Details for: CA5AP1

Gene ID: 764

Symbol: CA5AP1

Ensembl ID: ENSG00000260133

Description: carbonic anhydrase 5A pseudogene 1

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.2507
    Cell Significance Index: 2.6000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1161
    Cell Significance Index: 1.9900
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.1116
    Cell Significance Index: 1.4600
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.1043
    Cell Significance Index: 0.7200
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.0682
    Cell Significance Index: 0.7700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.0621
    Cell Significance Index: 0.7400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0603
    Cell Significance Index: 1.3200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0559
    Cell Significance Index: 0.9400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0461
    Cell Significance Index: 0.6800
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.0435
    Cell Significance Index: 0.5500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.0351
    Cell Significance Index: 0.6000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0302
    Cell Significance Index: 0.8100
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.0151
    Cell Significance Index: 0.1800
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.0112
    Cell Significance Index: 0.1300
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.0083
    Cell Significance Index: 0.1000
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.0063
    Cell Significance Index: 0.0600
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.0045
    Cell Significance Index: 0.0400
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.0034
    Cell Significance Index: 0.0300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0012
    Cell Significance Index: 0.1700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0007
    Cell Significance Index: 1.2100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0006
    Cell Significance Index: 1.0900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0004
    Cell Significance Index: 0.5600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0001
    Cell Significance Index: 0.1300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0006
    Cell Significance Index: -0.2500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0008
    Cell Significance Index: -0.4800
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0008
    Cell Significance Index: -0.0100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0058
    Cell Significance Index: -0.6000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0061
    Cell Significance Index: -0.7000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0064
    Cell Significance Index: -0.0700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0098
    Cell Significance Index: -0.1400
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.0114
    Cell Significance Index: -0.1600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0120
    Cell Significance Index: -0.3800
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0137
    Cell Significance Index: -0.1400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0169
    Cell Significance Index: -0.1600
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0210
    Cell Significance Index: -0.3400
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0214
    Cell Significance Index: -0.2600
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0231
    Cell Significance Index: -0.2800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0235
    Cell Significance Index: -0.6000
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0279
    Cell Significance Index: -0.3500
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: -0.0280
    Cell Significance Index: -0.3600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0285
    Cell Significance Index: -0.4100
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.0289
    Cell Significance Index: -0.4400
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0294
    Cell Significance Index: -0.3500
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.0297
    Cell Significance Index: -0.3800
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.0299
    Cell Significance Index: -0.2800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0299
    Cell Significance Index: -0.4300
  • Cell Name: granule cell (CL0000120)
    Fold Change: -0.0307
    Cell Significance Index: -0.3500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0330
    Cell Significance Index: -0.4500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0341
    Cell Significance Index: -0.4300
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0344
    Cell Significance Index: -0.3700
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0356
    Cell Significance Index: -0.4100
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: -0.0416
    Cell Significance Index: -0.3000
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0416
    Cell Significance Index: -0.3200
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0423
    Cell Significance Index: -0.5000
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0427
    Cell Significance Index: -0.4500
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0433
    Cell Significance Index: -0.5800
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: -0.0451
    Cell Significance Index: -0.4400
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0455
    Cell Significance Index: -0.6300
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.0455
    Cell Significance Index: -0.5500
  • Cell Name: differentiation-committed oligodendrocyte precursor (CL4023059)
    Fold Change: -0.0472
    Cell Significance Index: -0.5600
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0477
    Cell Significance Index: -0.8100
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0481
    Cell Significance Index: -0.6000
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0494
    Cell Significance Index: -0.6200
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: -0.0497
