Details for: CA3

Gene ID: 761

Symbol: CA3

Ensembl ID: ENSG00000164879

Description: carbonic anhydrase 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 4.04
    Marker Score: 3076
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 3.96
    Marker Score: 3173
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 3.59
    Marker Score: 30387
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.05
    Marker Score: 1194
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1165
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.51
    Marker Score: 1615
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 169060
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.44
    Marker Score: 5554
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 866
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.29
    Marker Score: 13334
  • Cell Name: interneuron (CL0000099)
    Fold Change: 1.19
    Marker Score: 542
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.16
    Marker Score: 71031
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.14
    Marker Score: 975
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.13
    Marker Score: 9724
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.11
    Marker Score: 1199
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.05
    Marker Score: 15681
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71815
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48040
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 506
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.96
    Marker Score: 9096
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.95
    Marker Score: 268
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 371
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5260
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2736
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.89
    Marker Score: 8378
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.89
    Marker Score: 1105
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.88
    Marker Score: 930
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.83
    Marker Score: 443
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.82
    Marker Score: 630
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.79
    Marker Score: 1284
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 699
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.76
    Marker Score: 3203
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.7
    Marker Score: 1639
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.67
    Marker Score: 202
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.66
    Marker Score: 2350
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.63
    Marker Score: 12589
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.62
    Marker Score: 410
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.6
    Marker Score: 4570
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.59
    Marker Score: 376.5
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.58
    Marker Score: 12297
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.58
    Marker Score: 9000
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.57
    Marker Score: 2359
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.57
    Marker Score: 163
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.56
    Marker Score: 1532
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 447
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.53
    Marker Score: 324
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.53
    Marker Score: 405
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.52
    Marker Score: 2163
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.52
    Marker Score: 151
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.5
    Marker Score: 184
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.49
    Marker Score: 276
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.49
    Marker Score: 426
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.48
    Marker Score: 7761
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.46
    Marker Score: 575
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.46
    Marker Score: 658
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.46
    Marker Score: 1204
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.46
    Marker Score: 1298
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.46
    Marker Score: 241
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.46
    Marker Score: 927
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.45
    Marker Score: 501
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.45
    Marker Score: 153
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.45
    Marker Score: 687
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.44
    Marker Score: 1565.5
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.44
    Marker Score: 181
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.43
    Marker Score: 142
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.43
    Marker Score: 2578
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.42
    Marker Score: 674
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.4
    Marker Score: 1645
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.38
    Marker Score: 8561
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.38
    Marker Score: 120
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.38
    Marker Score: 326
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.37
    Marker Score: 14114
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.37
    Marker Score: 119
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.36
    Marker Score: 387
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.35
    Marker Score: 92
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.34
    Marker Score: 12632
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.33
    Marker Score: 405
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.32
    Marker Score: 285
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.32
    Marker Score: 191
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.31
    Marker Score: 114
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.31
    Marker Score: 82
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.31
    Marker Score: 155
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.31
    Marker Score: 115.5
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.3
    Marker Score: 227
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.3
    Marker Score: 125
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.3
    Marker Score: 546
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.3
    Marker Score: 113
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.29
    Marker Score: 448
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.28
    Marker Score: 75
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.28
    Marker Score: 666
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.27
    Marker Score: 186
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.26
    Marker Score: 77
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.26
    Marker Score: 129

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Other Information

**Key characteristics:** * The CA3 gene is located on chromosome 17q21.1. * It is a large gene with a molecular weight of approximately 11,500 bp. * CA3 is expressed in a variety of cell types, including cell of skeletal muscle, pulmonary interstitial fibroblast, retinal bipolar neuron, corneal endothelial cell, colon goblet cell, skeletal muscle satellite stem cell, mural cell, caudal ganglionic eminence derived GABAergic cortical interneuron, granulocyte monocyte progenitor cell, and dopaminergic neuron. * CA3 protein is a transmembrane protein with a molecular weight of approximately 150 kDa. **Pathways and functions:** * CA3 is a key enzyme in the citric acid cycle, a metabolic pathway that breaks down glucose to produce energy. * It is also involved in the regulation of calcium levels in the body. * CA3 is a regulator of muscle contraction and relaxation. * It is also involved in the regulation of inflammation. **Clinical significance:** * Mutations in the CA3 gene have been linked to a number of human diseases, including diabetic ketoacidosis, lactic acidosis, and hypocalcemia. * These diseases are caused by abnormalities in the metabolism of carbon dioxide and bicarbonate. * CA3 is a potential target for treatment of these diseases.

Genular Protein ID: 3184628330

Symbol: CAH3_HUMAN

Name: N/A

UniProtKB Accession Codes:

P07451 B2R867 B3KUC8 O60842

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 15 DrugCentral 1 EC 2 EMBL 7 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 5 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCD-2DPAGE 1 UniProtKB 4 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 3086182

Title: Nucleotide sequence and derived amino acid sequence of a cDNA encoding human muscle carbonic anhydrase.

PubMed ID: 3086182

DOI: 10.1016/0378-1119(86)90103-4

PubMed ID: 3099285

Title: Nucleotide sequence, tissue-specific expression, and chromosome location of human carbonic anhydrase III: the human CAIII gene is located on the same chromosome as the closely linked CAI and CAII genes.

PubMed ID: 3099285

DOI: 10.1073/pnas.83.24.9571

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2824285

Title: Human muscle carbonic anhydrase: gene structure and DNA methylation patterns in fetal and adult tissues.

PubMed ID: 2824285

DOI: 10.1101/gad.1.6.594

PubMed ID: 9651514

Title: Sequence comparisons and functional studies of the proximal promoter of the carbonic anhydrase 3 (CA3) gene.

PubMed ID: 9651514

DOI: 10.1016/s0378-1119(98)00201-7

PubMed ID: 19186056

Title: A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases.

PubMed ID: 19186056

DOI: 10.1016/j.bmcl.2009.01.038

PubMed ID: 19206230

Title: Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors.

PubMed ID: 19206230

DOI: 10.1021/ja809683v

PubMed ID: 18618712

Title: Crystal structure of human carbonic anhydrase XIII and its complex with the inhibitor acetazolamide.

PubMed ID: 18618712

DOI: 10.1002/prot.22144

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 16042381

Title: Human carbonic anhydrase III: structural and kinetic study of catalysis and proton transfer.

PubMed ID: 16042381

DOI: 10.1021/bi050610h

PubMed ID: 17427958

Title: Structural and kinetic analysis of proton shuttle residues in the active site of human carbonic anhydrase III.

PubMed ID: 17427958

DOI: 10.1002/prot.21403

Sequence Information:

  • Length: 260
  • Mass: 29557
  • Checksum: A305334167233FCF
  • Sequence:
    • MAKEWGYASH NGPDHWHELF PNAKGENQSP VELHTKDIRH DPSLQPWSVS YDGGSAKTIL 
NNGKTCRVVF DDTYDRSMLR GGPLPGPYRL RQFHLHWGSS DDHGSEHTVD GVKYAAELHL 
VHWNPKYNTF KEALKQRDGI AVIGIFLKIG HENGEFQIFL DALDKIKTKG KEAPFTKFDP 
SCLFPACRDY WTYQGSFTTP PCEECIVWLL LKEPMTVSSD QMAKLRSLLS SAENEPPVPL 
VSNWRPPQPI NNRVVRASFK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.