Details for: CA8

Gene ID: 767

Symbol: CA8

Ensembl ID: ENSG00000178538

Description: carbonic anhydrase 8

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 118.1650
    Cell Significance Index: -18.3800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 81.6501
    Cell Significance Index: -20.7100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 42.0916
    Cell Significance Index: -17.1000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 17.9630
    Cell Significance Index: -17.1500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 17.8810
    Cell Significance Index: 391.5300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 16.0671
    Cell Significance Index: -19.8100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 6.3077
    Cell Significance Index: 86.0600
  • Cell Name: chandelier cell (CL4023083)
    Fold Change: 2.8782
    Cell Significance Index: 23.2400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 2.8434
    Cell Significance Index: 40.9000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 2.2126
    Cell Significance Index: 36.4600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.3448
    Cell Significance Index: 1214.2600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9233
    Cell Significance Index: 100.4300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8757
    Cell Significance Index: 142.4200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7614
    Cell Significance Index: 45.7100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6394
    Cell Significance Index: 28.9800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.5981
    Cell Significance Index: 33.5600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5113
    Cell Significance Index: 35.3600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4800
    Cell Significance Index: 22.5600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4340
    Cell Significance Index: 237.0400
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.3654
    Cell Significance Index: 5.1100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2420
    Cell Significance Index: 31.2600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.2090
    Cell Significance Index: 5.3400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1689
    Cell Significance Index: 16.7100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1506
    Cell Significance Index: 30.2200
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: 0.1419
    Cell Significance Index: 1.4200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1402
    Cell Significance Index: 4.0400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1324
    Cell Significance Index: 25.2000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1232
    Cell Significance Index: 44.1900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0425
    Cell Significance Index: 29.4100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0210
    Cell Significance Index: 4.1700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0101
    Cell Significance Index: 0.7500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0082
    Cell Significance Index: 1.4700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0046
    Cell Significance Index: 2.9100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0006
    Cell Significance Index: -0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0075
    Cell Significance Index: -14.1500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0141
    Cell Significance Index: -25.9200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0151
    Cell Significance Index: -23.1800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0197
    Cell Significance Index: -26.7800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0218
    Cell Significance Index: -16.5100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0232
    Cell Significance Index: -16.9900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0280
    Cell Significance Index: -20.7500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0356
    Cell Significance Index: -22.2200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0362
    Cell Significance Index: -20.3900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0488
    Cell Significance Index: -22.1400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0517
    Cell Significance Index: -1.3800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0568
    Cell Significance Index: -16.3300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0582
    Cell Significance Index: -1.2400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0668
    Cell Significance Index: -7.7800
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0844
    Cell Significance Index: -1.4600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0878
    Cell Significance Index: -3.0900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1011
    Cell Significance Index: -2.1900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1046
    Cell Significance Index: -12.8600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1047
    Cell Significance Index: -12.3500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.1056
    Cell Significance Index: -0.6500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1088
    Cell Significance Index: -2.2700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1103
    Cell Significance Index: -18.8300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1124
    Cell Significance Index: -23.6800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1202
    Cell Significance Index: -17.4700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1295
    Cell Significance Index: -7.9400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1356
    Cell Significance Index: -18.6200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1402
    Cell Significance Index: -16.0700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1459
    Cell Significance Index: -1.1900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1625
    Cell Significance Index: -3.3700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1787
    Cell Significance Index: -10.9900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1798
    Cell Significance Index: -18.3700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1959
    Cell Significance Index: -20.4000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2213
    Cell Significance Index: -16.9800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2374
    Cell Significance Index: -5.1300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2393
    Cell Significance Index: -18.9600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2394
    Cell Significance Index: -16.1000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2420
    Cell Significance Index: -12.5700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2848
    Cell Significance Index: -7.9600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3220
    Cell Significance Index: -16.7700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3263
    Cell Significance Index: -21.0500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3336
    Cell Significance Index: -7.0800
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.3400
    Cell Significance Index: -2.8900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3446
    Cell Significance Index: -4.9400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3561
    Cell Significance Index: -8.5400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3765
    Cell Significance Index: -19.0300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4074
    Cell Significance Index: -21.3900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4323
    Cell Significance Index: -19.1200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4366
    Cell Significance Index: -15.1700
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.4450
    Cell Significance Index: -3.6800
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.4472
    Cell Significance Index: -5.8000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.4573
    Cell Significance Index: -9.1800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4657
    Cell Significance Index: -11.9700
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.4876
    Cell Significance Index: -6.7700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4931
    Cell Significance Index: -22.9900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.4938
    Cell Significance Index: -20.2400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4955
    Cell Significance Index: -14.1400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5007
    Cell Significance Index: -17.5400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5015
    Cell Significance Index: -18.9900
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.5078
    Cell Significance Index: -6.5400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5135
    Cell Significance Index: -18.8500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.5334
    Cell Significance Index: -9.4300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5457
    Cell Significance Index: -13.6400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5463
    Cell Significance Index: -17.4000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5608
    Cell Significance Index: -15.0000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5660
    Cell Significance Index: -16.6700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Carbonic Anhydrase Activity:** CA8 exhibits carbonic anhydrase activity, which is essential for maintaining acid-base balance in cells. 2. **Tissue-Specific Expression:** CA8 is expressed in various cell types, including Purkinje cells, thymocytes, and renal cells, indicating its involvement in distinct cellular processes. 3. **Zinc Ion Binding:** CA8 binds to zinc ions, which is crucial for its enzymatic activity and protein-protein interactions. 4. **One-Carbon Metabolic Processes:** CA8 participates in one-carbon metabolic processes, which are vital for DNA synthesis, methylation, and other cellular functions. **Pathways and Functions:** CA8's involvement in various cellular processes can be attributed to its participation in the following pathways: 1. **Carbonate Dehydratase Activity:** CA8's carbonic anhydrase activity enables it to catalyze the dehydration of carbonic acid, producing bicarbonate and protons. 2. **One-Carbon Metabolic Process:** CA8's involvement in one-carbon metabolic processes is essential for maintaining the balance of one-carbon units, which are crucial for DNA synthesis and methylation. 3. **Calcium-Mediated Signaling:** CA8's interaction with calcium ions regulates calcium-mediated signaling pathways, which are vital for cellular responses to changes in calcium levels. 4. **Protein Binding:** CA8's ability to bind to proteins, including other carbonic anhydrases, enables it to participate in protein-protein interactions and regulate cellular processes. **Clinical Significance:** CA8's involvement in various cellular processes makes it an attractive target for therapeutic interventions. Abnormalities in CA8 expression have been linked to several diseases, including: 1. **Renal Disease:** CA8's expression in renal cells suggests its involvement in kidney function and disease. 2. **Neurological Disorders:** CA8's expression in Purkinje cells and other neurons indicates its potential role in neurological disorders, such as epilepsy and neurodegenerative diseases. 3. **Cancer:** CA8's expression in cancer cells suggests its involvement in tumor growth and metastasis. In conclusion, CA8's multifaceted role in various cellular processes highlights its importance in maintaining cellular homeostasis. Further research into CA8's functions and clinical significance will provide valuable insights into its potential as a therapeutic target for various diseases.

