Details for: CACNA1B
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: erythrocyte (CL0000232)
Fold Change: 4.73
Marker Score: 2,619 - Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 3.88
Marker Score: 17,966 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 3.77
Marker Score: 127,418 - Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
Fold Change: 3.24
Marker Score: 16,975 - Cell Name: stellate neuron (CL0000122)
Fold Change: 3.1
Marker Score: 16,655 - Cell Name: macroglial cell (CL0000126)
Fold Change: 3.06
Marker Score: 7,024 - Cell Name: pyramidal neuron (CL0000598)
Fold Change: 2.96
Marker Score: 4,970 - Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 2.86
Marker Score: 8,159 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 2.86
Marker Score: 56,797 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 2.85
Marker Score: 21,868 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 2.83
Marker Score: 42,334 - Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 2.7
Marker Score: 102,701 - Cell Name: granule cell (CL0000120)
Fold Change: 2.65
Marker Score: 19,983 - Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 2.57
Marker Score: 1,078 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 2.56
Marker Score: 10,604 - Cell Name: brainstem motor neuron (CL2000047)
Fold Change: 2.46
Marker Score: 1,427 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 2.4
Marker Score: 88,643 - Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 2.37
Marker Score: 9,144 - Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 2.3
Marker Score: 2,869 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 2.19
Marker Score: 20,601 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 2.18
Marker Score: 840 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.07
Marker Score: 127,542 - Cell Name: A2 amacrine cell (CL0004219)
Fold Change: 2.06
Marker Score: 652 - Cell Name: neuron (CL0000540)
Fold Change: 2.03
Marker Score: 8,250 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 2.02
Marker Score: 20,844 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.93
Marker Score: 18,303 - Cell Name: chromaffin cell (CL0000166)
Fold Change: 1.92
Marker Score: 2,705 - Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 1.92
Marker Score: 525 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.88
Marker Score: 16,150 - Cell Name: sympathetic neuron (CL0011103)
Fold Change: 1.86
Marker Score: 613 - Cell Name: interneuron (CL0000099)
Fold Change: 1.8
Marker Score: 821 - Cell Name: neuronal brush cell (CL0000555)
Fold Change: 1.76
Marker Score: 5,899 - Cell Name: CNS interneuron (CL0000402)
Fold Change: 1.74
Marker Score: 834 - Cell Name: ganglion interneuron (CL0000397)
Fold Change: 1.68
Marker Score: 511 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.65
Marker Score: 2,548 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 1.6
Marker Score: 34,169 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.58
Marker Score: 2,993 - Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 1.49
Marker Score: 670 - Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 1.49
Marker Score: 836 - Cell Name: mural cell (CL0008034)
Fold Change: 1.46
Marker Score: 167,430 - Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 1.38
Marker Score: 725 - Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.37
Marker Score: 869 - Cell Name: GABAergic neuron (CL0000617)
Fold Change: 1.26
Marker Score: 5,267 - Cell Name: mature astrocyte (CL0002627)
Fold Change: 1.13
Marker Score: 747 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.05
Marker Score: 2,143 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.02
Marker Score: 2,592 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.02
Marker Score: 15,954 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,799 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48,026 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,406 - Cell Name: microglial cell (CL0000129)
