Details for: CACNA1E

Gene ID: 777

Symbol: CACNA1E

Ensembl ID: ENSG00000198216

Description: calcium voltage-gated channel subunit alpha1 E

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 6.6074
    Cell Significance Index: 292.2600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 5.9498
    Cell Significance Index: 400.0700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 5.7384
    Cell Significance Index: 217.3000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 5.6823
    Cell Significance Index: 162.1600
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 3.6822
    Cell Significance Index: 49.1200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 3.6552
    Cell Significance Index: 87.6600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 3.6029
    Cell Significance Index: 1292.2800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 3.3403
    Cell Significance Index: 205.3100
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 3.2569
    Cell Significance Index: 24.9800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.9074
    Cell Significance Index: 583.2200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.5912
    Cell Significance Index: 97.5600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.5284
    Cell Significance Index: 970.7200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.4911
    Cell Significance Index: 32.6500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.4746
    Cell Significance Index: 1019.9000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1660
    Cell Significance Index: 37.3500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.9876
    Cell Significance Index: 12.2500
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.9539
    Cell Significance Index: 12.3700
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: 0.8284
    Cell Significance Index: 9.1400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4814
    Cell Significance Index: 91.6100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.2688
    Cell Significance Index: 8.5600
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.2386
    Cell Significance Index: 2.2700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2287
    Cell Significance Index: 206.4600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.2071
    Cell Significance Index: 6.7800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1856
    Cell Significance Index: 349.5400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.1285
    Cell Significance Index: 2.5400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1227
    Cell Significance Index: 4.3100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0930
    Cell Significance Index: 2.6800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0549
    Cell Significance Index: 0.9400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0539
    Cell Significance Index: 5.3300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0399
    Cell Significance Index: 5.8000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0306
    Cell Significance Index: 0.7700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0299
    Cell Significance Index: 4.8700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.0184
    Cell Significance Index: 0.2000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0055
    Cell Significance Index: -10.1400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0070
    Cell Significance Index: -9.5600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0115
    Cell Significance Index: -17.6900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0164
    Cell Significance Index: -0.3300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0480
    Cell Significance Index: -35.5800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0511
    Cell Significance Index: -37.4800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0542
    Cell Significance Index: -30.5900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0590
    Cell Significance Index: -26.7800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0643
    Cell Significance Index: -35.1400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0683
    Cell Significance Index: -42.6600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0687
    Cell Significance Index: -5.2700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0820
    Cell Significance Index: -1.1800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0839
    Cell Significance Index: -9.1300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0847
    Cell Significance Index: -16.8100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0958
    Cell Significance Index: -27.5700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1231
    Cell Significance Index: -5.3500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1696
    Cell Significance Index: -30.5700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1861
    Cell Significance Index: -39.1900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2255
    Cell Significance Index: -10.2200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2317
    Cell Significance Index: -39.5600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2616
    Cell Significance Index: -35.9300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2621
    Cell Significance Index: -32.2300
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.2726
    Cell Significance Index: -3.1800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.2853
    Cell Significance Index: -19.7300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3044
    Cell Significance Index: -35.4800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3076
    Cell Significance Index: -6.3800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.3094
    Cell Significance Index: -18.5800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3138
    Cell Significance Index: -6.7800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3242
    Cell Significance Index: -33.7600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3349
    Cell Significance Index: -9.3600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3454
