Details for: CACNA1D

Gene ID: 776

Symbol: CACNA1D

Ensembl ID: ENSG00000157388

Description: calcium voltage-gated channel subunit alpha1 D

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 4.43
    Marker Score: 2466
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 4.12
    Marker Score: 73208
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 3.12
    Marker Score: 14424
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 3
    Marker Score: 991
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.93
    Marker Score: 855
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.8
    Marker Score: 21464
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.78
    Marker Score: 55318
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.7
    Marker Score: 102354
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.68
    Marker Score: 40035
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.56
    Marker Score: 10632
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.54
    Marker Score: 2808
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.4
    Marker Score: 88646
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.38
    Marker Score: 6794
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 2.37
    Marker Score: 752
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.29
    Marker Score: 8857
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 2.25
    Marker Score: 1162
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.14
    Marker Score: 20158
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 2.1
    Marker Score: 714
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.07
    Marker Score: 3471
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.05
    Marker Score: 126278
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.05
    Marker Score: 858
  • Cell Name: neuron (CL0000540)
    Fold Change: 2.02
    Marker Score: 8207
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.97
    Marker Score: 20345
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.91
    Marker Score: 18184
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.87
    Marker Score: 16024
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.82
    Marker Score: 906
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.78
    Marker Score: 1038
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.65
    Marker Score: 451
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.64
    Marker Score: 2532
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.63
    Marker Score: 3838
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.61
    Marker Score: 1997
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.58
    Marker Score: 3205
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.54
    Marker Score: 496
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.52
    Marker Score: 802
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.52
    Marker Score: 2918
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168473
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.41
    Marker Score: 543
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.33
    Marker Score: 4729
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.29
    Marker Score: 5399
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.25
    Marker Score: 5410
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.24
    Marker Score: 6658
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.23
    Marker Score: 19259
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.23
    Marker Score: 495
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.21
    Marker Score: 7780
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.17
    Marker Score: 4167
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.14
    Marker Score: 329
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.12
    Marker Score: 291
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.11
    Marker Score: 1375
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.1
    Marker Score: 37152
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.09
    Marker Score: 220
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.05
    Marker Score: 330
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.04
    Marker Score: 376
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.04
    Marker Score: 602
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71802
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48027
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.99
    Marker Score: 577
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 505
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.95
    Marker Score: 1546
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.95
    Marker Score: 1089
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2735
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.91
    Marker Score: 288
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.91
    Marker Score: 544
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 324
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5126
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.87
    Marker Score: 3646
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.85
    Marker Score: 647
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.84
    Marker Score: 190
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.82
    Marker Score: 17475
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.81
    Marker Score: 1943
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.81
    Marker Score: 323
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.79
    Marker Score: 854
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.79
    Marker Score: 3320.5
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.79
    Marker Score: 295
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.77
    Marker Score: 2181
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.76
    Marker Score: 1071
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.75
    Marker Score: 906
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.74
    Marker Score: 388
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.74
    Marker Score: 353
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.73
    Marker Score: 670
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.72
    Marker Score: 11636
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 461
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.72
    Marker Score: 8090
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.71
    Marker Score: 748
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.71
    Marker Score: 3795
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.68
    Marker Score: 854
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.66
    Marker Score: 461
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.66
    Marker Score: 2153
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.64
    Marker Score: 204
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.64
    Marker Score: 683
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.61
    Marker Score: 228
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.6
    Marker Score: 312
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.6
    Marker Score: 156
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.6
    Marker Score: 2054
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.59
    Marker Score: 510

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Other Information

**Key characteristics:** - It is a calcium channel subunit, which is responsible for the flow of calcium ions across cell membranes. - It is a type of voltage-gated calcium channel, which means that its activity is influenced by the voltage across the cell membrane. - It is expressed in a variety of cell types, which suggests that it has a variety of functions. **Pathways and functions:** - It is involved in the regulation of insulin secretion by inhibiting the action of insulin-like growth factor-1 (IGF-1). - It is involved in the development of the nervous system by regulating the growth and differentiation of neurons. - It is involved in cardiac muscle cell action potential by opening calcium channels when the membrane potential reaches a certain threshold. - It is involved in sensory perception by modulating the activity of sensory neurons. **Clinical significance:** - Mutations in the CACNA1D gene have been linked to a number of neurological disorders, including autism, schizophrenia, and epilepsy. - These mutations can lead to changes in the expression of the CACNA1D protein, which can affect its function and lead to the development of neurological symptoms. **Additional notes:** - The CACNA1D gene is a large gene, with over 2000 nucleotides. - It is divided into 13 exons and 12 introns. - It is encoded by a single gene.

