Details for: CACNA2D1

Gene ID: 781

Symbol: CACNA2D1

Ensembl ID: ENSG00000153956

Description: calcium voltage-gated channel auxiliary subunit alpha2delta 1

Associated with

  • Calcium ion import across plasma membrane
    (GO:0098703)
  • Calcium ion transmembrane transport via high voltage-gated calcium channel
    (GO:0061577)
  • Calcium ion transport
    (GO:0006816)
  • Calcium ion transport into cytosol
    (GO:0060402)
  • Cardiac muscle cell action potential involved in contraction
    (GO:0086002)
  • Cellular response to amyloid-beta
    (GO:1904646)
  • Extracellular exosome
    (GO:0070062)
  • Gaba-ergic synapse
    (GO:0098982)
  • L-type voltage-gated calcium channel complex
    (GO:1990454)
  • Membrane depolarization during bundle of his cell action potential
    (GO:0086048)
  • Metal ion binding
    (GO:0046872)
  • Neuronal dense core vesicle
    (GO:0098992)
  • Plasma membrane
    (GO:0005886)
  • Presynaptic active zone membrane
    (GO:0048787)
  • Regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
    (GO:1902514)
  • Regulation of calcium ion transport
    (GO:0051924)
  • Regulation of heart rate by cardiac conduction
    (GO:0086091)
  • Regulation of membrane repolarization during action potential
    (GO:0098903)
  • Regulation of ventricular cardiac muscle cell membrane repolarization
    (GO:0060307)
  • Sarcoplasmic reticulum
    (GO:0016529)
  • Voltage-gated calcium channel activity
    (GO:0005245)
  • Voltage-gated calcium channel activity involved in bundle of his cell action potential
    (GO:0086057)
  • Voltage-gated calcium channel activity involved in cardiac muscle cell action potential
    (GO:0086007)
  • Voltage-gated calcium channel complex
    (GO:0005891)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 199.6303
    Cell Significance Index: -94.2500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 81.8650
    Cell Significance Index: -78.1600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 11.4077
    Cell Significance Index: 293.2300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 9.5019
    Cell Significance Index: 231.8400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 6.7547
    Cell Significance Index: 379.0400
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 5.7607
    Cell Significance Index: 92.9500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 5.0929
    Cell Significance Index: 342.4500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 5.0672
    Cell Significance Index: 388.8500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 4.4514
    Cell Significance Index: 76.2900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 4.4367
    Cell Significance Index: 126.6100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 3.4420
    Cell Significance Index: 152.2500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 3.3086
    Cell Significance Index: 125.2900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 3.2916
    Cell Significance Index: 660.3000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 3.0337
    Cell Significance Index: 59.2100
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 2.3777
    Cell Significance Index: 16.1100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.5621
    Cell Significance Index: 70.8100
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 1.3387
    Cell Significance Index: 13.9500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.6188
    Cell Significance Index: 427.9800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.5541
    Cell Significance Index: 34.0600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5130
    Cell Significance Index: 184.0100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.4993
    Cell Significance Index: 7.1700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.4554
    Cell Significance Index: 206.6700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4263
    Cell Significance Index: 42.1800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3825
    Cell Significance Index: 62.2200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2802
    Cell Significance Index: 8.9700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2323
    Cell Significance Index: 209.7200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.1836
    Cell Significance Index: 2.7100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1059
    Cell Significance Index: 162.9900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0596
    Cell Significance Index: 81.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0475
    Cell Significance Index: 89.3500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0197
    Cell Significance Index: 36.3900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0305
    Cell Significance Index: -1.8700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0507
    Cell Significance Index: -1.4600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0526
    Cell Significance Index: -1.8500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0626
    Cell Significance Index: -39.7500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0695
    Cell Significance Index: -51.5000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0888
    Cell Significance Index: -55.4700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1000
    Cell Significance Index: -2.6800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1152
    Cell Significance Index: -64.9700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.1167
    Cell Significance Index: -85.5600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.1170
    Cell Significance Index: -51.7500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.1399
    Cell Significance Index: -105.8800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.1495
    Cell Significance Index: -28.4600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.1719
    Cell Significance Index: -93.9000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.2200
    Cell Significance Index: -23.9300
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2524
    Cell Significance Index: -2.7500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2545
    Cell Significance Index: -34.9600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2790
    Cell Significance Index: -80.2700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2834
    Cell Significance Index: -41.2000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2851
    Cell Significance Index: -60.0400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.3531
    Cell Significance Index: -63.6500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3585
    Cell Significance Index: -37.3300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.4069
    Cell Significance Index: -80.7600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.4612
    Cell Significance Index: -78.7500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4664
    Cell Significance Index: -10.1100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.5346
    Cell Significance Index: -12.8200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.5614