    Cell Significance Index: -39.5800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.3460
    Cell Significance Index: -3.2800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3542
    Cell Significance Index: -41.7700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3560
    Cell Significance Index: -36.3700
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.3574
    Cell Significance Index: -4.5100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3591
    Cell Significance Index: -7.7800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.4486
    Cell Significance Index: -11.1900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4582
    Cell Significance Index: -16.0500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5400
    Cell Significance Index: -30.3000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5654
    Cell Significance Index: -12.0000
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.5950
    Cell Significance Index: -7.1200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.6379
    Cell Significance Index: -12.7200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6386
    Cell Significance Index: -33.5300
  • Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
    Fold Change: -0.6405
    Cell Significance Index: -6.5900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.6418
    Cell Significance Index: -33.4300
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.6662
    Cell Significance Index: -8.8800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.6687
    Cell Significance Index: -21.1500
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.7240
    Cell Significance Index: -4.7100
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.7337
    Cell Significance Index: -14.4400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.7760
    Cell Significance Index: -36.4700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.8591
    Cell Significance Index: -17.9300
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.8833
    Cell Significance Index: -7.6400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.8839
    Cell Significance Index: -41.2100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.9163
    Cell Significance Index: -21.1700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.9303
    Cell Significance Index: -23.2000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.9434
    Cell Significance Index: -24.2500
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -1.0837
    Cell Significance Index: -22.0500
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: -1.1195
    Cell Significance Index: -8.7800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.1338
    Cell Significance Index: -39.4000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.1462
    Cell Significance Index: -24.4100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -1.1547
    Cell Significance Index: -17.4000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -1.1944
    Cell Significance Index: -25.5300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -1.2082
    Cell Significance Index: -20.8900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -1.2244
    Cell Significance Index: -17.4300
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -1.2686
    Cell Significance Index: -19.3000
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron (CL4030065)
    Fold Change: -1.2795
    Cell Significance Index: -13.3700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.3357
    Cell Significance Index: -38.2900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure:** CACNA1E belongs to the voltage-gated calcium channel (VGCC) family, consisting of a large pore and four transmembrane domains. 2. **Function:** The alpha1E subunit is a critical component of the R-type calcium channel, responsible for regulating calcium ion influx in response to depolarization. 3. **Expression:** CACNA1E is highly expressed in neurons, with significant levels found in brainstem motor neurons, retinal bipolar neurons, and cerebral cortex neurons. 4. **Regulation:** The alpha1E subunit is subject to regulation by various factors, including calcium/calmodulin, dihydropyridine receptors, and beta subunits. **Pathways and Functions:** 1. **Calcium Signaling:** CACNA1E plays a crucial role in regulating calcium ion influx across neuronal membranes, influencing various physiological processes, including neurotransmission, energy metabolism, and insulin secretion. 2. **Neurotransmission:** The alpha1E subunit is involved in the regulation of synaptic transmission, particularly at chemical synapses, where it modulates the release of neurotransmitters. 3. **Energy Metabolism:** CACNA1E is also involved in regulating energy metabolism, particularly in the context of neuronal activity, where it influences the production of ATP and the regulation of metabolic pathways. 4. **Insulin Secretion:** The alpha1E subunit is expressed in pancreatic beta cells and plays a role in regulating insulin secretion in response to glucose stimuli. **Clinical Significance:** 1. **Neurological Disorders:** Mutations in CACNA1E have been associated with various neurological disorders, including epilepsy, migraines, and Parkinson's disease. 2. **Neuropsychiatric Disorders:** Alterations in CACNA1E expression have also been linked to neuropsychiatric disorders, such as schizophrenia and bipolar disorder. 3. **Cardiovascular Disease:** The alpha1E subunit is also involved in regulating calcium ion influx in cardiac myocytes, where it plays a role in the development of cardiovascular disease. 4. **Cancer:** CACNA1E has been implicated in the development and progression of certain types of cancer, including breast and prostate cancer. In conclusion, CACNA1E plays a vital role in regulating calcium signaling, neurotransmission, energy metabolism, and insulin secretion. Its dysregulation has been implicated in various neurological and cardiovascular disorders, highlighting the importance of this gene in human health and disease. Further research is necessary to fully elucidate the functions and clinical significance of CACNA1E.