Genular Protein ID: 3360881362

Symbol: CAC1D_HUMAN

Name: Voltage-dependent L-type calcium channel subunit alpha-1D

UniProtKB Accession Codes:

Q01668 B0FYA3 Q13916 Q13931 Q71UT1 Q9UDC3

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChEBI 3 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 39 DrugCentral 1 EMBL 9 EMDB 9 Ensembl 3 ExpressionAtlas 1 GO 26 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 5 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 6 PIR 1 PRINTS 3 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 4 RefSeq 3 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1309651

Title: Structure and functional expression of alpha 1, alpha 2, and beta subunits of a novel human neuronal calcium channel subtype.

PubMed ID: 1309651

DOI: 10.1016/0896-6273(92)90109-q

PubMed ID: 1309948

Title: Cloning of the alpha 1 subunit of a voltage-dependent calcium channel expressed in pancreatic beta cells.

PubMed ID: 1309948

DOI: 10.1073/pnas.89.2.584

PubMed ID: 7557998

Title: The structures of the human calcium channel alpha 1 subunit (CACNL1A2) and beta subunit (CACNLB3) genes.

PubMed ID: 7557998

DOI: 10.1006/geno.1995.1048

PubMed ID: 18482979

Title: Modulation of voltage- and Ca2+-dependent gating of CaV1.3 L-type calcium channels by alternative splicing of a C-terminal regulatory domain.

PubMed ID: 18482979

DOI: 10.1074/jbc.m802254200

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 9894156

Title: Genomic structure of the regulatory region of the voltage-gated calcium channel alpha 1D.

PubMed ID: 9894156

DOI: 10.1038/emm.1998.36

PubMed ID: 1335101

Title: Molecular diversity of neuronal-type calcium channels identified in small cell lung carcinoma.

PubMed ID: 1335101

DOI: 10.1016/s0025-6196(12)61144-6

PubMed ID: 21280120

Title: Loss of recognition by cross-reactive T cells and its relation to a C-terminus-induced conformational reorientation of an HLA-B*2705-bound peptide.

PubMed ID: 21280120

DOI: 10.1002/pro.559

PubMed ID: 21131953

Title: Loss of Ca(v)1.3 (CACNA1D) function in a human channelopathy with bradycardia and congenital deafness.

PubMed ID: 21131953

DOI: 10.1038/nn.2694

PubMed ID: 22495309

Title: Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations.

PubMed ID: 22495309

DOI: 10.1038/nature10989

PubMed ID: 22542183

Title: De novo gene disruptions in children on the autistic spectrum.

PubMed ID: 22542183

DOI: 10.1016/j.neuron.2012.04.009

PubMed ID: 23913001

Title: Somatic and germline CACNA1D calcium channel mutations in aldosterone-producing adenomas and primary aldosteronism.

PubMed ID: 23913001

DOI: 10.1038/ng.2695

PubMed ID: 25620733

Title: CACNA1D de novo mutations in autism spectrum disorders activate Cav1.3 L-type calcium channels.

PubMed ID: 25620733

DOI: 10.1016/j.biopsych.2014.11.020

PubMed ID: 28472301

Title: New gain-of-function mutation shows CACNA1D as recurrently mutated gene in autism spectrum disorders and epilepsy.