Fold Change: 0.94
Marker Score: 1,703 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5,334 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2,743 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.88
Marker Score: 671 - Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.87
Marker Score: 365 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,286 - Cell Name: astrocyte (CL0000127)
Fold Change: 0.84
Marker Score: 731 - Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 0.83
Marker Score: 960 - Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.82
Marker Score: 1,016 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1,263 - Cell Name: brush cell (CL0002204)
Fold Change: 0.77
Marker Score: 707 - Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 396 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.76
Marker Score: 454 - Cell Name: glutamatergic neuron (CL0000679)
Fold Change: 0.75
Marker Score: 7,629 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.7
Marker Score: 419 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.7
Marker Score: 179 - Cell Name: photoreceptor cell (CL0000210)
Fold Change: 0.68
Marker Score: 512 - Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.67
Marker Score: 212 - Cell Name: endocrine cell (CL0000163)
Fold Change: 0.65
Marker Score: 335 - Cell Name: starburst amacrine cell (CL0004232)
Fold Change: 0.64
Marker Score: 183 - Cell Name: precursor B cell (CL0000817)
Fold Change: 0.58
Marker Score: 386 - Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.58
Marker Score: 461 - Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.58
Marker Score: 1,195 - Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.56
Marker Score: 148 - Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
Fold Change: 0.55
Marker Score: 186 - Cell Name: myeloid cell (CL0000763)
Fold Change: 0.54
Marker Score: 862 - Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.52
Marker Score: 249 - Cell Name: visceromotor neuron (CL0005025)
Fold Change: 0.5
Marker Score: 146 - Cell Name: germ cell (CL0000586)
Fold Change: 0.5
Marker Score: 871 - Cell Name: meningeal macrophage (CL0000879)
Fold Change: 0.49
Marker Score: 139 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.47
Marker Score: 957 - Cell Name: glial cell (CL0000125)
Fold Change: 0.46
Marker Score: 511 - Cell Name: oligodendrocyte (CL0000128)
Fold Change: 0.45
Marker Score: 1,080 - Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 0.45
Marker Score: 504 - Cell Name: ependymal cell (CL0000065)
Fold Change: 0.45
Marker Score: 157 - Cell Name: melanocyte (CL0000148)
Fold Change: 0.45
Marker Score: 181 - Cell Name: mature microglial cell (CL0002629)
Fold Change: 0.44
Marker Score: 158 - Cell Name: pro-B cell (CL0000826)
Fold Change: 0.42
Marker Score: 406 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.4
Marker Score: 935 - Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.37
Marker Score: 372 - Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 0.37
Marker Score: 151 - Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.36
Marker Score: 206 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.36
Marker Score: 359 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.36
Marker Score: 116 - Cell Name: endothelial cell (CL0000115)
Fold Change: 0.33
Marker Score: 300 - Cell Name: mast cell (CL0000097)
Fold Change: 0.33
Marker Score: 192 - Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.32
Marker Score: 141 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.32
Marker Score: 185 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.3
Marker Score: 95 - Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.29
Marker Score: 74
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3918820872