Genular Protein ID: 1597205708

Symbol: CAC1E_HUMAN

Name: Voltage-dependent R-type calcium channel subunit alpha-1E

UniProtKB Accession Codes:

Q15878 B1AM12 B1AM13 B1AM14 Q14580 Q14581

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 12 EMBL 7 EMDB 4 Ensembl 3 ExpressionAtlas 1 GO 10 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 2 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7536609

Title: Molecular analysis and functional expression of the human type E neuronal Ca2+ channel alpha 1 subunit.

PubMed ID: 7536609

PubMed ID: 8071363

Title: Structure and functional characterization of neuronal alpha 1E calcium channel subtypes.

PubMed ID: 8071363

DOI: 10.1016/s0021-9258(17)31796-9

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15258581

Title: Mutations in EFHC1 cause juvenile myoclonic epilepsy.

PubMed ID: 15258581

DOI: 10.1038/ng1393

PubMed ID: 30343943

Title: De novo pathogenic variants in CACNA1E cause developmental and epileptic encephalopathy with contractures, macrocephaly, and dyskinesias.

PubMed ID: 30343943

DOI: 10.1016/j.ajhg.2018.09.006

PubMed ID: 18400181

Title: Crystal structure of the CaV2 IQ domain in complex with Ca2+/calmodulin: high-resolution mechanistic implications for channel regulation by Ca2+.

PubMed ID: 18400181

DOI: 10.1016/j.str.2008.01.011

Sequence Information:

  • Length: 2313
  • Mass: 261731
  • Checksum: CCC7F309C27C42F1
  • Sequence:
    • MARFGEAVVA RPGSGDGDSD QSRNRQGTPV PASGQAAAYK QTKAQRARTM ALYNPIPVRQ 
NCFTVNRSLF IFGEDNIVRK YAKKLIDWPP FEYMILATII ANCIVLALEQ HLPEDDKTPM 
SRRLEKTEPY FIGIFCFEAG IKIVALGFIF HKGSYLRNGW NVMDFIVVLS GILATAGTHF 
NTHVDLRTLR AVRVLRPLKL VSGIPSLQIV LKSIMKAMVP LLQIGLLLFF AILMFAIIGL 
EFYSGKLHRA CFMNNSGILE GFDPPHPCGV QGCPAGYECK DWIGPNDGIT QFDNILFAVL 
TVFQCITMEG WTTVLYNTND ALGATWNWLY FIPLIIIGSF FVLNLVLGVL SGEFAKERER 
VENRRAFMKL RRQQQIEREL NGYRAWIDKA EEVMLAEENK NAGTSALEVL RRATIKRSRT 
EAMTRDSSDE HCVDISSVGT PLARASIKSA KVDGVSYFRH KERLLRISIR HMVKSQVFYW 
IVLSLVALNT ACVAIVHHNQ PQWLTHLLYY AEFLFLGLFL LEMSLKMYGM GPRLYFHSSF 
