Details for: CACNA1E
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: brainstem motor neuron (CL2000047)
Fold Change: 3.29
Marker Score: 1,912 - Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: 3.14
Marker Score: 26,539 - Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 2.96
Marker Score: 8,451 - Cell Name: neuronal brush cell (CL0000555)
Fold Change: 2.96
Marker Score: 9,913 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 2.84
Marker Score: 95,888 - Cell Name: pyramidal neuron (CL0000598)
Fold Change: 2.76
Marker Score: 4,632 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 2.54
Marker Score: 37,941 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 2.52
Marker Score: 50,030 - Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 2.5
Marker Score: 94,888 - Cell Name: CNS interneuron (CL0000402)
Fold Change: 2.48
Marker Score: 1,190 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 2.45
Marker Score: 941 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 2.4
Marker Score: 18,387 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 2.31
Marker Score: 674 - Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 2.28
Marker Score: 8,817 - Cell Name: macroglial cell (CL0000126)
Fold Change: 2.1
Marker Score: 4,825 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.97
Marker Score: 121,359 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.97
Marker Score: 20,309 - Cell Name: stellate neuron (CL0000122)
Fold Change: 1.96
Marker Score: 10,549 - Cell Name: neuron (CL0000540)
Fold Change: 1.96
Marker Score: 7,988 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.93
Marker Score: 18,301 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.88
Marker Score: 16,114 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 1.86
Marker Score: 17,455 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.77
Marker Score: 3,354 - Cell Name: interneuron (CL0000099)
Fold Change: 1.64
Marker Score: 749 - Cell Name: granule cell (CL0000120)
Fold Change: 1.62
Marker Score: 12,224 - Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 1.62
Marker Score: 7,496 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.61
Marker Score: 1,171 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.46
Marker Score: 2,977 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.46
Marker Score: 2,248 - Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 1.44
Marker Score: 807 - Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.37
Marker Score: 872 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.32
Marker Score: 3,111 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.27
Marker Score: 857 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 1.24
Marker Score: 5,205 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 1.2
Marker Score: 44,210 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 1.2
Marker Score: 719 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.18
Marker Score: 488 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.17
Marker Score: 18,263 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.15
Marker Score: 4,814 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 1.1
Marker Score: 4,568 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.1
Marker Score: 504 - Cell Name: retinal cone cell (CL0000573)
Fold Change: 1.07
Marker Score: 3,078 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 1.04
