Details for: CA7

Gene ID: 766

Symbol: CA7

Ensembl ID: ENSG00000168748

Description: carbonic anhydrase 7

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 5.75
    Marker Score: 3183
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.26
    Marker Score: 2270.5
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.81
    Marker Score: 954
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.42
    Marker Score: 1587
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 873
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.15
    Marker Score: 480.5
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.14
    Marker Score: 7559
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.12
    Marker Score: 323
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.01
    Marker Score: 682.5
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71827
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48052
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1
    Marker Score: 513
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.99
    Marker Score: 466
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5353
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 329
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.87
    Marker Score: 1337
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.85
    Marker Score: 339.5
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.81
    Marker Score: 616
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1264
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.78
    Marker Score: 3263
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 400
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 691
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.71
    Marker Score: 676
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.71
    Marker Score: 181
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.7
    Marker Score: 1125
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.69
    Marker Score: 10770
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.69
    Marker Score: 454
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.66
    Marker Score: 1249
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.65
    Marker Score: 5610
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.65
    Marker Score: 1323
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.62
    Marker Score: 5864
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.6
    Marker Score: 479
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 151
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.54
    Marker Score: 5049
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.5
    Marker Score: 209
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.5
    Marker Score: 2083
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.49
    Marker Score: 2008
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.48
    Marker Score: 119
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.47
    Marker Score: 28948
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.47
    Marker Score: 323
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.46
    Marker Score: 268
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.44
    Marker Score: 251
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.43
    Marker Score: 883.5
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.41
    Marker Score: 1299
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.39
    Marker Score: 14431
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.38
    Marker Score: 231
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.38
    Marker Score: 121
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.35
    Marker Score: 211
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.34
    Marker Score: 342
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.33
    Marker Score: 337
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.31
    Marker Score: 150
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.31
    Marker Score: 99
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.31
    Marker Score: 183
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3
    Marker Score: 192
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.27
    Marker Score: 1294
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.27
    Marker Score: 69
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.25
    Marker Score: 709
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.24
    Marker Score: 178
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.24
    Marker Score: 383
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.24
    Marker Score: 571
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.24
    Marker Score: 109
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.24
    Marker Score: 108
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 66
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.23
    Marker Score: 284
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.23
    Marker Score: 133
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.22
    Marker Score: 118
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.21
    Marker Score: 8163
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.21
    Marker Score: 112
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.2
    Marker Score: 195
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2
    Marker Score: 68
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.19
    Marker Score: 83
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.18
    Marker Score: 121
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.17
    Marker Score: 3457
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.16
    Marker Score: 77
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.15
    Marker Score: 51
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.15
    Marker Score: 251
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.15
    Marker Score: 43
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.15
    Marker Score: 256
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.15
    Marker Score: 141
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.14
    Marker Score: 57
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.14
    Marker Score: 37
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 0.13
    Marker Score: 153
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.13
    Marker Score: 41
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 0.12
    Marker Score: 385.5
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.12
    Marker Score: 538
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.11
    Marker Score: 57
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.11
    Marker Score: 175
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.11
    Marker Score: 30
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.11
    Marker Score: 118
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.11
    Marker Score: 567.5
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.11
    Marker Score: 1088
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1
    Marker Score: 177
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.1
    Marker Score: 188
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.1
    Marker Score: 239.5
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.1
    Marker Score: 22
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.1
    Marker Score: 75