NCFDFGVTVG SIFEVVWAIF RPGTSFGISV LRALRLLRIF KITKYWASLR NLVVSLMSSM 
KSIISLLFLL FLFIVVFALL GMQLFGGRFN FNDGTPSANF DTFPAAIMTV FQILTGEDWN 
EVMYNGIRSQ GGVSSGMWSA IYFIVLTLFG NYTLLNVFLA IAVDNLANAQ ELTKDEQEEE 
EAFNQKHALQ KAKEVSPMSA PNMPSIERDR RRRHHMSMWE PRSSHLRERR RRHHMSVWEQ 
RTSQLRKHMQ MSSQEALNRE EAPTMNPLNP LNPLSSLNPL NAHPSLYRRP RAIEGLALGL 
ALEKFEEERI SRGGSLKGDG GDRSSALDNQ RTPLSLGQRE PPWLARPCHG NCDPTQQEAG 
GGEAVVTFED RARHRQSQRR SRHRRVRTEG KESSSASRSR SASQERSLDE AMPTEGEKDH 
ELRGNHGAKE PTIQEERAQD LRRTNSLMVS RGSGLAGGLD EADTPLVLPH PELEVGKHVV 
LTEQEPEGSS EQALLGNVQL DMGRVISQSE PDLSCITANT DKATTESTSV TVAIPDVDPL 
VDSTVVHISN KTDGEASPLK EAEIREDEEE VEKKKQKKEK RETGKAMVPH SSMFIFSTTN 
PIRRACHYIV NLRYFEMCIL LVIAASSIAL AAEDPVLTNS ERNKVLRYFD YVFTGVFTFE 
MVIKMIDQGL ILQDGSYFRD LWNILDFVVV VGALVAFALA NALGTNKGRD IKTIKSLRVL 
RVLRPLKTIK RLPKLKAVFD CVVTSLKNVF NILIVYKLFM FIFAVIAVQL FKGKFFYCTD 
SSKDTEKECI GNYVDHEKNK MEVKGREWKR HEFHYDNIIW ALLTLFTVST GEGWPQVLQH 
SVDVTEEDRG PSRSNRMEMS IFYVVYFVVF PFFFVNIFVA LIIITFQEQG DKMMEECSLE 
KNERACIDFA ISAKPLTRYM PQNRHTFQYR VWHFVVSPSF EYTIMAMIAL NTVVLMMKYY 
SAPCTYELAL KYLNIAFTMV FSLECVLKVI AFGFLNYFRD TWNIFDFITV IGSITEIILT 
DSKLVNTSGF NMSFLKLFRA ARLIKLLRQG YTIRILLWTF VQSFKALPYV CLLIAMLFFI 
YAIIGMQVFG NIKLDEESHI NRHNNFRSFF GSLMLLFRSA TGEAWQEIML SCLGEKGCEP 
DTTAPSGQNE NERCGTDLAY VYFVSFIFFC SFLMLNLFVA VIMDNFEYLT RDSSILGPHH 
LDEFVRVWAE YDRAACGRIH YTEMYEMLTL MSPPLGLGKR CPSKVAYKRL VLMNMPVAED 
MTVHFTSTLM ALIRTALDIK IAKGGADRQQ LDSELQKETL AIWPHLSQKM LDLLVPMPKA 
SDLTVGKIYA AMMIMDYYKQ SKVKKQRQQL EEQKNAPMFQ RMEPSSLPQE IIANAKALPY 
LQQDPVSGLS GRSGYPSMSP LSPQDIFQLA CMDPADDGQF QERQSLEPEV SELKSVQPSN 
HGIYLPSDTQ EHAGSGRASS MPRLTVDPQV VTDPSSMRRS FSTIRDKRSN SSWLEEFSME 
RSSENTYKSR RRSYHSSLRL SAHRLNSDSG HKSDTHRSGG RERGRSKERK HLLSPDVSRC 
NSEERGTQAD WESPERRQSR SPSEGRSQTP NRQGTGSLSE SSIPSVSDTS TPRRSRRQLP 
PVPPKPRPLL SYSSLIRHAG SISPPADGSE EGSPLTSQAL ESNNACLTES SNSPHPQQSQ 
HASPQRYISE PYLALHEDSH ASDCGEEETL TFEAAVATSL GRSNTIGSAP PLRHSWQMPN 
GHYRRRRRGG PGPGMMCGAV NNLLSDTEED DKC

