CA4 | ENSG00000167434 | NCBI 762

Details for: CA4

Gene ID: 762

Symbol: CA4

Ensembl ID: ENSG00000167434

Description: carbonic anhydrase 4

Associated with

Erythrocytes take up carbon dioxide and release oxygen
(R-HSA-1237044)
Erythrocytes take up oxygen and release carbon dioxide
(R-HSA-1247673)
Metabolism
(R-HSA-1430728)
O2/co2 exchange in erythrocytes
(R-HSA-1480926)
Reversible hydration of carbon dioxide
(R-HSA-1475029)
Transport of small molecules
(R-HSA-382551)
Apical plasma membrane
(GO:0016324)
Basolateral plasma membrane
(GO:0016323)
Bicarbonate transport
(GO:0015701)
Brush border membrane
(GO:0031526)
Carbonate dehydratase activity
(GO:0004089)
Cell surface
(GO:0009986)
Endoplasmic reticulum-golgi intermediate compartment
(GO:0005793)
External side of plasma membrane
(GO:0009897)
Extracellular exosome
(GO:0070062)
Golgi apparatus
(GO:0005794)
Membrane
(GO:0016020)
One-carbon metabolic process
(GO:0006730)
Perinuclear region of cytoplasm
(GO:0048471)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Rough endoplasmic reticulum
(GO:0005791)
Secretory granule membrane
(GO:0030667)
Trans-golgi network
(GO:0005802)
Transport vesicle membrane
(GO:0030658)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Carbonic anhydrase 4

Genular Protein ID: 390011699

Symbol: CAH4_HUMAN

Name: Carbonic anhydrase 4

UniProtKB Accession Codes:

P22748 B4DQA4 Q6FHI7

Database IDs:

Citations:

PubMed ID: 1311094

Title: Human carbonic anhydrase IV: cDNA cloning, sequence comparison, and expression in COS cell membranes.

PubMed ID: 1311094

DOI: 10.1073/pnas.89.4.1315

PubMed ID: 8325641

Title: Genomic organization and localization of gene for human carbonic anhydrase IV to chromosome 17q.

PubMed ID: 8325641

DOI: 10.1006/geno.1993.1247

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2111324

Title: Carbonic anhydrase IV from human lung. Purification, characterization, and comparison with membrane carbonic anhydrase from human kidney.

PubMed ID: 2111324

DOI: 10.1016/s0021-9258(19)38958-6

PubMed ID: 8809084

Title: Carbonic anhydrase IV: purification of a secretory form of the recombinant human enzyme and identification of the positions and importance of its disulfide bonds.

PubMed ID: 8809084

DOI: 10.1006/abbi.1996.0412

PubMed ID: 7625839

Title: Carbonic anhydrase IV: role of removal of C-terminal domain in glycosylphosphatidylinositol anchoring and realization of enzyme activity.

PubMed ID: 7625839

DOI: 10.1016/0003-9861(95)90015-2

PubMed ID: 16807956

Title: Carbonic anhydrase activators. Activation of isozymes I, II, IV, VA, VII, and XIV with l- and d-histidine and crystallographic analysis of their adducts with isoform II: engineering proton-transfer processes within the active site of an enzyme.

PubMed ID: 16807956

DOI: 10.1002/chem.200600159

PubMed ID: 16686544

Title: Carbonic anhydrase activators. Activation of isoforms I, II, IV, VA, VII, and XIV with L- and D-phenylalanine and crystallographic analysis of their adducts with isozyme II: stereospecific recognition within the active site of an enzyme and its consequences for the drug design.

PubMed ID: 16686544

DOI: 10.1021/jm0603320

PubMed ID: 17705204

Title: Saccharin inhibits carbonic anhydrases: possible explanation for its unpleasant metallic aftertaste.

PubMed ID: 17705204

DOI: 10.1002/anie.200701189

PubMed ID: 17127057

Title: Carbonic anhydrase activators: L-Adrenaline plugs the active site entrance of isozyme II, activating better isoforms I, IV, VA, VII, and XIV.

PubMed ID: 17127057

DOI: 10.1016/j.bmcl.2006.11.027

PubMed ID: 17314045

Title: Phosph(on)ate as a zinc-binding group in metalloenzyme inhibitors: X-ray crystal structure of the antiviral drug foscarnet complexed to human carbonic anhydrase I.

PubMed ID: 17314045

DOI: 10.1016/j.bmcl.2007.01.113

PubMed ID: 19186056

Title: A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases.

PubMed ID: 19186056

DOI: 10.1016/j.bmcl.2009.01.038

PubMed ID: 19206230

Title: Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors.

PubMed ID: 19206230

DOI: 10.1021/ja809683v

PubMed ID: 18618712

Title: Crystal structure of human carbonic anhydrase XIII and its complex with the inhibitor acetazolamide.

