Details for: CA11

Gene ID: 770

Symbol: CA11

Ensembl ID: ENSG00000063180

Description: carbonic anhydrase 11

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 102.7997
    Cell Significance Index: -15.9900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 60.9123
    Cell Significance Index: -15.4500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 38.8884
    Cell Significance Index: -16.0200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 32.7034
    Cell Significance Index: -15.4400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 29.4887
    Cell Significance Index: -11.9800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 12.9972
    Cell Significance Index: -16.0300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 12.5060
    Cell Significance Index: -11.9400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.7046
    Cell Significance Index: -14.4500
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 4.4279
    Cell Significance Index: 34.1300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.0724
    Cell Significance Index: -16.0700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 2.6775
    Cell Significance Index: 45.8900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.3638
    Cell Significance Index: 124.1100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.0516
    Cell Significance Index: -4.4900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.8314
    Cell Significance Index: 367.3700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.1430
    Cell Significance Index: 72.0400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.9375
    Cell Significance Index: 7.4900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.9152
    Cell Significance Index: 20.0400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.8333
    Cell Significance Index: 10.3400
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.7346
    Cell Significance Index: 9.8000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7232
    Cell Significance Index: 71.5500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.7135
    Cell Significance Index: 20.3600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.6638
    Cell Significance Index: 29.3600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6573
    Cell Significance Index: 593.5000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.6568
    Cell Significance Index: 24.8700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.6220
    Cell Significance Index: 7.4200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.5388
    Cell Significance Index: 36.2300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.5263
    Cell Significance Index: 6.7400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5000
    Cell Significance Index: 30.0200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4803
    Cell Significance Index: 65.9600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4667
    Cell Significance Index: 50.7600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4308
    Cell Significance Index: 22.3800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.3931
    Cell Significance Index: 45.8100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3743
    Cell Significance Index: 60.8800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3357
    Cell Significance Index: 120.4200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2836
    Cell Significance Index: 8.1700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2788
    Cell Significance Index: 7.5900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2766
    Cell Significance Index: 9.6100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2468
    Cell Significance Index: 17.0700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2386
    Cell Significance Index: 45.4000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2207
    Cell Significance Index: 39.7800
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.2145
    Cell Significance Index: 2.6000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2107
    Cell Significance Index: 93.1400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2028
    Cell Significance Index: 24.9400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.1932
    Cell Significance Index: 3.1000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.1672
    Cell Significance Index: 3.5800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1249
    Cell Significance Index: 3.4900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1153
    Cell Significance Index: 5.3800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0937
    Cell Significance Index: 5.7600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0823
    Cell Significance Index: 10.5600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0812
    Cell Significance Index: 1.7600
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.0636
    Cell Significance Index: 0.5600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0578
    Cell Significance Index: 31.5400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0349
    Cell Significance Index: 65.7200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0346
    Cell Significance Index: 1.5700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0329
    Cell Significance Index: 4.2600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0327
    Cell Significance Index: 1.1500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0293
    Cell Significance Index: 2.1800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0266
    Cell Significance Index: 18.3900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0210
    Cell Significance Index: 38.7500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0184
    Cell Significance Index: 11.6600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0101
    Cell Significance Index: 15.5100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0016
    Cell Significance Index: -2.1200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0019
    Cell Significance Index: -0.3700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0053
    Cell Significance Index: -3.9100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0058
    Cell Significance Index: -0.8500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0123
    Cell Significance Index: -9.3200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0138
    Cell Significance Index: -10.2000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0153
    Cell Significance Index: -6.9300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0158
    Cell Significance Index: -1.1200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0189
    Cell Significance Index: -3.2200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0195
    Cell Significance Index: -11.0100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0276
    Cell Significance Index: -17.2600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0291
    Cell Significance Index: -0.6200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0315
    Cell Significance Index: -3.2200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0407
    Cell Significance Index: -1.0700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0463
    Cell Significance Index: -13.3100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0561
    Cell Significance Index: -0.7700
  • Cell Name: theca cell (CL0000503)
    Fold Change: -0.0570
    Cell Significance Index: -0.3400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0724
    Cell Significance Index: -1.5200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0729
    Cell Significance Index: -15.3500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0746
    Cell Significance Index: -3.5100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0759
    Cell Significance Index: -8.9500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0790
    Cell Significance Index: -9.0500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1068
    Cell Significance Index: -2.6700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1111
    Cell Significance Index: -1.2100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1177
    Cell Significance Index: -1.9700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1303
    Cell Significance Index: -7.9900
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1329
    Cell Significance Index: -1.1300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1352
    Cell Significance Index: -10.7100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1352
    Cell Significance Index: -14.0800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1359
    Cell Significance Index: -2.8200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1626
    Cell Significance Index: -3.9000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1666
    Cell Significance Index: -10.7500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1708
    Cell Significance Index: -13.1100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1726
    Cell Significance Index: -8.9900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1810
    Cell Significance Index: -5.3300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1895
    Cell Significance Index: -6.0700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2030
    Cell Significance Index: -11.3900
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.2181
    Cell Significance Index: -1.8000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.2185
    Cell Significance Index: -3.1100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CA11 is a small, soluble protein (approximately 30 kDa) that belongs to the carbonic anhydrase family, characterized by its ability to catalyze the reversible hydration of carbon dioxide to bicarbonate and protons. Unlike other carbonic anhydrases, CA11 lacks the typical zinc ion binding site, which distinguishes it from other family members. Its unique structure and enzymatic activity enable CA11 to regulate pH homeostasis and modulate various cellular processes. **Pathways and Functions:** CA11 is primarily expressed in the nervous system, where it plays a crucial role in regulating neuronal function and synaptic transmission. In the retina, CA11 is highly expressed in GABAergic and glycinergic neurons, where it modulates the activity of these inhibitory neurons. In the brain, CA11 is also found in glutamatergic neurons, particularly in the L2/3-6 intratelencephalic projecting neurons, which are involved in sensory processing and learning. Moreover, CA11 is expressed in cardiac endothelial cells, where it regulates vascular permeability and blood pressure. The enzymatic activity of CA11 is crucial for maintaining acid-base balance in the nervous system. By catalyzing the hydration of CO2, CA11 generates bicarbonate ions, which can bind to carbonic anhydrase II, an enzyme involved in the regulation of pH homeostasis. This feedback loop ensures that the pH of the extracellular environment remains stable, which is essential for proper neuronal function. **Clinical Significance:** Dysregulation of CA11 has been implicated in various neurological and cardiovascular disorders, including: 1. **Retinal diseases:** Mutations in the CA11 gene have been associated with retinal degeneration and vision loss. CA11 plays a crucial role in maintaining the acid-base balance in the retina, and its dysregulation can lead to photoreceptor degeneration. 2. **Neuropsychiatric disorders:** CA11 has been linked to various neuropsychiatric disorders, including anxiety, depression, and schizophrenia. Alterations in CA11 expression and function have been observed in patients with these disorders, suggesting a potential role for CA11 in the pathophysiology of these conditions. 3. **Cardiovascular diseases:** CA11 is expressed in cardiac endothelial cells, where it regulates vascular permeability and blood pressure. Dysregulation of CA11 has been implicated in the development of cardiovascular diseases, including hypertension and atherosclerosis. In conclusion, CA11 is a unique protein that plays a crucial role in maintaining acid-base balance and regulating various physiological processes in the nervous system and cardiovascular system. Its dysregulation has been implicated in various neurological and cardiovascular disorders, highlighting the importance of further research into the functions and clinical significance of CA11.