Marker Score: 798 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,812 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48,037 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.99
Marker Score: 510 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.99
Marker Score: 1,093 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.98
Marker Score: 464 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,407 - Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
Fold Change: 0.95
Marker Score: 4,985 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,413 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.94
Marker Score: 376 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5,338 - Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.93
Marker Score: 1,145 - Cell Name: microglial cell (CL0000129)
Fold Change: 0.92
Marker Score: 1,681 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2,741 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.91
Marker Score: 327 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,288 - Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 0.86
Marker Score: 3,065 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1,264 - Cell Name: brush cell (CL0002204)
Fold Change: 0.78
Marker Score: 710 - Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.77
Marker Score: 399 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.76
Marker Score: 246 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.72
Marker Score: 464 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.7
Marker Score: 180 - Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.69
Marker Score: 330 - Cell Name: precursor B cell (CL0000817)
Fold Change: 0.68
Marker Score: 447 - Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.66
Marker Score: 297 - Cell Name: glial cell (CL0000125)
Fold Change: 0.66
Marker Score: 723 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.64
Marker Score: 202 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 0.64
Marker Score: 8,541 - Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 0.64
Marker Score: 799 - Cell Name: ganglion interneuron (CL0000397)
Fold Change: 0.64
Marker Score: 194 - Cell Name: GABAergic neuron (CL0000617)
Fold Change: 0.63
Marker Score: 2,633 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.63
Marker Score: 375 - Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.62
Marker Score: 161 - Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.62
Marker Score: 491 - Cell Name: mature astrocyte (CL0002627)
Fold Change: 0.61
Marker Score: 405 - Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 0.59
Marker Score: 2,081 - Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.57
Marker Score: 150 - Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.56
Marker Score: 234 - Cell Name: meningeal macrophage (CL0000879)
Fold Change: 0.56
Marker Score: 157 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.55
Marker Score: 175 - Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 0.55
Marker Score: 630 - Cell Name: glutamatergic neuron (CL0000679)
Fold Change: 0.51
Marker Score: 5,146 - Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.49
Marker Score: 218 - Cell Name: goblet cell (CL0000160)
Fold Change: 0.49
Marker Score: 3,256 - Cell Name: myeloid cell (CL0000763)
Fold Change: 0.48
Marker Score: 774 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 0.48