    Cell Significance Index: -7.0000
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.5670
    Cell Significance Index: -7.1400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.5904
    Cell Significance Index: -75.6900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.5912
    Cell Significance Index: -40.8900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.6230
    Cell Significance Index: -76.6000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.6307
    Cell Significance Index: -13.8100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.7226
    Cell Significance Index: -93.3500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.8173
    Cell Significance Index: -95.2500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.8527
    Cell Significance Index: -51.1900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.8714
    Cell Significance Index: -99.8300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.8797
    Cell Significance Index: -100.4200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.9002
    Cell Significance Index: -28.6700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.9097
    Cell Significance Index: -92.9300
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.9646
    Cell Significance Index: -12.1800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.0202
    Cell Significance Index: -33.4000
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -1.0780
    Cell Significance Index: -14.3800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.1657
    Cell Significance Index: -92.3300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -1.1724
    Cell Significance Index: -82.9200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -1.1856
    Cell Significance Index: -88.3600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.1912
    Cell Significance Index: -75.0800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -1.2243
    Cell Significance Index: -18.4500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.2454
    Cell Significance Index: -65.3900
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -1.3105
    Cell Significance Index: -16.8100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -1.3819
    Cell Significance Index: -38.6200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -1.4585
    Cell Significance Index: -31.1800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -1.4626
    Cell Significance Index: -31.6000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -1.4869
    Cell Significance Index: -77.4500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -1.6005
    Cell Significance Index: -83.1400
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -1.6112
    Cell Significance Index: -19.5300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -1.6131
    Cell Significance Index: -75.2100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -1.6439
    Cell Significance Index: -77.2600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.6719
    Cell Significance Index: -58.5700
  • Cell Name: neural cell (CL0002319)
    Fold Change: -1.8871
    Cell Significance Index: -22.0200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -1.9051
    Cell Significance Index: -37.6700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -1.9756
    Cell Significance Index: -49.2800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -2.0606
    Cell Significance Index: -42.7500
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -2.1155
    Cell Significance Index: -15.3800
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -2.2544
    Cell Significance Index: -21.4500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -2.3123
    Cell Significance Index: -39.9800
  • Cell Name: neuron (CL0000540)
    Fold Change: -2.3620
    Cell Significance Index: -22.3900
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -2.3794
    Cell Significance Index: -15.4800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -2.4978
    Cell Significance Index: -108.6100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -2.5285
    Cell Significance Index: -92.8200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -2.5543
    Cell Significance Index: -51.2800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure:** The alpha2delta 1 subunit is a small, cytoplasmic protein that associates with the alpha1 subunit of the L-type calcium channel to form a functional calcium channel complex. 2. **Function:** CACNA2D1 regulates calcium ion transport across the plasma membrane and into the cytosol, influencing various cellular processes, including cardiac muscle contraction, neuronal function, and cell signaling. 3. **Expression:** CACNA2D1 is widely expressed in various tissues, including neuronal and cardiac tissues, and is also found in extracellular exosomes and dense core vesicles. 4. **Regulation:** CACNA2D1 is regulated by various factors, including calcium ion binding, phosphorylation, and interaction with other proteins. **Pathways and Functions:** 1. **Calcium Ion Transport:** CACNA2D1 regulates calcium ion transport across the plasma membrane and into the cytosol, influencing various cellular processes, including cardiac muscle contraction, neuronal function, and cell signaling. 2. **Cardiac Muscle Contraction:** CACNA2D1 is essential for regulating cardiac muscle contraction, as it modulates the activity of L-type calcium channels, which are critical for the contraction of cardiac muscle cells. 3. **Neuronal Function:** CACNA2D1 is involved in regulating neuronal function, including neurotransmitter release and synaptic plasticity, through its modulation of calcium ion transport. 4. **Cell Signaling:** CACNA2D1 is also involved in cell signaling pathways, including the regulation of calcium-dependent signaling cascades. 5. **Regulation of Heart Rate:** CACNA2D1 regulates heart rate by modulating the activity of L-type calcium channels in cardiac conduction cells. **Clinical Significance:** 1. **Cardiac Arrhythmias:** Mutations in CACNA2D1 have been implicated in cardiac arrhythmias, including long QT syndrome and Brugada syndrome. 2. **Neurodegenerative Disorders:** CACNA2D1 has been implicated in neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease, where it plays a role in regulating calcium ion transport and neuronal function. 3. **Cancer:** CACNA2D1 has been found to be overexpressed in various types of cancer, including breast cancer and prostate cancer, where it may contribute to tumorigenesis and metastasis. 4. **Therapeutic Targets:** CACNA2D1 is a potential therapeutic target for the treatment of various diseases, including cardiac arrhythmias, neurodegenerative disorders, and cancer. In conclusion, CACNA2D1 is a crucial gene that plays a pivotal role in regulating calcium ion transport and cardiac function. Its dysregulation has been implicated in various diseases, including cardiac arrhythmias, neurodegenerative disorders, and cancer. Further research is needed to fully understand the mechanisms by which CACNA2D1 regulates calcium ion transport and to identify potential therapeutic targets for the treatment of these diseases.

