Details for: CA5A

Gene ID: 763

Symbol: CA5A

Ensembl ID: ENSG00000174990

Description: carbonic anhydrase 5A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 19.3513
    Cell Significance Index: -3.0100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 12.3001
    Cell Significance Index: 206.8800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 11.3545
    Cell Significance Index: -2.8800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 6.9660
    Cell Significance Index: -2.8300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 6.1001
    Cell Significance Index: -2.8800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 3.3230
    Cell Significance Index: 55.9800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 2.4494
    Cell Significance Index: -3.0200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.3173
    Cell Significance Index: 459.8700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.0482
    Cell Significance Index: 64.2700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.4980
    Cell Significance Index: -1.0900
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.4365
    Cell Significance Index: 2.3800
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.4168
    Cell Significance Index: 5.8500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.3974
    Cell Significance Index: 6.8100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3062
    Cell Significance Index: 58.2800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.3005
    Cell Significance Index: 4.4400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.2529
    Cell Significance Index: 4.6800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2006
    Cell Significance Index: 19.8500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1668
    Cell Significance Index: 150.5700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1573
    Cell Significance Index: 3.3500
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.1433
    Cell Significance Index: 0.8300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1109
    Cell Significance Index: 18.0300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1078
    Cell Significance Index: 11.7300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0955
    Cell Significance Index: 2.0700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0925
    Cell Significance Index: 5.8300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0923
    Cell Significance Index: 2.6600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0726
    Cell Significance Index: 0.9900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0713
    Cell Significance Index: 4.2800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0649
    Cell Significance Index: 1.7400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0604
    Cell Significance Index: 1.5100
  • Cell Name: obsolete animal cell (CL0000548)
    Fold Change: 0.0523
    Cell Significance Index: 0.5300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0480
    Cell Significance Index: 3.3200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0474
    Cell Significance Index: 2.1500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.0438
    Cell Significance Index: 1.0600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0433
    Cell Significance Index: 2.2500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.0363
    Cell Significance Index: 0.7800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0300
    Cell Significance Index: 6.0200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0140
    Cell Significance Index: 2.5300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0122
    Cell Significance Index: 1.7700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0116
    Cell Significance Index: 4.1600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0049
    Cell Significance Index: 9.2200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0034
    Cell Significance Index: 0.1200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0030
    Cell Significance Index: 4.5900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0024
    Cell Significance Index: 4.4200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0012
    Cell Significance Index: 1.6400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0010
    Cell Significance Index: -0.4400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0014
    Cell Significance Index: -0.2400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0014
    Cell Significance Index: -0.0200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0016
    Cell Significance Index: -1.0400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0017
    Cell Significance Index: -0.7300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0028
    Cell Significance Index: -0.0400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0033
    Cell Significance Index: -2.4700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0035
    Cell Significance Index: -1.9300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0036
    Cell Significance Index: -2.7200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0037
    Cell Significance Index: -0.1600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0040
    Cell Significance Index: -2.9500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0040
    Cell Significance Index: -0.3100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0045
    Cell Significance Index: -2.5400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0050
    Cell Significance Index: -0.1600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0053
    Cell Significance Index: -0.6100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0055
    Cell Significance Index: -1.5700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0103
    Cell Significance Index: -0.0700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0131
    Cell Significance Index: -1.3400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0132
    Cell Significance Index: -1.5400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0135
    Cell Significance Index: -2.8500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0151
    Cell Significance Index: -1.8600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0168
    Cell Significance Index: -1.1300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0173
    Cell Significance Index: -0.9100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0194
    Cell Significance Index: -2.5100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0205
    Cell Significance Index: -2.8100
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0226
    Cell Significance Index: -0.3000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0229
    Cell Significance Index: -1.4800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0237
    Cell Significance Index: -1.0500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0253
    Cell Significance Index: -0.8000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0255
    Cell Significance Index: -1.1900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0256
    Cell Significance Index: -0.9700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0267
    Cell Significance Index: -2.7800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0272
    Cell Significance Index: -3.2100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0272
    Cell Significance Index: -0.7600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0281
    Cell Significance Index: -1.7300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0305
    Cell Significance Index: -2.2700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0348
    Cell Significance Index: -0.6800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0396
    Cell Significance Index: -0.9700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0431
    Cell Significance Index: -1.1500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0471
    Cell Significance Index: -1.5000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0471
    Cell Significance Index: -2.2200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0490
    Cell Significance Index: -2.7500
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0492
    Cell Significance Index: -0.3200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0494
    Cell Significance Index: -1.7300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0495
    Cell Significance Index: -2.5800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0514
    Cell Significance Index: -1.3200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0516
    Cell Significance Index: -1.4100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0547
    Cell Significance Index: -0.8200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0571
    Cell Significance Index: -1.8700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0571
    Cell Significance Index: -0.8600
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0579
    Cell Significance Index: -0.8000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0604
    Cell Significance Index: -1.7800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0607
    Cell Significance Index: -1.3300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0610
    Cell Significance Index: -0.9000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0617
    Cell Significance Index: -1.3100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0644
    Cell Significance Index: -1.3400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CA5A shares structural and functional similarities with other carbonic anhydrases, with a conserved catalytic domain and a zinc ion-binding site. The enzyme exhibits high specificity for bicarbonate, with a Km value of 1.5 mM. CA5A is primarily expressed in cells involved in ion transport, metabolism, and immune responses, including kidney proximal convoluted tubule epithelial cells, colon goblet cells, hepatocytes, and lymphoid lineage-restricted progenitor cells. The enzyme's expression is also elevated in certain types of cancer, such as hepatocellular carcinoma and colorectal cancer. **Pathways and Functions** CA5A plays a critical role in various cellular processes, including: 1. **Carbon dioxide transport**: CA5A catalyzes the reversible hydration of carbon dioxide, which is essential for maintaining acid-base balance in the body. 2. **Ion transport**: CA5A facilitates the transport of ions, such as bicarbonate and hydrogen ions, across cell membranes, which is crucial for maintaining proper ion homeostasis. 3. **Metabolism**: CA5A is involved in the regulation of metabolic pathways, including glycolysis and the one-carbon metabolic process. 4. **Immune responses**: CA5A has been implicated in the regulation of immune cell function, including the activation of innate lymphoid cells. **Clinical Significance** CA5A has been implicated in various diseases and disorders, including: 1. **Kidney disease**: Elevated CA5A expression has been associated with kidney diseases, such as diabetic nephropathy and chronic kidney disease. 2. **Cancer**: CA5A expression has been elevated in certain types of cancer, including hepatocellular carcinoma and colorectal cancer. 3. **Metabolic disorders**: CA5A has been implicated in metabolic disorders, such as obesity and type 2 diabetes. 4. **Immune-mediated disorders**: CA5A has been implicated in immune-mediated disorders, such as rheumatoid arthritis and lupus. In conclusion, CA5A is a critical enzyme that plays a vital role in maintaining cellular homeostasis, particularly in the kidneys, liver, and immune system. Its dysregulation has been implicated in various diseases and disorders, highlighting the importance of further research into the molecular mechanisms underlying CA5A function and its clinical significance.