Marker Score: 10,255 - Cell Name: oligodendrocyte (CL0000128)
Fold Change: 0.48
Marker Score: 1,144 - Cell Name: astrocyte (CL0000127)
Fold Change: 0.46
Marker Score: 402 - Cell Name: melanocyte (CL0000148)
Fold Change: 0.46
Marker Score: 186 - Cell Name: pro-B cell (CL0000826)
Fold Change: 0.44
Marker Score: 428 - Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.37
Marker Score: 374 - Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.37
Marker Score: 1,059 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.37
Marker Score: 181 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.35
Marker Score: 353 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 0.28
Marker Score: 6,319 - Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.28
Marker Score: 158 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.28
Marker Score: 162
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1597205708
Symbol: CAC1E_HUMAN
Name: Voltage-dependent R-type calcium channel subunit alpha-1E
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7536609
Title: Molecular analysis and functional expression of the human type E neuronal Ca2+ channel alpha 1 subunit.
PubMed ID: 7536609
PubMed ID: 8071363
Title: Structure and functional characterization of neuronal alpha 1E calcium channel subtypes.
PubMed ID: 8071363
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15258581
Title: Mutations in EFHC1 cause juvenile myoclonic epilepsy.
PubMed ID: 15258581
DOI: 10.1038/ng1393
PubMed ID: 30343943
Title: De novo pathogenic variants in CACNA1E cause developmental and epileptic encephalopathy with contractures, macrocephaly, and dyskinesias.
PubMed ID: 30343943
PubMed ID: 18400181
Title: Crystal structure of the CaV2 IQ domain in complex with Ca2+/calmodulin: high-resolution mechanistic implications for channel regulation by Ca2+.
PubMed ID: 18400181
Sequence Information:
- Length: 2313
- Mass: 261731
- Checksum: CCC7F309C27C42F1
- Sequence:
MARFGEAVVA RPGSGDGDSD QSRNRQGTPV PASGQAAAYK QTKAQRARTM ALYNPIPVRQ NCFTVNRSLF IFGEDNIVRK YAKKLIDWPP FEYMILATII ANCIVLALEQ HLPEDDKTPM SRRLEKTEPY FIGIFCFEAG IKIVALGFIF HKGSYLRNGW NVMDFIVVLS GILATAGTHF NTHVDLRTLR AVRVLRPLKL VSGIPSLQIV LKSIMKAMVP LLQIGLLLFF AILMFAIIGL EFYSGKLHRA CFMNNSGILE GFDPPHPCGV QGCPAGYECK DWIGPNDGIT QFDNILFAVL TVFQCITMEG WTTVLYNTND ALGATWNWLY FIPLIIIGSF FVLNLVLGVL SGEFAKERER VENRRAFMKL RRQQQIEREL NGYRAWIDKA EEVMLAEENK NAGTSALEVL RRATIKRSRT EAMTRDSSDE HCVDISSVGT PLARASIKSA KVDGVSYFRH KERLLRISIR HMVKSQVFYW IVLSLVALNT ACVAIVHHNQ PQWLTHLLYY AEFLFLGLFL LEMSLKMYGM GPRLYFHSSF NCFDFGVTVG SIFEVVWAIF RPGTSFGISV LRALRLLRIF KITKYWASLR NLVVSLMSSM KSIISLLFLL FLFIVVFALL GMQLFGGRFN FNDGTPSANF DTFPAAIMTV FQILTGEDWN EVMYNGIRSQ GGVSSGMWSA IYFIVLTLFG NYTLLNVFLA IAVDNLANAQ ELTKDEQEEE EAFNQKHALQ KAKEVSPMSA PNMPSIERDR RRRHHMSMWE PRSSHLRERR RRHHMSVWEQ RTSQLRKHMQ MSSQEALNRE EAPTMNPLNP LNPLSSLNPL NAHPSLYRRP RAIEGLALGL ALEKFEEERI SRGGSLKGDG GDRSSALDNQ RTPLSLGQRE PPWLARPCHG NCDPTQQEAG GGEAVVTFED RARHRQSQRR SRHRRVRTEG KESSSASRSR SASQERSLDE AMPTEGEKDH ELRGNHGAKE PTIQEERAQD LRRTNSLMVS RGSGLAGGLD EADTPLVLPH PELEVGKHVV LTEQEPEGSS EQALLGNVQL DMGRVISQSE PDLSCITANT DKATTESTSV TVAIPDVDPL VDSTVVHISN KTDGEASPLK EAEIREDEEE VEKKKQKKEK RETGKAMVPH SSMFIFSTTN PIRRACHYIV NLRYFEMCIL LVIAASSIAL AAEDPVLTNS ERNKVLRYFD YVFTGVFTFE MVIKMIDQGL ILQDGSYFRD LWNILDFVVV VGALVAFALA NALGTNKGRD IKTIKSLRVL RVLRPLKTIK RLPKLKAVFD CVVTSLKNVF