Genular Protein ID: 2342004387

Symbol: Q59FG1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59FG1

Database IDs:

ARBA 16 BioGRID-ORCS 1 CTD 1 ChEBI 2 DNASU 1 DisGeNET 1 EMBL 2 GO 7 Gene3D 3 InterPro 8 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 1 PRINTS 2 PROSITE 2 PeptideAtlas 1 Pfam 3 RefSeq 3 RuleBase 1 SAM 3 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 1869
  • Mass: 211937
  • Checksum: 22262D31FB729EA0
  • Sequence:
    • AGTSALEVLR RATIKRSRTE AMTRDSSDEH CVDISSVGTP LARASIKSAK VDGVSYFRHK 
ERLLRISIRH MVKSQVFYWI VLSLVALNTA CVAIVHHNQP QWLTHLLYYA EFLFLGLFLL 
EMSLKMYGMG PRLYFHSSFN CFDFGVTVGS IFEVVWAIFR PGTSFGISVL RALRLLRIFK 
ITKYWASLRN LVVSLMSSMK SIISLLFLLF LFIVVFALLG MQLFGGRFNF NDGTPSANFD 
TFPAAIMTVF QILTGEDWNE VMYNGIRSQG GVSSGMWSAI YFIVLTLFGN YTLLNVFLAI 
AVDNLANAQE LTKDEQEEEE AFNQKHALQK AKEVSPMSAP NMPSIERDRR RRHHMSMWEP 
RSSHLRERRR RHHMSVWEQR TSQLRKHMQM SSQEALNREE APTMNPLNPL NPLSSLNPLN 
AHPSLYRRPR AIEGLALGLA LEKFEEERIS RGGSLKGDGG DRSSALDNQR TPLSLGQREP 
PWLARPCHGN CDPTQQEAGG GEAVVTFEDR ARHRQSQRRS RHRRVRTEGK ESSSASRSRS 
ASQERSLDEA MPTEGEKDHE LRGNHGAKEP TIQEERAQDL RRTNSLMVSR GSGLAGGLDE 
ADTPLVLPHP ELEVGKHVVL TEQEPEGSSE QALLGNVQLD MGRVISQSEP DLSCITANTD 
KATTESTSVT VAIPDVDPLV DSTVVHISNK TDGEASPLKE AEIREDEEEV EKKKQKKEKR 
ETGKAMVPHS SMFIFSTTNP IRRACHYIVN LRYFEMCILL VIAASSIALA AEDPVLTNSE 
RNKVLRYFDY VFTGVFTFEM VIKMIDQGLI LQDGSYFRDL WNILDFVVVV GALVAFALAN 
ALGTNKGRDI KTIKSLRVLR VLRPLKTIKR LPKLKAVFDC VVTSLKNVFN ILIVYKLFMF 
IFAVIAVQLF KGKFFYCTDS SKDTEKECIG NYVDHEKNKM EVKGREWKRH EFHYDNIIWA 
LLTLFTVSTG EGWPQVLQHS VDVTEEDRGP SRSNRMEMSI FYVVYFVVFP FFFVNIFVAL 
IIITFQEQGD KMMEECSLEK NERACIDFAI SAKPLTRYMP QNRHTFQYRV WHFVVSPSFE 
YTIMAMIALN TVVLMMKYYS APCTYELALK YLNIAFTMVF SLECVLKVIA FGFLNYFRDT 
WNIFDFITVI GSITEIILTD SKLVNTSGFN MSFLKLFRAA RLIKLLRQGY TIRILLWTFV 
QSFKALPYVC LLIAMLFFIY AIIGMQVFGN IKLDEESHIN RHNNFRSFFG SLMLLFRSAT 
GEAWQEIMLS CLGEKGCEPD TTAPSGQNEN ERCGTDLAYV YFVSFIFFCS FLMLNLFVAV 
IMDNFEYLTR DSSILGPHHL DEFVRVWAEY DRAACGRIHY TEMYEMLTLM SPPLGLGKRC 
PSKVAYKRLV LMNMPVAEDM TVHFTSTLMA LIRTALDIKI AKGGADRQQL DSELQKETLA 
IWPHLSQKML DLLVPMPKAS DLTVGKIYAA MMIMDYYKQS KVKKQRQQLE EQKNAPMFQR 
MEPSSLPQEI IANAKALPYL QQDPVSGLSG RSGYPSMSPL SPQDIFQLAC MDPTDDGQFQ 
ERQSLVVTDP SSMRRSFSTI RDKRSNSSWL EEFSMERSSE NTYKSRRRSY HSSLRLSAHR 
LNSDSGHKSD THRSGGRERG RSKERKHLLS PDVSRCNSEE RGTQADWESP ERRQSRSPSE 
GRSQTPNRQG TGSLSESSIP SVSDTSTPRR SRRQLPPVPP KPRPLLSYSS LIRHAGSISP 
PADGSEEGSP LTSQALESNN ACLTESSNSP HPQQSQHASP QRYISEPYLA LHEDSHASDC 
GEEETLTFEA AVATSLGRSN TIGSAPPLRH SWQMPNGHYR RRRRGGPGPG MMCGAVNNLL 
SDTEEDDKC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.