Genular Protein ID: 2454406713

Symbol: CAH5A_HUMAN

Name: Carbonate dehydratase VA

UniProtKB Accession Codes:

P35218 B2RPF2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 6 DrugCentral 1 EC 1 EMBL 12 Ensembl 1 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 3 SABIO-RK 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8356065

Title: Human mitochondrial carbonic anhydrase: cDNA cloning, expression, subcellular localization, and mapping to chromosome 16.

PubMed ID: 8356065

DOI: 10.1073/pnas.90.16.7623

PubMed ID: 7490083

Title: Genomic organization of the human gene (CA5) and pseudogene for mitochondrial carbonic anhydrase V and their localization to chromosomes 16q and 16p.

PubMed ID: 7490083

DOI: 10.1006/geno.1995.1177

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16807956

Title: Carbonic anhydrase activators. Activation of isozymes I, II, IV, VA, VII, and XIV with l- and d-histidine and crystallographic analysis of their adducts with isoform II: engineering proton-transfer processes within the active site of an enzyme.

PubMed ID: 16807956

DOI: 10.1002/chem.200600159

PubMed ID: 16686544

Title: Carbonic anhydrase activators. Activation of isoforms I, II, IV, VA, VII, and XIV with L- and D-phenylalanine and crystallographic analysis of their adducts with isozyme II: stereospecific recognition within the active site of an enzyme and its consequences for the drug design.

PubMed ID: 16686544

DOI: 10.1021/jm0603320

PubMed ID: 17127057

Title: Carbonic anhydrase activators: L-Adrenaline plugs the active site entrance of isozyme II, activating better isoforms I, IV, VA, VII, and XIV.

PubMed ID: 17127057

DOI: 10.1016/j.bmcl.2006.11.027

PubMed ID: 17314045

Title: Phosph(on)ate as a zinc-binding group in metalloenzyme inhibitors: X-ray crystal structure of the antiviral drug foscarnet complexed to human carbonic anhydrase I.

PubMed ID: 17314045

DOI: 10.1016/j.bmcl.2007.01.113

PubMed ID: 19186056

Title: A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases.

PubMed ID: 19186056

DOI: 10.1016/j.bmcl.2009.01.038

PubMed ID: 19206230

Title: Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors.

PubMed ID: 19206230

DOI: 10.1021/ja809683v

PubMed ID: 18618712

Title: Crystal structure of human carbonic anhydrase XIII and its complex with the inhibitor acetazolamide.

PubMed ID: 18618712

DOI: 10.1002/prot.22144

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24530203

Title: Mitochondrial carbonic anhydrase VA deficiency resulting from CA5A alterations presents with hyperammonemia in early childhood.

PubMed ID: 24530203

DOI: 10.1016/j.ajhg.2014.01.006

Sequence Information:

  • Length: 305
  • Mass: 34750
  • Checksum: C4E998D269AB1FE5
  • Sequence:
    • MLGRNTWKTS AFSFLVEQMW APLWSRSMRP GRWCSQRSCA WQTSNNTLHP LWTVPVSVPG 
GTRQSPINIQ WRDSVYDPQL KPLRVSYEAA SCLYIWNTGY LFQVEFDDAT EASGISGGPL 
ENHYRLKQFH FHWGAVNEGG SEHTVDGHAY PAELHLVHWN SVKYQNYKEA VVGENGLAVI 
GVFLKLGAHH QTLQRLVDIL PEIKHKDARA AMRPFDPSTL LPTCWDYWTY AGSLTTPPLT 
ESVTWIIQKE PVEVAPSQLS AFRTLLFSAL GEEEKMMVNN YRPLQPLMNR KVWASFQATN 
EGTRS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.