Genular Protein ID: 3494326383

Symbol: CA2D1_HUMAN

Name: Voltage-dependent calcium channel subunit alpha-2/delta-1

UniProtKB Accession Codes:

P54289 Q17R45 Q9UD80 Q9UD81 Q9UD82

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CORUM 1 CTD 1 ChEBI 3 ChEMBL 1 ChiTaRS 1 ComplexPortal 8 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 17 DrugCentral 1 EMBL 4 EMDB 29 Ensembl 2 ExpressionAtlas 1 GO 21 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 29 PDBsum 29 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 RefSeq 5 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1309651

Title: Structure and functional expression of alpha 1, alpha 2, and beta subunits of a novel human neuronal calcium channel subtype.

PubMed ID: 1309651

DOI: 10.1016/0896-6273(92)90109-q

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8107964

Title: Human neuronal voltage-dependent calcium channels: studies on subunit structure and role in channel assembly.

PubMed ID: 8107964

DOI: 10.1016/0028-3908(93)90004-m

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 22054663

Title: Identification of a disulfide bridge essential for structure and function of the voltage-gated Ca(2+) channel alpha(2)delta-1 auxiliary subunit.

PubMed ID: 22054663

DOI: 10.1016/j.ceca.2011.10.002

PubMed ID: 34234349

Title: Structure of human Cav2.2 channel blocked by the painkiller ziconotide.

PubMed ID: 34234349

DOI: 10.1038/s41586-021-03699-6

PubMed ID: 35293990

Title: Biallelic CACNA2D1 loss-of-function variants cause early-onset developmental epileptic encephalopathy.

PubMed ID: 35293990

DOI: 10.1093/brain/awac081

Sequence Information:

  • Length: 1103
  • Mass: 124568
  • Checksum: 0749685DE9DB0700
  • Sequence:
    • MAAGCLLALT LTLFQSLLIG PSSEEPFPSA VTIKSWVDKM QEDLVTLAKT ASGVNQLVDI 
YEKYQDLYTV EPNNARQLVE IAARDIEKLL SNRSKALVRL ALEAEKVQAA HQWREDFASN 
EVVYYNAKDD LDPEKNDSEP GSQRIKPVFI EDANFGRQIS YQHAAVHIPT DIYEGSTIVL 
NELNWTSALD EVFKKNREED PSLLWQVFGS ATGLARYYPA SPWVDNSRTP NKIDLYDVRR 
RPWYIQGAAS PKDMLILVDV SGSVSGLTLK LIRTSVSEML ETLSDDDFVN VASFNSNAQD 
VSCFQHLVQA NVRNKKVLKD AVNNITAKGI TDYKKGFSFA FEQLLNYNVS RANCNKIIML 
FTDGGEERAQ EIFNKYNKDK KVRVFTFSVG QHNYDRGPIQ WMACENKGYY YEIPSIGAIR 
INTQEYLDVL GRPMVLAGDK AKQVQWTNVY LDALELGLVI TGTLPVFNIT GQFENKTNLK 
NQLILGVMGV DVSLEDIKRL TPRFTLCPNG YYFAIDPNGY VLLHPNLQPK PIGVGIPTIN 
LRKRRPNIQN PKSQEPVTLD FLDAELENDI KVEIRNKMID GESGEKTFRT LVKSQDERYI 
DKGNRTYTWT PVNGTDYSLA LVLPTYSFYY IKAKLEETIT QARYSETLKP DNFEESGYTF 
IAPRDYCNDL KISDNNTEFL LNFNEFIDRK TPNNPSCNAD LINRVLLDAG FTNELVQNYW 
SKQKNIKGVK ARFVVTDGGI TRVYPKEAGE NWQENPETYE DSFYKRSLDN DNYVFTAPYF 
NKSGPGAYES GIMVSKAVEI YIQGKLLKPA VVGIKIDVNS WIENFTKTSI RDPCAGPVCD 
CKRNSDVMDC VILDDGGFLL MANHDDYTNQ IGRFFGEIDP SLMRHLVNIS VYAFNKSYDY 
QSVCEPGAAP KQGAGHRSAY VPSVADILQI GWWATAAAWS ILQQFLLSLT FPRLLEAVEM 
EDDDFTASLS KQSCITEQTQ YFFDNDSKSF SGVLDCGNCS RIFHGEKLMN TNLIFIMVES 
KGTCPCDTRL LIQAEQTSDG PNPCDMVKQP RYRKGPDVCF DNNVLEDYTD CGGVSGLNPS 
LWYIIGIQFL LLWLVSGSTH RLL

