Details for: CACNA1B
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 120.4902
Cell Significance Index: -48.9500 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 5.7624
Cell Significance Index: 2066.8800 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 5.2093
Cell Significance Index: 230.4200 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 4.9072
Cell Significance Index: 185.8300 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 4.6354
Cell Significance Index: 132.2800 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 3.9943
Cell Significance Index: 268.5800 - Cell Name: hippocampal interneuron (CL1001569)
Fold Change: 3.5926
Cell Significance Index: 46.5900 - Cell Name: midget ganglion cell of retina (CL4023188)
Fold Change: 3.3379
Cell Significance Index: 34.7700 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 3.3378
Cell Significance Index: 669.5600 - Cell Name: cortical interneuron (CL0008031)
Fold Change: 3.1677
Cell Significance Index: 75.9700 - Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: 2.9244
Cell Significance Index: 39.0100 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 2.8677
Cell Significance Index: 176.2600 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 2.7860
Cell Significance Index: 1926.8900 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 2.7854
Cell Significance Index: 60.9900 - Cell Name: pyramidal neuron (CL0000598)
Fold Change: 2.1910
Cell Significance Index: 16.8100 - Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: 0.4090
Cell Significance Index: 5.1000 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.2410
Cell Significance Index: 4.1300 - Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 0.2047
Cell Significance Index: 1.6900 - Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 0.1261
Cell Significance Index: 1.2000 - Cell Name: glutamatergic neuron (CL0000679)
Fold Change: 0.0486
Cell Significance Index: 0.5300 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: 0.0112
Cell Significance Index: 0.2300 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 0.0010
Cell Significance Index: 0.0200 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0122
Cell Significance Index: -22.9900 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0176
Cell Significance Index: -32.4500 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0207
Cell Significance Index: -28.1700 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0215
Cell Significance Index: -33.1000 - Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: -0.0293
Cell Significance Index: -0.3700 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0504
Cell Significance Index: -37.3000 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0753
Cell Significance Index: -57.0100 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0774
Cell Significance Index: -49.1600 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0810
Cell Significance Index: -45.6900 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0959
Cell Significance Index: -52.3500 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0998
Cell Significance Index: -62.3200 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.1018
Cell Significance Index: -46.1900 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.1381
Cell Significance Index: -4.5200 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1466
Cell Significance Index: -42.1800 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.1750
Cell Significance Index: -4.3600 - Cell Name: neural cell (CL0002319)
Fold Change: -0.1800
Cell Significance Index: -2.1000 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.1814
Cell Significance Index: -5.0700 - Cell Name: GABAergic neuron (CL0000617)
Fold Change: -0.2060
Cell Significance Index: -2.6000 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.2108
Cell Significance Index: -9.1700 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.2182
Cell Significance Index: -6.9500 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.2381
Cell Significance Index: -3.4100 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.2412
Cell Significance Index: -47.8600 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.2420
Cell Significance Index: -13.5800 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2480
Cell Significance Index: -52.2300 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.2502
Cell Significance Index: -45.1000 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.2841
Cell Significance Index: -6.0300 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.2958
Cell Significance Index: -6.3900 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.3086
Cell Significance Index: -52.7000 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.3231
Cell Significance Index: -46.9600 - Cell Name: neuron (CL0000540)
Fold Change: -0.3524
Cell Significance Index: -3.3400 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.3757
Cell Significance Index: -51.5900 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.3780
Cell Significance Index: -46.4800 - Cell Name: inhibitory interneuron (CL0000498)
Fold Change: -0.3863
Cell Significance Index: -4.6200 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.4899
Cell Significance Index: -57.0900 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.4912
