Details for: DDR1

Gene ID: 780

Symbol: DDR1

Ensembl ID: ENSG00000204580

Description: discoidin domain receptor tyrosine kinase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 135.8995
    Cell Significance Index: -34.4700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 76.7925
    Cell Significance Index: -31.2000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 32.3019
    Cell Significance Index: -30.8400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 27.9085
    Cell Significance Index: -34.4100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.3083
    Cell Significance Index: -38.3300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.7455
    Cell Significance Index: -34.5100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 3.5344
    Cell Significance Index: 183.6000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 3.0915
    Cell Significance Index: 71.4300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.9562
    Cell Significance Index: -6.4700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.5887
    Cell Significance Index: 421.0300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.3480
    Cell Significance Index: 63.9100
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.5039
    Cell Significance Index: 9.2600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.3307
    Cell Significance Index: 19.9400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.3298
    Cell Significance Index: 28.8100
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 1.2508
    Cell Significance Index: 2.8200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.1719
    Cell Significance Index: 33.7700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.1388
    Cell Significance Index: 205.3000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.0893
    Cell Significance Index: 50.7900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.0745
    Cell Significance Index: 80.0800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.0642
    Cell Significance Index: 29.7400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.9070
    Cell Significance Index: 117.1800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8992
    Cell Significance Index: 110.5700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7977
    Cell Significance Index: 352.6700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6408
    Cell Significance Index: 349.9600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5804
    Cell Significance Index: 524.0400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5677
    Cell Significance Index: 26.6800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5642
    Cell Significance Index: 39.0200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5131
    Cell Significance Index: 36.2900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4154
    Cell Significance Index: 23.3100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.3704
    Cell Significance Index: 12.8700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.3500
    Cell Significance Index: 12.3000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3331
    Cell Significance Index: 63.3900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3268
    Cell Significance Index: 8.1700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.3209
    Cell Significance Index: 2.9600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3051
    Cell Significance Index: 52.0900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2925
    Cell Significance Index: 6.2300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.2262
    Cell Significance Index: 3.2200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2204
    Cell Significance Index: 21.8000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2079
    Cell Significance Index: 6.6600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1273
    Cell Significance Index: 45.6600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1096
    Cell Significance Index: 21.7500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.0789
    Cell Significance Index: 0.6300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0627
    Cell Significance Index: 2.8400
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.0539
    Cell Significance Index: 0.3200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0533
    Cell Significance Index: 1.3700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0225
    Cell Significance Index: 16.5200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0044
    Cell Significance Index: 3.0100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0010
    Cell Significance Index: 0.1300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0009
    Cell Significance Index: -1.6700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0055
    Cell Significance Index: -4.1900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0094
    Cell Significance Index: -17.3300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0116
    Cell Significance Index: -0.3100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0130
    Cell Significance Index: -20.0000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0182
    Cell Significance Index: -13.5000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0215
    Cell Significance Index: -13.6300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0272
    Cell Significance Index: -16.9800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0305
    Cell Significance Index: -41.4400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0434
    Cell Significance Index: -2.1900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0446
    Cell Significance Index: -25.1600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0570
    Cell Significance Index: -0.5900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0732
    Cell Significance Index: -33.2100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0809
    Cell Significance Index: -9.2400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0917
    Cell Significance Index: -18.3900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0931
    Cell Significance Index: -9.5100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0938
    Cell Significance Index: -1.2800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0944
    Cell Significance Index: -10.8100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0954
    Cell Significance Index: -20.0900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1225
    Cell Significance Index: -16.8200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1278
    Cell Significance Index: -36.7600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1341
    Cell Significance Index: -5.4900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1388
    Cell Significance Index: -20.1800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1575
    Cell Significance Index: -8.2700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1658
    Cell Significance Index: -3.6300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.1708
    Cell Significance Index: -18.5800
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.2058
    Cell Significance Index: -2.6500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2108
    Cell Significance Index: -24.5700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2634
    Cell Significance Index: -6.9300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3042
    Cell Significance Index: -35.8700
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.3344
    Cell Significance Index: -2.1000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3365
    Cell Significance Index: -35.0400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3885
    Cell Significance Index: -23.8200
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.4002
    Cell Significance Index: -3.3100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4148
    Cell Significance Index: -32.8500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.4557
    Cell Significance Index: -7.8800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4982
    Cell Significance Index: -25.9500
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.5022
    Cell Significance Index: -5.1800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5115
    Cell Significance Index: -15.0700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.5254
    Cell Significance Index: -40.3200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.5405
    Cell Significance Index: -34.8700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.6382
    Cell Significance Index: -10.6800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6450
    Cell Significance Index: -40.6600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6712
    Cell Significance Index: -24.6400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.6812
    Cell Significance Index: -14.1300
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.6927
    Cell Significance Index: -7.3600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7499
    Cell Significance Index: -33.1700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.8625
    Cell Significance Index: -32.6600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.8708
    Cell Significance Index: -5.9000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.9057
    Cell Significance Index: -22.6200
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.9112
    Cell Significance Index: -7.0100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.9190
    Cell Significance Index: -22.2600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** DDR1 is characterized by its unique discoidin domain, which is responsible for binding to collagen and other extracellular matrix components. This binding event triggers a series of downstream signaling events, including the activation of tyrosine kinases and the phosphorylation of various substrates. DDR1 is also a member of the receptor tyrosine kinase (RTK) family, which is known for its ability to regulate cell growth, differentiation, and survival. The expression of DDR1 is highly tissue-specific, with significant levels found in epithelial cells, suggesting its role in maintaining tissue integrity and responding to environmental changes. **Pathways and Functions** DDR1 is involved in several signaling pathways that regulate various cellular processes, including: 1. **Cell adhesion and migration**: DDR1 plays a crucial role in regulating cell-matrix interactions, particularly in the context of wound healing, smooth muscle cell migration, and epithelial-to-mesenchymal transition (EMT). 2. **Extracellular matrix organization**: DDR1 helps regulate the organization and remodeling of the extracellular matrix, which is essential for maintaining tissue homeostasis and responding to environmental changes. 3. **Cell proliferation and differentiation**: DDR1 can regulate cell growth and differentiation, particularly in the context of tissue development and repair. 4. **Signaling pathways**: DDR1 is involved in various signaling pathways, including the ERK1/2 cascade, the PI3K/AKT pathway, and the MAPK/ERK pathway, which regulate cell growth, differentiation, and survival. **Clinical Significance** DDR1 has been implicated in various diseases and disorders, including: 1. **Cancer**: DDR1 has been shown to be overexpressed in several types of cancer, including breast, lung, and colon cancer, suggesting its potential role in tumor progression and metastasis. 2. **Cardiovascular disease**: DDR1 has been implicated in the development of cardiovascular disease, particularly in the context of atherosclerosis and smooth muscle cell migration. 3. **Neurological disorders**: DDR1 has been shown to be involved in the development of neurological disorders, including Alzheimer's disease and Parkinson's disease, suggesting its potential role in neuroinflammation and neurodegeneration. 4. **Wound healing**: DDR1 plays a crucial role in wound healing, particularly in the context of skin regeneration and tissue repair. In conclusion, DDR1 is a critical regulator of cell-matrix interactions, tissue homeostasis, and signaling pathways. Its dysregulation has been implicated in various diseases and disorders, highlighting its potential as a therapeutic target for the treatment of various human diseases.