Genular Protein ID: 1996319903

Symbol: E7ERK3_HUMAN

Name: N/A

UniProtKB Accession Codes:

E7ERK3

Database IDs:

ARBA 3 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 ExpressionAtlas 1 GO 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 3 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 2 Pfam 2 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 309
  • Mass: 34621
  • Checksum: 7A3D8ADCAA481D7C
  • Sequence:
    • MAAGCLLALT LTLFQSLLIG PSSEEPFPSA VTIKSWVDKM QEDLVTLAKT ASGVNQLVDI 
YEKYQDLYTV EPNNARQLVE IAARDIEKLL SNRSKALVRL ALEAEKVQAA HQWREDFASN 
EVVYYNAKDD LDPEKNDSEP GSQRIKPVFI EDANFGRQIS YQHAAVHIPT DIYEGSTIVL 
NELNWTSALD EVFKKNREED PSLLWQVFGS ATGLARYYPA SPWVDNSRTP NKIDLYDVRR 
RPWYIQGAAS PKDMLILVDV SGSVSGLTLK LIRTSVSEML ETLSDDDFVN VASDSKEISP 
SPEEIFNAE

Genular Protein ID: 882760827

Symbol: Q9UIU0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9UIU0

Database IDs:

ARBA 8 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 38 GO 2 Gene3D 2 IntAct 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 3 Reactome 1 RefSeq 1 SAM 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 10534405

Title: Genomic structure and functional expression of a human alpha(2)/delta calcium channel subunit gene (CACNA2).

PubMed ID: 10534405

DOI: 10.1006/geno.1999.5941

Sequence Information:

  • Length: 1110
  • Mass: 125308
  • Checksum: 8358DC6AD489C074
  • Sequence:
    • MAAGCLLALT LTLFQSLLIG PSSEEPFPSA VTIKSWVDKM QEDLVTLAKT ASGVNQLVDI 
YEKYQDLYTV EPNNARQLVE IAARDIEKLL SNRSKALVRL ALEAEKVQAA HQWREDFASN 
EVVYYNAKDD LDPEKNDSEP GSQRIKPVFI EDANFGRQIS YQHAAVHIPT DIYEGSTIVL 
NELNWTSALD EVFKKNREED PSLLWQVFGS ATGLARYYPA SPWVDNSRTP NKIDLYDVRR 
RPWYIQGAAS PKDMLILVDV SGSVSGLTLK LIRTSVSEML ETLSDDDFVN VASFNSNAQD 
VSCFQHLVQA NVRNKKVLKD AVNNITAKGI TDYKKGFSFA FEQLLNYNVS RANCNKIIML 
FTDGGEERAQ EIFNKYNKDK KVRVFTFSVG QHNYDRGPIQ WMACENKGYY YEIPSIGAIR 
INTQEYLDVL GRPMVLAGDK AKQVQWTNVY LDALELGLVI TGTLPVFNIT GQFENKTNLK 
NQLILGVMGV DVSLEDIKRL TPRFTLCPNG YYFAIDPNGY VLLHPNLQPK PIGVGIPTIN 
LRKRRPNIQN PKSQEPVTLD FLDAELENDI KVEIRNKMID GESGEKTFRT LVKSQDERYI 
DKGNRTYTWT PVNGTDYSLA LVLPTYSFYY IKAKLEETIT QARSKKGKMK DSETLKPDNF 
EESGYTFIAP RDYCNDLKIS DNNTEFLLNF NEFIDRKTPN NPSCNADLIN RVLLDAGFTN 
ELVQNYWSKQ KNIKGVKARF VVTDGGITRV YPKEAGENWQ ENPETYEDSF YKRSLDNDNY 
VFTAPYFNKS GPGAYESGIM VSKAVEIYIQ GKLLKPAVVG IKIDVNSWIE NFTKTSIRDP 
CAGPVCDCKR NSDVMDCVIL DDGGFLLMAN HDDYTNQIGR FFGEIDPSLM RHLVNISVYA 
FNKSYDYQSV CEPGAAPKQG AGHRSAYVPS VADILQIGWW ATAAAWSILQ QFLLSLTFPR 
LLEAVEMEDD DFTASLSKQS CITEQTQYFF DNDSKSFSGV LDCGNCSRIF HGEKLMNTNL 
IFIMVESKGT CPCDTRLLIQ AEQTSDGPNP CDMVKQPRYR KGPDVCFDNN VLEDYTDCGG 
VSGLNPSLWY IIGIQFLLLW LVSGSTHRLL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.