Symbol: CAC1B_HUMAN
Name: Voltage-dependent N-type calcium channel subunit alpha-1B
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1321501
Title: Structure and functional expression of an omega-conotoxin-sensitive human N-type calcium channel.
PubMed ID: 1321501
PubMed ID: 15164053
Title: DNA sequence and analysis of human chromosome 9.
PubMed ID: 15164053
DOI: 10.1038/nature02465
PubMed ID: 9030575
Title: Isolation and characterization of the 5'-upstream region of the human N-type calcium channel alpha1B subunit gene. Chromosomal localization and promoter analysis.
PubMed ID: 9030575
PubMed ID: 25296916
Title: CACNA1B mutation is linked to unique myoclonus-dystonia syndrome.
PubMed ID: 25296916
DOI: 10.1093/hmg/ddu513
PubMed ID: 26157024
Title: The CACNA1B R1389H variant is not associated with myoclonus-dystonia in a large European multicentric cohort.
PubMed ID: 26157024
DOI: 10.1093/hmg/ddv255
PubMed ID: 30982612
Title: Bi-allelic loss-of-function CACNA1B mutations in progressive epilepsy-dyskinesia.
PubMed ID: 30982612
PubMed ID: 34234349
Title: Structure of human Cav2.2 channel blocked by the painkiller ziconotide.
PubMed ID: 34234349
Sequence Information:
- Length: 2339
- Mass: 262496
- Checksum: 17A45C6D1E76B39D
- Sequence:
MVRFGDELGG RYGGPGGGER ARGGGAGGAG GPGPGGLQPG QRVLYKQSIA QRARTMALYN PIPVKQNCFT VNRSLFVFSE DNVVRKYAKR ITEWPPFEYM ILATIIANCI VLALEQHLPD GDKTPMSERL DDTEPYFIGI FCFEAGIKII ALGFVFHKGS YLRNGWNVMD FVVVLTGILA TAGTDFDLRT LRAVRVLRPL KLVSGIPSLQ VVLKSIMKAM VPLLQIGLLL FFAILMFAII GLEFYMGKFH KACFPNSTDA EPVGDFPCGK EAPARLCEGD TECREYWPGP NFGITNFDNI LFAILTVFQC ITMEGWTDIL YNTNDAAGNT WNWLYFIPLI IIGSFFMLNL VLGVLSGEFA KERERVENRR AFLKLRRQQQ IERELNGYLE WIFKAEEVML AEEDRNAEEK SPLDVLKRAA TKKSRNDLIH AEEGEDRFAD LCAVGSPFAR ASLKSGKTES SSYFRRKEKM FRFFIRRMVK AQSFYWVVLC VVALNTLCVA MVHYNQPRRL TTTLYFAEFV FLGLFLTEMS LKMYGLGPRS YFRSSFNCFD FGVIVGSVFE VVWAAIKPGS SFGISVLRAL RLLRIFKVTK YWSSLRNLVV SLLNSMKSII SLLFLLFLFI VVFALLGMQL FGGQFNFQDE TPTTNFDTFP AAILTVFQIL TGEDWNAVMY HGIESQGGVS KGMFSSFYFI VLTLFGNYTL LNVFLAIAVD NLANAQELTK DEEEMEEAAN QKLALQKAKE VAEVSPMSAA NISIAARQQN SAKARSVWEQ RASQLRLQNL RASCEALYSE MDPEERLRFA TTRHLRPDMK THLDRPLVVE LGRDGARGPV GGKARPEAAE APEGVDPPRR HHRHRDKDKT PAAGDQDRAE APKAESGEPG AREERPRPHR SHSKEAAGPP EARSERGRGP GPEGGRRHHR RGSPEEAAER EPRRHRAHRH QDPSKECAGA KGERRARHRG GPRAGPREAE SGEEPARRHR ARHKAQPAHE AVEKETTEKE ATEKEAEIVE ADKEKELRNH QPREPHCDLE TSGTVTVGPM HTLPSTCLQK VEEQPEDADN QRNVTRMGSQ PPDPNTIVHI PVMLTGPLGE ATVVPSGNVD LESQAEGKKE VEADDVMRSG PRPIVPYSSM FCLSPTNLLR RFCHYIVTMR YFEVVILVVI ALSSIALAAE DPVRTDSPRN NALKYLDYIF TGVFTFEMVI KMIDLGLLLH PGAYFRDLWN ILDFIVVSGA LVAFAFSGSK GKDINTIKSL RVLRVLRPLK TIKRLPKLKA VFDCVVNSLK NVLNILIVYM LFMFIFAVIA VQLFKGKFFY CTDESKELER DCRGQYLDYE KEEVEAQPRQ WKKYDFHYDN VLWALLTLFT VSTGEGWPMV LKHSVDATYE EQGPSPGYRM ELSIFYVVYF VVFPFFFVNI FVALIIITFQ EQGDKVMSEC SLEKNERACI DFAISAKPLT RYMPQNRQSF QYKTWTFVVS PPFEYFIMAM IALNTVVLMM KFYDAPYEYE LMLKCLNIVF TSMFSMECVL KIIAFGVLNY FRDAWNVFDF VTVLGSITDI LVTEIAETNN FINLSFLRLF RAARLIKLLR QGYTIRILLW TFVQSFKALP YVCLLIAMLF FIYAIIGMQV FGNIALDDDT SINRHNNFRT FLQALMLLFR SATGEAWHEI MLSCLSNQAC DEQANATECG SDFAYFYFVS FIFLCSFLML NLFVAVIMDN FEYLTRDSSI LGPHHLDEFI RVWAEYDPAA CGRISYNDMF EMLKHMSPPL GLGKKCPARV AYKRLVRMNM PISNEDMTVH FTSTLMALIR TALEIKLAPA GTKQHQCDAE LRKEISVVWA NLPQKTLDLL VPPHKPDEMT VGKVYAALMI FDFYKQNKTT RDQMQQAPGG LSQMGPVSLF HPLKATLEQT QPAVLRGARV FLRQKSSTSL SNGGAIQNQE SGIKESVSWG TQRTQDAPHE ARPPLERGHS TEIPVGRSGA LAVDVQMQSI TRRGPDGEPQ PGLESQGRAA SMPRLAAETQ PVTDASPMKR SISTLAQRPR GTHLCSTTPD RPPPSQASSH HHHHRCHRRR DRKQRSLEKG PSLSADMDGA PSSAVGPGLP PGEGPTGCRR ERERRQERGR SQERRQPSSS SSEKQRFYSC DRFGGREPPK PKPSLSSHPT SPTAGQEPGP HPQGSGSVNG SPLLSTSGAS TPGRGGRRQL PQTPLTPRPS ITYKTANSSP IHFAGAQTSL PAFSPGRLSR GLSEHNALLQ RDPLSQPLAP GSRIGSDPYL GQRLDSEASV HALPEDTLTF EEAVATNSGR SSRTSYVSSL TSQSHPLRRV PNGYHCTLGL SSGGRARHSY HHPDQDHWC
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.