Genular Protein ID: 3925507648

Symbol: DDR1_HUMAN

Name: Epithelial discoidin domain-containing receptor 1

UniProtKB Accession Codes:

Q08345 B5A975 B5A976 B7Z2K0 Q14196 Q16562 Q2L6H3 Q4LE50 Q5ST11 Q5ST12 Q6NSK4 Q9UD35 Q9UD36 Q9UD37 Q9UD86 Q9UDL2

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 2 CORUM 1 CPTAC 2 CTD 1 ChEBI 16 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EC 2 EMBL 39 Ensembl 44 EvolutionaryTrace 1 ExpressionAtlas 1 GO 30 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 34 PDBsum 34 PIR 2 PRINTS 1 PRO 1 PROSITE 6 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 RNAct 1 Reactome 1 RefSeq 15 Rhea 3 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8226977

Title: Molecular cloning of trkE, a novel trk-related putative tyrosine kinase receptor isolated from normal human keratinocytes and widely expressed by normal human tissues.

PubMed ID: 8226977

DOI: 10.1016/s0021-9258(20)80524-9

PubMed ID: 8390675

Title: A receptor tyrosine kinase found in breast carcinoma cells has an extracellular discoidin I-like domain.

PubMed ID: 8390675

DOI: 10.1073/pnas.90.12.5677

PubMed ID: 7848919

Title: Isolation and characterization of an epithelial-specific receptor tyrosine kinase from an ovarian cancer cell line.