Genular Protein ID: 568900898

Symbol: CAH8_HUMAN

Name: Carbonic anhydrase-related protein

UniProtKB Accession Codes:

P35219 A8K0A5 B3KQZ7 Q32MY2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTC 1 CTD 1 ChEBI 2 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 9 Ensembl 1 EvolutionaryTrace 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 4 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8482548

Title: The deduced amino acid sequence of human carbonic anhydrase-related protein (CARP) is 98% identical to the mouse homologue.

PubMed ID: 8482548

DOI: 10.1016/0378-1119(93)90385-g

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 19360879

Title: Crystal structure of human carbonic anhydrase-related protein VIII reveals the basis for catalytic silencing.

PubMed ID: 19360879

DOI: 10.1002/prot.22411

PubMed ID: 19461874

Title: CA8 mutations cause a novel syndrome characterized by ataxia and mild mental retardation with predisposition to quadrupedal gait.

PubMed ID: 19461874

DOI: 10.1371/journal.pgen.1000487

Sequence Information:

  • Length: 290
  • Mass: 32973
  • Checksum: C142711660A972DB
  • Sequence:
    • MADLSFIEDT VAFPEKEEDE EEEEEGVEWG YEEGVEWGLV FPDANGEYQS PINLNSREAR 
YDPSLLDVRL SPNYVVCRDC EVTNDGHTIQ VILKSKSVLS GGPLPQGHEF ELYEVRFHWG 
RENQRGSEHT VNFKAFPMEL HLIHWNSTLF GSIDEAVGKP HGIAIIALFV QIGKEHVGLK 
AVTEILQDIQ YKGKSKTIPC FNPNTLLPDP LLRDYWVYEG SLTIPPCSEG VTWILFRYPL 
TISQLQIEEF RRLRTHVKGA ELVEGCDGIL GDNFRPTQPL SDRVIRAAFQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.