Details for: CA12
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 25.1900
Cell Significance Index: -24.0500 - Cell Name: columnar/cuboidal epithelial cell (CL0000075)
Fold Change: 18.2372
Cell Significance Index: 69.8300 - Cell Name: epithelial cell of sweat gland (CL1000448)
Fold Change: 13.8247
Cell Significance Index: 9.8800 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 9.4182
Cell Significance Index: -25.2300 - Cell Name: epidermal cell (CL0000362)
Fold Change: 8.2946
Cell Significance Index: 18.7000 - Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 7.5964
Cell Significance Index: 46.7500 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 6.9365
Cell Significance Index: 94.6400 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 6.4004
Cell Significance Index: 178.8700 - Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 6.3358
Cell Significance Index: 21.7600 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 4.0620
Cell Significance Index: -8.8900 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 3.8603
Cell Significance Index: 200.5300 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 3.3848
Cell Significance Index: 153.4200 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 3.1133
Cell Significance Index: 137.7100 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: 3.0966
Cell Significance Index: 46.4000 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 2.8653
Cell Significance Index: 108.5000 - Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 1.4290
Cell Significance Index: 4.2500 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.3781
Cell Significance Index: 102.7100 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 1.3620
Cell Significance Index: 20.7200 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.3203
Cell Significance Index: 238.0000 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.3037
Cell Significance Index: 248.1000 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.2091
Cell Significance Index: 119.6100 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.9444
Cell Significance Index: 116.1200 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.8985
Cell Significance Index: 146.1400 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.8940
Cell Significance Index: 63.2300 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.7082
Cell Significance Index: 519.2600 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.6615
Cell Significance Index: 361.2600 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.5500
Cell Significance Index: 25.6500 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.5459
Cell Significance Index: 93.2100 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.5284
Cell Significance Index: 36.5400 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.5214
Cell Significance Index: 16.7000 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.4754
Cell Significance Index: 55.4000 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.4683
Cell Significance Index: 207.0300 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.4513
Cell Significance Index: 407.4500 - Cell Name: large intestine goblet cell (CL1000320)
Fold Change: 0.4355
Cell Significance Index: 4.7200 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.4135
Cell Significance Index: 82.0700 - Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 0.3470
Cell Significance Index: 3.3100 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.1983
Cell Significance Index: 6.8900 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.1718
Cell Significance Index: 8.0800 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1437
Cell Significance Index: 5.0500 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 0.1389
Cell Significance Index: 3.3700 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.1267
Cell Significance Index: 3.6500 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.1183
Cell Significance Index: 1.8300 - Cell Name: glioblast (CL0000030)
Fold Change: 0.0748
Cell Significance Index: 0.4700 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.0694
Cell Significance Index: 8.9700 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.0674
Cell Significance Index: 1.4600 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.0579
Cell Significance Index: 36.1800 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.0530
Cell Significance Index: 2.6800 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0515
Cell Significance Index: 23.3800 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0449
Cell Significance Index: 16.1100 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0334
Cell Significance Index: 23.1200 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0220
Cell Significance Index: 0.5500 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0064
Cell Significance Index: -11.9700 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0112
Cell Significance Index: -8.2600 - Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: -0.0118
Cell Significance Index: -0.0900 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0125
Cell Significance Index: -1.2800 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0137
Cell Significance Index: -25.2200 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0147
Cell Significance Index: -22.6300 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0163
Cell Significance Index: -12.3100 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0175
Cell Significance Index: -9.8600 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0198
Cell Significance Index: -26.8700 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.0272
Cell Significance Index: -0.5800 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0378
Cell Significance Index: -7.5900 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0380
Cell Significance Index: -24.1300 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.0523
Cell Significance Index: -4.1400 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0554
Cell Significance Index: -11.6600 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0600
Cell Significance Index: -17.2500 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0765
Cell Significance Index: -8.7600 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.1064
Cell Significance Index: -14.6100 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.1177
Cell Significance Index: -15.0900 - Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: -0.1265
Cell Significance Index: -1.1400 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.1302
Cell Significance Index: -2.8500 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1615
Cell Significance Index: -23.4700 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.1777
Cell Significance Index: -20.2800 - Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: -0.2050
Cell Significance Index: -2.6400 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2052
Cell Significance Index: -21.3700 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.2054
Cell Significance Index: -5.5900 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.2096
Cell Significance Index: -12.8500 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.2894
Cell Significance Index: -2.6700 - Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: -0.3135
Cell Significance Index: -4.3500 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.3331
Cell Significance Index: -25.5600 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.3398
Cell Significance Index: -22.8500 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.3407
Cell Significance Index: -6.6500 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.3722
Cell Significance Index: -23.4600 - Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: -0.4037
Cell Significance Index: -2.6800 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.4250
Cell Significance Index: -17.4100 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.4301
Cell Significance Index: -22.5800 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.4350
Cell Significance Index: -24.4100 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.4484
Cell Significance Index: -27.5600 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.4602
Cell Significance Index: -23.9700 - Cell Name: keratinocyte (CL0000312)
Fold Change: -0.4632
Cell Significance Index: -11.5700 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.4715
Cell Significance Index: -9.7800 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.4745
Cell Significance Index: -17.4200 - Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: -0.5753
Cell Significance Index: -5.5400 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.5789
Cell Significance Index: -14.8800 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.5918
Cell Significance Index: -17.4300 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: -0.6148
Cell Significance Index: -4.4700 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.6296
Cell Significance Index: -22.0600 - Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: -0.6338
Cell Significance Index: -6.6600 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.6556
Cell Significance Index: -17.2400 - Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: -0.6622
Cell Significance Index: -6.0400
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 4203576834
Symbol: CAH12_HUMAN
Name: Carbonate dehydratase XII
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9636197
Title: Human carbonic anhydrase XII: cDNA cloning, expression, and chromosomal localization of a carbonic anhydrase gene that is overexpressed in some renal cell cancers.
