_HUMAN

Name: N/A

UniProtKB Accession Codes:

P07451 B2R867 B3KUC8 O60842

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 15 DrugCentral 1 EC 2 EMBL 7 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 3086182

Title: Nucleotide sequence and derived amino acid sequence of a cDNA encoding human muscle carbonic anhydrase.

PubMed ID: 3086182

DOI: 10.1016/0378-1119(86)90103-4

PubMed ID: 3099285

Title: Nucleotide sequence, tissue-specific expression, and chromosome location of human carbonic anhydrase III: the human CAIII gene is located on the same chromosome as the closely linked CAI and CAII genes.

PubMed ID: 3099285

DOI: 10.1073/pnas.83.24.9571

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2824285

Title: Human muscle carbonic anhydrase: gene structure and DNA methylation patterns in fetal and adult tissues.

PubMed ID: 2824285

DOI: 10.1101/gad.1.6.594

PubMed ID: 9651514

Title: Sequence comparisons and functional studies of the proximal promoter of the carbonic anhydrase 3 (CA3) gene.

PubMed ID: 9651514

DOI: 10.1016/s0378-1119(98)00201-7

PubMed ID: 19186056

Title: A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases.

PubMed ID: 19186056

DOI: 10.1016/j.bmcl.2009.01.038

PubMed ID: 19206230

Title: Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors.

PubMed ID: 19206230

DOI: 10.1021/ja809683v

PubMed ID: 18618712

Title: Crystal structure of human carbonic anhydrase XIII and its complex with the inhibitor acetazolamide.

PubMed ID: 18618712

DOI: 10.1002/prot.22144

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 16042381

Title: Human carbonic anhydrase III: structural and kinetic study of catalysis and proton transfer.

PubMed ID: 16042381

DOI: 10.1021/bi050610h

PubMed ID: 17427958

Title: Structural and kinetic analysis of proton shuttle residues in the active site of human carbonic anhydrase III.

PubMed ID: 17427958

DOI: 10.1002/prot.21403

Sequence Information:

  • Length: 260
  • Mass: 29557
  • Checksum: A305334167233FCF
  • Sequence:
    • MAKEWGYASH NGPDHWHELF PNAKGENQSP VELHTKDIRH DPSLQPWSVS YDGGSAKTIL 
NNGKTCRVVF DDTYDRSMLR GGPLPGPYRL RQFHLHWGSS DDHGSEHTVD GVKYAAELHL 
VHWNPKYNTF KEALKQRDGI AVIGIFLKIG HENGEFQIFL DALDKIKTKG KEAPFTKFDP 
SCLFPACRDY WTYQGSFTTP PCEECIVWLL LKEPMTVSSD QMAKLRSLLS SAENEPPVPL 
VSNWRPPQPI NNRVVRASFK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.