PubMed ID: 7848919

PubMed ID: 8302582

Title: Identification and chromosomal mapping of a receptor tyrosine kinase with a putative phospholipid binding sequence in its ectodomain.

PubMed ID: 8302582

PubMed ID: 8977099

Title: Receptor protein tyrosine kinase DDR is up-regulated by p53 protein.

PubMed ID: 8977099

DOI: 10.1016/s0014-5793(96)01234-3

PubMed ID: 8796349

Title: The genomic structure of discoidin receptor tyrosine kinase.

PubMed ID: 8796349

DOI: 10.1101/gr.6.7.620

PubMed ID: 8622863

Title: Identification of two isoforms of the Cak receptor kinase that are coexpressed in breast tumor cell lines.

PubMed ID: 8622863

PubMed ID: 18593464

Title: Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis.

PubMed ID: 18593464

DOI: 10.1186/ar2447

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16702430

Title: Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity.

PubMed ID: 16702430

DOI: 10.1534/genetics.106.057034

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 24509848

Title: Glycosylation at Asn211 regulates the activation state of the discoidin domain receptor 1 (DDR1).

PubMed ID: 24509848

DOI: 10.1074/jbc.m113.541102

PubMed ID: 7845687

Title: Distinct structural characteristics of discoidin I subfamily receptor tyrosine kinases and complementary expression in human cancer.

PubMed ID: 7845687

PubMed ID: 7834423

Title: Expression of growth factor receptors, the focal adhesion kinase, and other tyrosine kinases in human soft tissue tumors.

PubMed ID: 7834423

DOI: 10.1007/bf02303537

PubMed ID: 8247543

Title: A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes.

PubMed ID: 8247543

PubMed ID: 9659899

Title: The discoidin domain receptor tyrosine kinases are activated by collagen.

PubMed ID: 9659899

DOI: 10.1016/s1097-2765(00)80003-9

PubMed ID: 12065315

Title: Tyrosine kinase activity of discoidin domain receptor 1 is necessary for smooth muscle cell migration and matrix metalloproteinase expression.

PubMed ID: 12065315

DOI: 10.1161/01.res.0000022166.74073.f8

PubMed ID: 16337946

Title: Pinpointing phosphotyrosine-dependent interactions downstream of the collagen receptor DDR1.

PubMed ID: 16337946

DOI: 10.1016/j.febslet.2005.11.035

PubMed ID: 16234985

Title: Discoidin domain receptor-1a (DDR1a) promotes glioma cell invasion and adhesion in association with matrix metalloproteinase-2.

PubMed ID: 16234985

DOI: 10.1007/s11060-005-6874-1

PubMed ID: 18190796

Title: KIBRA interacts with discoidin domain receptor 1 to modulate collagen-induced signalling.

PubMed ID: 18190796

DOI: 10.1016/j.bbamcr.2007.12.007

PubMed ID: 19401332

Title: The collagen receptor DDR1 regulates cell spreading and motility by associating with myosin IIA.

PubMed ID: 19401332

DOI: 10.1242/jcs.046219

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20432435

Title: DDR1 regulates the stabilization of cell surface E-cadherin and E-cadherin-mediated cell aggregation.

PubMed ID: 20432435

DOI: 10.1002/jcp.22134

PubMed ID: 20093046

Title: Collagen stimulates discoidin domain receptor 1-mediated migration of smooth muscle cells through Src.

PubMed ID: 20093046

DOI: 10.1016/j.carpath.2009.12.006

PubMed ID: 20884741

Title: Discoidin domain receptor 1 regulates bronchial epithelial repair and matrix metalloproteinase production.

PubMed ID: 20884741

DOI: 10.1183/09031936.00039710

PubMed ID: 21044884

Title: Collagen binding specificity of the discoidin domain receptors: binding sites on collagens II and III and molecular determinants for collagen IV recognition by DDR1.

PubMed ID: 21044884

DOI: 10.1016/j.matbio.2010.10.004

PubMed ID: 22483115

Title: Structure of the discoidin domain receptor 1 extracellular region bound to an inhibitory Fab fragment reveals features important for signaling.

PubMed ID: 22483115

DOI: 10.1016/j.str.2012.02.011

PubMed ID: 23899692

Title: Discovery of a potent and selective DDR1 receptor tyrosine kinase inhibitor.