PubMed ID: 9636197
PubMed ID: 9770531
Title: Down-regulation of transmembrane carbonic anhydrases in renal cell carcinoma cell lines by wild-type von Hippel-Lindau transgenes.
PubMed ID: 9770531
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 17705204
Title: Saccharin inhibits carbonic anhydrases: possible explanation for its unpleasant metallic aftertaste.
PubMed ID: 17705204
PubMed ID: 17314045
Title: Phosph(on)ate as a zinc-binding group in metalloenzyme inhibitors: X-ray crystal structure of the antiviral drug foscarnet complexed to human carbonic anhydrase I.
PubMed ID: 17314045
PubMed ID: 17407288
Title: Structural analysis of charge discrimination in the binding of inhibitors to human carbonic anhydrases I and II.
PubMed ID: 17407288
DOI: 10.1021/ja068359w
PubMed ID: 19186056
Title: A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases.
PubMed ID: 19186056
PubMed ID: 19206230
Title: Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors.
PubMed ID: 19206230
DOI: 10.1021/ja809683v
PubMed ID: 18618712
Title: Crystal structure of human carbonic anhydrase XIII and its complex with the inhibitor acetazolamide.
PubMed ID: 18618712
DOI: 10.1002/prot.22144
PubMed ID: 26911677
Title: Loss of carbonic anhydrase XII function in individuals with elevated sweat chloride concentration and pulmonary airway disease.
PubMed ID: 26911677
DOI: 10.1093/hmg/ddw065
PubMed ID: 11493685
Title: Crystal structure of the dimeric extracellular domain of human carbonic anhydrase XII, a bitopic membrane protein overexpressed in certain cancer tumor cells.
PubMed ID: 11493685
PubMed ID: 21035102
Title: Hyperchlorhidrosis caused by homozygous mutation in CA12, encoding carbonic anhydrase XII.
PubMed ID: 21035102
PubMed ID: 21184099
Title: Autosomal recessive hyponatremia due to isolated salt wasting in sweat associated with a mutation in the active site of carbonic cnhydrase 12.
PubMed ID: 21184099
Sequence Information:
- Length: 354
- Mass: 39451
- Checksum: 9016216BF2CA6C0C
- Sequence:
MPRRSLHAAA VLLLVILKEQ PSSPAPVNGS KWTYFGPDGE NSWSKKYPSC GGLLQSPIDL HSDILQYDAS LTPLEFQGYN LSANKQFLLT NNGHSVKLNL PSDMHIQGLQ SRYSATQLHL HWGNPNDPHG SEHTVSGQHF AAELHIVHYN SDLYPDASTA SNKSEGLAVL AVLIEMGSFN PSYDKIFSHL QHVKYKGQEA FVPGFNIEEL LPERTAEYYR YRGSLTTPPC NPTVLWTVFR NPVQISQEQL LALETALYCT HMDDPSPREM INNFRQVQKF DERLVYTSFS QVQVCTAAGL SLGIILSLAL AGILGICIVV VVSIWLFRRK SIKKGDNKGV IYKPATKMET EAHA
Genular Protein ID: 499028068
Symbol: B3KUB4_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 11181995
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 16572171
Title: Analysis of the DNA sequence and duplication history of human chromosome 15.
PubMed ID: 16572171
DOI: 10.1038/nature04601
Sequence Information:
- Length: 283
- Mass: 31857
- Checksum: F0A4459547CCAF8E
- Sequence:
MPRRSLHAAA VLLLVILKEQ PSSPAPVNGS KWTYFVKLNL PSDMHIQGLQ SRYSATQLHL HWGNPNDPHG SEHTVSGQHF AAELHIVHYN SDLYPDASTA SNKSEGLAVL AVLIEMGSFN PSYDKIFSHL QHVKYKGQEA FVPGFNIEEL LPERTAEYYR YRGSLTTPPC NPTVLWTVFR NPVQISQEQL LALETALYCT HMDDPSPREM INNFRQVQKF DERLVYTSFS QGIILSLALA GILGICIVVV VSIWLFRRKS IKKGDNKGVI YKPATKMETE AHA
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.