Details for: CA7

Gene ID: 766

Symbol: CA7

Ensembl ID: ENSG00000168748

Description: carbonic anhydrase 7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 5.6907
    Cell Significance Index: 85.2700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.8046
    Cell Significance Index: 60.7600
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.7723
    Cell Significance Index: 47.3900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.7437
    Cell Significance Index: -7.3500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.6735
    Cell Significance Index: 35.6400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9919
    Cell Significance Index: 107.8900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5684
    Cell Significance Index: 39.3100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4220
    Cell Significance Index: 84.6500
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.3266
    Cell Significance Index: 3.5400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2697
    Cell Significance Index: 26.6800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.2618
    Cell Significance Index: 7.4700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.2553
    Cell Significance Index: 2.6400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.2236
    Cell Significance Index: 4.7800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2048
    Cell Significance Index: 9.0600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1875
    Cell Significance Index: 35.6900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.1804
    Cell Significance Index: 6.8300
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: 0.1718
    Cell Significance Index: 2.2900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1672
    Cell Significance Index: 7.5800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1531
    Cell Significance Index: 4.9100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1465
    Cell Significance Index: 9.8500
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.0700
    Cell Significance Index: 0.5000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0562
    Cell Significance Index: 1.6200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0561
    Cell Significance Index: 1.9700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0529
    Cell Significance Index: 36.6100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0420
    Cell Significance Index: 1.0500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0419
    Cell Significance Index: 0.5300
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0406
    Cell Significance Index: 0.5700
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.0405
    Cell Significance Index: 0.5400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.0311
    Cell Significance Index: 0.6600
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: 0.0237
    Cell Significance Index: 0.2600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0182
    Cell Significance Index: 6.5400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.0135
    Cell Significance Index: 0.4300
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.0113
    Cell Significance Index: 0.0700
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.0063
    Cell Significance Index: 0.0600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0044
    Cell Significance Index: 0.4500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.0031
    Cell Significance Index: 0.1000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0019
    Cell Significance Index: 3.4400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.0012
    Cell Significance Index: 0.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0002
    Cell Significance Index: -0.4200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0006
    Cell Significance Index: -0.9400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0023
    Cell Significance Index: -3.1700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0039
    Cell Significance Index: -0.0800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0066
    Cell Significance Index: -5.0200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0073
    Cell Significance Index: -3.9700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0077
    Cell Significance Index: -5.7300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0101
    Cell Significance Index: -5.7000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0115
    Cell Significance Index: -7.2900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0117
    Cell Significance Index: -3.3700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0126
    Cell Significance Index: -5.7300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0131
    Cell Significance Index: -2.6000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0133
    Cell Significance Index: -0.1900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0134
    Cell Significance Index: -0.2700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0140
    Cell Significance Index: -0.2300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0228
    Cell Significance Index: -0.8000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0237
    Cell Significance Index: -0.6100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0298
    Cell Significance Index: -4.0900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0302
    Cell Significance Index: -0.6300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0304
    Cell Significance Index: -5.1900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0305
    Cell Significance Index: -2.3400
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0337
    Cell Significance Index: -0.4200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0367
    Cell Significance Index: -3.8200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0376
    Cell Significance Index: -0.4100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0377
    Cell Significance Index: -2.3100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0380
    Cell Significance Index: -0.3600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0422
    Cell Significance Index: -7.6100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0430
    Cell Significance Index: -6.2600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0444
    Cell Significance Index: -5.0900
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.0452
    Cell Significance Index: -0.5700
  • Cell Name: L5 intratelencephalic projecting glutamatergic neuron (CL4030064)
    Fold Change: -0.0472
    Cell Significance Index: -0.5100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0483
    Cell Significance Index: -5.6300
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0506
    Cell Significance Index: -0.5900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0513
    Cell Significance Index: -2.3900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0526
    Cell Significance Index: -2.7600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0542
    Cell Significance Index: -3.0400
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0544
    Cell Significance Index: -0.8200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0546
    Cell Significance Index: -1.0800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0549
    Cell Significance Index: -0.9400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0633
    Cell Significance Index: -0.7900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0639
    Cell Significance Index: -7.8600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0645
    Cell Significance Index: -1.8000
  • Cell Name: lung resident memory CD8-positive, alpha-beta T cell (CL4033039)
    Fold Change: -0.0656
    Cell Significance Index: -0.5800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0732
    Cell Significance Index: -1.8700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0734
    Cell Significance Index: -3.0100
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.0852
    Cell Significance Index: -0.9400
  • Cell Name: respiratory suprabasal cell (CL4033048)
    Fold Change: -0.0854
    Cell Significance Index: -0.7700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0915
    Cell Significance Index: -3.3600
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0983
    Cell Significance Index: -0.8500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0985
    Cell Significance Index: -4.9800
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0986
    Cell Significance Index: -1.2500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0999
    Cell Significance Index: -1.3700
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.1035
    Cell Significance Index: -1.1000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1050
    Cell Significance Index: -3.3200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1095
    Cell Significance Index: -2.1400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1172
    Cell Significance Index: -3.3600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1176
    Cell Significance Index: -7.2300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1205
    Cell Significance Index: -3.0100
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.1212
    Cell Significance Index: -1.0000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1223
    Cell Significance Index: -2.5600
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1238
    Cell Significance Index: -1.5600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1275
    Cell Significance Index: -4.4300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CA7 is a zinc-dependent enzyme that catalyzes the reversible hydration of carbon dioxide to bicarbonate and protons. This reaction is essential for maintaining acid-base balance in various tissues, including the brain, kidneys, and red blood cells. CA7 is also involved in the regulation of chloride transport, which is critical for maintaining proper fluid balance and osmoregulation. Additionally, CA7 plays a role in one-carbon metabolism, a process that is essential for the synthesis of nucleotides, amino acids, and other biomolecules. **Pathways and Functions:** CA7 is involved in several key pathways, including: 1. **Carbonate dehydratase activity**: CA7 catalyzes the reversible hydration of carbon dioxide to bicarbonate and protons, which is essential for maintaining acid-base balance in various tissues. 2. **Neuron cellular homeostasis**: CA7 plays a crucial role in regulating pH levels and ion transport in neurons, which is essential for maintaining proper neuronal function and synaptic transmission. 3. **One-carbon metabolic process**: CA7 is involved in the synthesis of nucleotides, amino acids, and other biomolecules, which is essential for cell growth and division. 4. **Regulation of chloride transport**: CA7 regulates chloride transport, which is critical for maintaining proper fluid balance and osmoregulation. 5. **Zinc ion binding**: CA7 binds zinc ions, which is essential for its catalytic activity and stability. **Clinical Significance:** CA7 has been implicated in various diseases, including: 1. **Neurodegenerative disorders**: CA7 has been shown to play a role in neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease, where its expression is reduced. 2. **Cancer**: CA7 has been found to be overexpressed in certain types of cancer, including glioblastoma and ovarian cancer, where it is thought to promote tumor growth and metastasis. 3. **Cardiovascular disease**: CA7 has been implicated in cardiovascular disease, where its expression is altered in response to hypertension and atherosclerosis. 4. **Inflammatory disorders**: CA7 has been shown to play a role in inflammatory disorders, such as rheumatoid arthritis and multiple sclerosis, where its expression is altered in response to inflammation. In conclusion, CA7 is a multifunctional enzyme that plays a crucial role in maintaining cellular homeostasis and regulating various physiological processes. Its dysregulation has been implicated in various diseases, highlighting its potential as a therapeutic target. Further research is needed to fully elucidate the role of CA7 in human disease and to explore its therapeutic potential.

