Details for: CA11

Gene ID: 770

Symbol: CA11

Ensembl ID: ENSG00000063180

Description: carbonic anhydrase 11

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.13
    Marker Score: 4319
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.93
    Marker Score: 2333
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.57
    Marker Score: 1480
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.49
    Marker Score: 91843
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.34
    Marker Score: 2544
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.28
    Marker Score: 12202
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.27
    Marker Score: 2578
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.25
    Marker Score: 1923.5
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.2
    Marker Score: 10333
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.14
    Marker Score: 478.5
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.03
    Marker Score: 16118
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1
    Marker Score: 9422
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1
    Marker Score: 601
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71777
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48000
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30404
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 488
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.94
    Marker Score: 1295
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 442
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.92
    Marker Score: 252
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2725
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.9
    Marker Score: 468
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.89
    Marker Score: 5074
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.87
    Marker Score: 222
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.87
    Marker Score: 3540.5
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5266
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 310
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.85
    Marker Score: 12699
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.84
    Marker Score: 16749
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.78
    Marker Score: 5080
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.77
    Marker Score: 28432
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.77
    Marker Score: 512
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.77
    Marker Score: 240
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.76
    Marker Score: 246
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.76
    Marker Score: 1232
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.75
    Marker Score: 796.5
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.74
    Marker Score: 829
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.74
    Marker Score: 2105
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.73
    Marker Score: 559
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 378
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.73
    Marker Score: 3021
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.73
    Marker Score: 1521
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.73
    Marker Score: 2805
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.72
    Marker Score: 5539
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.72
    Marker Score: 7435
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.71
    Marker Score: 648
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.71
    Marker Score: 284
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7
    Marker Score: 2924
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.69
    Marker Score: 222
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.68
    Marker Score: 153
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.67
    Marker Score: 25336
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 170
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.66
    Marker Score: 1797
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.65
    Marker Score: 310
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.65
    Marker Score: 377
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.64
    Marker Score: 1077
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.63
    Marker Score: 1076
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.63
    Marker Score: 876
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.63
    Marker Score: 187
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.61
    Marker Score: 206
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.57
    Marker Score: 2641
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.56
    Marker Score: 1189.5
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.55
    Marker Score: 128
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 435
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.54
    Marker Score: 575
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.54
    Marker Score: 2260
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.54
    Marker Score: 171
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.54
    Marker Score: 1445
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.53
    Marker Score: 1259
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.53
    Marker Score: 586
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.53
    Marker Score: 2190
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.52
    Marker Score: 5896
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.52
    Marker Score: 180
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.52
    Marker Score: 544
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.52
    Marker Score: 330
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.52
    Marker Score: 339
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.51
    Marker Score: 5127
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.48
    Marker Score: 1102
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.48
    Marker Score: 639
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.47
    Marker Score: 1341
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.47
    Marker Score: 208
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.47
    Marker Score: 230
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.47
    Marker Score: 1144
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.46
    Marker Score: 185
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.46
    Marker Score: 649
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.46
    Marker Score: 9784
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.45
    Marker Score: 1143
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.45
    Marker Score: 2429
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.44
    Marker Score: 130
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.44
    Marker Score: 3311
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.44
    Marker Score: 454
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.44
    Marker Score: 441.5
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.43
    Marker Score: 307
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.42
    Marker Score: 448
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.41
    Marker Score: 273
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.41
    Marker Score: 106
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.4
    Marker Score: 366
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.4
    Marker Score: 235
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.4
    Marker Score: 13355

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Other Information

**Key characteristics:** * Gene Name: CA11 * Ensembl ID: ENSG00000063180 * Protein: CAH11_HUMAN * Function: Carbonic anhydrase * Pathway: Basolateral plasma membrane, Carbonate dehydratase activity, Extracellular region, Hydro-lyase activity, One-carbon metabolic process, Zinc ion binding * Expression: Significantly expressed in GABAergic amacrine cell, glycinergic neuron, glycinergic amacrine cell, L2/3-6 intratelencephalic projecting glutamatergic neuron, cardiac endothelial cell, corticothalamic-projecting glutamatergic cortical neuron, immature innate lymphoid cell, L5 extratelencephalic projecting glutamatergic cortical neuron, L6b glutamatergic cortical neuron, OFF retinal ganglion cell **Pathways and functions:** The CA11 gene is involved in multiple pathways and functions, including: * Regulation of calcium and phosphate homeostasis * Regulation of the blood-brain barrier * Regulation of neuronal excitability * Regulation of synaptic plasticity * Tumor growth and metastasis **Clinical significance:** The CA11 gene has been implicated in several human diseases, including: * Autism spectrum disorder * Schizophrenia * Depression * Epilepsy * Cancer Mutations in the CA11 gene have been linked to the development of these disorders.

Genular Protein ID: 2826976511

Symbol: CAH11_HUMAN

Name: Carbonic anhydrase-related protein 11

UniProtKB Accession Codes:

O75493 O60596 Q6FHI1 Q9UEC4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 7 Ensembl 1 ExpressionAtlas 1 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9878543

Title: Sequence and tissue expression of a novel human carbonic anhydrase-related protein, CARP-2, mapping to chromosome 19q13.3.

PubMed ID: 9878543

DOI: 10.1006/bbrc.1998.9449

PubMed ID: 10350627

Title: cDNA sequence, mRNA expression, and chromosomal localization of human carbonic anhydrase-related protein, CA-RP XI.

PubMed ID: 10350627

DOI: 10.1016/s0167-4838(99)00067-9

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9878252

Title: Evolutionarily conserved, 'acatalytic' carbonic anhydrase-related protein XI contains a sequence motif present in the neuropeptide sauvagine: the human CA-RP XI gene (CA11) is embedded between the secretor gene cluster and the DBP gene at 19q13.3.

PubMed ID: 9878252

DOI: 10.1006/geno.1998.5585

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

Sequence Information:

  • Length: 328
  • Mass: 36238
  • Checksum: A4FC408718B2E857
  • Sequence:
    • MGAAARLSAP RALVLWAALG AAAHIGPAPD PEDWWSYKDN LQGNFVPGPP FWGLVNAAWS 
LCAVGKRQSP VDVELKRVLY DPFLPPLRLS TGGEKLRGTL YNTGRHVSFL PAPRPVVNVS 
GGPLLYSHRL SELRLLFGAR DGAGSEHQIN HQGFSAEVQL IHFNQELYGN FSAASRGPNG 
LAILSLFVNV ASTSNPFLSR LLNRDTITRI SYKNDAYFLQ DLSLELLFPE SFGFITYQGS 
LSTPPCSETV TWILIDRALN ITSLQMHSLR LLSQNPPSQI FQSLSGNSRP LQPLAHRALR 
GNRDPRHPER RCRGPNYRLH VDGVPHGR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.