Details for: CA6

Gene ID: 765

Symbol: CA6

Ensembl ID: ENSG00000131686

Description: carbonic anhydrase 6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 32.1494
    Cell Significance Index: 444.5300
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 23.6051
    Cell Significance Index: 492.3000
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 22.4108
    Cell Significance Index: 124.7400
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 14.2424
    Cell Significance Index: 61.2500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 3.2246
    Cell Significance Index: -1.3100
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 2.1164
    Cell Significance Index: 21.6200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 1.4245
    Cell Significance Index: -1.3600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.4164
    Cell Significance Index: -3.1000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4577
    Cell Significance Index: 90.8400
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.1834
    Cell Significance Index: 2.3200
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.1724
    Cell Significance Index: 1.4100
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.1496
    Cell Significance Index: 1.6900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1319
    Cell Significance Index: 2.2600
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0997
    Cell Significance Index: 1.2600
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.0850
    Cell Significance Index: 0.9500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0838
    Cell Significance Index: 1.8400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0812
    Cell Significance Index: 10.4900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0756
    Cell Significance Index: 2.0300
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0438
    Cell Significance Index: 0.6200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0436
    Cell Significance Index: 0.6000
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.0397
    Cell Significance Index: 0.4800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0295
    Cell Significance Index: 0.4200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0208
    Cell Significance Index: 0.6100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0202
    Cell Significance Index: 0.9500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0076
    Cell Significance Index: 1.5200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0067
    Cell Significance Index: 12.4000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0065
    Cell Significance Index: 1.8700
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.0053
    Cell Significance Index: 0.0500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0044
    Cell Significance Index: 0.6400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0020
    Cell Significance Index: 0.7200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0012
    Cell Significance Index: 2.2000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0010
    Cell Significance Index: 1.5500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0006
    Cell Significance Index: 0.3700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0002
    Cell Significance Index: -0.2500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0003
    Cell Significance Index: -0.0500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0005
    Cell Significance Index: -0.0900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0016
    Cell Significance Index: -1.1800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0017
    Cell Significance Index: -0.7500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0017
    Cell Significance Index: -1.2300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0020
    Cell Significance Index: -1.1000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0021
    Cell Significance Index: -1.2000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0025
    Cell Significance Index: -1.0900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0034
    Cell Significance Index: -0.1600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0059
    Cell Significance Index: -1.2500
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.0059
    Cell Significance Index: -0.0600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0083
    Cell Significance Index: -1.0200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0085
    Cell Significance Index: -0.9800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0091
    Cell Significance Index: -1.2500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0091
    Cell Significance Index: -0.1300
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.0092
    Cell Significance Index: -0.0500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0098
    Cell Significance Index: -1.0200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0102
    Cell Significance Index: -1.0500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0119
    Cell Significance Index: -0.8900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0126
    Cell Significance Index: -0.8500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0143
    Cell Significance Index: -1.1000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0168
    Cell Significance Index: -0.2900
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0174
    Cell Significance Index: -0.1800
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0188
    Cell Significance Index: -0.2000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0205
    Cell Significance Index: -0.9100
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0206
    Cell Significance Index: -0.3000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0208
    Cell Significance Index: -1.2800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0219
    Cell Significance Index: -1.1400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0222
    Cell Significance Index: -1.4300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0225
    Cell Significance Index: -1.1700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0229
    Cell Significance Index: -0.7300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0230
    Cell Significance Index: -1.2900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0232
    Cell Significance Index: -0.8800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0237
    Cell Significance Index: -0.7800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0240
    Cell Significance Index: -0.8400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0260
    Cell Significance Index: -0.4800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0283
    Cell Significance Index: -0.6000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0285
    Cell Significance Index: -0.9000
  • Cell Name: osteoclast (CL0000092)
    Fold Change: -0.0296
    Cell Significance Index: -0.3000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0312
    Cell Significance Index: -0.8900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0321
    Cell Significance Index: -0.8000
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0324
    Cell Significance Index: -0.4500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0328
    Cell Significance Index: -0.8800
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: -0.0341
    Cell Significance Index: -0.3600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0342
    Cell Significance Index: -0.5800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0345
    Cell Significance Index: -0.8600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0368
    Cell Significance Index: -1.3500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0374
    Cell Significance Index: -0.7400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0375
    Cell Significance Index: -0.8100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0387
    Cell Significance Index: -1.1400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0388
    Cell Significance Index: -0.9400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0393
    Cell Significance Index: -0.7900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0415
    Cell Significance Index: -1.0900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0415
    Cell Significance Index: -0.8100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0420
    Cell Significance Index: -0.6200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0422
    Cell Significance Index: -1.2100
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0427
    Cell Significance Index: -0.5900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0427
    Cell Significance Index: -1.5000
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.0434
    Cell Significance Index: -0.6100
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0436
    Cell Significance Index: -0.5200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0458
    Cell Significance Index: -1.1700
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.0476
    Cell Significance Index: -0.5400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0489
    Cell Significance Index: -1.0200
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: -0.0490
    Cell Significance Index: -0.4900
  • Cell Name: brush cell (CL0002204)
    Fold Change: -0.0491
    Cell Significance Index: -0.4500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0502
    Cell Significance Index: -1.2800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CA6 is a zinc-dependent enzyme that catalyzes the reversible hydration of carbon dioxide (CO2) to bicarbonate (HCO3-) and protons (H+). This reaction is essential for maintaining acid-base homeostasis in various tissues, including the salivary gland, where it is expressed in acinar cells. CA6 is also involved in the regulation of pH levels in extracellular spaces, such as the extracellular matrix and the cerebrospinal fluid. **Pathways and Functions:** CA6 participates in several metabolic pathways, including: 1. **Carbonate dehydratase activity**: CA6 catalyzes the reversible hydration of CO2, which is essential for maintaining acid-base homeostasis. 2. **One-carbon metabolic process**: CA6 is involved in the regulation of one-carbon metabolism, which is crucial for DNA synthesis and repair. 3. **Detection of chemical stimulus involved in sensory perception of bitter taste**: CA6 is expressed in goblet cells, where it may play a role in the detection of bitter taste compounds. 4. **Exosome formation**: CA6 is involved in the formation of exosomes, which are small extracellular vesicles that play a role in intercellular communication. **Significantly Expressed Cells:** CA6 is expressed in various cell types, including: 1. **Acinar cell of salivary gland**: CA6 is expressed in acinar cells of the salivary gland, where it regulates pH levels and maintains acid-base homeostasis. 2. **Double negative thymocyte**: CA6 is expressed in double negative thymocytes, which are precursor cells to T lymphocytes. 3. **Duct epithelial cell**: CA6 is expressed in duct epithelial cells of the salivary gland, where it regulates pH levels and maintains acid-base homeostasis. 4. **Granulocyte monocyte progenitor cell**: CA6 is expressed in granulocyte monocyte progenitor cells, which are precursor cells to granulocytes and monocytes. **Clinical Significance:** CA6 has been implicated in various diseases, including: 1. **Salivary gland disorders**: CA6 has been shown to play a role in the pathogenesis of salivary gland disorders, such as sialadenitis and sialadenitis-associated lymphoma. 2. **Cancer**: CA6 has been overexpressed in various types of cancer, including breast, lung, and colon cancer. 3. **Neurological disorders**: CA6 has been implicated in neurological disorders, such as epilepsy and Alzheimer's disease. 4. **Immune system disorders**: CA6 has been shown to play a role in immune system disorders, such as autoimmune diseases and immunodeficiency disorders. In conclusion, CA6 is a multifaceted enzyme that plays a crucial role in various physiological processes, including metabolism, exosome formation, and sensory perception. Its expression in various cell types and its involvement in various diseases highlight the importance of CA6 in the immune system and beyond. Further research is needed to fully elucidate the functions and clinical significance of CA6.