Genular Protein ID: 1019553735

Symbol: CAH7_HUMAN

Name: Carbonic anhydrase 7

UniProtKB Accession Codes:

P43166 Q541F0 Q86YU0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 9 DrugCentral 1 EC 2 EMBL 10 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 11 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 4 Rhea 1 SABIO-RK 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1783392

Title: Characterization of the human gene for a newly discovered carbonic anhydrase, CA VII, and its localization to chromosome 16.

PubMed ID: 1783392

DOI: 10.1016/0888-7543(91)90006-z

PubMed ID: 10493829

Title: Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.

PubMed ID: 10493829

DOI: 10.1006/geno.1999.5927

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16807956

Title: Carbonic anhydrase activators. Activation of isozymes I, II, IV, VA, VII, and XIV with l- and d-histidine and crystallographic analysis of their adducts with isoform II: engineering proton-transfer processes within the active site of an enzyme.

PubMed ID: 16807956

DOI: 10.1002/chem.200600159

PubMed ID: 16686544

Title: Carbonic anhydrase activators. Activation of isoforms I, II, IV, VA, VII, and XIV with L- and D-phenylalanine and crystallographic analysis of their adducts with isozyme II: stereospecific recognition within the active site of an enzyme and its consequences for the drug design.

PubMed ID: 16686544

DOI: 10.1021/jm0603320

PubMed ID: 17705204

Title: Saccharin inhibits carbonic anhydrases: possible explanation for its unpleasant metallic aftertaste.

PubMed ID: 17705204

DOI: 10.1002/anie.200701189

PubMed ID: 17127057

Title: Carbonic anhydrase activators: L-Adrenaline plugs the active site entrance of isozyme II, activating better isoforms I, IV, VA, VII, and XIV.

PubMed ID: 17127057

DOI: 10.1016/j.bmcl.2006.11.027

PubMed ID: 17314045

Title: Phosph(on)ate as a zinc-binding group in metalloenzyme inhibitors: X-ray crystal structure of the antiviral drug foscarnet complexed to human carbonic anhydrase I.

PubMed ID: 17314045

DOI: 10.1016/j.bmcl.2007.01.113

PubMed ID: 19186056

Title: A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases.

PubMed ID: 19186056

DOI: 10.1016/j.bmcl.2009.01.038

PubMed ID: 19206230

Title: Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors.

PubMed ID: 19206230

DOI: 10.1021/ja809683v

Sequence Information:

  • Length: 264
  • Mass: 29658
  • Checksum: 7AD559FC6E07EF96
  • Sequence:
    • MTGHHGWGYG QDDGPSHWHK LYPIAQGDRQ SPINIISSQA VYSPSLQPLE LSYEACMSLS 
ITNNGHSVQV DFNDSDDRTV VTGGPLEGPY RLKQFHFHWG KKHDVGSEHT VDGKSFPSEL 
HLVHWNAKKY STFGEAASAP DGLAVVGVFL ETGDEHPSMN RLTDALYMVR FKGTKAQFSC 
FNPKCLLPAS RHYWTYPGSL TTPPLSESVT WIVLREPICI SERQMGKFRS LLFTSEDDER 
IHMVNNFRPP QPLKGRVVKA SFRA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.