Cell Significance Index: -51.1500 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.5005
Cell Significance Index: -38.4100 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.5090
Cell Significance Index: -58.3200 - Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
Fold Change: -0.5592
Cell Significance Index: -6.1700 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.6631
Cell Significance Index: -16.5400 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.6893
Cell Significance Index: -36.1900 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.7253
Cell Significance Index: -25.4100 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.8332
Cell Significance Index: -17.3900 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.9107
Cell Significance Index: -57.4000 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.9367
Cell Significance Index: -48.7900 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -0.9933
Cell Significance Index: -6.7300 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -1.0667
Cell Significance Index: -13.2300 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -1.0814
Cell Significance Index: -50.8300 - Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
Fold Change: -1.0837
Cell Significance Index: -14.4500 - Cell Name: myeloid dendritic cell (CL0000782)
Fold Change: -1.0978
Cell Significance Index: -8.6100 - Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
Fold Change: -1.1007
Cell Significance Index: -21.9500 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: -1.1386
Cell Significance Index: -22.4100 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -1.1583
Cell Significance Index: -42.5200 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -1.1729
Cell Significance Index: -20.2800 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -1.3461
Cell Significance Index: -47.3000 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: -1.3462
Cell Significance Index: -13.5600 - Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: -1.3726
Cell Significance Index: -8.9300 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -1.4016
Cell Significance Index: -72.8100 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -1.4371
Cell Significance Index: -36.9400 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -1.4394
Cell Significance Index: -67.1100 - Cell Name: peg cell (CL4033014)
Fold Change: -1.4970
Cell Significance Index: -34.5900 - Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
Fold Change: -1.6180
Cell Significance Index: -16.6400 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -1.6330
Cell Significance Index: -47.0500 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -1.7048
Cell Significance Index: -36.4400 - Cell Name: lens fiber cell (CL0011004)
Fold Change: -1.7775
Cell Significance Index: -56.2200 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -1.8106
Cell Significance Index: -45.2600 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -1.8297
Cell Significance Index: -37.2300 - Cell Name: keratinocyte (CL0000312)
Fold Change: -1.8321
Cell Significance Index: -45.7600 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -1.8370
Cell Significance Index: -52.6600 - Cell Name: granulosa cell (CL0000501)
Fold Change: -1.9333
Cell Significance Index: -50.8400 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -1.9920
Cell Significance Index: -53.1900 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -2.0008
Cell Significance Index: -53.5200 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -2.0192
Cell Significance Index: -59.4800 - Cell Name: type I muscle cell (CL0002211)
Fold Change: -2.0296
Cell Significance Index: -49.5200 - Cell Name: erythrocyte (CL0000232)
Fold Change: -2.0341
Cell Significance Index: -51.8300 - Cell Name: hippocampal astrocyte (CL0002604)
Fold Change: -2.0889
Cell Significance Index: -29.2100 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -2.1459
Cell Significance Index: -46.4900 - Cell Name: interneuron (CL0000099)
Fold Change: -2.1677
Cell Significance Index: -25.3200 - Cell Name: secretory cell (CL0000151)
Fold Change: -2.1738
Cell Significance Index: -15.0800
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3918820872
Symbol: CAC1B_HUMAN
Name: Voltage-dependent N-type calcium channel subunit alpha-1B
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1321501
Title: Structure and functional expression of an omega-conotoxin-sensitive human N-type calcium channel.
PubMed ID: 1321501
PubMed ID: 15164053
Title: DNA sequence and analysis of human chromosome 9.
PubMed ID: 15164053
DOI: 10.1038/nature02465
PubMed ID: 9030575
Title: Isolation and characterization of the 5'-upstream region of the human N-type calcium channel alpha1B subunit gene. Chromosomal localization and promoter analysis.
PubMed ID: 9030575
PubMed ID: 25296916
Title: CACNA1B mutation is linked to unique myoclonus-dystonia syndrome.
PubMed ID: 25296916
DOI: 10.1093/hmg/ddu513
PubMed ID: 26157024
Title: The CACNA1B R1389H variant is not associated with myoclonus-dystonia in a large European multicentric cohort.
PubMed ID: 26157024
DOI: 10.1093/hmg/ddv255
PubMed ID: 30982612
Title: Bi-allelic loss-of-function CACNA1B mutations in progressive epilepsy-dyskinesia.
PubMed ID: 30982612
PubMed ID: 34234349
Title: Structure of human Cav2.2 channel blocked by the painkiller ziconotide.
