Details for: DDR1

Gene ID: 780

Symbol: DDR1

Ensembl ID: ENSG00000204580

Description: discoidin domain receptor tyrosine kinase 1

Associated with

Other Information

Genular Protein ID: 3925507648

Symbol: DDR1_HUMAN

Name: Epithelial discoidin domain-containing receptor 1

UniProtKB Accession Codes:

Q08345 B5A975 B5A976 B7Z2K0 Q14196 Q16562 Q2L6H3 Q4LE50 Q5ST11 Q5ST12 Q6NSK4 Q9UD35 Q9UD36 Q9UD37 Q9UD86 Q9UDL2

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 2 CORUM 1 CPTAC 2 CTD 1 ChEBI 16 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EC 2 EMBL 39 EPD 1 Ensembl 44 ExpressionAtlas 1 GO 30 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 43 PDBsum 34 PIR 2 PRINTS 1 PRO 1 PROSITE 6 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 RNAct 1 Reactome 1 RefSeq 15 Rhea 3 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8226977

Title: Molecular cloning of trkE, a novel trk-related putative tyrosine kinase receptor isolated from normal human keratinocytes and widely expressed by normal human tissues.

PubMed ID: 8226977

DOI: 10.1016/s0021-9258(20)80524-9

PubMed ID: 8390675

Title: A receptor tyrosine kinase found in breast carcinoma cells has an extracellular discoidin I-like domain.

PubMed ID: 8390675

DOI: 10.1073/pnas.90.12.5677

PubMed ID: 7848919

Title: Isolation and characterization of an epithelial-specific receptor tyrosine kinase from an ovarian cancer cell line.

PubMed ID: 7848919

PubMed ID: 8302582

Title: Identification and chromosomal mapping of a receptor tyrosine kinase with a putative phospholipid binding sequence in its ectodomain.

PubMed ID: 8302582

PubMed ID: 8977099

Title: Receptor protein tyrosine kinase DDR is up-regulated by p53 protein.

PubMed ID: 8977099

DOI: 10.1016/s0014-5793(96)01234-3

PubMed ID: 8796349

Title: The genomic structure of discoidin receptor tyrosine kinase.

PubMed ID: 8796349

DOI: 10.1101/gr.6.7.620

PubMed ID: 8622863

Title: Identification of two isoforms of the Cak receptor kinase that are coexpressed in breast tumor cell lines.

PubMed ID: 8622863

PubMed ID: 18593464

Title: Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis.

PubMed ID: 18593464

DOI: 10.1186/ar2447

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16702430

Title: Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity.

PubMed ID: 16702430

DOI: 10.1534/genetics.106.057034

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 24509848

Title: Glycosylation at Asn211 regulates the activation state of the discoidin domain receptor 1 (DDR1).

PubMed ID: 24509848

DOI: 10.1074/jbc.m113.541102

PubMed ID: 7845687

Title: Distinct structural characteristics of discoidin I subfamily receptor tyrosine kinases and complementary expression in human cancer.

PubMed ID: 7845687

PubMed ID: 7834423

Title: Expression of growth factor receptors, the focal adhesion kinase, and other tyrosine kinases in human soft tissue tumors.

PubMed ID: 7834423

DOI: 10.1007/bf02303537

PubMed ID: 8247543

Title: A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes.

PubMed ID: 8247543

PubMed ID: 9659899

Title: The discoidin domain receptor tyrosine kinases are activated by collagen.

PubMed ID: 9659899

DOI: 10.1016/s1097-2765(00)80003-9

PubMed ID: 12065315

Title: Tyrosine kinase activity of discoidin domain receptor 1 is necessary for smooth muscle cell migration and matrix metalloproteinase expression.

PubMed ID: 12065315

DOI: 10.1161/01.res.0000022166.74073.f8

PubMed ID: 16337946

Title: Pinpointing phosphotyrosine-dependent interactions downstream of the collagen receptor DDR1.

PubMed ID: 16337946

DOI: 10.1016/j.febslet.2005.11.035

PubMed ID: 16234985

Title: Discoidin domain receptor-1a (DDR1a) promotes glioma cell invasion and adhesion in association with matrix metalloproteinase-2.

PubMed ID: 16234985

DOI: 10.1007/s11060-005-6874-1

PubMed ID: 18190796

Title: KIBRA interacts with discoidin domain receptor 1 to modulate collagen-induced signalling.

PubMed ID: 18190796

DOI: 10.1016/j.bbamcr.2007.12.007

PubMed ID: 19401332

Title: The collagen receptor DDR1 regulates cell spreading and motility by associating with myosin IIA.

PubMed ID: 19401332

DOI: 10.1242/jcs.046219

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20432435

Title: DDR1 regulates the stabilization of cell surface E-cadherin and E-cadherin-mediated cell aggregation.

PubMed ID: 20432435

DOI: 10.1002/jcp.22134

PubMed ID: 20093046

Title: Collagen stimulates discoidin domain receptor 1-mediated migration of smooth muscle cells through Src.