Genular Protein ID: 2149029244

Symbol: CAH6_HUMAN

Name: Carbonic anhydrase 6

UniProtKB Accession Codes:

P23280 E7EMQ1 Q5FBW3 Q5FC00 Q96QX8 Q9UF03

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 5 DrugCentral 1 EC 2 EMBL 12 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRIDE 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 1 RefSeq 3 Rhea 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1899030

Title: Human secreted carbonic anhydrase: cDNA cloning, nucleotide sequence, and hybridization histochemistry.

PubMed ID: 1899030

DOI: 10.1021/bi00216a035

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 17705204

Title: Saccharin inhibits carbonic anhydrases: possible explanation for its unpleasant metallic aftertaste.

PubMed ID: 17705204

DOI: 10.1002/anie.200701189

PubMed ID: 17314045

Title: Phosph(on)ate as a zinc-binding group in metalloenzyme inhibitors: X-ray crystal structure of the antiviral drug foscarnet complexed to human carbonic anhydrase I.

PubMed ID: 17314045

DOI: 10.1016/j.bmcl.2007.01.113

PubMed ID: 19186056

Title: A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases.

PubMed ID: 19186056

DOI: 10.1016/j.bmcl.2009.01.038

PubMed ID: 19206230

Title: Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors.

PubMed ID: 19206230

DOI: 10.1021/ja809683v

PubMed ID: 4628675

Title: Crystal structure of human erythrocyte carbonic anhydrase C. VI. The three-dimensional structure at high resolution in relation to other mammalian carbonic anhydrases.

PubMed ID: 4628675

DOI: 10.1101/sqb.1972.036.01.030

Sequence Information:

  • Length: 308
  • Mass: 35367
  • Checksum: 6EBFF15085E7112D
  • Sequence:
    • MRALVLLLSL FLLGGQAQHV SDWTYSEGAL DEAHWPQHYP ACGGQRQSPI NLQRTKVRYN 
PSLKGLNMTG YETQAGEFPM VNNGHTVQIS LPSTMRMTVA DGTVYIAQQM HFHWGGASSE 
ISGSEHTVDG IRHVIEIHIV HYNSKYKSYD IAQDAPDGLA VLAAFVEVKN YPENTYYSNF 
ISHLANIKYP GQRTTLTGLD VQDMLPRNLQ HYYTYHGSLT TPPCTENVHW FVLADFVKLS 
RTQVWKLENS LLDHRNKTIH NDYRRTQPLN HRVVESNFPN QEYTLGSEFQ FYLHKIEEIL 
DYLRRALN

Genular Protein ID: 828724567

Symbol: B4DUH8_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DUH8

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 5 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 3 Gene3D 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 1 RefSeq 3 Rhea 1 RuleBase 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 312
  • Mass: 35789
  • Checksum: 639AB9D76F67FFB1
  • Sequence:
    • MCSTMRALVL LLSLFLLGGQ AQHVSDWTYS EGALDEAHWP QHYPACGGQR QSPINLQRTK 
VRYNPSLKGL NMTGYETQAG EFPMVNNGHT VQISLPSTMR MTVADGTVYI AQQMHFHWGG 
ASSEISGSEH TVDGIRHVIE IHIVHYNSKY KSYDIAQDAP DGLAVLAAFV EVKNYPENTY 
YSNFISHLAN IKYPGQRTTL TGLDVQDMLP RNLQHYYTYH GSLTTPPCTE NVHWFVLADF 
VKLSRTQVWK LENSLLDHRN KTIHNDYRRT QPLNHRVVES NFPNQEYTLG SEFQFYLHKI 
EEILDYLRRA LN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.