PubMed ID: 28472301

DOI: 10.1093/hmg/ddx175

Sequence Information:

  • Length: 2161
  • Mass: 245141
  • Checksum: 31B0ADFCDB30B575
  • Sequence:
    • MMMMMMMKKM QHQRQQQADH ANEANYARGT RLPLSGEGPT SQPNSSKQTV LSWQAAIDAA 
RQAKAAQTMS TSAPPPVGSL SQRKRQQYAK SKKQGNSSNS RPARALFCLS LNNPIRRACI 
SIVEWKPFDI FILLAIFANC VALAIYIPFP EDDSNSTNHN LEKVEYAFLI IFTVETFLKI 
IAYGLLLHPN AYVRNGWNLL DFVIVIVGLF SVILEQLTKE TEGGNHSSGK SGGFDVKALR 
AFRVLRPLRL VSGVPSLQVV LNSIIKAMVP LLHIALLVLF VIIIYAIIGL ELFIGKMHKT 
CFFADSDIVA EEDPAPCAFS GNGRQCTANG TECRSGWVGP NGGITNFDNF AFAMLTVFQC 
ITMEGWTDVL YWMNDAMGFE LPWVYFVSLV IFGSFFVLNL VLGVLSGEFS KEREKAKARG 
DFQKLREKQQ LEEDLKGYLD WITQAEDIDP ENEEEGGEEG KRNTSMPTSE TESVNTENVS 
GEGENRGCCG SLCQAISKSK LSRRWRRWNR FNRRRCRAAV KSVTFYWLVI VLVFLNTLTI 
SSEHYNQPDW LTQIQDIANK VLLALFTCEM LVKMYSLGLQ AYFVSLFNRF DCFVVCGGIT 
ETILVELEIM SPLGISVFRC VRLLRIFKVT RHWTSLSNLV ASLLNSMKSI ASLLLLLFLF 
IIIFSLLGMQ LFGGKFNFDE TQTKRSTFDN FPQALLTVFQ ILTGEDWNAV MYDGIMAYGG 
PSSSGMIVCI YFIILFICGN YILLNVFLAI AVDNLADAES LNTAQKEEAE EKERKKIARK 
ESLENKKNNK PEVNQIANSD NKVTIDDYRE EDEDKDPYPP CDVPVGEEEE EEEEDEPEVP 
AGPRPRRISE LNMKEKIAPI PEGSAFFILS KTNPIRVGCH KLINHHIFTN LILVFIMLSS 
AALAAEDPIR SHSFRNTILG YFDYAFTAIF TVEILLKMTT FGAFLHKGAF CRNYFNLLDM 
LVVGVSLVSF GIQSSAISVV KILRVLRVLR PLRAINRAKG LKHVVQCVFV AIRTIGNIMI 
VTTLLQFMFA CIGVQLFKGK FYRCTDEAKS NPEECRGLFI LYKDGDVDSP VVRERIWQNS 
DFNFDNVLSA MMALFTVSTF EGWPALLYKA IDSNGENIGP IYNHRVEISI FFIIYIIIVA 
FFMMNIFVGF VIVTFQEQGE KEYKNCELDK NQRQCVEYAL KARPLRRYIP KNPYQYKFWY 
VVNSSPFEYM MFVLIMLNTL CLAMQHYEQS KMFNDAMDIL NMVFTGVFTV EMVLKVIAFK 
PKGYFSDAWN TFDSLIVIGS IIDVALSEAD PTESENVPVP TATPGNSEES NRISITFFRL 
FRVMRLVKLL SRGEGIRTLL WTFIKSFQAL PYVALLIAML FFIYAVIGMQ MFGKVAMRDN 
NQINRNNNFQ TFPQAVLLLF RCATGEAWQE IMLACLPGKL CDPESDYNPG EEYTCGSNFA 
IVYFISFYML CAFLIINLFV AVIMDNFDYL TRDWSILGPH HLDEFKRIWS EYDPEAKGRI 
KHLDVVTLLR RIQPPLGFGK LCPHRVACKR LVAMNMPLNS DGTVMFNATL FALVRTALKI 
KTEGNLEQAN EELRAVIKKI WKKTSMKLLD QVVPPAGDDE VTVGKFYATF LIQDYFRKFK 
KRKEQGLVGK YPAKNTTIAL QAGLRTLHDI GPEIRRAISC DLQDDEPEET KREEEDDVFK 
RNGALLGNHV NHVNSDRRDS LQQTNTTHRP LHVQRPSIPP ASDTEKPLFP PAGNSVCHNH 
HNHNSIGKQV PTSTNANLNN ANMSKAAHGK RPSIGNLEHV SENGHHSSHK HDREPQRRSS 
VKRTRYYETY IRSDSGDEQL PTICREDPEI HGYFRDPHCL GEQEYFSSEE CYEDDSSPTW 
SRQNYGYYSR YPGRNIDSER PRGYHHPQGF LEDDDSPVCY DSRRSPRRRL LPPTPASHRR 
SSFNFECLRR QSSQEEVPSS PIFPHRTALP LHLMQQQIMA VAGLDSSKAQ KYSPSHSTRS 
WATPPATPPY RDWTPCYTPL IQVEQSEALD QVNGSLPSLH RSSWYTDEPD ISYRTFTPAS 
LTVPSSFRNK NSDKQRSADS LVEAVLISEG LGRYARDPKF VSATKHEIAD ACDLTIDEME 
SAASTLLNGN VRPRANGDVG PLSHRQDYEL QDFGPGYSDE EPDPGRDEED LADEMICITT 
L