PubMed ID: 23899692

DOI: 10.1021/cb400430t

PubMed ID: 24768818

Title: Structural mechanisms determining inhibition of the collagen receptor DDR1 by selective and multi-targeted type II kinase inhibitors.

PubMed ID: 24768818

DOI: 10.1016/j.jmb.2014.04.014

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 913
  • Mass: 101128
  • Checksum: C96913EA906C481E
  • Sequence:
    • MGPEALSSLL LLLLVASGDA DMKGHFDPAK CRYALGMQDR TIPDSDISAS SSWSDSTAAR 
HSRLESSDGD GAWCPAGSVF PKEEEYLQVD LQRLHLVALV GTQGRHAGGL GKEFSRSYRL 
RYSRDGRRWM GWKDRWGQEV ISGNEDPEGV VLKDLGPPMV ARLVRFYPRA DRVMSVCLRV 
ELYGCLWRDG LLSYTAPVGQ TMYLSEAVYL NDSTYDGHTV GGLQYGGLGQ LADGVVGLDD 
FRKSQELRVW PGYDYVGWSN HSFSSGYVEM EFEFDRLRAF QAMQVHCNNM HTLGARLPGG 
VECRFRRGPA MAWEGEPMRH NLGGNLGDPR ARAVSVPLGG RVARFLQCRF LFAGPWLLFS 
EISFISDVVN NSSPALGGTF PPAPWWPPGP PPTNFSSLEL EPRGQQPVAK AEGSPTAILI 
GCLVAIILLL LLIIALMLWR LHWRRLLSKA ERRVLEEELT VHLSVPGDTI LINNRPGPRE 
PPPYQEPRPR GNPPHSAPCV PNGSALLLSN PAYRLLLATY ARPPRGPGPP TPAWAKPTNT 
QAYSGDYMEP EKPGAPLLPP PPQNSVPHYA EADIVTLQGV TGGNTYAVPA LPPGAVGDGP 
PRVDFPRSRL RFKEKLGEGQ FGEVHLCEVD SPQDLVSLDF PLNVRKGHPL LVAVKILRPD 
ATKNARNDFL KEVKIMSRLK DPNIIRLLGV CVQDDPLCMI TDYMENGDLN QFLSAHQLED 
KAAEGAPGDG QAAQGPTISY PMLLHVAAQI ASGMRYLATL NFVHRDLATR NCLVGENFTI 
KIADFGMSRN LYAGDYYRVQ GRAVLPIRWM AWECILMGKF TTASDVWAFG VTLWEVLMLC 
RAQPFGQLTD EQVIENAGEF FRDQGRQVYL SRPPACPQGL YELMLRCWSR ESEQRPPFSQ 
LHRFLAEDAL NTV

Genular Protein ID: 281256178

Symbol: A0A0A0MSX3_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0A0MSX3

Database IDs:

ARBA 6 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 1 Ensembl 5 GO 4 Gene3D 3 GeneTree 1 HGNC 1 InterPro 10 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 8 PeptideAtlas 1 Pfam 3 Proteomes 2 ProteomicsDB 1 RefSeq 1 Rhea 3 SAM 2 SMART 2 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 767
  • Mass: 85452
  • Checksum: 3273D2EB76647830
  • Sequence:
    • MGPEALSSLL LLLLVASGDA DMKGHFDPAK CRYALGMQDR TIPDSDISAS SSWSDSTAAR 
HSRLESSDGD GAWCPAGSVF PKEEEYLQVD LQRLHLVALV GTQGRHAGGL GKEFSRSYRL 
RYSRDGRRWM GWKDRWGQEV ISGNEDPEGV VLKDLGPPMV ARLVRFYPRA DRVMSVCLRV 
ELYGCLWRDG LLSYTAPVGQ TMYLSEAVYL NDSTYDGHTV GGLQYGGLGQ LADGVVGLDD 
FRKSQELRVW PGYDYVGWSN HSFSSGYVEM EFEFDRLRAF QAMQVHCNNM HTLGARLPGG 
VECRFRRGPA MAWEGEPMRH NLGGNLGDPR ARAVSVPLGG RVARFLQCRF LFAGPWLLFS 
EISFISDVVN NSSPALGGTF PPAPWWPPGP PPTNFSSLEL EPRGQQPVAK AEGSPTAILI 
GCLVAIILLL LLIIALMLWR LHWRRLLSKV LESHPRTRSP GLVGIRPTPL PVSPMALVHL 
CEVDSPQDLV SLDFPLNVRK GHPLLVAVKI LRPDATKNAR NDFLKEVKIM SRLKDPNIIR 
LLGVCVQDDP LCMITDYMEN GDLNQFLSAH QLEDKAAEGA PGDGQAAQGP TISYPMLLHV 
AAQIASGMRY LATLNFVHRD LATRNCLVGE NFTIKIADFG MSRNLYAGDY YRVQGRAVLP 
IRWMAWECIL MGKFTTASDV WAFGVTLWEV LMLCRAQPFG QLTDEQVIEN AGEFFRDQGR 
QVYLSRPPAC PQGLYELMLR CWSRESEQRP PFSQLHRFLA EDALNTV