PubMed ID: 18618712

DOI: 10.1002/prot.22144

PubMed ID: 8942978

Title: Crystal structure of the secretory form of membrane-associated human carbonic anhydrase IV at 2.8-A resolution.

PubMed ID: 8942978

DOI: 10.1073/pnas.93.24.13589

PubMed ID: 20363633

Title: Thioether benzenesulfonamide inhibitors of carbonic anhydrases II and IV: structure-based drug design, synthesis, and biological evaluation.

PubMed ID: 20363633

DOI: 10.1016/j.bmc.2010.03.014

PubMed ID: 15563508

Title: Mutant carbonic anhydrase 4 impairs pH regulation and causes retinal photoreceptor degeneration.

PubMed ID: 15563508

DOI: 10.1093/hmg/ddi023

PubMed ID: 17652713

Title: Identification and characterization of a novel mutation in the carbonic anhydrase IV gene that causes retinitis pigmentosa.

PubMed ID: 17652713

DOI: 10.1167/iovs.06-1515

PubMed ID: 20450258

Title: Screening for the carbonic anhydrase IV gene mutations in Chinese retinitis pigmentosa patients.

PubMed ID: 20450258

DOI: 10.3109/02713680903503512

Sequence Information:

Length: 312
Mass: 35032
Checksum: EF5F182474ABE9B0
Sequence:

MRMLLALLAL SAARPSASAE SHWCYEVQAE SSNYPCLVPV KWGGNCQKDR QSPINIVTTK 
AKVDKKLGRF FFSGYDKKQT WTVQNNGHSV MMLLENKASI SGGGLPAPYQ AKQLHLHWSD 
LPYKGSEHSL DGEHFAMEMH IVHEKEKGTS RNVKEAQDPE DEIAVLAFLV EAGTQVNEGF 
QPLVEALSNI PKPEMSTTMA ESSLLDLLPK EEKLRHYFRY LGSLTTPTCD EKVVWTVFRE 
PIQLHREQIL AFSQKLYYDK EQTVSMKDNV RPLQQLGQRT VIKSGAPGRP LPWALPALLG 
PMLACLLAGF LR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CA4

Associated with

Other Information

Human carbonic anhydrase IV: cDNA cloning, sequence comparison, and expression in COS cell membranes. PubMed ID: 1311094

Genomic organization and localization of gene for human carbonic anhydrase IV to chromosome 17q. PubMed ID: 8325641

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. PubMed ID: 16625196

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Carbonic anhydrase IV from human lung. Purification, characterization, and comparison with membrane carbonic anhydrase from human kidney. PubMed ID: 2111324

Carbonic anhydrase IV: purification of a secretory form of the recombinant human enzyme and identification of the positions and importance of its disulfide bonds. PubMed ID: 8809084

Carbonic anhydrase IV: role of removal of C-terminal domain in glycosylphosphatidylinositol anchoring and realization of enzyme activity. PubMed ID: 7625839

Carbonic anhydrase activators. Activation of isozymes I, II, IV, VA, VII, and XIV with l- and d-histidine and crystallographic analysis of their adducts with isoform II: engineering proton-transfer processes within the active site of an enzyme. PubMed ID: 16807956

Carbonic anhydrase activators. Activation of isoforms I, II, IV, VA, VII, and XIV with L- and D-phenylalanine and crystallographic analysis of their adducts with isozyme II: stereospecific recognition within the active site of an enzyme and its consequences for the drug design. PubMed ID: 16686544

Saccharin inhibits carbonic anhydrases: possible explanation for its unpleasant metallic aftertaste. PubMed ID: 17705204

Carbonic anhydrase activators: L-Adrenaline plugs the active site entrance of isozyme II, activating better isoforms I, IV, VA, VII, and XIV. PubMed ID: 17127057

Phosph(on)ate as a zinc-binding group in metalloenzyme inhibitors: X-ray crystal structure of the antiviral drug foscarnet complexed to human carbonic anhydrase I. PubMed ID: 17314045

A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases. PubMed ID: 19186056

Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors. PubMed ID: 19206230

Crystal structure of human carbonic anhydrase XIII and its complex with the inhibitor acetazolamide. PubMed ID: 18618712

Crystal structure of the secretory form of membrane-associated human carbonic anhydrase IV at 2.8-A resolution. PubMed ID: 8942978

Thioether benzenesulfonamide inhibitors of carbonic anhydrases II and IV: structure-based drug design, synthesis, and biological evaluation. PubMed ID: 20363633

Mutant carbonic anhydrase 4 impairs pH regulation and causes retinal photoreceptor degeneration. PubMed ID: 15563508

Identification and characterization of a novel mutation in the carbonic anhydrase IV gene that causes retinitis pigmentosa. PubMed ID: 17652713

Screening for the carbonic anhydrase IV gene mutations in Chinese retinitis pigmentosa patients. PubMed ID: 20450258