Genular Protein ID: 2826976511

Symbol: CAH11_HUMAN

Name: Carbonic anhydrase-related protein 11

UniProtKB Accession Codes:

O75493 O60596 Q6FHI1 Q9UEC4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EMBL 7 Ensembl 1 ExpressionAtlas 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9878543

Title: Sequence and tissue expression of a novel human carbonic anhydrase-related protein, CARP-2, mapping to chromosome 19q13.3.

PubMed ID: 9878543

DOI: 10.1006/bbrc.1998.9449

PubMed ID: 10350627

Title: cDNA sequence, mRNA expression, and chromosomal localization of human carbonic anhydrase-related protein, CA-RP XI.

PubMed ID: 10350627

DOI: 10.1016/s0167-4838(99)00067-9

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9878252

Title: Evolutionarily conserved, 'acatalytic' carbonic anhydrase-related protein XI contains a sequence motif present in the neuropeptide sauvagine: the human CA-RP XI gene (CA11) is embedded between the secretor gene cluster and the DBP gene at 19q13.3.

PubMed ID: 9878252

DOI: 10.1006/geno.1998.5585

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

Sequence Information:

  • Length: 328
  • Mass: 36238
  • Checksum: A4FC408718B2E857
  • Sequence:
    • MGAAARLSAP RALVLWAALG AAAHIGPAPD PEDWWSYKDN LQGNFVPGPP FWGLVNAAWS 
LCAVGKRQSP VDVELKRVLY DPFLPPLRLS TGGEKLRGTL YNTGRHVSFL PAPRPVVNVS 
GGPLLYSHRL SELRLLFGAR DGAGSEHQIN HQGFSAEVQL IHFNQELYGN FSAASRGPNG 
LAILSLFVNV ASTSNPFLSR LLNRDTITRI SYKNDAYFLQ DLSLELLFPE SFGFITYQGS 
LSTPPCSETV TWILIDRALN ITSLQMHSLR LLSQNPPSQI FQSLSGNSRP LQPLAHRALR 
GNRDPRHPER RCRGPNYRLH VDGVPHGR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.