Genular Protein ID: 3135583056

Symbol: A0A024RCQ1_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A024RCQ1

Database IDs:

ARBA 6 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 6 ExpressionAtlas 1 GO 6 Gene3D 3 HOGENOM 1 InterPro 10 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 8 Pfam 3 RefSeq 4 Rhea 3 SAM 3 SMART 2 SMR 1 SUPFAM 2 VEuPathDB 1

Sequence Information:

  • Length: 876
  • Mass: 97174
  • Checksum: E02881598CC7CD0B
  • Sequence:
    • MGPEALSSLL LLLLVASGDA DMKGHFDPAK CRYALGMQDR TIPDSDISAS SSWSDSTAAR 
HSRLESSDGD GAWCPAGSVF PKEEEYLQVD LQRLHLVALV GTQGRHAGGL GKEFSRSYRL 
RYSRDGRRWM GWKDRWGQEV ISGNEDPEGV VLKDLGPPMV ARLVRFYPRA DRVMSVCLRV 
ELYGCLWRDG LLSYTAPVGQ TMYLSEAVYL NDSTYDGHTV GGLQYGGLGQ LADGVVGLDD 
FRKSQELRVW PGYDYVGWSN HSFSSGYVEM EFEFDRLRAF QAMQVHCNNM HTLGARLPGG 
VECRFRRGPA MAWEGEPMRH NLGGNLGDPR ARAVSVPLGG RVARFLQCRF LFAGPWLLFS 
EISFISDVVN NSSPALGGTF PPAPWWPPGP PPTNFSSLEL EPRGQQPVAK AEGSPTAILI 
GCLVAIILLL LLIIALMLWR LHWRRLLSKA ERRVLEEELT VHLSVPGDTI LINNRPGPRE 
PPPYQEPRPR GNPPHSAPCV PNGSAYSGDY MEPEKPGAPL LPPPPQNSVP HYAEADIVTL 
QGVTGGNTYA VPALPPGAVG DGPPRVDFPR SRLRFKEKLG EGQFGEVHLC EVDSPQDLVS 
LDFPLNVRKG HPLLVAVKIL RPDATKNARN DFLKEVKIMS RLKDPNIIRL LGVCVQDDPL 
CMITDYMENG DLNQFLSAHQ LEDKAAEGAP GDGQAAQGPT ISYPMLLHVA AQIASGMRYL 
ATLNFVHRDL ATRNCLVGEN FTIKIADFGM SRNLYAGDYY RVQGRAVLPI RWMAWECILM 
GKFTTASDVW AFGVTLWEVL MLCRAQPFGQ LTDEQVIENA GEFFRDQGRQ VYLSRPPACP 
QGLYELMLRC WSRESEQRPP FSQLHRFLAE DALNTV

Genular Protein ID: 2764873674

Symbol: Q96T61_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q96T61

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 NCBI Taxonomy 1 OrthoDB 1 PeptideAtlas 1 RefSeq 1

Sequence Information:

  • Length: 62
  • Mass: 7069
  • Checksum: 753DBEDCF5ADCCC3
  • Sequence:
    • ILLLLLIIAL MLWRLHWRRL LSKVLESHPR TRSPGLVGIR PTPLPVSPMA LVHLCEVDSP 
QD

Genular Protein ID: 1719175820

Symbol: Q96T62_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q96T62

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 NCBI Taxonomy 1 OrthoDB 1 PeptideAtlas 1 RefSeq 1 SAM 2

Sequence Information:

  • Length: 82
  • Mass: 9236
  • Checksum: 9C69684457B0F7D2
  • Sequence:
    • ILLLLLIIAL MLWRLHWRRL LSKAERRVLE EELTVHLSVP GDTILINNRP GPREPPPYQE 
PRPRGNPPHS APCVPNGSGA PV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.