Details for: CACNA2D1

Gene ID: 781

Symbol: CACNA2D1

Ensembl ID: ENSG00000153956

Description: calcium voltage-gated channel auxiliary subunit alpha2delta 1

Associated with

  • Calcium ion import across plasma membrane
    (GO:0098703)
  • Calcium ion transmembrane transport via high voltage-gated calcium channel
    (GO:0061577)
  • Calcium ion transport
    (GO:0006816)
  • Calcium ion transport into cytosol
    (GO:0060402)
  • Cardiac muscle cell action potential involved in contraction
    (GO:0086002)
  • Cellular response to amyloid-beta
    (GO:1904646)
  • Extracellular exosome
    (GO:0070062)
  • Gaba-ergic synapse
    (GO:0098982)
  • L-type voltage-gated calcium channel complex
    (GO:1990454)
  • Membrane depolarization during bundle of his cell action potential
    (GO:0086048)
  • Metal ion binding
    (GO:0046872)
  • Neuronal dense core vesicle
    (GO:0098992)
  • Plasma membrane
    (GO:0005886)
  • Presynaptic active zone membrane
    (GO:0048787)
  • Regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
    (GO:1902514)
  • Regulation of calcium ion transport
    (GO:0051924)
  • Regulation of heart rate by cardiac conduction
    (GO:0086091)
  • Regulation of membrane repolarization during action potential
    (GO:0098903)
  • Regulation of ventricular cardiac muscle cell membrane repolarization
    (GO:0060307)
  • Sarcoplasmic reticulum
    (GO:0016529)
  • Voltage-gated calcium channel activity
    (GO:0005245)
  • Voltage-gated calcium channel activity involved in bundle of his cell action potential
    (GO:0086057)
  • Voltage-gated calcium channel activity involved in cardiac muscle cell action potential
    (GO:0086007)
  • Voltage-gated calcium channel complex
    (GO:0005891)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3
    Cell Significance Index: 1
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.18
    Cell Significance Index: 1
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.14
    Cell Significance Index: 1
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.1
    Cell Significance Index: 1
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.1
    Cell Significance Index: 1
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.06
    Cell Significance Index: 1
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.05
    Cell Significance Index: 1
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 1.04
    Cell Significance Index: 1
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.03
    Cell Significance Index: 1
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.01
    Cell Significance Index: 1
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 1.01
    Cell Significance Index: 1
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: cell (CL0000000)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: glioblast (CL0000030)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron (CL4030065)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: Merkel cell (CL0000242)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: flat midget bipolar cell (CL4033033)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: invaginating midget bipolar cell (CL4033034)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: mural cell (CL0008034)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: diffuse bipolar 2 cell (CL4033028)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: L5 intratelencephalic projecting glutamatergic neuron (CL4030064)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: diffuse bipolar 1 cell (CL4033027)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: medial ganglionic eminence derived GABAergic cortical interneuron (CL4023069)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: H1 horizontal cell (CL0004217)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: diffuse bipolar 4 cell (CL4033031)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: diffuse bipolar 3a cell (CL4033029)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.98
    Cell Significance Index: 1

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure:** The alpha2delta 1 subunit is a small, cytoplasmic protein that associates with the alpha1 subunit of the L-type calcium channel to form a functional calcium channel complex. 2. **Function:** CACNA2D1 regulates calcium ion transport across the plasma membrane and into the cytosol, influencing various cellular processes, including cardiac muscle contraction, neuronal function, and cell signaling. 3. **Expression:** CACNA2D1 is widely expressed in various tissues, including neuronal and cardiac tissues, and is also found in extracellular exosomes and dense core vesicles. 4. **Regulation:** CACNA2D1 is regulated by various factors, including calcium ion binding, phosphorylation, and interaction with other proteins. **Pathways and Functions:** 1. **Calcium Ion Transport:** CACNA2D1 regulates calcium ion transport across the plasma membrane and into the cytosol, influencing various cellular processes, including cardiac muscle contraction, neuronal function, and cell signaling. 2. **Cardiac Muscle Contraction:** CACNA2D1 is essential for regulating cardiac muscle contraction, as it modulates the activity of L-type calcium channels, which are critical for the contraction of cardiac muscle cells. 3. **Neuronal Function:** CACNA2D1 is involved in regulating neuronal function, including neurotransmitter release and synaptic plasticity, through its modulation of calcium ion transport. 4. **Cell Signaling:** CACNA2D1 is also involved in cell signaling pathways, including the regulation of calcium-dependent signaling cascades. 5. **Regulation of Heart Rate:** CACNA2D1 regulates heart rate by modulating the activity of L-type calcium channels in cardiac conduction cells. **Clinical Significance:** 1. **Cardiac Arrhythmias:** Mutations in CACNA2D1 have been implicated in cardiac arrhythmias, including long QT syndrome and Brugada syndrome. 2. **Neurodegenerative Disorders:** CACNA2D1 has been implicated in neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease, where it plays a role in regulating calcium ion transport and neuronal function. 3. **Cancer:** CACNA2D1 has been found to be overexpressed in various types of cancer, including breast cancer and prostate cancer, where it may contribute to tumorigenesis and metastasis. 4. **Therapeutic Targets:** CACNA2D1 is a potential therapeutic target for the treatment of various diseases, including cardiac arrhythmias, neurodegenerative disorders, and cancer. In conclusion, CACNA2D1 is a crucial gene that plays a pivotal role in regulating calcium ion transport and cardiac function. Its dysregulation has been implicated in various diseases, including cardiac arrhythmias, neurodegenerative disorders, and cancer. Further research is needed to fully understand the mechanisms by which CACNA2D1 regulates calcium ion transport and to identify potential therapeutic targets for the treatment of these diseases.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.