NILIVYKLFM FIFAVIAVQL FKGKFFYCTD SSKDTEKECI GNYVDHEKNK MEVKGREWKR HEFHYDNIIW ALLTLFTVST GEGWPQVLQH SVDVTEEDRG PSRSNRMEMS IFYVVYFVVF PFFFVNIFVA LIIITFQEQG DKMMEECSLE KNERACIDFA ISAKPLTRYM PQNRHTFQYR VWHFVVSPSF EYTIMAMIAL NTVVLMMKYY SAPCTYELAL KYLNIAFTMV FSLECVLKVI AFGFLNYFRD TWNIFDFITV IGSITEIILT DSKLVNTSGF NMSFLKLFRA ARLIKLLRQG YTIRILLWTF VQSFKALPYV CLLIAMLFFI YAIIGMQVFG NIKLDEESHI NRHNNFRSFF GSLMLLFRSA TGEAWQEIML SCLGEKGCEP DTTAPSGQNE NERCGTDLAY VYFVSFIFFC SFLMLNLFVA VIMDNFEYLT RDSSILGPHH LDEFVRVWAE YDRAACGRIH YTEMYEMLTL MSPPLGLGKR CPSKVAYKRL VLMNMPVAED MTVHFTSTLM ALIRTALDIK IAKGGADRQQ LDSELQKETL AIWPHLSQKM LDLLVPMPKA SDLTVGKIYA AMMIMDYYKQ SKVKKQRQQL EEQKNAPMFQ RMEPSSLPQE IIANAKALPY LQQDPVSGLS GRSGYPSMSP LSPQDIFQLA CMDPADDGQF QERQSLEPEV SELKSVQPSN HGIYLPSDTQ EHAGSGRASS MPRLTVDPQV VTDPSSMRRS FSTIRDKRSN SSWLEEFSME RSSENTYKSR RRSYHSSLRL SAHRLNSDSG HKSDTHRSGG RERGRSKERK HLLSPDVSRC NSEERGTQAD WESPERRQSR SPSEGRSQTP NRQGTGSLSE SSIPSVSDTS TPRRSRRQLP PVPPKPRPLL SYSSLIRHAG SISPPADGSE EGSPLTSQAL ESNNACLTES SNSPHPQQSQ HASPQRYISE PYLALHEDSH ASDCGEEETL TFEAAVATSL GRSNTIGSAP PLRHSWQMPN GHYRRRRRGG PGPGMMCGAV NNLLSDTEED DKC
Genular Protein ID: 2342004387
Symbol: Q59FG1_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 1869
- Mass: 211937
- Checksum: 22262D31FB729EA0
- Sequence:
AGTSALEVLR RATIKRSRTE AMTRDSSDEH CVDISSVGTP LARASIKSAK VDGVSYFRHK ERLLRISIRH MVKSQVFYWI VLSLVALNTA CVAIVHHNQP QWLTHLLYYA EFLFLGLFLL EMSLKMYGMG PRLYFHSSFN CFDFGVTVGS IFEVVWAIFR PGTSFGISVL RALRLLRIFK ITKYWASLRN LVVSLMSSMK SIISLLFLLF LFIVVFALLG MQLFGGRFNF NDGTPSANFD TFPAAIMTVF QILTGEDWNE VMYNGIRSQG GVSSGMWSAI YFIVLTLFGN YTLLNVFLAI AVDNLANAQE LTKDEQEEEE AFNQKHALQK AKEVSPMSAP NMPSIERDRR RRHHMSMWEP RSSHLRERRR RHHMSVWEQR TSQLRKHMQM SSQEALNREE APTMNPLNPL NPLSSLNPLN AHPSLYRRPR AIEGLALGLA LEKFEEERIS RGGSLKGDGG DRSSALDNQR TPLSLGQREP PWLARPCHGN CDPTQQEAGG GEAVVTFEDR ARHRQSQRRS RHRRVRTEGK ESSSASRSRS ASQERSLDEA MPTEGEKDHE LRGNHGAKEP TIQEERAQDL RRTNSLMVSR GSGLAGGLDE ADTPLVLPHP ELEVGKHVVL TEQEPEGSSE QALLGNVQLD MGRVISQSEP DLSCITANTD KATTESTSVT VAIPDVDPLV DSTVVHISNK TDGEASPLKE AEIREDEEEV EKKKQKKEKR ETGKAMVPHS SMFIFSTTNP IRRACHYIVN LRYFEMCILL VIAASSIALA AEDPVLTNSE RNKVLRYFDY VFTGVFTFEM VIKMIDQGLI LQDGSYFRDL WNILDFVVVV GALVAFALAN ALGTNKGRDI KTIKSLRVLR VLRPLKTIKR LPKLKAVFDC VVTSLKNVFN ILIVYKLFMF IFAVIAVQLF KGKFFYCTDS SKDTEKECIG NYVDHEKNKM EVKGREWKRH EFHYDNIIWA LLTLFTVSTG EGWPQVLQHS VDVTEEDRGP SRSNRMEMSI FYVVYFVVFP FFFVNIFVAL IIITFQEQGD KMMEECSLEK NERACIDFAI SAKPLTRYMP QNRHTFQYRV WHFVVSPSFE YTIMAMIALN TVVLMMKYYS APCTYELALK YLNIAFTMVF SLECVLKVIA FGFLNYFRDT WNIFDFITVI GSITEIILTD SKLVNTSGFN MSFLKLFRAA RLIKLLRQGY TIRILLWTFV QSFKALPYVC LLIAMLFFIY AIIGMQVFGN IKLDEESHIN RHNNFRSFFG SLMLLFRSAT GEAWQEIMLS CLGEKGCEPD TTAPSGQNEN ERCGTDLAYV YFVSFIFFCS FLMLNLFVAV IMDNFEYLTR DSSILGPHHL DEFVRVWAEY DRAACGRIHY TEMYEMLTLM SPPLGLGKRC PSKVAYKRLV LMNMPVAEDM TVHFTSTLMA LIRTALDIKI AKGGADRQQL DSELQKETLA IWPHLSQKML DLLVPMPKAS DLTVGKIYAA MMIMDYYKQS KVKKQRQQLE EQKNAPMFQR MEPSSLPQEI IANAKALPYL QQDPVSGLSG RSGYPSMSPL SPQDIFQLAC MDPTDDGQFQ ERQSLVVTDP SSMRRSFSTI RDKRSNSSWL EEFSMERSSE NTYKSRRRSY HSSLRLSAHR LNSDSGHKSD THRSGGRERG RSKERKHLLS PDVSRCNSEE RGTQADWESP ERRQSRSPSE GRSQTPNRQG TGSLSESSIP SVSDTSTPRR SRRQLPPVPP KPRPLLSYSS LIRHAGSISP PADGSEEGSP LTSQALESNN ACLTESSNSP HPQQSQHASP QRYISEPYLA LHEDSHASDC GEEETLTFEA AVATSLGRSN TIGSAPPLRH SWQMPNGHYR RRRRGGPGPG MMCGAVNNLL SDTEEDDKC
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.