PubMed ID: 34234349
Sequence Information:
- Length: 2339
- Mass: 262496
- Checksum: 17A45C6D1E76B39D
- Sequence:
MVRFGDELGG RYGGPGGGER ARGGGAGGAG GPGPGGLQPG QRVLYKQSIA QRARTMALYN PIPVKQNCFT VNRSLFVFSE DNVVRKYAKR ITEWPPFEYM ILATIIANCI VLALEQHLPD GDKTPMSERL DDTEPYFIGI FCFEAGIKII ALGFVFHKGS YLRNGWNVMD FVVVLTGILA TAGTDFDLRT LRAVRVLRPL KLVSGIPSLQ VVLKSIMKAM VPLLQIGLLL FFAILMFAII GLEFYMGKFH KACFPNSTDA EPVGDFPCGK EAPARLCEGD TECREYWPGP NFGITNFDNI LFAILTVFQC ITMEGWTDIL YNTNDAAGNT WNWLYFIPLI IIGSFFMLNL VLGVLSGEFA KERERVENRR AFLKLRRQQQ IERELNGYLE WIFKAEEVML AEEDRNAEEK SPLDVLKRAA TKKSRNDLIH AEEGEDRFAD LCAVGSPFAR ASLKSGKTES SSYFRRKEKM FRFFIRRMVK AQSFYWVVLC VVALNTLCVA MVHYNQPRRL TTTLYFAEFV FLGLFLTEMS LKMYGLGPRS YFRSSFNCFD FGVIVGSVFE VVWAAIKPGS SFGISVLRAL RLLRIFKVTK YWSSLRNLVV SLLNSMKSII SLLFLLFLFI VVFALLGMQL FGGQFNFQDE TPTTNFDTFP AAILTVFQIL TGEDWNAVMY HGIESQGGVS KGMFSSFYFI VLTLFGNYTL LNVFLAIAVD NLANAQELTK DEEEMEEAAN QKLALQKAKE VAEVSPMSAA NISIAARQQN SAKARSVWEQ RASQLRLQNL RASCEALYSE MDPEERLRFA TTRHLRPDMK THLDRPLVVE LGRDGARGPV GGKARPEAAE APEGVDPPRR HHRHRDKDKT PAAGDQDRAE APKAESGEPG AREERPRPHR SHSKEAAGPP EARSERGRGP GPEGGRRHHR RGSPEEAAER EPRRHRAHRH QDPSKECAGA KGERRARHRG GPRAGPREAE SGEEPARRHR ARHKAQPAHE AVEKETTEKE ATEKEAEIVE ADKEKELRNH QPREPHCDLE TSGTVTVGPM HTLPSTCLQK VEEQPEDADN QRNVTRMGSQ PPDPNTIVHI PVMLTGPLGE ATVVPSGNVD LESQAEGKKE VEADDVMRSG PRPIVPYSSM FCLSPTNLLR RFCHYIVTMR YFEVVILVVI ALSSIALAAE DPVRTDSPRN NALKYLDYIF TGVFTFEMVI KMIDLGLLLH PGAYFRDLWN ILDFIVVSGA LVAFAFSGSK GKDINTIKSL RVLRVLRPLK TIKRLPKLKA VFDCVVNSLK NVLNILIVYM LFMFIFAVIA VQLFKGKFFY CTDESKELER DCRGQYLDYE KEEVEAQPRQ WKKYDFHYDN VLWALLTLFT VSTGEGWPMV LKHSVDATYE EQGPSPGYRM ELSIFYVVYF VVFPFFFVNI FVALIIITFQ EQGDKVMSEC SLEKNERACI DFAISAKPLT RYMPQNRQSF QYKTWTFVVS PPFEYFIMAM IALNTVVLMM KFYDAPYEYE LMLKCLNIVF TSMFSMECVL KIIAFGVLNY FRDAWNVFDF VTVLGSITDI LVTEIAETNN FINLSFLRLF RAARLIKLLR QGYTIRILLW TFVQSFKALP YVCLLIAMLF FIYAIIGMQV FGNIALDDDT SINRHNNFRT FLQALMLLFR SATGEAWHEI MLSCLSNQAC DEQANATECG SDFAYFYFVS FIFLCSFLML NLFVAVIMDN FEYLTRDSSI LGPHHLDEFI RVWAEYDPAA CGRISYNDMF EMLKHMSPPL GLGKKCPARV AYKRLVRMNM PISNEDMTVH FTSTLMALIR TALEIKLAPA GTKQHQCDAE LRKEISVVWA NLPQKTLDLL VPPHKPDEMT VGKVYAALMI FDFYKQNKTT RDQMQQAPGG LSQMGPVSLF HPLKATLEQT QPAVLRGARV FLRQKSSTSL SNGGAIQNQE SGIKESVSWG TQRTQDAPHE ARPPLERGHS TEIPVGRSGA LAVDVQMQSI TRRGPDGEPQ PGLESQGRAA SMPRLAAETQ PVTDASPMKR SISTLAQRPR GTHLCSTTPD RPPPSQASSH HHHHRCHRRR DRKQRSLEKG PSLSADMDGA PSSAVGPGLP PGEGPTGCRR ERERRQERGR SQERRQPSSS SSEKQRFYSC DRFGGREPPK PKPSLSSHPT SPTAGQEPGP HPQGSGSVNG SPLLSTSGAS TPGRGGRRQL PQTPLTPRPS ITYKTANSSP IHFAGAQTSL PAFSPGRLSR GLSEHNALLQ RDPLSQPLAP GSRIGSDPYL GQRLDSEASV HALPEDTLTF EEAVATNSGR SSRTSYVSSL TSQSHPLRRV PNGYHCTLGL SSGGRARHSY HHPDQDHWC
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.