Genular Protein ID: 3201312509

Symbol: A0A1B0GUN6_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A1B0GUN6

Database IDs:

ARBA 14 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChEBI 3 ChiTaRS 1 DNASU 1 EMBL 6 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 4 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 8 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 2 PRINTS 3 PeptideAtlas 2 Pfam 4 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SAM 2 SMART 2 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

Sequence Information:

  • Length: 2146
  • Mass: 243705
  • Checksum: FE9180FDE7745CC5
  • Sequence:
    • MMMMMMMKKM QHQRQQQADH ANEANYARGT RLPLSGEGPT SQPNSSKQTV LSWQAAIDAA 
RQAKAAQTMS TSAPPPVGSL SQRKRQQYAK SKKQGNSSNS RPARALFCLS LNNPIRRACI 
SIVEWKPFDI FILLAIFANC VALAIYIPFP EDDSNSTNHN LEKVEYAFLI IFTVETFLKI 
IAYGLLLHPN AYVRNGWNLL DFVIVIVGLF SVILEQLTKE TEGGNHSSGK SGGFDVKALR 
AFRVLRPLRL VSGVPSLQVV LNSIIKAMVP LLHIALLVLF VIIIYAIIGL ELFIGKMHKT 
CFFADSDIVA EEDPAPCAFS GNGRQCTANG TECRSGWVGP NGGITNFDNF AFAMLTVFQC 
ITMEGWTDVL YWVNDAIGWE WPWVYFVSLI ILGSFFVLNL VLGVLSGEFS KEREKAKARG 
DFQKLREKQQ LEEDLKGYLD WITQAEDIDP ENEEEGGEEG KRNTSMPTSE TESVNTENVS 
GEGENRGCCG SLCQAISKSK LSRRWRRWNR FNRRRCRAAV KSVTFYWLVI VLVFLNTLTI 
SSEHYNQPDW LTQIQDIANK VLLALFTCEM LVKMYSLGLQ AYFVSLFNRF DCFVVCGGIT 
ETILVELEIM SPLGISVFRC VRLLRIFKVT RHWTSLSNLV ASLLNSMKSI ASLLLLLFLF 
IIIFSLLGMQ LFGGKFNFDE TQTKRSTFDN FPQALLTVFQ ILTGEDWNAV MYDGIMAYGG 
PSSSGMIVCI YFIILFICGN YILLNVFLAI AVDNLADAES LNTAQKEEAE EKERKKIARK 
ESLENKKNNK PEVNQIANSD NKVTIDDYRE EDEDKDPYPP CDVPVGEEEE EEEEDEPEVP 
AGPRPRRISE LNMKEKIAPI PEGSAFFILS KTNPIRVGCH KLINHHIFTN LILVFIMLSS 
AALAAEDPIR SHSFRNTILG YFDYAFTAIF TVEILLKMTT FGAFLHKGAF CRNYFNLLDM 
LVVGVSLVSF GIQSSAISVV KILRVLRVLR PLRAINRAKG LKHVVQCVFV AIRTIGNIMI 