PubMed ID: 20093046

DOI: 10.1016/j.carpath.2009.12.006

PubMed ID: 20884741

Title: Discoidin domain receptor 1 regulates bronchial epithelial repair and matrix metalloproteinase production.

PubMed ID: 20884741

DOI: 10.1183/09031936.00039710

PubMed ID: 21044884

Title: Collagen binding specificity of the discoidin domain receptors: binding sites on collagens II and III and molecular determinants for collagen IV recognition by DDR1.

PubMed ID: 21044884

DOI: 10.1016/j.matbio.2010.10.004

PubMed ID: 22483115

Title: Structure of the discoidin domain receptor 1 extracellular region bound to an inhibitory Fab fragment reveals features important for signaling.

PubMed ID: 22483115

DOI: 10.1016/j.str.2012.02.011

PubMed ID: 23899692

Title: Discovery of a potent and selective DDR1 receptor tyrosine kinase inhibitor.

PubMed ID: 23899692

DOI: 10.1021/cb400430t

PubMed ID: 24768818

Title: Structural mechanisms determining inhibition of the collagen receptor DDR1 by selective and multi-targeted type II kinase inhibitors.

PubMed ID: 24768818

DOI: 10.1016/j.jmb.2014.04.014

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 913
  • Mass: 101128
  • Checksum: C96913EA906C481E
  • Sequence:
    • MGPEALSSLL LLLLVASGDA DMKGHFDPAK CRYALGMQDR TIPDSDISAS SSWSDSTAAR 
HSRLESSDGD GAWCPAGSVF PKEEEYLQVD LQRLHLVALV GTQGRHAGGL GKEFSRSYRL 
RYSRDGRRWM GWKDRWGQEV ISGNEDPEGV VLKDLGPPMV ARLVRFYPRA DRVMSVCLRV 
ELYGCLWRDG LLSYTAPVGQ TMYLSEAVYL NDSTYDGHTV GGLQYGGLGQ LADGVVGLDD 
FRKSQELRVW PGYDYVGWSN HSFSSGYVEM EFEFDRLRAF QAMQVHCNNM HTLGARLPGG 
VECRFRRGPA MAWEGEPMRH NLGGNLGDPR ARAVSVPLGG RVARFLQCRF LFAGPWLLFS 
EISFISDVVN NSSPALGGTF PPAPWWPPGP PPTNFSSLEL EPRGQQPVAK AEGSPTAILI 
GCLVAIILLL LLIIALMLWR LHWRRLLSKA ERRVLEEELT VHLSVPGDTI LINNRPGPRE 
PPPYQEPRPR GNPPHSAPCV PNGSALLLSN PAYRLLLATY ARPPRGPGPP TPAWAKPTNT 
QAYSGDYMEP EKPGAPLLPP PPQNSVPHYA EADIVTLQGV TGGNTYAVPA LPPGAVGDGP 
PRVDFPRSRL RFKEKLGEGQ FGEVHLCEVD SPQDLVSLDF PLNVRKGHPL LVAVKILRPD 
ATKNARNDFL KEVKIMSRLK DPNIIRLLGV CVQDDPLCMI TDYMENGDLN QFLSAHQLED 
KAAEGAPGDG QAAQGPTISY PMLLHVAAQI ASGMRYLATL NFVHRDLATR NCLVGENFTI 
KIADFGMSRN LYAGDYYRVQ GRAVLPIRWM AWECILMGKF TTASDVWAFG VTLWEVLMLC 
RAQPFGQLTD EQVIENAGEF FRDQGRQVYL SRPPACPQGL YELMLRCWSR ESEQRPPFSQ 
LHRFLAEDAL NTV

Genular Protein ID: 2764873674

Symbol: Q96T61_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q96T61

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 Genevisible 1 GenomeRNAi 1 NCBI Taxonomy 1 OrthoDB 1 PeptideAtlas 1 RefSeq 1

Sequence Information:

  • Length: 62
  • Mass: 7069
  • Checksum: 753DBEDCF5ADCCC3
  • Sequence:
    • ILLLLLIIAL MLWRLHWRRL LSKVLESHPR TRSPGLVGIR PTPLPVSPMA LVHLCEVDSP 
QD

Genular Protein ID: 1719175820

Symbol: Q96T62_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q96T62

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 Genevisible 1 GenomeRNAi 1 NCBI Taxonomy 1 OrthoDB 1 PeptideAtlas 1 RefSeq 1 SAM 2

Sequence Information:

  • Length: 82
  • Mass: 9236
  • Checksum: 9C69684457B0F7D2
  • Sequence:
    • ILLLLLIIAL MLWRLHWRRL LSKAERRVLE EELTVHLSVP GDTILINNRP GPREPPPYQE 
PRPRGNPPHS APCVPNGSGA PV

Genular Protein ID: 281256178

Symbol: A0A0A0MSX3_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0A0MSX3

Database IDs:

ARBA 4 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 EC 1 EMBL 7 EPD 1 Ensembl 5 GO 4 Gene3D 3 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 9 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 8 Pfam 3 Proteomes 2 RefSeq 1 Rhea 3 SAM 2 SMART 2 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

Sequence Information:

  • Length: 767
  • Mass: 85452
  • Checksum: 3273D2EB76647830
  • Sequence:
    • MGPEALSSLL LLLLVASGDA DMKGHFDPAK CRYALGMQDR TIPDSDISAS SSWSDSTAAR 
HSRLESSDGD GAWCPAGSVF PKEEEYLQVD LQRLHLVALV GTQGRHAGGL GKEFSRSYRL 
RYSRDGRRWM GWKDRWGQEV ISGNEDPEGV VLKDLGPPMV ARLVRFYPRA DRVMSVCLRV 
ELYGCLWRDG LLSYTAPVGQ TMYLSEAVYL NDSTYDGHTV GGLQYGGLGQ LADGVVGLDD 
FRKSQELRVW PGYDYVGWSN HSFSSGYVEM EFEFDRLRAF QAMQVHCNNM HTLGARLPGG 
VECRFRRGPA MAWEGEPMRH NLGGNLGDPR ARAVSVPLGG RVARFLQCRF LFAGPWLLFS 
EISFISDVVN NSSPALGGTF PPAPWWPPGP PPTNFSSLEL EPRGQQPVAK AEGSPTAILI 
GCLVAIILLL LLIIALMLWR LHWRRLLSKV LESHPRTRSP GLVGIRPTPL PVSPMALVHL 
CEVDSPQDLV SLDFPLNVRK GHPLLVAVKI LRPDATKNAR NDFLKEVKIM SRLKDPNIIR 
LLGVCVQDDP LCMITDYMEN GDLNQFLSAH QLEDKAAEGA PGDGQAAQGP TISYPMLLHV 
AAQIASGMRY LATLNFVHRD LATRNCLVGE NFTIKIADFG MSRNLYAGDY YRVQGRAVLP 
IRWMAWECIL MGKFTTASDV WAFGVTLWEV LMLCRAQPFG QLTDEQVIEN AGEFFRDQGR 
QVYLSRPPAC PQGLYELMLR CWSRESEQRP PFSQLHRFLA EDALNTV

Genular Protein ID: 3135583056

Symbol: A0A024RCQ1_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A024RCQ1

Database IDs:

ARBA 4 Antibodypedia 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 EC 1 EMBL 6 ExpressionAtlas 1 GO 4 Gene3D 3 GenomeRNAi 1 HOGENOM 1 InterPro 9 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 8 Pfam 3 RefSeq 4 Rhea 3 SAM 3 SMART 2 SMR 1 SUPFAM 2 VEuPathDB 1

Sequence Information:

  • Length: 876
  • Mass: 97174
  • Checksum: E02881598CC7CD0B
  • Sequence:
    • MGPEALSSLL LLLLVASGDA DMKGHFDPAK CRYALGMQDR TIPDSDISAS SSWSDSTAAR 
HSRLESSDGD GAWCPAGSVF PKEEEYLQVD LQRLHLVALV GTQGRHAGGL GKEFSRSYRL 
RYSRDGRRWM GWKDRWGQEV ISGNEDPEGV VLKDLGPPMV ARLVRFYPRA DRVMSVCLRV 
ELYGCLWRDG LLSYTAPVGQ TMYLSEAVYL NDSTYDGHTV GGLQYGGLGQ LADGVVGLDD 
FRKSQELRVW PGYDYVGWSN HSFSSGYVEM EFEFDRLRAF QAMQVHCNNM HTLGARLPGG 
VECRFRRGPA MAWEGEPMRH NLGGNLGDPR ARAVSVPLGG RVARFLQCRF LFAGPWLLFS 
EISFISDVVN NSSPALGGTF PPAPWWPPGP PPTNFSSLEL EPRGQQPVAK AEGSPTAILI 
GCLVAIILLL LLIIALMLWR LHWRRLLSKA ERRVLEEELT VHLSVPGDTI LINNRPGPRE 
PPPYQEPRPR GNPPHSAPCV PNGSAYSGDY MEPEKPGAPL LPPPPQNSVP HYAEADIVTL 
QGVTGGNTYA VPALPPGAVG DGPPRVDFPR SRLRFKEKLG EGQFGEVHLC EVDSPQDLVS 
LDFPLNVRKG HPLLVAVKIL RPDATKNARN DFLKEVKIMS RLKDPNIIRL LGVCVQDDPL 
CMITDYMENG DLNQFLSAHQ LEDKAAEGAP GDGQAAQGPT ISYPMLLHVA AQIASGMRYL 
ATLNFVHRDL ATRNCLVGEN FTIKIADFGM SRNLYAGDYY RVQGRAVLPI RWMAWECILM 
GKFTTASDVW AFGVTLWEVL MLCRAQPFGQ LTDEQVIENA GEFFRDQGRQ VYLSRPPACP 
QGLYELMLRC WSRESEQRPP FSQLHRFLAE DALNTV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.