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Other Information

**Key characteristics:** - The protein is a transmembrane protein with a molecular weight of approximately 150 kDa. - It is a member of the carbonic anhydrase family of enzymes, which are involved in the dehydrogenation of carbon species. - It is expressed in a variety of cell types, suggesting a role in maintaining cellular pH. **Pathways and functions:** - The protein is involved in the regulation of cellular pH through the dehydrogenation of carbon dioxide. - It is a key regulator of the body's acid-base balance, as it helps to maintain a constant pH level within cells. - It is involved in the regulation of synaptic transmission in neurons, as it is expressed in neurons and is involved in the reuptake of neurotransmitters. - It is also involved in the regulation of chloride transport in cells, as it is expressed in cells that are involved in chloride reabsorption. **Clinical significance:** - Mutations in the CA7 gene have been linked to several human diseases, including cerebral palsy, epilepsy, and metabolic disorders. - These mutations can lead to a decrease in the expression of the protein, which can result in a decrease in its activity and a build-up of carbon dioxide in the cells. - This can lead to a decrease in cellular pH and a variety of neurological symptoms. **Conclusion:** The CA7 gene is an important regulator of cellular pH, and its mutations can lead to several human diseases.

Genular Protein ID: 1019553735

Symbol: CAH7_HUMAN

Name: Carbonic anhydrase 7

UniProtKB Accession Codes:

P43166 Q541F0 Q86YU0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 9 DrugCentral 1 EC 2 EMBL 10 Ensembl 2 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 11 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 4 Rhea 1 SABIO-RK 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1783392

Title: Characterization of the human gene for a newly discovered carbonic anhydrase, CA VII, and its localization to chromosome 16.

PubMed ID: 1783392

DOI: 10.1016/0888-7543(91)90006-z

PubMed ID: 10493829

Title: Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.

PubMed ID: 10493829

DOI: 10.1006/geno.1999.5927

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16807956

Title: Carbonic anhydrase activators. Activation of isozymes I, II, IV, VA, VII, and XIV with l- and d-histidine and crystallographic analysis of their adducts with isoform II: engineering proton-transfer processes within the active site of an enzyme.

PubMed ID: 16807956

DOI: 10.1002/chem.200600159

PubMed ID: 16686544

Title: Carbonic anhydrase activators. Activation of isoforms I, II, IV, VA, VII, and XIV with L- and D-phenylalanine and crystallographic analysis of their adducts with isozyme II: stereospecific recognition within the active site of an enzyme and its consequences for the drug design.

PubMed ID: 16686544

DOI: 10.1021/jm0603320

PubMed ID: 17705204

Title: Saccharin inhibits carbonic anhydrases: possible explanation for its unpleasant metallic aftertaste.

PubMed ID: 17705204

DOI: 10.1002/anie.200701189

PubMed ID: 17127057

Title: Carbonic anhydrase activators: L-Adrenaline plugs the active site entrance of isozyme II, activating better isoforms I, IV, VA, VII, and XIV.

PubMed ID: 17127057

DOI: 10.1016/j.bmcl.2006.11.027

PubMed ID: 17314045

Title: Phosph(on)ate as a zinc-binding group in metalloenzyme inhibitors: X-ray crystal structure of the antiviral drug foscarnet complexed to human carbonic anhydrase I.

PubMed ID: 17314045

DOI: 10.1016/j.bmcl.2007.01.113

PubMed ID: 19186056

Title: A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases.

PubMed ID: 19186056

DOI: 10.1016/j.bmcl.2009.01.038

PubMed ID: 19206230

Title: Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors.

PubMed ID: 19206230

DOI: 10.1021/ja809683v

Sequence Information:

  • Length: 264
  • Mass: 29658
  • Checksum: 7AD559FC6E07EF96
  • Sequence:
    • MTGHHGWGYG QDDGPSHWHK LYPIAQGDRQ SPINIISSQA VYSPSLQPLE LSYEACMSLS 
ITNNGHSVQV DFNDSDDRTV VTGGPLEGPY RLKQFHFHWG KKHDVGSEHT VDGKSFPSEL 
HLVHWNAKKY STFGEAASAP DGLAVVGVFL ETGDEHPSMN RLTDALYMVR FKGTKAQFSC 
FNPKCLLPAS RHYWTYPGSL TTPPLSESVT WIVLREPICI SERQMGKFRS LLFTSEDDER 
IHMVNNFRPP QPLKGRVVKA SFRA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.