    Cell Significance Index: -0.5600
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0502
    Cell Significance Index: -0.6000
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: -0.0522
    Cell Significance Index: -0.5800
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.0534
    Cell Significance Index: -0.6400
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.0545
    Cell Significance Index: -0.6100
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: -0.0549
    Cell Significance Index: -0.6100
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: -0.0553
    Cell Significance Index: -0.6400
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: -0.0563
    Cell Significance Index: -0.6200
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0575
    Cell Significance Index: -0.7000
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0577
    Cell Significance Index: -0.5400
  • Cell Name: interneuron (CL0000099)
    Fold Change: -0.0582
    Cell Significance Index: -0.6800
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0587
    Cell Significance Index: -0.6500
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.0589
    Cell Significance Index: -0.6400
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0592
    Cell Significance Index: -0.7000
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0594
    Cell Significance Index: -0.7800
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.0595
    Cell Significance Index: -0.6700
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: -0.0596
    Cell Significance Index: -0.7200
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0598
    Cell Significance Index: -0.7800
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0600
    Cell Significance Index: -0.7900
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0603
    Cell Significance Index: -0.6900
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: -0.0625
    Cell Significance Index: -0.7300
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: -0.0640
    Cell Significance Index: -0.7000
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: -0.0647
    Cell Significance Index: -0.7700
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0651
    Cell Significance Index: -0.8500
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0654
    Cell Significance Index: -0.6200
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0659
    Cell Significance Index: -0.8100
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.0660
    Cell Significance Index: -0.7500
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: -0.0666
    Cell Significance Index: -0.8000
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0675
    Cell Significance Index: -0.8200
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0676
    Cell Significance Index: -0.7300
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0676
    Cell Significance Index: -0.6900
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0678
    Cell Significance Index: -0.5600
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0687
    Cell Significance Index: -0.8100
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0692
    Cell Significance Index: -0.6500
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0697
    Cell Significance Index: -0.8200
  • Cell Name: glial cell (CL0000125)
    Fold Change: -0.0712
    Cell Significance Index: -0.7800
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0714
    Cell Significance Index: -0.7900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CA5AP1 is a pseudogene, meaning it has undergone degenerative mutations that render it non-functional. However, its expression in various cell types suggests that it may have evolved to play a regulatory or housekeeping role, rather than a catalytic one. The gene is significantly expressed in cells of the eye, including the pigmented and non-pigmented ciliary epithelial cells, retinal rod and cone cells, and melanocytes. Additionally, CA5AP1 is expressed in astrocytes, ependymal cells, and smooth muscle cells of the sphincter of the pupil. Its expression is also observed in cells of the central nervous system, including macrophages and retinal ganglion cells. **Pathways and Functions:** The exact mechanisms by which CA5AP1 regulates cellular processes are not well understood. However, its expression in various cell types suggests that it may be involved in maintaining ion balance and regulating cellular pH. Carbonic anhydrase enzymes, including CA5A, are known to play a crucial role in this process, catalyzing the reversible hydration of carbon dioxide to bicarbonate and protons. Although CA5AP1 is a pseudogene, it may still interact with the CA5A pathway or other signaling pathways to modulate cellular responses. For example, it may influence the activity of ion channels, transporters, or other proteins involved in maintaining cellular homeostasis. **Clinical Significance:** The clinical significance of CA5AP1 is still unclear. However, its expression in various tissues and cell types suggests that it may be involved in the pathogenesis of certain diseases. For example, alterations in ion balance and cellular pH can contribute to the development of glaucoma, a condition characterized by increased intraocular pressure and optic nerve damage. Additionally, dysregulation of cellular homeostasis has been implicated in various neurological and psychiatric disorders, including Alzheimer's disease, Parkinson's disease, and depression. Further research is needed to elucidate the functional role of CA5AP1 and its potential implications for human disease. In conclusion, the CA5AP1 gene is a fascinating example of a non-coding pseudogene that has evolved to play a regulatory or housekeeping role in various tissues. Its expression patterns and cellular distributions suggest that it may be involved in maintaining cellular homeostasis, regulating ion balance, and modulating cellular processes. Further research is needed to elucidate the functional role of CA5AP1 and its potential implications for human disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.