VTTLLQFMFA CIGVQLFKGK FYRCTDEAKS NPEECRGLFI LYKDGDVDSP VVRERIWQNS 
DFNFDNVLSA MMALFTVSTF EGWPALLYKA IDSNGENIGP IYNHRVEISI FFIIYIIIVA 
FFMMNIFVGF VIVTFQEQGE KEYKNCELDK NQRQCVEYAL KARPLRRYIP KNPYQYKFWY 
VVNSSPFEYM MFVLIMLNTL CLAMQHYEQS KMFNDAMDIL NMVFTGVFTV EMVLKVIAFK 
PKGYFSDAWN TFDSLIVIGS IIDVALSEAD NSEESNRISI TFFRLFRVMR LVKLLSRGEG 
IRTLLWTFIK SFQALPYVAL LIAMLFFIYA VIGMQMFGKV AMRDNNQINR NNNFQTFPQA 
VLLLFRCATG EAWQEIMLAC LPGKLCDPES DYNPGEEYTC GSNFAIVYFI SFYMLCAFLI 
INLFVAVIMD NFDYLTRDWS ILGPHHLDEF KRIWSEYDPE AKGRIKHLDV VTLLRRIQPP 
LGFGKLCPHR VACKRLVAMN MPLNSDGTVM FNATLFALVR TALKIKTEGN LEQANEELRA 
VIKKIWKKTS MKLLDQVVPP AGDDEVTVGK FYATFLIQDY FRKFKKRKEQ GLVGKYPAKN 
TTIALQAGLR TLHDIGPEIR RAISCDLQDD EPEETKREEE DDVFKRNGAL LGNHVNHVNS 
DRRDSLQQTN TTHRPLHVQR PSIPPASDTE KPLFPPAGNS VCHNHHNHNS IGKQVPTSTN 
ANLNNANMSK AAHGKRPSIG NLEHVSENGH HSSHKHDREP QRRSSVKRTR YYETYIRSDS 
GDEQLPTICR EDPEIHGYFR DPHCLGEQEY FSSEECYEDD SSPTWSRQNY GYYSRYPGRN 
IDSERPRGYH HPQGFLEDDD SPVCYDSRRS PRRRLLPPTP ASHRRSSFNF ECLRRQSSQE 
EVPSSPIFPH RTALPLHLMQ QQIMAVAGLD SSKAQKYSPS HSTRSWATPP ATPPYRDWTP 
CYTPLIQVEQ SEALDQVNGS LPSLHRSSWY TDEPDISYRT FTPASLTVPS SFRNKNSDKQ 
RSADSLVEAV LISEGLGRYA RDPKFVSATK HEIADACDLT IDEMESAAST LLNGNVRPRA 
NGDVGPLSHR QDYELQDFGP GYSDEEPDPG RDEEDLADEM ICITTL

Genular Protein ID: 3566809199

Symbol: Q59GD8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59GD8

Database IDs:

ARBA 13 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChEBI 3 ChiTaRS 1 DNASU 1 EMBL 2 ExpressionAtlas 1 GO 3 Gene3D 4 GenomeRNAi 1 InterPro 7 KEGG 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 2 PRINTS 2 PeptideAtlas 1 Pfam 4 PharmGKB 1 ProteomicsDB 1 RefSeq 2 RuleBase 1 SMART 2 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Sequence Information:

  • Length: 1854
  • Mass: 211464
  • Checksum: 73DE6B07DF531A39
  • Sequence:
    • ANGTECRSGW VGPNGGITNF DNFAFAMLTV FQCITMEGWT DVLYWMNDAM GFELPWVYFV 
SLVIFGSFFV LNLVLGVLSG EFSKEREKAK ARGDFQKLRE KQQLEEDLKG YLDWITQAED 
IDPENEEEGG EEGKRNTSMP TSETESVNTE NVSGEGENRG CCGSLWCWWR RRGAAKAGPS 
GCRRWGQAIS KSKLSRRWRR WNRFNRRRCR AAVKSVTFYW LVIVLVFLNT LTISSEHYNQ 
PDWLTQIQDI ANKVLLALFT CEMLVKMYSL GLQAYFVSLF NRFDCFVVCG GITETILVEL 
EIMSPLGISV FRCVRLLRIF KVTRHWTSLS NLVASLLNSM KSIASLLLLL FLFIIIFSLL 
GMQLFGGKFN FDETQTKRST FDNFPQALLT VFQILTGEDW NAVMYDGIMA YGGPSSSGMI 
VCIYFIILFI CGNYILLNVF LAIAVDNLAD AESLNTAQKE EAEEKERKKI ARKESLENKK 
NNKPEVNQIA NSDNKVTIDD YREEDEDKDP YPPCDVPVGE EEEEEEEDEP EVPAGPRPRR 
ISELNMKEKI APIPEGSAFF ILSKTNPIRV GCHKLINHHI FTNLILVFIM LSSAALAAED 
PIRSHSFRNT ILGYFDYAFT AIFTVEILLK MTTFGAFLHK GAFCRNYFNL LDMLVVGVSL 
VSFGIQSSAI SVVKILRVLR VLRPLRAINR AKGLKHVVQC VFVAIRTIGN IMIVTTLLQF 
MFACIGVQLF KGKFYRCTDE AKSNPEECRG LFILYKDGDV DSPVVRERIW QNSDFNFDNV 
LSAMMALFTV STFEGWPALL YKAIDSNGEN IGPIYNHRVE ISIFFIIYII IVAFFMMNIF 
VGFVIVTFQE QGEKEYKNCE LDKNQRQCVE YALKARPLRR YIPKNPYQYK FWYVVNSSPF 
EYMMFVLIML NTLCLAMQHY EQSKMFNDAM DILNMVFTGV FTVEMVLKVI AFKPKHYFTD 
AWNTFDALIV VGSVVDIAIT EVNPTESENV PVPTATPGNS EESNRISITF FRLFRVMRLV 
KLLSRGEGIR TLLWTFIKSF QALPYVALLI AMLFFIYAVI GMQMFGKVAM RDNNQINRNN 
NFQTFPQAVL LLFRCATGEA WQEIMLACLP GKLCDPESDY NPGEEYTCGS NFAIVYFISF 
YMLCAFLIIN LFVAVIMDNF DYLTRDWSIL GPHHLDEFKR IWSEYDPEAK GRIKHLDVVT 
LLRRIQPPLG FGKLCPHRVA CKRLVAMNMP LNSDGTVMFN ATLFALVRTA LKIKTEGNLE 
QANEELRAVI KKIWKKTSMK LLDQVVPPAG DDEVTVGKFY ATFLIQDYFR KFKKRKEQGL 
VGKYPAKNTT IALQAGLRTL HDIGPEIRRA ISCDLQDDEP EETKREEEDD VFKRNGALLG 
NHVNHVNSDR RDSLQQTNTT HRPLHVQRPS IPPASDTEKP LFPPAGNSVC HNHHNHNSIG 
KQVPTSTNAN LNNANMSKAA HGKRPSIGNL EHVSENGHHS SHKHDREPQR RSSVKRTRYY 
ETYIRSDSGD EQLPTICRED PEIHGYFRDP HCLGEQEYFS SEECYEDDSS PTWSRQNYGY 
YSRYPGRNID SERPRGYHHP QGFLEDDDSP VCYDSRRSPR RRLLPPTPAS HRRSSFNFEC 
LRRQSSQEEV PSSPIFPHRT ALPLHLMQQQ IMAVAGLDSS KAQKYSPSHS TRSWATPPAT 
PPYRDWTPCY TPLIQVEQSE ALDQVNGSLP SLHRSSWYTD EPDISYRTFT PASLTVPSSF 
RNKNSDKQRS ADSLVEAVLI SEGLGRYARD PKFVSATKHE IADACDLTID EMESAASTLL 
NGNVRPRANG DVGPLSHRQD YELQDFGPGY SDEEPDPGRD EEDLADEMIC ITTL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.